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Protein

Isocitrate dehydrogenase [NAD] subunit, mitochondrial

Gene

Idh3b

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processTricarboxylic acid cycleUniRule annotation

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)

Names & Taxonomyi

Protein namesi
Recommended name:
Isocitrate dehydrogenase [NAD] subunit, mitochondrialUniRule annotation
Gene namesi
Name:Idh3bImported
ORF Names:mCG_9915Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2158650 Idh3b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

MitochondrionUniRule annotation

Expressioni

Gene expression databases

BgeeiENSMUSG00000027406 Expressed in 293 organ(s), highest expression level in heart left ventricle

Interactioni

Protein-protein interaction databases

ComplexPortaliCPX-556 Mitochondrial isocitrate dehydrogenase complex (NAD+)
IntActiQ91VA7, 10 interactors
Q91VA7, 10 interactors
STRINGi10090.ENSMUSP00000028892

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini49 – 375Iso_dhInterPro annotationAdd BLAST327

Sequence similaritiesi

Belongs to the isocitrate and isopropylmalate dehydrogenases family.UniRule annotation

Keywords - Domaini

Transit peptideUniRule annotation

Phylogenomic databases

eggNOGiKOG0784 Eukaryota
COG0473 LUCA
GeneTreeiENSGT00590000083091
HOGENOMiHOG000021113
HOVERGENiHBG052080
OMAiKVRTADM
OrthoDBiEOG091G094X
TreeFamiTF315033

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004434 Isocitrate_DH_NAD
IPR024084 IsoPropMal-DH-like_dom
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00175 mito_nad_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91VA7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAALSNVRWL TRAVLAARNS GAWRGLGTST AHAASQSQAQ DVRVEGAFPV
60 70 80 90 100
TMLPGDGVGP ELMHAVKEVF KAAAVPVEFK EHHLSEVQNM ASEEKLEQVL
110 120 130 140 150
SSMKENKVAI IGKIYTPMEY KGELASYDMQ LRRKLDLFAN VVHVKSLPGY
160 170 180 190 200
KTRHNNLDLV IIREQTEGEY SSLEHESAKG VIECLKIVTR TKSQRIAKFA
210 220 230 240 250
FDYATKKGRS KVTAVHKANI MKLGDGLFLQ CCEEVAELYP KIKFETMIID
260 270 280 290 300
NCCMQLVQNP YQFDVLVMPN LYGNIIDNLA AGLVGGAGVV PGESYSAEYA
310 320 330 340 350
VFETGARHPF AQAVGRNIAN PTAMLLSATN MLRHLNLEYH SSMIADAVKK
360 370 380
VIKAGKVRTR DMGGYSTTTD FIKSVIGHLH PHGG
Length:384
Mass (Da):42,195
Last modified:December 1, 2001 - v1
Checksum:i49162354C2A4DFBE
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
V9GXV0V9GXV0_MOUSE
Isocitrate dehydrogenase 3 (NAD+) b...
Idh3b
80Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833804 Genomic DNA No translation available.
BC009022 mRNA Translation: AAH09022.1
AY035212 mRNA Translation: AAK64606.1
CH466519 Genomic DNA Translation: EDL28255.1
RefSeqiNP_570954.1, NM_130884.4
UniGeneiMm.29590

Genome annotation databases

EnsembliENSMUST00000028892; ENSMUSP00000028892; ENSMUSG00000027406
GeneIDi170718
UCSCiuc008min.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL833804 Genomic DNA No translation available.
BC009022 mRNA Translation: AAH09022.1
AY035212 mRNA Translation: AAK64606.1
CH466519 Genomic DNA Translation: EDL28255.1
RefSeqiNP_570954.1, NM_130884.4
UniGeneiMm.29590

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-556 Mitochondrial isocitrate dehydrogenase complex (NAD+)
IntActiQ91VA7, 10 interactors
Q91VA7, 10 interactors
STRINGi10090.ENSMUSP00000028892

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028892; ENSMUSP00000028892; ENSMUSG00000027406
GeneIDi170718
UCSCiuc008min.2 mouse

Organism-specific databases

CTDi3420
MGIiMGI:2158650 Idh3b

Phylogenomic databases

eggNOGiKOG0784 Eukaryota
COG0473 LUCA
GeneTreeiENSGT00590000083091
HOGENOMiHOG000021113
HOVERGENiHBG052080
OMAiKVRTADM
OrthoDBiEOG091G094X
TreeFamiTF315033

Enzyme and pathway databases

ReactomeiR-MMU-71403 Citric acid cycle (TCA cycle)

Miscellaneous databases

ChiTaRSiIdh3b mouse
PROiPR:Q91VA7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027406 Expressed in 293 organ(s), highest expression level in heart left ventricle

Family and domain databases

InterProiView protein in InterPro
IPR019818 IsoCit/isopropylmalate_DH_CS
IPR004434 Isocitrate_DH_NAD
IPR024084 IsoPropMal-DH-like_dom
PfamiView protein in Pfam
PF00180 Iso_dh, 1 hit
SMARTiView protein in SMART
SM01329 Iso_dh, 1 hit
TIGRFAMsiTIGR00175 mito_nad_idh, 1 hit
PROSITEiView protein in PROSITE
PS00470 IDH_IMDH, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ91VA7_MOUSE
AccessioniPrimary (citable) accession number: Q91VA7
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 136 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Proteomics identificationCombined sources, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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