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Entry version 137 (16 Oct 2019)
Sequence version 1 (01 Dec 2001)
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Protein

ATP-binding cassette sub-family A member 7

Gene

Abca7

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Probable ATP-binding cassette (ABC) transporter that plays a role in lipid homeostasis and macrophage-mediated phagocytosis (PubMed:12917409, PubMed:15550377, PubMed:16908670, PubMed:27472885, PubMed:27030769, PubMed:20495215). Binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells (PubMed:12917409). May also mediate cholesterol efflux (By similarity). May regulate cellular ceramide homeostasis during keratinocyte differentiation (By similarity). Involved in lipid raft organization and CD1D localization on thymocytes and antigen-presenting cells, which plays an important role in natural killer T-cell development and activation (PubMed:28091533). Plays a role in phagocytosis of apoptotic cells by macrophages (PubMed:16908670). Macrophage phagocytosis is stimulated by APOA1 or APOA2, probably by stabilization of ABCA7 (PubMed:20495215). Also involved in phagocytic clearance of amyloid-beta by microglia cells and macrophages (PubMed:27472885). Further limits amyloid-beta production by playing a role in the regulation of amyloid-beta A4 precursor protein (APP) endocytosis and/or processing (PubMed:26260791, PubMed:27030769).By similarity8 Publications

Caution

There are conflicting results concerning the role of ABCA7 in lipid transport. ABCA7 was described to play a role in apolipoprotein-mediated phospholipid and cholesterol efflux when expressed in HEK293 cells (PubMed:12917409, PubMed:27472885). However, another report shows that ABCA7 deficiency does not influence cholesterol and phospholipid efflux in mouse primary macrophages, but leads to lower serum HDL cholesterol levels and a reduction in fat mass in female mice (PubMed:15550377).3 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi838 – 845ATP 1PROSITE-ProRule annotation8
Nucleotide bindingi1841 – 1848ATP 2PROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processPhagocytosis, Transport
LigandATP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-MMU-1369062 ABC transporters in lipid homeostasis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ATP-binding cassette sub-family A member 7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Abca7
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1351646 Abca7

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei22 – 42HelicalSequence analysisAdd BLAST21
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini43 – 546ExtracellularBy similarityAdd BLAST504
Transmembranei547 – 567HelicalSequence analysisAdd BLAST21
Transmembranei590 – 610HelicalSequence analysisAdd BLAST21
Transmembranei623 – 643HelicalSequence analysisAdd BLAST21
Transmembranei652 – 672HelicalSequence analysisAdd BLAST21
Transmembranei678 – 698HelicalSequence analysisAdd BLAST21
Transmembranei732 – 752HelicalSequence analysisAdd BLAST21
Transmembranei846 – 866HelicalSequence analysisAdd BLAST21
Transmembranei1246 – 1266HelicalSequence analysisAdd BLAST21
Topological domaini1267 – 1551ExtracellularBy similarityAdd BLAST285
Transmembranei1552 – 1572HelicalSequence analysisAdd BLAST21
Transmembranei1598 – 1618HelicalSequence analysisAdd BLAST21
Transmembranei1635 – 1655HelicalSequence analysisAdd BLAST21
Transmembranei1663 – 1683HelicalSequence analysisAdd BLAST21
Transmembranei1743 – 1763HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Cell projection, Cytoplasm, Endosome, Golgi apparatus, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

According to one study, knockout mice are not viable and heterozygous knockout mice display impaired phagocytosis of apoptotic cells (PubMed:16908670). However, another study shows that knockout mice are viable and females have less visceral fat and lower total serum and high density lipoprotein cholesterol level (PubMed:15550377). Knockout mice exhibit altered lipid profile in mouse brains, compromised spatial memory and increased BACE1 activity (PubMed:27030769). Display an increase in amyloid-beta protein 42 (Abeta42) from 4 to 24 weeks of age, whereas amyloid-beta protein 40 (Abeta40) is increased at 4 weeks and decreased at 24 weeks of age (PubMed:26260791). Increased endocytotic uptake of APP into endosomes in primary microglia cells (PubMed:26260791). Reduced phagocytic uptake of Abeta42 and Abeta40 by microglia cells and phagocytes (PubMed:27472885). Decreased macrophage phagocytosis in the peritoneal cavity (PubMed:20495215). Decreased surface CD1D expression on double positive thymocytes, on antigen-presenting thymocytes, on peripheral antigen-presenting cells in the spleen and on peritoneal macrophages (PubMed:28091533). Increased accumulation of CD1D to late endosomes (PubMed:28091533). Impaired natural killer T (NKT) cell development with a 2-fold decrease in frequencies and total numbers of NKT cells in the thymus and a reduction of peripheral NKT cells in spleen and liver (PubMed:28091533). Reduced proliferation during early stages of NKT development and reduced expression of Egr2 in NKT cells (PubMed:28091533). Decreased number of plasma membrane lipid rafts on thymocytes and a reduction of CAV1 and CD1D clusters in macrophages (PubMed:28091533). RNAi-mediated knockdown reduces phagocytosis of apoptotic cells by macrophages (PubMed:16908670).7 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002506751 – 2159ATP-binding cassette sub-family A member 7Add BLAST2159

