UniProtKB - Q91V37 (VATO_MOUSE)
V-type proton ATPase 21 kDa proteolipid subunit c''
Atp6v0b
Functioni
Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity).
V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity).
By similaritySites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 98 | Essential for proton translocationBy similarity | 1 |
GO - Molecular functioni
- P-type proton-exporting transporter activity Source: MGI
GO - Biological processi
- proton transmembrane transport Source: MGI
Keywordsi
Biological process | Hydrogen ion transport, Ion transport, Transport |
Enzyme and pathway databases
Reactomei | R-MMU-1222556, ROS and RNS production in phagocytes R-MMU-77387, Insulin receptor recycling R-MMU-917977, Transferrin endocytosis and recycling R-MMU-9639288, Amino acids regulate mTORC1 R-MMU-983712, Ion channel transport |
Protein family/group databases
TCDBi | 3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
Names & Taxonomyi
Protein namesi | Recommended name: V-type proton ATPase 21 kDa proteolipid subunit c''CuratedShort name: V-ATPase 21 kDa proteolipid subunit c''Curated Alternative name(s): 23 kDa subunit of V-ATPase Vacuolar proton pump 21 kDa proteolipid subunit c''Curated |
Gene namesi | Name:Atp6v0b Synonyms:Atp6f |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1890510, Atp6v0b |
VEuPathDBi | HostDB:ENSMUSG00000033379 |
Subcellular locationi
Other locations
- clathrin-coated vesicle membrane By similarity; Multi-pass membrane protein Sequence analysis
Endosome
- endosome Source: MGI
Other locations
- integral component of membrane Source: MGI
- vacuolar proton-transporting V-type ATPase complex Source: MGI
- vacuolar proton-transporting V-type ATPase, V0 domain Source: UniProtKB
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 3 | LumenalSequence analysis | 3 | |
Transmembranei | 4 – 24 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 25 – 51 | CytoplasmicSequence analysisAdd BLAST | 27 | |
Transmembranei | 52 – 72 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 73 – 90 | LumenalSequence analysisAdd BLAST | 18 | |
Transmembranei | 91 – 111 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 112 – 137 | CytoplasmicSequence analysisAdd BLAST | 26 | |
Transmembranei | 138 – 158 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 159 – 175 | LumenalSequence analysisAdd BLAST | 17 | |
Transmembranei | 176 – 196 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 197 – 205 | CytoplasmicSequence analysis | 9 |
Keywords - Cellular componenti
Cytoplasmic vesicle, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000071778 | 1 – 205 | V-type proton ATPase 21 kDa proteolipid subunit c''Add BLAST | 205 |
Proteomic databases
PaxDbi | Q91V37 |
PRIDEi | Q91V37 |
PTM databases
PhosphoSitePlusi | Q91V37 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000033379, Expressed in facial nucleus and 325 other tissues |
ExpressionAtlasi | Q91V37, baseline and differential |
Genevisiblei | Q91V37, MM |
Interactioni
Subunit structurei
V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits ATP6AP1/Ac45 and ATP6AP2/PRR (By similarity).
Interacts with IFITM3 (PubMed:22467717).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 227579, 1 interactor |
STRINGi | 10090.ENSMUSP00000047682 |
Miscellaneous databases
RNActi | Q91V37, protein |
Family & Domainsi
Sequence similaritiesi
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0233, Eukaryota |
GeneTreei | ENSGT00550000075120 |
HOGENOMi | CLU_085752_0_0_1 |
InParanoidi | Q91V37 |
OMAi | PYAWAST |
OrthoDBi | 1408246at2759 |
PhylomeDBi | Q91V37 |
TreeFami | TF314946 |
Family and domain databases
Gene3Di | 1.20.120.610, 1 hit |
InterProi | View protein in InterPro IPR002379, ATPase_proteolipid_c-like_dom IPR000245, ATPase_proteolipid_csu IPR035921, F/V-ATP_Csub_sf |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 2 hits |
