UniProtKB - Q91V41 (RAB14_MOUSE)
Protein
Ras-related protein Rab-14
Gene
Rab14
Organism
Mus musculus (Mouse)
Status
Functioni
Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity).By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 18 – 26 | GTPBy similarity | 9 | |
Nucleotide bindingi | 66 – 70 | GTPBy similarity | 5 | |
Nucleotide bindingi | 124 – 127 | GTPBy similarity | 4 | |
Nucleotide bindingi | 154 – 156 | GTPBy similarity | 3 |
GO - Molecular functioni
- GDP binding Source: UniProtKB
- GTPase activity Source: UniProtKB
- GTP binding Source: UniProtKB
- myosin V binding Source: MGI
GO - Biological processi
- apical protein localization Source: MGI
- body fluid secretion Source: MGI
- defense response to bacterium Source: InterPro
- endocytic recycling Source: UniProtKB
- fibroblast growth factor receptor signaling pathway Source: UniProtKB
- Golgi to endosome transport Source: UniProtKB
- intracellular protein transport Source: GO_Central
- phagolysosome assembly involved in apoptotic cell clearance Source: GO_Central
- regulation of embryonic development Source: UniProtKB
- regulation of protein localization Source: UniProtKB
Keywordsi
Biological process | Protein transport, Transport |
Ligand | GTP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-MMU-1660499, Synthesis of PIPs at the plasma membrane R-MMU-6798695, Neutrophil degranulation R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Names & Taxonomyi
Protein namesi | Recommended name: Ras-related protein Rab-14 |
Gene namesi | Name:Rab14 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1915615, Rab14 |
Subcellular locationi
Golgi apparatus
- Golgi apparatus membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
- trans-Golgi network membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
Endosome
- Recycling endosome By similarity
- Early endosome membrane By similarity; Lipid-anchor Curated; Cytoplasmic side Curated
Other locations
- phagosome By similarity
Note: Recruited to recycling endosomes by DENND6A. Recruited to phagosomes containing S.aureus or M.tuberculosis.By similarity
Cytosol
- cytosol Source: MGI
Endoplasmic reticulum
- rough endoplasmic reticulum Source: MGI
Endosome
- early endosome Source: MGI
- early endosome membrane Source: UniProtKB-SubCell
- late endosome Source: MGI
- recycling endosome Source: UniProtKB
Golgi apparatus
- Golgi membrane Source: UniProtKB-SubCell
- Golgi stack Source: MGI
- trans-Golgi network Source: InterPro
Lysosome
- lysosome Source: MGI
Plasma Membrane
- apical plasma membrane Source: MGI
- plasma membrane Source: MGI
Other locations
- alveolar lamellar body Source: MGI
- anchored component of synaptic vesicle membrane Source: MGI
- cytoplasmic vesicle membrane Source: Reactome
- endomembrane system Source: GO_Central
- intracellular membrane-bounded organelle Source: MGI
- nuclear outer membrane-endoplasmic reticulum membrane network Source: MGI
- perinuclear region of cytoplasm Source: MGI
- phagocytic vesicle Source: UniProtKB
- trans-Golgi network transport vesicle Source: MGI
- transport vesicle Source: MGI
Keywords - Cellular componenti
Cytoplasmic vesicle, Endosome, Golgi apparatus, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Initiator methioninei | RemovedBy similarity | |||
ChainiPRO_0000121186 | 2 – 215 | Ras-related protein Rab-14Add BLAST | 214 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 2 | N-acetylalanineBy similarity | 1 | |
Lipidationi | 213 | S-geranylgeranyl cysteineBy similarity | 1 | |
Modified residuei | 215 | Cysteine methyl esterBy similarity | 1 | |
Lipidationi | 215 | S-geranylgeranyl cysteineBy similarity | 1 |
Keywords - PTMi
Acetylation, Lipoprotein, Methylation, PrenylationProteomic databases
EPDi | Q91V41 |
jPOSTi | Q91V41 |
MaxQBi | Q91V41 |
PaxDbi | Q91V41 |
PRIDEi | Q91V41 |
2D gel databases
UCD-2DPAGEi | Q91V41 |
PTM databases
iPTMneti | Q91V41 |
PhosphoSitePlusi | Q91V41 |
SwissPalmi | Q91V41 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000026878, Expressed in secondary oocyte and 311 other tissues |
ExpressionAtlasi | Q91V41, baseline and differential |
Genevisiblei | Q91V41, MM |
Interactioni
Subunit structurei
Interacts with ZFYVE20 (By similarity).
