Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein phosphatase 1 regulatory subunit 14A

Gene

Ppp1r14a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Inhibitor of PPP1CA. Has over 1000-fold higher inhibitory activity when phosphorylated, creating a molecular switch for regulating the phosphorylation status of PPP1CA substrates and smooth muscle contraction (By similarity).By similarity

GO - Molecular functioni

  • protein serine/threonine phosphatase inhibitor activity Source: GO_Central

GO - Biological processi

  • cellular response to drug Source: MGI
  • regulation of phosphorylation Source: InterPro

Keywordsi

Molecular functionProtein phosphatase inhibitor

Enzyme and pathway databases

ReactomeiR-MMU-5625740 RHO GTPases activate PKNs

Names & Taxonomyi

Protein namesi
Recommended name:
Protein phosphatase 1 regulatory subunit 14A
Alternative name(s):
17 kDa PKC-potentiated inhibitory protein of PP1
Protein kinase C-potentiated inhibitor protein of 17 kDa
Short name:
CPI-17
Gene namesi
Name:Ppp1r14a
Synonyms:Cpi17
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:1931139 Ppp1r14a

Subcellular locationi

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000714871 – 147Protein phosphatase 1 regulatory subunit 14AAdd BLAST147

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei26PhosphoserineCombined sources1
Modified residuei38Phosphothreonine; by PKCBy similarity1
Modified residuei128PhosphoserineBy similarity1
Modified residuei134PhosphoserineBy similarity1
Modified residuei136PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ91VC7
PaxDbiQ91VC7
PeptideAtlasiQ91VC7
PRIDEiQ91VC7

PTM databases

iPTMnetiQ91VC7
PhosphoSitePlusiQ91VC7

Expressioni

Gene expression databases

BgeeiENSMUSG00000037166 Expressed in 208 organ(s), highest expression level in aorta
ExpressionAtlasiQ91VC7 baseline and differential
GenevisibleiQ91VC7 MM

Interactioni

Protein-protein interaction databases

IntActiQ91VC7, 1 interactor
MINTiQ91VC7
STRINGi10090.ENSMUSP00000035642

Structurei

3D structure databases

ProteinModelPortaliQ91VC7
SMRiQ91VC7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni35 – 120InhibitoryAdd BLAST86

Sequence similaritiesi

Belongs to the PP1 inhibitor family.Curated

Phylogenomic databases

eggNOGiENOG410IZE6 Eukaryota
ENOG4111Q1J LUCA
GeneTreeiENSGT00390000003608
HOGENOMiHOG000231993
HOVERGENiHBG054419
InParanoidiQ91VC7
KOiK12328
OMAiLHKQPGF
OrthoDBiEOG091G122D
PhylomeDBiQ91VC7
TreeFamiTF105546

Family and domain databases

Gene3Di1.10.150.220, 1 hit
InterProiView protein in InterPro
IPR008025 CPI-17
IPR036658 CPI-17_sf
PANTHERiPTHR16188 PTHR16188, 1 hit
PfamiView protein in Pfam
PF05361 PP1_inhibitor, 1 hit
SUPFAMiSSF81790 SSF81790, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VC7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAQRLGKRV LSKLQSPSRA RGPGGSPSGL QKRHARVTVK YDRRELQRRL
60 70 80 90 100
DVEKWIDGCL EELYRGRESD MPDEVNIDEL LELDSEEERC RKIQGLLEAC
110 120 130 140
ANPTEDFVQE LLAKLRGLHK QPGFPQPSPS DDPSLSPRQD RAHTAPP
Length:147
Mass (Da):16,649
Last modified:December 1, 2001 - v1
Checksum:i1E29065ACEB39C4D
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A140LI58A0A140LI58_MOUSE
Protein phosphatase 1 regulatory su...
Ppp1r14a
168Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti113A → G in AAK35214 (Ref. 2) Curated1
Sequence conflicti135L → P in AAK35214 (Ref. 2) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050672 mRNA Translation: AAL25830.1
AF352573 mRNA Translation: AAK35214.1
BC010832 mRNA Translation: AAH10832.1
CCDSiCCDS21070.1
RefSeqiNP_081007.2, NM_026731.3
UniGeneiMm.2343

Genome annotation databases

EnsembliENSMUST00000048187; ENSMUSP00000035642; ENSMUSG00000037166
GeneIDi68458
KEGGimmu:68458
UCSCiuc009gbn.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY050672 mRNA Translation: AAL25830.1
AF352573 mRNA Translation: AAK35214.1
BC010832 mRNA Translation: AAH10832.1
CCDSiCCDS21070.1
RefSeqiNP_081007.2, NM_026731.3
UniGeneiMm.2343

3D structure databases

ProteinModelPortaliQ91VC7
SMRiQ91VC7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91VC7, 1 interactor
MINTiQ91VC7
STRINGi10090.ENSMUSP00000035642

PTM databases

iPTMnetiQ91VC7
PhosphoSitePlusiQ91VC7

Proteomic databases

MaxQBiQ91VC7
PaxDbiQ91VC7
PeptideAtlasiQ91VC7
PRIDEiQ91VC7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000048187; ENSMUSP00000035642; ENSMUSG00000037166
GeneIDi68458
KEGGimmu:68458
UCSCiuc009gbn.1 mouse

Organism-specific databases

CTDi94274
MGIiMGI:1931139 Ppp1r14a

Phylogenomic databases

eggNOGiENOG410IZE6 Eukaryota
ENOG4111Q1J LUCA
GeneTreeiENSGT00390000003608
HOGENOMiHOG000231993
HOVERGENiHBG054419
InParanoidiQ91VC7
KOiK12328
OMAiLHKQPGF
OrthoDBiEOG091G122D
PhylomeDBiQ91VC7
TreeFamiTF105546

Enzyme and pathway databases

ReactomeiR-MMU-5625740 RHO GTPases activate PKNs

Miscellaneous databases

PROiPR:Q91VC7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037166 Expressed in 208 organ(s), highest expression level in aorta
ExpressionAtlasiQ91VC7 baseline and differential
GenevisibleiQ91VC7 MM

Family and domain databases

Gene3Di1.10.150.220, 1 hit
InterProiView protein in InterPro
IPR008025 CPI-17
IPR036658 CPI-17_sf
PANTHERiPTHR16188 PTHR16188, 1 hit
PfamiView protein in Pfam
PF05361 PP1_inhibitor, 1 hit
SUPFAMiSSF81790 SSF81790, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPP14A_MOUSE
AccessioniPrimary (citable) accession number: Q91VC7
Secondary accession number(s): Q99MB9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 9, 2004
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 112 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again