PRINTSi | PR00122, VACATPASE |
SUPFAMi | SSF81333, SSF81333, 2 hits |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All
10 20 30 40 50
MTGLELLYLG IFVAFWACMV VVGICYTIFD LGFRFDVAWF LTETSPFMWS
60 70 80 90 100
NLGIGLAISL SVVGAAWGIY ITGSSIIGGG VKAPRIKTKN LVSIIFCEAV
110 120 130 140 150
AIYGIIMAIV ISNMAEPFSA TEPKAIGHRN YHAGYSMFGA GLTVGLSNLF
160 170 180 190 200
CGVCVGIVGS GAALADAQNP SLFVKILIVE IFGSAIGLFG VIVAILQTSR
VKMGD
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A0A0MQJ5 | A0A0A0MQJ5_MOUSE | V-type proton ATPase 21 kDa proteol... | Atp6v0b | 158 | Annotation score: | ||
M0QW50 | M0QW50_MOUSE | V-type proton ATPase 21 kDa proteol... | Atp6v0b | 84 | Annotation score: | ||
M0QWE4 | M0QWE4_MOUSE | V-type proton ATPase 21 kDa proteol... | Atp6v0b | 107 | Annotation score: | ||
A0A0A0MQI2 | A0A0A0MQI2_MOUSE | V-type proton ATPase 21 kDa proteol... | Atp6v0b | 18 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060654 mRNA Translation: BAB61954.1 AB060655 Genomic DNA Translation: BAB61955.1 AF356006 mRNA Translation: AAL02096.1 AF356007 Genomic DNA Translation: AAL02097.1 |
CCDSi | CCDS18540.1 |
RefSeqi | NP_291095.1, NM_033617.3 |
Genome annotation databases
Ensembli | ENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379 |
GeneIDi | 114143 |
KEGGi | mmu:114143 |
UCSCi | uc008ujc.1, mouse |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB060654 mRNA Translation: BAB61954.1 AB060655 Genomic DNA Translation: BAB61955.1 AF356006 mRNA Translation: AAL02096.1 AF356007 Genomic DNA Translation: AAL02097.1 |
CCDSi | CCDS18540.1 |
RefSeqi | NP_291095.1, NM_033617.3 |
3D structure databases
SMRi | Q91V37 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 227579, 1 interactor |
STRINGi | 10090.ENSMUSP00000047682 |
Protein family/group databases
TCDBi | 3.A.2.2.6, the h(+)- or na(+)-translocating f-type, v-type and a-type atpase (f-atpase) superfamily |
PTM databases
PhosphoSitePlusi | Q91V37 |
Proteomic databases
PaxDbi | Q91V37 |
PRIDEi | Q91V37 |
Protocols and materials databases
Antibodypediai | 32422, 85 antibodies from 17 providers |
DNASUi | 114143 |
Genome annotation databases
Ensembli | ENSMUST00000036380; ENSMUSP00000047682; ENSMUSG00000033379 |
GeneIDi | 114143 |
KEGGi | mmu:114143 |
UCSCi | uc008ujc.1, mouse |
Organism-specific databases
CTDi | 533 |
MGIi | MGI:1890510, Atp6v0b |
VEuPathDBi | HostDB:ENSMUSG00000033379 |
Phylogenomic databases
eggNOGi | KOG0233, Eukaryota |
GeneTreei | ENSGT00550000075120 |
HOGENOMi | CLU_085752_0_0_1 |
InParanoidi | Q91V37 |
OMAi | PYAWAST |
OrthoDBi | 1408246at2759 |
PhylomeDBi | Q91V37 |
TreeFami | TF314946 |
Enzyme and pathway databases
Reactomei | R-MMU-1222556, ROS and RNS production in phagocytes R-MMU-77387, Insulin receptor recycling R-MMU-917977, Transferrin endocytosis and recycling R-MMU-9639288, Amino acids regulate mTORC1 R-MMU-983712, Ion channel transport |
Miscellaneous databases
BioGRID-ORCSi | 114143, 22 hits in 66 CRISPR screens |
ChiTaRSi | Atp6v0b, mouse |
PROi | PR:Q91V37 |
RNActi | Q91V37, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000033379, Expressed in facial nucleus and 325 other tissues |
ExpressionAtlasi | Q91V37, baseline and differential |
Genevisiblei | Q91V37, MM |
Family and domain databases
Gene3Di | 1.20.120.610, 1 hit |
InterProi | View protein in InterPro IPR002379, ATPase_proteolipid_c-like_dom IPR000245, ATPase_proteolipid_csu IPR035921, F/V-ATP_Csub_sf |
Pfami | View protein in Pfam PF00137, ATP-synt_C, 2 hits |
PRINTSi | PR00122, VACATPASE |
SUPFAMi | SSF81333, SSF81333, 2 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | VATO_MOUSE | |
Accessioni | Q91V37Primary (citable) accession number: Q91V37 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 24, 2004 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 143 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families