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Protein

Plasmalemma vesicle-associated protein

Gene

Plvap

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the formation of stomatal and fenestral diaphragms of caveolae. May function in microvascular permeability (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

  • MAPK cascade Source: MGI
  • positive regulation of cellular extravasation Source: UniProtKB
  • tumor necrosis factor-mediated signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
Plasmalemma vesicle-associated protein
Alternative name(s):
MECA-32 antigen
Plasmalemma vesicle protein 1
Short name:
PV-1
Gene namesi
Name:Plvap
Synonyms:Pv1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1890497 Plvap

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26CytoplasmicSequence analysisAdd BLAST26
Transmembranei27 – 47Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini48 – 438ExtracellularSequence analysisAdd BLAST391

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000584631 – 438Plasmalemma vesicle-associated proteinAdd BLAST438

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi82N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi88N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi112N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi150N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

MaxQBiQ91VC4
PaxDbiQ91VC4
PRIDEiQ91VC4

PTM databases

iPTMnetiQ91VC4
PhosphoSitePlusiQ91VC4

Expressioni

Tissue specificityi

Expressed in lung, kidney, spleen, heart, muscle, eye, pancreas, thyroid, thymus, submaxillary gland, prostate, epididymis, uterus and liver.2 Publications

Developmental stagei

Expressed in embryo at 7 dpc. Expressed in the brain vasculature at 12 up to 16 dpc, whereupon it disappears.2 Publications

Gene expression databases

CleanExiMM_PLVAP

Interactioni

Subunit structurei

Homodimer.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi220001, 1 interactor
IntActiQ91VC4, 3 interactors
MINTiQ91VC4
STRINGi10090.ENSMUSP00000035404

Structurei

3D structure databases

ProteinModelPortaliQ91VC4
SMRiQ91VC4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili140 – 160Sequence analysisAdd BLAST21
Coiled coili189 – 224Sequence analysisAdd BLAST36
Coiled coili281 – 383Sequence analysisAdd BLAST103

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi393 – 411Pro-richAdd BLAST19

Keywords - Domaini

Coiled coil, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJNT Eukaryota
ENOG410Y4AG LUCA
HOGENOMiHOG000115581
HOVERGENiHBG082152
InParanoidiQ91VC4
KOiK17309
PhylomeDBiQ91VC4

Family and domain databases

InterProiView protein in InterPro
IPR009538 PV-1
PANTHERiPTHR21687 PTHR21687, 1 hit
PfamiView protein in Pfam
PF06637 PV-1, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VC4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLSMDRSPY ARTGDQQRGC WYYLRYFFLF VSLIQFLIIL GLVLFMIYGN
60 70 80 90 100
VHATTESSLR ATEIRADSLY SQVVGLSASQ ANLSKQLNIS LLVKETVMQQ
110 120 130 140 150
LLTTRREMER INASFRQCQG DLITYINYNR FIAAIILSEK QCQEQLKEVN
160 170 180 190 200
KTCEALLFKL GEKVKTLEME VAKEKAVCSK DKESLLAGKR QTEEQLEACG
210 220 230 240 250
KARERQQQEQ QVTEENLRKV QSLCIPLDQE KFQADVLSAW RDSLIYRTLE
260 270 280 290 300
TLPYHYQLMP EYASLRRTCE SLPGIMTTKI EELARGLRAG IERVTRENAE
310 320 330 340 350
LRRQKLELER AAQAAQEARA RAGTEAQARE TQLRAECARQ TQLALEEKAA
360 370 380 390 400
LRAQRDNLER ELEARKRELE QLRTEVDVRI SALDTCVKAK SLPAVPPRVS
410 420 430
GPPPNPPPID PASLEEFKKR ILESQRLPVV NPAAQPSG
Length:438
Mass (Da):49,933
Last modified:December 1, 2001 - v1
Checksum:i2566D9633F6C9809
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X924G3X924_MOUSE
Plasmalemma vesicle-associated prot...
Plvap mCG_10378
438Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti192T → A in AAK20902 (PubMed:11401446).Curated1
Sequence conflicti192T → A in AAK20039 (PubMed:11401446).Curated1
Sequence conflicti277 – 278TT → PP in AAK20902 (PubMed:11401446).Curated2
Sequence conflicti277 – 278TT → PP in AAK20039 (PubMed:11401446).Curated2
Sequence conflicti283L → M in AAK20902 (PubMed:11401446).Curated1
Sequence conflicti283L → M in AAK20039 (PubMed:11401446).Curated1
Sequence conflicti287L → V in AAK20902 (PubMed:11401446).Curated1
Sequence conflicti287L → V in AAK20039 (PubMed:11401446).Curated1
Sequence conflicti314A → R in AAK20902 (PubMed:11401446).Curated1
Sequence conflicti314A → R in AAK20039 (PubMed:11401446).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369900 mRNA Translation: AAK54730.1
AF348402 Genomic DNA Translation: AAK20902.1
AF348403 mRNA Translation: AAK20039.1
BC013517 mRNA Translation: AAH13517.1
CCDSiCCDS22396.1
RefSeqiNP_115774.2, NM_032398.2
UniGeneiMm.260768

Genome annotation databases

GeneIDi84094
KEGGimmu:84094

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369900 mRNA Translation: AAK54730.1
AF348402 Genomic DNA Translation: AAK20902.1
AF348403 mRNA Translation: AAK20039.1
BC013517 mRNA Translation: AAH13517.1
CCDSiCCDS22396.1
RefSeqiNP_115774.2, NM_032398.2
UniGeneiMm.260768

3D structure databases

ProteinModelPortaliQ91VC4
SMRiQ91VC4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi220001, 1 interactor
IntActiQ91VC4, 3 interactors
MINTiQ91VC4
STRINGi10090.ENSMUSP00000035404

PTM databases

iPTMnetiQ91VC4
PhosphoSitePlusiQ91VC4

Proteomic databases

MaxQBiQ91VC4
PaxDbiQ91VC4
PRIDEiQ91VC4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi84094
KEGGimmu:84094

Organism-specific databases

CTDi83483
MGIiMGI:1890497 Plvap

Phylogenomic databases

eggNOGiENOG410IJNT Eukaryota
ENOG410Y4AG LUCA
HOGENOMiHOG000115581
HOVERGENiHBG082152
InParanoidiQ91VC4
KOiK17309
PhylomeDBiQ91VC4

Miscellaneous databases

PROiPR:Q91VC4
SOURCEiSearch...

Gene expression databases

CleanExiMM_PLVAP

Family and domain databases

InterProiView protein in InterPro
IPR009538 PV-1
PANTHERiPTHR21687 PTHR21687, 1 hit
PfamiView protein in Pfam
PF06637 PV-1, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPLVAP_MOUSE
AccessioniPrimary (citable) accession number: Q91VC4
Secondary accession number(s): Q99JB1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 30, 2005
Last sequence update: December 1, 2001
Last modified: June 20, 2018
This is version 105 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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