UniProtKB - Q91VH1 (PAQR1_MOUSE)
Protein
Adiponectin receptor protein 1
Gene
Adipor1
Organism
Mus musculus (Mouse)
Status
Functioni
Receptor for ADIPOQ, an essential hormone secreted by adipocytes that regulates glucose and lipid metabolism (PubMed:17327425, PubMed:17268472, PubMed:24742672). Required for normal glucose and fat homeostasis and for maintaining a normal body weight (PubMed:17327425, PubMed:24742672). ADIPOQ-binding activates a signaling cascade that leads to increased AMPK activity, and ultimately to increased fatty acid oxidation, increased glucose uptake and decreased gluconeogenesis (PubMed:12802337, PubMed:17327425, PubMed:17268472, PubMed:24742672). Has high affinity for globular adiponectin and low affinity for full-length adiponectin (PubMed:12802337).4 Publications
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 191 | ZincBy similarity | 1 | |
Metal bindingi | 337 | ZincBy similarity | 1 | |
Metal bindingi | 341 | ZincBy similarity | 1 |
GO - Molecular functioni
- adipokinetic hormone receptor activity Source: UniProtKB
- adiponectin binding Source: MGI
- identical protein binding Source: MGI
- metal ion binding Source: UniProtKB-KW
- protein kinase binding Source: MGI
- signaling receptor activity Source: MGI
GO - Biological processi
- adiponectin-activated signaling pathway Source: MGI
- fatty acid oxidation Source: UniProtKB
- glucose homeostasis Source: UniProtKB
- hormone-mediated signaling pathway Source: UniProtKB
- leptin-mediated signaling pathway Source: MGI
- negative regulation of cell growth Source: MGI
- negative regulation of epithelial cell migration Source: MGI
- negative regulation of epithelial to mesenchymal transition Source: MGI
- negative regulation of NIK/NF-kappaB signaling Source: MGI
- negative regulation of receptor signaling pathway via JAK-STAT Source: MGI
- positive regulation of cold-induced thermogenesis Source: YuBioLab
- positive regulation of insulin receptor signaling pathway Source: MGI
- positive regulation of receptor signaling pathway via JAK-STAT Source: MGI
- regulation of glucose metabolic process Source: UniProtKB
- regulation of lipid metabolic process Source: UniProtKB
Keywordsi
Molecular function | Receptor |
Biological process | Fatty acid metabolism, Lipid metabolism |
Ligand | Metal-binding, Zinc |
Enzyme and pathway databases
Reactomei | R-MMU-163680, AMPK inhibits chREBP transcriptional activation activity |
Names & Taxonomyi
Protein namesi | Recommended name: Adiponectin receptor protein 11 PublicationAlternative name(s): Progestin and adipoQ receptor family member 1By similarity Progestin and adipoQ receptor family member I |
Gene namesi | |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1919924, Adipor1 |
Subcellular locationi
Plasma membrane
- Cell membrane 1 Publication; Multi-pass membrane protein By similarity
Note: Localized to the cell membrane and intracellular organelles.By similarity
Plasma Membrane
- intrinsic component of plasma membrane Source: UniProtKB
- plasma membrane Source: MGI
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 136 | CytoplasmicBy similarityAdd BLAST | 136 | |
Transmembranei | 137 – 157 | Helical; Name=1By similarityAdd BLAST | 21 | |
Topological domaini | 158 – 170 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 171 – 191 | Helical; Name=2By similarityAdd BLAST | 21 | |
Topological domaini | 192 – 203 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 204 – 224 | Helical; Name=3By similarityAdd BLAST | 21 | |
Topological domaini | 225 – 234 | ExtracellularBy similarity | 10 | |