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi75 ↔ 222By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi309N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi1359 ↔ 1373By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q91V24

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91V24

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91V24

PRoteomics IDEntifications database

More...
PRIDEi
Q91V24

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
2142

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91V24

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91V24

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q91V24

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Widely expressed with higher expression in brain, lung, adrenal gland, spleen and hematopoietic tissues (at protein level) (PubMed:12917409, PubMed:15550377, PubMed:27472885). In the brain, expressed in cortex, cerebellum, hippocampus, olfactory bulb, neurons, astrocytes and microglia (at protein level) (PubMed:26260791). Also expressed in adipocytes and macrophages (at protein level) (PubMed:15550377, PubMed:27472885). Expressed in thymocytes (at protein level) (PubMed:28091533). Highly expressed in spleen and hematopoietic tissues (PubMed:11435699). Expressed in brain, lung, macrophages, microglia, oligodendrocytes and neurons (PubMed:27472885).6 Publications

<p>This subsection of the ‘Expression’ section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified ‘at the protein level’.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

Widely expressed during embryogenesis (PubMed:11435699). Expressed in newborn mice with increasing expression from 4 to 24 weeks of age (PubMed:26260791).2 Publications

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Up-regulated during differentiation from monocytes to macrophages (PubMed:27472885). Down-regulated by digoxin.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000035722 Expressed in 215 organ(s), highest expression level in dorsal pancreas

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q91V24 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91V24 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

Protein interaction database and analysis system

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IntActi
Q91V24, 1 interactor

STRING: functional protein association networks

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STRINGi
10090.ENSMUSP00000128121

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q91V24

Database of comparative protein structure models

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ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini804 – 1035ABC transporter 1PROSITE-ProRule annotationAdd BLAST232
Domaini1807 – 2039ABC transporter 2PROSITE-ProRule annotationAdd BLAST233

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG0059 Eukaryota
COG1131 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161439

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91V24

KEGG Orthology (KO)

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KOi
K05645

Database of Orthologous Groups

More...
OrthoDBi
131191at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030369 ABCA7
IPR027417 P-loop_NTPase

The PANTHER Classification System

More...
PANTHERi
PTHR19229 PTHR19229, 1 hit
PTHR19229:SF49 PTHR19229:SF49, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

