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Protein

Histamine N-methyltransferase

Gene

Hnmt

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=5.8 µM for S-adenosyl-L-methionine1 Publication
  2. KM=5.3 µM for histamine1 Publication

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘Function’ section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei28SubstratePROSITE-ProRule annotation1
    Binding sitei60S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
    Binding sitei89S-adenosyl-L-methioninePROSITE-ProRule annotation1
    Binding sitei94S-adenosyl-L-methioninePROSITE-ProRule annotation1
    Binding sitei120S-adenosyl-L-methionine; via amide nitrogenPROSITE-ProRule annotation1
    Binding sitei143S-adenosyl-L-methionine; via carbonyl oxygenPROSITE-ProRule annotation1
    Binding sitei284SubstratePROSITE-ProRule annotation1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    • histamine N-methyltransferase activity Source: UniProtKB
    • N-methyltransferase activity Source: MGI

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionMethyltransferase, Transferase
    LigandS-adenosyl-L-methionine

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-70921 Histidine catabolism

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Histamine N-methyltransferase (EC:2.1.1.81 Publication)
    Short name:
    HMT
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Hnmt
    Synonyms:Hmt
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:2153181 Hnmt

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000840221 – 295Histamine N-methyltransferaseAdd BLAST295

    Proteomic databases

    MaxQB - The MaxQuant DataBase

    More...
    MaxQBi
    Q91VF2

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q91VF2

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q91VF2

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q91VF2

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q91VF2

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000026986 Expressed in 201 organ(s), highest expression level in liver

    CleanEx database of gene expression profiles

    More...
    CleanExi
    MM_HNMT

    ExpressionAtlas, Differential and Baseline Expression

    More...
    ExpressionAtlasi
    Q91VF2 baseline and differential

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q91VF2 MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    <p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

    Monomer.By similarity

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000062747

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

    More...
    ProteinModelPortali
    Q91VF2

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q91VF2

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    <p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

    Belongs to the class I-like SAM-binding methyltransferase superfamily. HNMT family.PROSITE-ProRule annotation

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    ENOG410IGS0 Eukaryota
    ENOG410ZU1D LUCA

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT00390000002862

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    HOG000231790

    The HOVERGEN Database of Homologous Vertebrate Genes

    More...
    HOVERGENi
    HBG051914

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q91VF2

    KEGG Orthology (KO)

    More...
    KOi
    K00546

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    MDISDCF

    Database of Orthologous Groups

    More...
    OrthoDBi
    EOG091G0DY6

    Database for complete collections of gene phylogenies

    More...
    PhylomeDBi
    Q91VF2

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF331080

    Family and domain databases

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016673 HHMT-like
    IPR029063 SAM-dependent_MTases

    PIRSF; a whole-protein classification database

    More...
    PIRSFi
    PIRSF016616 HHMT, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF53335 SSF53335, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS51597 SAM_HNMT, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q91VF2-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MASCMRSLFS DQGRYVESFR RFLNNSTEHQ CMQEFMDKKL PGIIARIGEA
    60 70 80 90 100
    KAEIKILSVG GGAGEVDLQI LSKVQAQYPG ICINNEVVEP SAEQIVKYKE
    110 120 130 140 150
    LVAKTSNMEN IKFSWHKETS SEYQKRMLEE EEEPPKWDFI HMIQMLYYVK
    160 170 180 190 200
    DIPATLKFFH GLLAASAKIL IILVSGTSGW EKLWKKYGSR LPRDDLCQYV
    210 220 230 240 250
    TSSDLAQILD DLGIKYECYD LVSTMDITDC FIDGNENGDL LWDFLTETCN
    260 270 280 290
    FSKTAPLDLK AEIMKDLQEP EFSVKKEGKV LFNNNLSFIV VEANV
    Length:295
    Mass (Da):33,665
    Last modified:December 1, 2001 - v1
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i04FA324ED14A51CA
    GO

