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Protein

Ras-related protein Rab-14

Gene

Rab14

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulates, together with its guanine nucleotide exchange factor, DENND6A, the specific endocytic transport of ADAM10, N-cadherin/CDH2 shedding and cell-cell adhesion (By similarity). Involved in membrane trafficking between the Golgi complex and endosomes during early embryonic development. Regulates the Golgi to endosome transport of FGFR-containing vesicles during early development, a key process for developing basement membrane and epiblast and primitive endoderm lineages during early postimplantation development. May act by modulating the kinesin KIF16B-cargo association to endosomes (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi18 – 26GTPBy similarity9
Nucleotide bindingi66 – 70GTPBy similarity5
Nucleotide bindingi124 – 127GTPBy similarity4
Nucleotide bindingi154 – 156GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-14
Gene namesi
Name:Rab14
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1915615 Rab14

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Endosome, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00001211862 – 215Ras-related protein Rab-14Add BLAST214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineBy similarity1
Lipidationi213S-geranylgeranyl cysteineBy similarity1
Modified residuei215Cysteine methyl esterBy similarity1
Lipidationi215S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Acetylation, Lipoprotein, Methylation, Prenylation

Proteomic databases

EPDiQ91V41
MaxQBiQ91V41
PaxDbiQ91V41
PRIDEiQ91V41

2D gel databases

UCD-2DPAGEiQ91V41

PTM databases

iPTMnetiQ91V41
PhosphoSitePlusiQ91V41
SwissPalmiQ91V41

Expressioni

Gene expression databases

BgeeiENSMUSG00000026878 Expressed in 296 organ(s), highest expression level in secondary oocyte
CleanExiMM_RAB14
ExpressionAtlasiQ91V41 baseline and differential
GenevisibleiQ91V41 MM

Interactioni

Subunit structurei

Interacts with ZFYVE20 (By similarity). Interacts with KIF16B.By similarity1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi212822, 8 interactors
IntActiQ91V41, 11 interactors
MINTiQ91V41
STRINGi10090.ENSMUSP00000028238

Structurei

3D structure databases

ProteinModelPortaliQ91V41
SMRiQ91V41
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi40 – 48Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0097 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ91V41
KOiK07881
OMAiGVQHKPA
OrthoDBiEOG091G0QOB
PhylomeDBiQ91V41
TreeFamiTF300032

Family and domain databases

CDDicd04122 Rab14, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030702 Rab14
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24073:SF654 PTHR24073:SF654, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q91V41-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATAPYNYSY IFKYIIIGDM GVGKSCLLHQ FTEKKFMADC PHTIGVEFGT
60 70 80 90 100
RIIEVSGQKI KLQIWDTAGQ ERFRAVTRSY YRGAAGALMV YDITRRSTYN
110 120 130 140 150
HLSSWLTDAR NLTNPNTVII LIGNKADLEA QRDVTYEEAK QFAEENGLLF
160 170 180 190 200
LEASAKTGEN VEDAFLEAAK KIYQNIQDGS LDLNAAESGV QHKPSAPQGG
210
RLTSEPQPQR EGCGC
Length:215
Mass (Da):23,897
Last modified:January 23, 2007 - v3
Checksum:iBC8A8B98FB9944AC
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
Q50HX3Q50HX3_MOUSE
RAB14 protein variant
Rab14 rab14
197Annotation score:
A0A2R8VHW9A0A2R8VHW9_MOUSE
Ras-related protein Rab-14
Rab14
83Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002704 mRNA Translation: BAB22298.1
BC009085 mRNA Translation: AAH09085.1
BC025139 mRNA Translation: AAH25139.1
BC056648 mRNA Translation: AAH56648.1
CCDSiCCDS15959.1
RefSeqiNP_080973.1, NM_026697.3
UniGeneiMm.198264

Genome annotation databases

EnsembliENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878
GeneIDi68365
KEGGimmu:68365
UCSCiuc008jjz.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK002704 mRNA Translation: BAB22298.1
BC009085 mRNA Translation: AAH09085.1
BC025139 mRNA Translation: AAH25139.1
BC056648 mRNA Translation: AAH56648.1
CCDSiCCDS15959.1
RefSeqiNP_080973.1, NM_026697.3
UniGeneiMm.198264

3D structure databases

ProteinModelPortaliQ91V41
SMRiQ91V41
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi212822, 8 interactors
IntActiQ91V41, 11 interactors
MINTiQ91V41
STRINGi10090.ENSMUSP00000028238

PTM databases

iPTMnetiQ91V41
PhosphoSitePlusiQ91V41
SwissPalmiQ91V41

2D gel databases

UCD-2DPAGEiQ91V41

Proteomic databases

EPDiQ91V41
MaxQBiQ91V41
PaxDbiQ91V41
PRIDEiQ91V41

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000028238; ENSMUSP00000028238; ENSMUSG00000026878
GeneIDi68365
KEGGimmu:68365
UCSCiuc008jjz.1 mouse

Organism-specific databases

CTDi51552
MGIiMGI:1915615 Rab14

Phylogenomic databases

eggNOGiKOG0097 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000118841
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ91V41
KOiK07881
OMAiGVQHKPA
OrthoDBiEOG091G0QOB
PhylomeDBiQ91V41
TreeFamiTF300032

Enzyme and pathway databases

ReactomeiR-MMU-1660499 Synthesis of PIPs at the plasma membrane
R-MMU-6798695 Neutrophil degranulation
R-MMU-8873719 RAB geranylgeranylation
R-MMU-8876198 RAB GEFs exchange GTP for GDP on RABs

Miscellaneous databases

ChiTaRSiRab14 mouse
PROiPR:Q91V41
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000026878 Expressed in 296 organ(s), highest expression level in secondary oocyte
CleanExiMM_RAB14
ExpressionAtlasiQ91V41 baseline and differential
GenevisibleiQ91V41 MM

Family and domain databases

CDDicd04122 Rab14, 1 hit
InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR030702 Rab14
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PANTHERiPTHR24073:SF654 PTHR24073:SF654, 1 hit
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB14_MOUSE
AccessioniPrimary (citable) accession number: Q91V41
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: January 23, 2007
Last modified: November 7, 2018
This is version 156 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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