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Protein

Ester hydrolase C11orf54 homolog

Gene
N/A
Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi266Zinc; catalyticBy similarity1
Metal bindingi268Zinc; catalyticBy similarity1
Metal bindingi278Zinc; catalyticBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase
LigandMetal-binding, Zinc

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Ester hydrolase C11orf54 homolog (EC:3.1.-.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 9

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:1918234 4931406C07Rik

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002460301 – 315Ester hydrolase C11orf54 homologAdd BLAST315

Proteomic databases

Encyclopedia of Proteome Dynamics

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EPDi
Q91V76

MaxQB - The MaxQuant DataBase

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MaxQBi
Q91V76

PaxDb, a database of protein abundance averages across all three domains of life

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PaxDbi
Q91V76

PeptideAtlas

More...
PeptideAtlasi
Q91V76

PRoteomics IDEntifications database

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PRIDEi
Q91V76

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

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iPTMneti
Q91V76

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91V76

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q91V76

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000031938 Expressed in 290 organ(s), highest expression level in adult mammalian kidney

CleanEx database of gene expression profiles

More...
CleanExi
MM_4931406C07RIK

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q91V76 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91V76 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Monomer.By similarity

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q91V76, 3 interactors

Molecular INTeraction database

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MINTi
Q91V76

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000034414

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q91V76

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q91V76

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4048 Eukaryota
ENOG410ZYMI LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000017214

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000013153

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG081215

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q91V76

Identification of Orthologs from Complete Genome Data

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OMAi
HTHCFSH

Database of Orthologous Groups

More...
OrthoDBi
EOG091G0J69

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91V76

TreeFam database of animal gene trees

More...
TreeFami
TF313169

Family and domain databases

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR015021 DUF1907

The PANTHER Classification System

More...
PANTHERi
PTHR13204 PTHR13204, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08925 DUF1907, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01168 DUF1907, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91V76-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MACSEFSFHM PSLEELAEVL QKGLTDNFAD VQVSVVDCPD LTKEPFTFPV
60 70 80 90 100
RGICGQTRIA EVGGVPYLLP LVNKKKVYDL NEIAKVIKLP GAFILGAGAG
110 120 130 140 150
PFQTLGFNSE FMPIVQTASE HNQPVNGSYF AHKNPADGAC LLEKYSQKYH
160 170 180 190 200
DFGCALLANL FASEGQPGKV IEVQAKRRTG ELNFVSCMRQ TLEEHYGDKP
210 220 230 240 250
VGMGGTFIVQ KGKVKAHIMP AEFSSCPLNS DEAVNKWLHF YEMKAPLVCL
260 270 280 290 300
PVFVSKDPGL DLRLEHTHFF SHHGEGGHYH YDTTPDTVEY LGYFSPAQFL
310
YRIDQPKETH AFGRD
Length:315
Mass (Da):34,996
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7F4B343E9EAAF50E
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1L1SSF8A0A1L1SSF8_MOUSE
RIKEN cDNA 4931406C07 gene
4931406C07Rik mCG_22659
282Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A1L1ST86A0A1L1ST86_MOUSE
RIKEN cDNA 4931406C07 gene
4931406C07Rik
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AK088123 mRNA Translation: BAC40160.1
AK147073 mRNA Translation: BAE27654.1
CT010296 mRNA Translation: CAJ18504.1
BC011540 mRNA Translation: AAH11540.1
BC016078 mRNA Translation: AAH16078.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS22835.1

NCBI Reference Sequences

More...
RefSeqi
NP_001186413.1, NM_001199484.1
NP_001186414.1, NM_001199485.1
NP_598493.1, NM_133732.3
XP_006510659.1, XM_006510596.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Mm.261842

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000034414; ENSMUSP00000034414; ENSMUSG00000031938
ENSMUST00000178977; ENSMUSP00000136335; ENSMUSG00000031938
ENSMUST00000180339; ENSMUSP00000136717; ENSMUSG00000031938

Database of genes from NCBI RefSeq genomes

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GeneIDi
70984

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:70984

UCSC genome browser

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UCSCi
uc009ofm.2 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK088123 mRNA Translation: BAC40160.1
AK147073 mRNA Translation: BAE27654.1
CT010296 mRNA Translation: CAJ18504.1
BC011540 mRNA Translation: AAH11540.1
BC016078 mRNA Translation: AAH16078.1
CCDSiCCDS22835.1
RefSeqiNP_001186413.1, NM_001199484.1
NP_001186414.1, NM_001199485.1
NP_598493.1, NM_133732.3
XP_006510659.1, XM_006510596.2
UniGeneiMm.261842

3D structure databases

ProteinModelPortaliQ91V76
SMRiQ91V76
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91V76, 3 interactors
MINTiQ91V76
STRINGi10090.ENSMUSP00000034414

PTM databases

iPTMnetiQ91V76
PhosphoSitePlusiQ91V76
SwissPalmiQ91V76

Proteomic databases

EPDiQ91V76
MaxQBiQ91V76
PaxDbiQ91V76
PeptideAtlasiQ91V76
PRIDEiQ91V76

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000034414; ENSMUSP00000034414; ENSMUSG00000031938
ENSMUST00000178977; ENSMUSP00000136335; ENSMUSG00000031938
ENSMUST00000180339; ENSMUSP00000136717; ENSMUSG00000031938
GeneIDi70984
KEGGimmu:70984
UCSCiuc009ofm.2 mouse

Organism-specific databases

MGIiMGI:1918234 4931406C07Rik

Phylogenomic databases

eggNOGiKOG4048 Eukaryota
ENOG410ZYMI LUCA
GeneTreeiENSGT00390000017214
HOGENOMiHOG000013153
HOVERGENiHBG081215
InParanoidiQ91V76
OMAiHTHCFSH
OrthoDBiEOG091G0J69
PhylomeDBiQ91V76
TreeFamiTF313169

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q91V76

Gene expression databases

BgeeiENSMUSG00000031938 Expressed in 290 organ(s), highest expression level in adult mammalian kidney
CleanExiMM_4931406C07RIK
ExpressionAtlasiQ91V76 baseline and differential
GenevisibleiQ91V76 MM

Family and domain databases

InterProiView protein in InterPro
IPR015021 DUF1907
PANTHERiPTHR13204 PTHR13204, 1 hit
PfamiView protein in Pfam
PF08925 DUF1907, 1 hit
SMARTiView protein in SMART
SM01168 DUF1907, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCK054_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91V76
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: December 1, 2001
Last modified: September 12, 2018
This is version 117 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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