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SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q91V24-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MALGTQLMLL LWKNYTYRRR QPIQLLVELL WPLFLFFILV AVRHSHPPLE
60 70 80 90 100
HHECHFPNKP LPSAGTVPWL QGLVCNVNNS CFQHPTPGEK PGVLSNFKDS
110 120 130 140 150
LISRLLADTR TVLGGHSIQD MLDALGKLIP VLRAVGGGAR PQESDQPTSQ
160 170 180 190 200
GSVTKLLEKI LQRASLDPVL GQAQDSMRKF SDAIRDLAQE LLTLPSLMEL
210 220 230 240 250
RALLRRPRGS AGSLELVSEA LCSTKGPSSP GGLSLNWYEA NQLNEFMGPE
260 270 280 290 300
VAPALPDNSL SPACSEFVGT LDDHPVSRLL WRRLKPLILG KILFAPDTNF
310 320 330 340 350
TRKLMAQVNQ TFEELALLRD LHELWGVLGP QIFNFMNDST NVAMLQRLLD
360 370 380 390 400
VGGTGQRQQT PRAQKKLEAI KDFLDPSRGG YSWREAHADM GRLAGILGQM
410 420 430 440 450
MECVSLDKLE AVPSEEALVS RALELLGERR LWAGIVFLSP EHPLDPSELS
460 470 480 490 500
SPALSPGHLR FKIRMDIDDV TRTNKIRDKF WDPGPSADPF MDLRYVWGGF
510 520 530 540 550
VYLQDLLEQA AVRVLGGGNS RTGLYLQQMP HPCYVDDVFL RVLSRSLPLF
560 570 580 590 600
LTLAWIYSVA LTVKAVVREK ETRLRETMRA MGLSRAVLWL GWFLSCLGPF
610 620 630 640 650
LVSAALLVLV LKLGNILPYS HPVVIFLFLA AFAVATVAQS FLLSAFFSRA
660 670 680 690 700
NLAAACGGLA YFALYLPYVL CVAWRERLHL GGLLAASLLS PVAFGFGCES
710 720 730 740 750
LALLEEQGDG AQWHNLGTGP AEDVFSLAQV SAFLLLDAVI YGLALWYLEA
760 770 780 790 800
VCPGQYGIPE PWNFPFRRSY WCGPGPPKSS VLAPAPQDPK VLVEEPPLGL
810 820 830 840 850
VPGVSIRGLK KHFRGCPQPA LQGLNLDFYE GHITAFLGHN GAGKTTTLSI
860 870 880 890 900
LSGLFPPSSG SASILGHDVQ TNMAAIRPHL GICPQYNVLF DMLTVEEHVW
910 920 930 940 950
FYGRLKGVSA AAMGPERERL IRDVGLTLKR DTQTRHLSGG MQRKLSVAIA
960 970 980 990 1000
FVGGSRVVIM DEPTAGVDPA SRRGIWELLL KYREGRTLIL STHHLDEAEL
1010 1020 1030 1040 1050
LGDRVAMVAG GSLCCCGSPL FLRRHLGCGY YLTLVKSSQS LVTHDAKGDS
1060 1070 1080 1090 1100
EDPRREKKSD GNGRTSDTAF TRGTSDKSNQ APAPGAVPIT PSTARILELV
1110 1120 1130 1140 1150
QQHVPGAQLV EDLPHELLLV LPYAGALDGS FAMVFQELDQ QLELLGLTGY
1160 1170 1180 1190 1200
GISDTNLEEI FLKVVEDAHR EGGDSRPQLH LRTCTPQPPT GPEASVLENG
1210 1220 1230 1240 1250
ELAPQGLAPN AAQVQGWTLT CQQLRALLHK RFLLARRSRR GLFAQVVLPA
1260 1270 1280 1290 1300
LFVGLALFFS LIVPPFGQYP PLQLSPAMYG PQVSFFSEDA PGDPNRMKLL
1310 1320 1330 1340 1350
EALLGEAGLQ EPSMQDKDAR GSECTHSLAC YFTVPEVPPD VASILASGNW
1360 1370 1380 1390 1400
TPESPSPACQ CSQPGARRLL PDCPAGAGGP PPPQAVAGLG EVVQNLTGRN
1410 1420 1430 1440 1450
VSDFLVKTYP SLVRRGLKTK KWVDEVRYGG FSLGGRDPDL PTGHEVVRTL
1460 1470 1480 1490 1500
AEIRALLSPQ PGNALDRILN NLTQWALGLD ARNSLKIWFN NKGWHAMVAF
1510 1520 1530 1540 1550
VNRANNGLLH ALLPSGPVRH AHSITTLNHP LNLTKEQLSE ATLIASSVDV
1560 1570 1580 1590 1600
LVSICVVFAM SFVPASFTLV LIEERITRAK HLQLVSGLPQ TLYWLGNFLW
1610 1620 1630 1640 1650
DMCNYLVAVC IVVFIFLAFQ QRAYVAPENL PALLLLLLLY GWSITPLMYP
1660 1670 1680 1690 1700
ASFFFSVPST AYVVLTCINL FIGINSSMAT FVLELLSDQN LQEVSRILKQ
1710 1720 1730 1740 1750
VFLIFPHFCL GRGLIDMVRN QAMADAFERL GDKQFQSPLR WDIIGKNLLA
1760 1770 1780 1790 1800
MMAQGPLFLL ITLLLQHRNR LLPQSKPRLL PPLGEEDEDV AQERERVTKG
1810 1820 1830 1840 1850
ATQGDVLVLR DLTKVYRGQR NPAVDRLCLG IPPGECFGLL GVNGAGKTST
1860 1870 1880 1890 1900
FRMVTGDTLP SSGEAVLAGH NVAQERSAAH RSMGYCPQSD AIFDLLTGRE
1910 1920 1930 1940 1950
HLELFARLRG VPEAQVAQTA LSGLVRLGLP SYADRPAGTY SGGNKRKLAT
1960 1970 1980 1990 2000
ALALVGDPAV VFLDEPTTGM DPSARRFLWN SLLSVVREGR SVVLTSHSME
2010 2020 2030 2040 2050
ECEALCTRLA IMVNGRFRCL GSSQHLKGRF GAGHTLTLRV PPDQPEPAIA
2060 2070 2080 2090 2100
FIRITFPGAE LREVHGSRLR FQLPPGGRCT LTRVFRELAA QGRAHGVEDF
2110 2120 2130 2140 2150
SVSQTTLEEV FLYFSKDQGE EEESSRQEAE EEEVSKPGRQ HPKRVSRFLE