Transmembranei | 235 – 255 | Helical; Name=4By similarityAdd BLAST | 21 | |
Topological domaini | 256 – 264 | CytoplasmicBy similarity | 9 | |
Transmembranei | 265 – 285 | Helical; Name=5By similarityAdd BLAST | 21 | |
Topological domaini | 286 – 298 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 299 – 319 | Helical; Name=6By similarityAdd BLAST | 21 | |
Topological domaini | 320 – 337 | CytoplasmicBy similarityAdd BLAST | 18 | |
Transmembranei | 338 – 358 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 359 – 375 | ExtracellularBy similarityAdd BLAST | 17 |
Keywords - Cellular componenti
Cell membrane, MembranePathology & Biotechi
Disruption phenotypei
Mutant mice are viable and fertile, but display defects in glucose and lipid homeostasis. The precise phenotype may depend on experimental details and genetic background. Mutant mice have normal body weight, but increased plasma glucose and insulin levels (PubMed:17268472). Mutant male mice, but not female mice, display increased body weight gain on standard chow, in spite of similar food intake as wild-type (PubMed:17327425). Mutant mice display increased body weight, both on standard chow and on high fat and high sucrose diet (PubMed:24742672). Male mice have increased total body fat mass after 15 weeks, and have increased weights of both white and brown adipose tissue (PubMed:17327425, PubMed:24742672). Mutant mice have impaired glucose tolerance (PubMed:24742672). Male mice have decreased glucose tolerance, but no significant change in the insulin response (PubMed:17327425). Female mice display increased fasting glucose levels, but unchanged fasting insulin levels (PubMed:17327425). Male and female mice display increased levels of liver triglycerides relative to wild-type (PubMed:17327425, PubMed:24742672). Male mice display decreased locomotor activity and decreased energy expenditure relative to wild-type (PubMed:17327425). Mutant mice display normal revascularization after chronic limb ischemia caused by severing of blood vessels (PubMed:24742672). Hepatocytes from mice lacking both Adipor1 and Adipor2 show loss of adiponectin binding and lack of adiponectin-mediated activation of AMPK and Ppara (PubMed:17268472). Mice lacking both Adipor1 and Adipor2 display elevated glucose and insulin levels in blood plasma, indicative of glucose intolerance and insulin resistance (PubMed:17268472).3 Publications
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000218828 | 1 – 375 | Adiponectin receptor protein 1Add BLAST | 375 |
Proteomic databases
MaxQBi | Q91VH1 |
PaxDbi | Q91VH1 |
PRIDEi | Q91VH1 |
PTM databases
iPTMneti | Q91VH1 |
PhosphoSitePlusi | Q91VH1 |
Expressioni
Tissue specificityi
Detected in brain and quadriceps muscle (at protein level) (PubMed:17327425). Widely expressed (PubMed:12802337). Expressed in heart, kidney, liver, lung, skeletal muscle, white adipose tissue, brown adipose tissue, aorta and spleen (PubMed:12802337, PubMed:24742672). Weakly expressed in brain and testis (PubMed:12802337).4 Publications
Gene expression databases
Bgeei | ENSMUSG00000026457, Expressed in blood and 325 other tissues |
Genevisiblei | Q91VH1, MM |
Interactioni
Subunit structurei
May form homooligomers and heterooligomers with ADIPOR2 (By similarity).
Interacts with APPL2 (via BAR domain); hinders the accessibility of APPL1 to ADIPOR1; negatively regulates adiponectin signaling; ADIPOQ dissociates this interaction and facilitates the recruitment of APPL1 to ADIPOR1 (PubMed:19661063).
Interacts with APPL1; ADIPOQ enhances this interaction; inhibites adiponectin-stimulated binding of APPL2 to ADIPOR1 (PubMed:19661063).