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AF297037 mRNA Translation: AAL09305.1
    AF298150
    , AF297039, AF297040, AF297041, AF297042, AF297043 Genomic DNA Translation: AAL09306.1
    AB070523 Genomic DNA Translation: BAB84320.1
    AB070524 mRNA Translation: BAB84318.1
    AK050129 mRNA Translation: BAC34081.1
    AK160131 mRNA Translation: BAE35648.1
    BC033928 mRNA Translation: AAH33928.1

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS15731.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_536710.1, NM_080462.2
    XP_006497734.1, XM_006497671.3

    UniGene gene-oriented nucleotide sequence clusters

    More...
    UniGenei
    Mm.33120

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000051416; ENSMUSP00000062747; ENSMUSG00000026986
    ENSMUST00000114497; ENSMUSP00000110141; ENSMUSG00000026986
    ENSMUST00000114498; ENSMUSP00000110142; ENSMUSG00000026986

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    140483

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:140483

    UCSC genome browser

    More...
    UCSCi
    uc008iok.2 mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AF297037 mRNA Translation: AAL09305.1
    AF298150
    , AF297039, AF297040, AF297041, AF297042, AF297043 Genomic DNA Translation: AAL09306.1
    AB070523 Genomic DNA Translation: BAB84320.1
    AB070524 mRNA Translation: BAB84318.1
    AK050129 mRNA Translation: BAC34081.1
    AK160131 mRNA Translation: BAE35648.1
    BC033928 mRNA Translation: AAH33928.1
    CCDSiCCDS15731.1
    RefSeqiNP_536710.1, NM_080462.2
    XP_006497734.1, XM_006497671.3
    UniGeneiMm.33120

    3D structure databases

    ProteinModelPortaliQ91VF2
    SMRiQ91VF2
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000062747

    PTM databases

    iPTMnetiQ91VF2
    PhosphoSitePlusiQ91VF2

    Proteomic databases

    MaxQBiQ91VF2
    PaxDbiQ91VF2
    PRIDEiQ91VF2

    Protocols and materials databases

    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENSMUST00000051416; ENSMUSP00000062747; ENSMUSG00000026986
    ENSMUST00000114497; ENSMUSP00000110141; ENSMUSG00000026986
    ENSMUST00000114498; ENSMUSP00000110142; ENSMUSG00000026986
    GeneIDi140483
    KEGGimmu:140483
    UCSCiuc008iok.2 mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    3176
    MGIiMGI:2153181 Hnmt

    Phylogenomic databases

    eggNOGiENOG410IGS0 Eukaryota
    ENOG410ZU1D LUCA
    GeneTreeiENSGT00390000002862
    HOGENOMiHOG000231790
    HOVERGENiHBG051914
    InParanoidiQ91VF2
    KOiK00546
    OMAiMDISDCF
    OrthoDBiEOG091G0DY6
    PhylomeDBiQ91VF2
    TreeFamiTF331080

    Enzyme and pathway databases

    ReactomeiR-MMU-70921 Histidine catabolism

    Miscellaneous databases

    Protein Ontology

    More...
    PROi
    PR:Q91VF2

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000026986 Expressed in 201 organ(s), highest expression level in liver
    CleanExiMM_HNMT
    ExpressionAtlasiQ91VF2 baseline and differential
    GenevisibleiQ91VF2 MM

    Family and domain databases

    InterProiView protein in InterPro
    IPR016673 HHMT-like
    IPR029063 SAM-dependent_MTases
    PIRSFiPIRSF016616 HHMT, 1 hit
    SUPFAMiSSF53335 SSF53335, 1 hit
    PROSITEiView protein in PROSITE
    PS51597 SAM_HNMT, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

    More...
    ProtoNeti
    Search...

    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiHNMT_MOUSE
    <p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91VF2
    Secondary accession number(s): Q3TVH0
    <p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: December 1, 2001
    Last modified: December 5, 2018
    This is version 121 of the entry and version 1 of the sequence. See complete history.
    <p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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