DPSSVETMI
Length:2,159
Mass (Da):236,884
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iCD2BE3FE0D8B822B
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9Q6G4E9Q6G4_MOUSE
ATP-binding cassette sub-family A m...
Abca7
2,167Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF31434 differs from that shown. Reason: Frameshift.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti1944N → D in AAF31434 (PubMed:10708515).Curated1
Sequence conflicti2004A → R in AAF31434 (PubMed:10708515).Curated1
Sequence conflicti2069L → M in AAF31434 (PubMed:10708515).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AF287141 mRNA Translation: AAK56862.1
AF287142 Genomic DNA Translation: AAK56863.1
AF213395 mRNA Translation: AAF31434.1 Frameshift.

The Consensus CDS (CCDS) project

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CCDSi
CCDS24004.1

NCBI Reference Sequences

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RefSeqi
NP_038878.1, NM_013850.1
XP_017169446.1, XM_017313957.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000043866; ENSMUSP00000043090; ENSMUSG00000035722
ENSMUST00000132517; ENSMUSP00000115111; ENSMUSG00000035722

Database of genes from NCBI RefSeq genomes

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GeneIDi
27403

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:27403

UCSC genome browser

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UCSCi
uc007gba.1 mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF287141 mRNA Translation: AAK56862.1
AF287142 Genomic DNA Translation: AAK56863.1
AF213395 mRNA Translation: AAF31434.1 Frameshift.
CCDSiCCDS24004.1
RefSeqiNP_038878.1, NM_013850.1
XP_017169446.1, XM_017313957.1

3D structure databases

SMRiQ91V24
ModBaseiSearch...

Protein-protein interaction databases

IntActiQ91V24, 1 interactor
STRINGi10090.ENSMUSP00000128121

PTM databases

GlyConnecti2142
iPTMnetiQ91V24
PhosphoSitePlusiQ91V24
SwissPalmiQ91V24

Proteomic databases

EPDiQ91V24
MaxQBiQ91V24
PaxDbiQ91V24
PRIDEiQ91V24

Genome annotation databases

EnsembliENSMUST00000043866; ENSMUSP00000043090; ENSMUSG00000035722
ENSMUST00000132517; ENSMUSP00000115111; ENSMUSG00000035722
GeneIDi27403
KEGGimmu:27403
UCSCiuc007gba.1 mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
10347
MGIiMGI:1351646 Abca7

Phylogenomic databases

eggNOGiKOG0059 Eukaryota
COG1131 LUCA
GeneTreeiENSGT00940000161439
InParanoidiQ91V24
KOiK05645
OrthoDBi131191at2759

Enzyme and pathway databases

ReactomeiR-MMU-1369062 ABC transporters in lipid homeostasis

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Abca7 mouse

Protein Ontology

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PROi
PR:Q91V24

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000035722 Expressed in 215 organ(s), highest expression level in dorsal pancreas
ExpressionAtlasiQ91V24 baseline and differential
GenevisibleiQ91V24 MM

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR026082 ABCA
IPR030369 ABCA7
IPR027417 P-loop_NTPase
PANTHERiPTHR19229 PTHR19229, 1 hit
PTHR19229:SF49 PTHR19229:SF49, 1 hit
PfamiView protein in Pfam
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00211 ABC_TRANSPORTER_1, 1 hit
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiABCA7_MOUSE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91V24
Secondary accession number(s): Q9JL36
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: October 16, 2019
This is version 137 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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