Interacts with KIF16B.
By similarity1 PublicationGO - Molecular functioni
- myosin V binding Source: MGI
Protein-protein interaction databases
BioGRIDi | 212822, 19 interactors |
IntActi | Q91V41, 11 interactors |
MINTi | Q91V41 |
STRINGi | 10090.ENSMUSP00000028238 |
Miscellaneous databases
RNActi | Q91V41, protein |
Family & Domainsi
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 40 – 48 | Effector regionBy similarity | 9 |
Sequence similaritiesi
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
InParanoidi | Q91V41 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | Q91V41 |
TreeFami | TF300032 |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All
Q91V41-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Computationally mapped potential isoform sequencesi
There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8VHW9 | A0A2R8VHW9_MOUSE | Ras-related protein Rab-14 | Rab14 | 83 | Annotation score: | ||
Q50HX3 | Q50HX3_MOUSE | RAB14 protein variant | Rab14 rab14 | 197 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002704 mRNA Translation: BAB22298.1 BC009085 mRNA Translation: AAH09085.1 BC025139 mRNA Translation: AAH25139.1 BC056648 mRNA Translation: AAH56648.1 |
CCDSi | CCDS15959.1 |
RefSeqi | NP_080973.1, NM_026697.3 |
Genome annotation databases
Ensembli | ENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878 |
GeneIDi | 68365 |
KEGGi | mmu:68365 |
UCSCi | uc008jjz.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK002704 mRNA Translation: BAB22298.1 BC009085 mRNA Translation: AAH09085.1 BC025139 mRNA Translation: AAH25139.1 BC056648 mRNA Translation: AAH56648.1 |
CCDSi | CCDS15959.1 |
RefSeqi | NP_080973.1, NM_026697.3 |
3D structure databases
SMRi | Q91V41 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 212822, 19 interactors |
IntActi | Q91V41, 11 interactors |
MINTi | Q91V41 |
STRINGi | 10090.ENSMUSP00000028238 |
PTM databases
iPTMneti | Q91V41 |
PhosphoSitePlusi | Q91V41 |
SwissPalmi | Q91V41 |
2D gel databases
UCD-2DPAGEi | Q91V41 |
Proteomic databases
EPDi | Q91V41 |
jPOSTi | Q91V41 |
MaxQBi | Q91V41 |
PaxDbi | Q91V41 |
PRIDEi | Q91V41 |
Protocols and materials databases
Antibodypediai | 15967, 159 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878 |
GeneIDi | 68365 |
KEGGi | mmu:68365 |
UCSCi | uc008jjz.1, mouse |
Organism-specific databases
CTDi | 51552 |
MGIi | MGI:1915615, Rab14 |
Phylogenomic databases
eggNOGi | KOG0097, Eukaryota |
GeneTreei | ENSGT00940000155178 |
InParanoidi | Q91V41 |
OMAi | QRDVTFE |
OrthoDBi | 1146851at2759 |
PhylomeDBi | Q91V41 |
TreeFami | TF300032 |
Enzyme and pathway databases
Reactomei | R-MMU-1660499, Synthesis of PIPs at the plasma membrane R-MMU-6798695, Neutrophil degranulation R-MMU-8873719, RAB geranylgeranylation R-MMU-8876198, RAB GEFs exchange GTP for GDP on RABs |
Miscellaneous databases
BioGRID-ORCSi | 68365, 3 hits in 12 CRISPR screens |
ChiTaRSi | Rab14, mouse |
PROi | PR:Q91V41 |
RNActi | Q91V41, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000026878, Expressed in secondary oocyte and 311 other tissues |
ExpressionAtlasi | Q91V41, baseline and differential |
Genevisiblei | Q91V41, MM |
Family and domain databases
CDDi | cd04122, Rab14, 1 hit |
InterProi | View protein in InterPro IPR027417, P-loop_NTPase IPR030702, Rab14 IPR005225, Small_GTP-bd_dom IPR001806, Small_GTPase |
PANTHERi | PTHR24073:SF1098, PTHR24073:SF1098, 1 hit |
Pfami | View protein in Pfam PF00071, Ras, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
TIGRFAMsi | TIGR00231, small_GTP, 1 hit |
PROSITEi | View protein in PROSITE PS51419, RAB, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | RAB14_MOUSE | |
Accessioni | Q91V41Primary (citable) accession number: Q91V41 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 26, 2004 |
Last sequence update: | January 23, 2007 | |
Last modified: | December 2, 2020 | |
This is version 169 of the entry and version 3 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencing, Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families