By similarity1 PublicationBinary interactionsi
Q91VH1
With | #Exp. | IntAct |
---|---|---|
APPL1 [Q9UKG1] from Homo sapiens. | 3 | EBI-992398,EBI-741243 |
GO - Molecular functioni
- adiponectin binding Source: MGI
- identical protein binding Source: MGI
- protein kinase binding Source: MGI
Protein-protein interaction databases
IntActi | Q91VH1, 2 interactors |
STRINGi | 10090.ENSMUSP00000107856 |
Miscellaneous databases
RNActi | Q91VH1, protein |
Family & Domainsi
Domaini
The N-terminus is cytoplasmic and the C-terminus is extracellular, contrary to what is observed for G-protein coupled receptors. Unlike G-protein coupled receptors, transmembrane helices are not kinked or tilted relative to the plane of the membrane.By similarity
Sequence similaritiesi
Belongs to the ADIPOR family.Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000154563 |
HOGENOMi | CLU_023075_1_0_1 |
InParanoidi | Q91VH1 |
OMAi | RVTVGEC |
OrthoDBi | 1524940at2759 |
PhylomeDBi | Q91VH1 |
TreeFami | TF313640 |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91VH1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSHKGSAGA QGNGAPSGNR EADTVELAEL GPLLEEKGKR AASSPAKAEE
60 70 80 90 100
DQACPVPQEE EEEVRVLTLP LQAHHAMEKM EEFVYKVWEG RWRVIPYDVL
110 120 130 140 150
PDWLKDNDYL LHGHRPPMPS FRACFKSIFR IHTETGNIWT HLLGFVLFLF
160 170 180 190 200
LGILTMLRPN MYFMAPLQEK VVFGMFFLGA VLCLSFSWLF HTVYCHSEKV
210 220 230 240 250
SRTFSKLDYS GIALLIMGSF VPWLYYSFYC SPQPRLIYLS IVCVLGISAI
260 270 280 290 300
IVAQWDRFAT PKHRQTRAGV FLGLGLSGVV PTMHFTIAEG FVKATTVGQM
310 320 330 340 350
GWFFLMAVMY ITGAGLYAAR IPERFFPGKF DIWFQSHQIF HVLVVAAAFV
360 370
HFYGVSNLQE FRYGLEGGCT DDSLL
Sequence cautioni
The sequence BAB28509 differs from that shown. Reason: Frameshift. This frameshift abolishes the stop codon.Curated
The sequence BAB28509 differs from that shown. Reason: Erroneous termination. Truncated C-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012847 mRNA Translation: BAB28509.1 Sequence problems. BC014875 mRNA Translation: AAH14875.1 |
CCDSi | CCDS15309.1 |
RefSeqi | NP_001292998.1, NM_001306069.1 NP_082596.2, NM_028320.4 |
Genome annotation databases
Ensembli | ENSMUST00000027727; ENSMUSP00000027727; ENSMUSG00000026457 ENSMUST00000112237; ENSMUSP00000107856; ENSMUSG00000026457 |
GeneIDi | 72674 |
KEGGi | mmu:72674 |
UCSCi | uc007crx.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK012847 mRNA Translation: BAB28509.1 Sequence problems. BC014875 mRNA Translation: AAH14875.1 |
CCDSi | CCDS15309.1 |
RefSeqi | NP_001292998.1, NM_001306069.1 NP_082596.2, NM_028320.4 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q91VH1, 2 interactors |
STRINGi | 10090.ENSMUSP00000107856 |
PTM databases
iPTMneti | Q91VH1 |
PhosphoSitePlusi | Q91VH1 |
Proteomic databases
MaxQBi | Q91VH1 |
PaxDbi | Q91VH1 |
PRIDEi | Q91VH1 |
Protocols and materials databases
Antibodypediai | 34534, 400 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000027727; ENSMUSP00000027727; ENSMUSG00000026457 ENSMUST00000112237; ENSMUSP00000107856; ENSMUSG00000026457 |
GeneIDi | 72674 |
KEGGi | mmu:72674 |
UCSCi | uc007crx.1, mouse |
Organism-specific databases
CTDi | 51094 |
MGIi | MGI:1919924, Adipor1 |
Phylogenomic databases
eggNOGi | KOG0748, Eukaryota |
GeneTreei | ENSGT00940000154563 |
HOGENOMi | CLU_023075_1_0_1 |
InParanoidi | Q91VH1 |
OMAi | RVTVGEC |
OrthoDBi | 1524940at2759 |
PhylomeDBi | Q91VH1 |
TreeFami | TF313640 |
Enzyme and pathway databases
Reactomei | R-MMU-163680, AMPK inhibits chREBP transcriptional activation activity |
Miscellaneous databases
BioGRID-ORCSi | 72674, 5 hits in 17 CRISPR screens |
ChiTaRSi | Adipor1, mouse |
PROi | PR:Q91VH1 |
RNActi | Q91VH1, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026457, Expressed in blood and 325 other tissues |
Genevisiblei | Q91VH1, MM |
Family and domain databases
InterProi | View protein in InterPro IPR004254, AdipoR/HlyIII-related |
PANTHERi | PTHR20855, PTHR20855, 1 hit |
Pfami | View protein in Pfam PF03006, HlyIII, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | PAQR1_MOUSE | |
Accessioni | Q91VH1Primary (citable) accession number: Q91VH1 Secondary accession number(s): Q9CZA0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 14, 2003 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 135 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families