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Entry version 110 (12 Aug 2020)
Sequence version 1 (01 Dec 2001)
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Protein

Electron transfer flavoprotein regulatory factor 1

Gene

Etfrf1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a regulator of the electron transfer flavoprotein by promoting the removal of flavin from the ETF holoenzyme (composed of ETFA and ETFB).By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Electron transfer flavoprotein regulatory factor 1By similarity
Alternative name(s):
Growth hormone-inducible soluble protein1 Publication
LYR motif-containing protein 5By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Etfrf1By similarity
Synonyms:Lyrm5Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1914886, Etfrf1

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Mitochondrion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002511831 – 86Electron transfer flavoprotein regulatory factor 1Add BLAST86

Proteomic databases

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q91V16

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q91V16

PeptideAtlas

More...
PeptideAtlasi
Q91V16

PRoteomics IDEntifications database

More...
PRIDEi
Q91V16

PTM databases

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q91V16

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000040370, Expressed in brown adipose tissue and 286 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q91V16, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

homotetramer.

Interacts with NDUFAB1.

Interacts with ETFA.

Interacts with ETFB.

By similarity

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000107354

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q91V16, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the complex I LYR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502S4S4, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000001810

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_141157_2_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q91V16

Identification of Orthologs from Complete Genome Data

More...
OMAi
KKRYYEP

Database of Orthologous Groups

More...
OrthoDBi
1606295at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q91V16

TreeFam database of animal gene trees

More...
TreeFami
TF300251

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR008011, Complex1_LYR

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF05347, Complex1_LYR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q91V16-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MANSLRGEVL TLYKNLLYLG RDYPKGADYF KRRLKNVFLK NKDVEDPEKI
60 70 80
KELIARGEFV MKELEALYFL RKYRAMKQRY YSDTKV
Length:86
Mass (Da):10,391
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD9643C6FC573C3BC
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti28D → G3 Publications1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF412298 mRNA Translation: AAL07804.1
AF412299 mRNA Translation: AAL07805.1
AF412300 mRNA Translation: AAL07806.1
AY753325 mRNA Translation: AAV31717.1
AK015530 mRNA Translation: BAC25464.1
CU207316 Genomic DNA No translation available.
BC021522 mRNA Translation: AAH21522.1
AY490388 Genomic DNA Translation: AAT72334.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS39706.1

NCBI Reference Sequences

More...
RefSeqi
NP_001157100.1, NM_001163628.1
NP_598449.1, NM_133688.3
XP_006507045.1, XM_006506982.2
XP_006507046.1, XM_006506983.3
XP_006507047.1, XM_006506984.2
XP_017177210.1, XM_017321721.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000039729; ENSMUSP00000039433; ENSMUSG00000040370
ENSMUST00000111719; ENSMUSP00000107348; ENSMUSG00000040370
ENSMUST00000111721; ENSMUSP00000107350; ENSMUSG00000040370
ENSMUST00000111723; ENSMUSP00000107352; ENSMUSG00000040370
ENSMUST00000111724; ENSMUSP00000107353; ENSMUSG00000040370
ENSMUST00000111725; ENSMUSP00000107354; ENSMUSG00000040370
ENSMUST00000111726; ENSMUSP00000107355; ENSMUSG00000040370

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
67636

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:67636

UCSC genome browser

More...
UCSCi
uc009erf.2, mouse

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF412298 mRNA Translation: AAL07804.1
AF412299 mRNA Translation: AAL07805.1
AF412300 mRNA Translation: AAL07806.1
AY753325 mRNA Translation: AAV31717.1
AK015530 mRNA Translation: BAC25464.1
CU207316 Genomic DNA No translation available.
BC021522 mRNA Translation: AAH21522.1
AY490388 Genomic DNA Translation: AAT72334.1
CCDSiCCDS39706.1
RefSeqiNP_001157100.1, NM_001163628.1
NP_598449.1, NM_133688.3
XP_006507045.1, XM_006506982.2
XP_006507046.1, XM_006506983.3
XP_006507047.1, XM_006506984.2
XP_017177210.1, XM_017321721.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000107354

PTM databases

PhosphoSitePlusiQ91V16

Proteomic databases

MaxQBiQ91V16
PaxDbiQ91V16
PeptideAtlasiQ91V16
PRIDEiQ91V16

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
48706, 39 antibodies

Genome annotation databases

EnsembliENSMUST00000039729; ENSMUSP00000039433; ENSMUSG00000040370
ENSMUST00000111719; ENSMUSP00000107348; ENSMUSG00000040370
ENSMUST00000111721; ENSMUSP00000107350; ENSMUSG00000040370
ENSMUST00000111723; ENSMUSP00000107352; ENSMUSG00000040370
ENSMUST00000111724; ENSMUSP00000107353; ENSMUSG00000040370
ENSMUST00000111725; ENSMUSP00000107354; ENSMUSG00000040370
ENSMUST00000111726; ENSMUSP00000107355; ENSMUSG00000040370
GeneIDi67636
KEGGimmu:67636
UCSCiuc009erf.2, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
144363
MGIiMGI:1914886, Etfrf1

Phylogenomic databases

eggNOGiENOG502S4S4, Eukaryota
GeneTreeiENSGT00390000001810
HOGENOMiCLU_141157_2_0_1
InParanoidiQ91V16
OMAiKKRYYEP
OrthoDBi1606295at2759
PhylomeDBiQ91V16
TreeFamiTF300251

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
67636, 1 hit in 18 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Lyrm5, mouse

Protein Ontology

More...
PROi
PR:Q91V16
RNActiQ91V16, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000040370, Expressed in brown adipose tissue and 286 other tissues
GenevisibleiQ91V16, MM

Family and domain databases

InterProiView protein in InterPro
IPR008011, Complex1_LYR
PfamiView protein in Pfam
PF05347, Complex1_LYR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiETFR1_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91V16
Secondary accession number(s): B2KFC1, Q675B1, Q8VDL7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: December 1, 2001
Last modified: August 12, 2020
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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