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Entry version 185 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein
Submitted name:

Alpha globin 1

Gene

Hba-a1

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi59Iron (heme distal ligand)PROSITE-ProRule annotation1
Metal bindingi88Iron (heme proximal ligand)PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processOxygen transportPROSITE-ProRule annotationARBA annotation, Transport
LigandHemePROSITE-ProRule annotationARBA annotation, Iron, Metal-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alpha globin 1Imported
Submitted name:
Alpha globin 2Imported
Submitted name:
Alpha-globinImported
Submitted name:
Globin c1Imported
Submitted name:
Hemoglobin alpha, adult chain 1Imported
Submitted name:
Hemoglobin alpha, adult chain 2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Hba-a1Imported
Synonyms:Glnc1Imported, haemaglobin alpha 1Imported, haemaglobin alpha 2Imported, Hba-a2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 11

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:96015, Hba-a1
MGI:96016, Hba-a2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q91VB8

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91VB8

PRoteomics IDEntifications database

More...
PRIDEi
Q91VB8

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000069917, Expressed in spleen and 48 other tissues

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q91VB8, 1 interactor

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91VB8

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini3 – 142GLOBINInterPro annotationAdd BLAST140

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the globin family.PROSITE-ProRule annotationARBA annotation

Phylogenomic databases

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000154590

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_003827_10_2_1

KEGG Orthology (KO)

More...
KOi
K13822

Identification of Orthologs from Complete Genome Data

More...
OMAi
FHHFDLS

Database of Orthologous Groups

More...
OrthoDBi
1398217at2759

TreeFam database of animal gene trees

More...
TreeFami
TF332328

Family and domain databases

Conserved Domains Database

More...
CDDi
cd08927, Hb-alpha_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.490.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000971, Globin
IPR009050, Globin-like_sf
IPR012292, Globin/Proto
IPR002338, Haemoglobin_a-typ
IPR002339, Haemoglobin_pi

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00042, Globin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00612, ALPHAHAEM
PR00815, PIHAEM

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF46458, SSF46458, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS01033, GLOBIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VB8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVLSGEDKSN IKAAWGKIGG HGAEYGAEAL ERMFASFPTT KTYFPHFDVS
60 70 80 90 100
HGSAQVKGHG KKVADALANA AGHLDDLPGA LSALSDLHAH KLRVDPVNFK
110 120 130 140
LLSHCLLVTL ASHHPADFTP AVHASLDKFL ASVSTVLTSK YR
Length:142
Mass (Da):15,112
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2F6A3712E555CB4A
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
P01942HBA_MOUSE
Hemoglobin subunit alpha
Hba Hba-a1
142Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AL662780 Genomic DNA No translation available.
BC043020 mRNA Translation: AAH43020.1
AY016021 Genomic DNA Translation: AAL32371.1
AY016021 Genomic DNA Translation: AAL32372.1
EF605472 Genomic DNA Translation: ABU54054.1
AK003077 mRNA Translation: BAB22552.1
AK005434 mRNA Translation: BAB24028.1
AK010923 mRNA Translation: BAB27269.1
AK010927 mRNA Translation: BAB27272.1
AK010933 mRNA Translation: BAB27277.1
AK010937 mRNA Translation: BAB27279.1
AK010987 mRNA Translation: BAB27307.1
AK011018 mRNA Translation: BAB27336.1
AK011023 mRNA Translation: BAB27340.1
AK011025 mRNA Translation: BAB27342.1
AK011028 mRNA Translation: BAB27344.1
AK011030 mRNA Translation: BAB27346.1
AK011055 mRNA Translation: BAB27364.1
AK011073 mRNA Translation: BAB27378.1
AK011121 mRNA Translation: BAB27414.1
AK012329 mRNA Translation: BAB28166.1
AK012348 mRNA Translation: BAB28179.1
AK012755 mRNA Translation: BAB28446.1
AK019138 mRNA Translation: BAB31564.1
AK028173 mRNA Translation: BAC25790.1
AK171893 mRNA Translation: BAE42724.1
LT548154 Genomic DNA Translation: SAI82198.1

NCBI Reference Sequences

More...
RefSeqi
NP_001077424.1, NM_001083955.1
NP_032244.2, NM_008218.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
110257
15122

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:110257
mmu:15122

UCSC genome browser

More...
UCSCi
uc007ijk.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL662780 Genomic DNA No translation available.
BC043020 mRNA Translation: AAH43020.1
AY016021 Genomic DNA Translation: AAL32371.1
AY016021 Genomic DNA Translation: AAL32372.1
EF605472 Genomic DNA Translation: ABU54054.1
AK003077 mRNA Translation: BAB22552.1
AK005434 mRNA Translation: BAB24028.1
AK010923 mRNA Translation: BAB27269.1
AK010927 mRNA Translation: BAB27272.1
AK010933 mRNA Translation: BAB27277.1
AK010937 mRNA Translation: BAB27279.1
AK010987 mRNA Translation: BAB27307.1
AK011018 mRNA Translation: BAB27336.1
AK011023 mRNA Translation: BAB27340.1
AK011025 mRNA Translation: BAB27342.1
AK011028 mRNA Translation: BAB27344.1
AK011030 mRNA Translation: BAB27346.1
AK011055 mRNA Translation: BAB27364.1
AK011073 mRNA Translation: BAB27378.1
AK011121 mRNA Translation: BAB27414.1
AK012329 mRNA Translation: BAB28166.1
AK012348 mRNA Translation: BAB28179.1
AK012755 mRNA Translation: BAB28446.1
AK019138 mRNA Translation: BAB31564.1
AK028173 mRNA Translation: BAC25790.1
AK171893 mRNA Translation: BAE42724.1
LT548154 Genomic DNA Translation: SAI82198.1
RefSeqiNP_001077424.1, NM_001083955.1
NP_032244.2, NM_008218.2

3D structure databases

SMRiQ91VB8
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ91VB8, 1 interactor

Proteomic databases

jPOSTiQ91VB8
MaxQBiQ91VB8
PRIDEiQ91VB8

Protocols and materials databases

The DNASU plasmid repository

More...
DNASUi
110257

Genome annotation databases

EnsembliENSMUST00000093207; ENSMUSP00000090895; ENSMUSG00000069917
ENSMUST00000093209; ENSMUSP00000090897; ENSMUSG00000069919
GeneIDi110257
15122
KEGGimmu:110257
mmu:15122
UCSCiuc007ijk.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
110257
15122
MGIiMGI:96015, Hba-a1
MGI:96016, Hba-a2

Phylogenomic databases

GeneTreeiENSGT00940000154590
HOGENOMiCLU_003827_10_2_1
KOiK13822
OMAiFHHFDLS
OrthoDBi1398217at2759
TreeFamiTF332328

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
110257, 0 hits in 14 CRISPR screens
15122, 1 hit in 11 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Hba-a1, mouse

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000069917, Expressed in spleen and 48 other tissues

Family and domain databases

CDDicd08927, Hb-alpha_like, 1 hit
Gene3Di1.10.490.10, 1 hit
InterProiView protein in InterPro
IPR000971, Globin
IPR009050, Globin-like_sf
IPR012292, Globin/Proto
IPR002338, Haemoglobin_a-typ
IPR002339, Haemoglobin_pi
PfamiView protein in Pfam
PF00042, Globin, 1 hit
PRINTSiPR00612, ALPHAHAEM
PR00815, PIHAEM
SUPFAMiSSF46458, SSF46458, 1 hit
PROSITEiView protein in PROSITE
PS01033, GLOBIN, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ91VB8_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91VB8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 185 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Proteomics identificationCombined sources, Reference proteomeImported
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