Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Collagen alpha-1(XXVI) chain

Gene

Col26a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • positive regulation of cell-substrate adhesion Source: MGI

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXVI) chain
Alternative name(s):
Alpha-1 type XXVI collagen
EMI domain-containing protein 2
Emilin and multimerin domain-containing protein 2
Short name:
Emu2
Gene namesi
Name:Col26a1
Synonyms:Col26a, Emid2, Emu2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2155345 Col26a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Extracellular matrix, Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_000000782621 – 440Collagen alpha-1(XXVI) chainAdd BLAST420

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi56 ↔ 118PROSITE-ProRule annotation
Glycosylationi70N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi83 ↔ 89PROSITE-ProRule annotation
Disulfide bondi117 ↔ 126PROSITE-ProRule annotation
Glycosylationi132N-linked (GlcNAc...) asparagineSequence analysis1

Post-translational modificationi

Hydroxylated on proline residues.
N-glycosylated.

Keywords - PTMi

Disulfide bond, Glycoprotein, Hydroxylation

Proteomic databases

PaxDbiQ91VF6
PRIDEiQ91VF6

PTM databases

iPTMnetiQ91VF6
PhosphoSitePlusiQ91VF6

Expressioni

Tissue specificityi

Specifically expressed in the testis and ovary in adult tissues.1 Publication

Developmental stagei

At E9.5 it is expressed in the somites and in mesenchymal cells of the head and the branchial arches. At E14.5 it is expressed in the surrounding mesenchyme of the kidney and the inner ear. Expression is also observed in the spinal nerves and ganglia, the mesenchyme of the skull, the diaphragm, and the skeletal muscles.

Gene expression databases

BgeeiENSMUSG00000004415 Expressed in 162 organ(s), highest expression level in ear vesicle
CleanExiMM_EMID2
GenevisibleiQ91VF6 MM

Interactioni

Subunit structurei

Homotrimer or heterotrimer.

Protein-protein interaction databases

ComplexPortaliCPX-3007 Collagen type XXVI trimer
STRINGi10090.ENSMUSP00000052095

Structurei

3D structure databases

ProteinModelPortaliQ91VF6
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini52 – 128EMIPROSITE-ProRule annotationAdd BLAST77
Domaini199 – 267Collagen-like 1Add BLAST69
Domaini302 – 334Collagen-like 2Add BLAST33

Keywords - Domaini

Collagen, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IFDY Eukaryota
ENOG410YHYD LUCA
GeneTreeiENSGT00660000095314
HOGENOMiHOG000038011
HOVERGENiHBG096014
InParanoidiQ91VF6
OMAiPPPWNED
OrthoDBiEOG091G0C3E
PhylomeDBiQ91VF6
TreeFamiTF336589

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011489 EMI_domain
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF07546 EMI, 1 hit
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q91VF6-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MKLVLLLPWA CCCLCGSALA TGFLYPFPAA ALQQHGYPEQ GAGSPGNGYS
60 70 80 90 100
SRRHWCHHTV TRTVSCQVQN GSETVVQRVY QSCRWPGPCA NLVSYRTLIR
110 120 130 140 150
PTYRVSYRTV TALEWRCCPG FTGSNCEEEC MNCTRLSDMS ERLTTLEAKV
160 170 180 190 200
LLLEAAEQPS GPDNDLPPPQ STPPTWNEDF LPDAIPIAHP GPRRRRPTGP
210 220 230 240 250
AGPPGQMGPP GPAGPPGSKG EQGQTGEKGP VGPPGLLGPP GPRGLPGEMG
260 270 280 290 300
RPGPPGPPGP AGSPGLLPNT PQGVLYSLQT PTDKENGDSQ LNPAVVDTVL
310 320 330 340 350
TGIPGPRGPP GPPGPPGPHG PPGPPGAPGS QGLVDERVVA RPSGEPSVKE
360 370 380 390 400
EEDKASAAEG EGVQQLREAL KILAERVLIL EHMIGVHDPL ASPEGGSGQD
410 420 430 440
AALRANLKMK RGGPRPDGIL AALLGPDPAQ KSADQAGDRK
Length:440
Mass (Da):45,810
Last modified:December 1, 2001 - v1
Checksum:i10843475F53A2BB0
GO
Isoform 2 (identifier: Q91VF6-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     94-95: Missing.

Note: May be due to a competing acceptor splice site.
Show »
Length:438
Mass (Da):45,560
Checksum:i39B82CC8401F88BD
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00844894 – 95Missing in isoform 2. 2 Publications2

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085837 mRNA Translation: BAB96760.1
AJ416092 mRNA Translation: CAC94779.1
BC075713 mRNA Translation: AAH75713.1
CCDSiCCDS19755.1 [Q91VF6-1]
CCDS84976.1 [Q91VF6-2]
RefSeqiNP_001333628.1, NM_001346699.1 [Q91VF6-2]
NP_077794.2, NM_024474.2 [Q91VF6-1]
UniGeneiMm.295020

Genome annotation databases

EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415 [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415 [Q91VF6-2]
GeneIDi140709
KEGGimmu:140709
UCSCiuc009aay.1 mouse [Q91VF6-1]
uc009aaz.1 mouse [Q91VF6-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085837 mRNA Translation: BAB96760.1
AJ416092 mRNA Translation: CAC94779.1
BC075713 mRNA Translation: AAH75713.1
CCDSiCCDS19755.1 [Q91VF6-1]
CCDS84976.1 [Q91VF6-2]
RefSeqiNP_001333628.1, NM_001346699.1 [Q91VF6-2]
NP_077794.2, NM_024474.2 [Q91VF6-1]
UniGeneiMm.295020

3D structure databases

ProteinModelPortaliQ91VF6
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-3007 Collagen type XXVI trimer
STRINGi10090.ENSMUSP00000052095

PTM databases

iPTMnetiQ91VF6
PhosphoSitePlusiQ91VF6

Proteomic databases

PaxDbiQ91VF6
PRIDEiQ91VF6

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000057497; ENSMUSP00000052095; ENSMUSG00000004415 [Q91VF6-1]
ENSMUST00000111103; ENSMUSP00000106732; ENSMUSG00000004415 [Q91VF6-2]
GeneIDi140709
KEGGimmu:140709
UCSCiuc009aay.1 mouse [Q91VF6-1]
uc009aaz.1 mouse [Q91VF6-2]

Organism-specific databases

CTDi136227
MGIiMGI:2155345 Col26a1

Phylogenomic databases

eggNOGiENOG410IFDY Eukaryota
ENOG410YHYD LUCA
GeneTreeiENSGT00660000095314
HOGENOMiHOG000038011
HOVERGENiHBG096014
InParanoidiQ91VF6
OMAiPPPWNED
OrthoDBiEOG091G0C3E
PhylomeDBiQ91VF6
TreeFamiTF336589

Enzyme and pathway databases

ReactomeiR-MMU-1442490 Collagen degradation
R-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Miscellaneous databases

PROiPR:Q91VF6
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000004415 Expressed in 162 organ(s), highest expression level in ear vesicle
CleanExiMM_EMID2
GenevisibleiQ91VF6 MM

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
IPR011489 EMI_domain
PfamiView protein in Pfam
PF01391 Collagen, 2 hits
PF07546 EMI, 1 hit
PROSITEiView protein in PROSITE
PS51041 EMI, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCOQA1_MOUSE
AccessioniPrimary (citable) accession number: Q91VF6
Secondary accession number(s): Q8K4P3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2003
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again