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Protein

Visual system homeobox 1

Gene

Vsx1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Binds to the 37-bp core of the locus control region (LCR) of the red/green visual pigment gene cluster. May regulate the activity of the LCR and the cone opsin genes at earlier stages of development (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi171 – 230HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

  • neuron development Source: MGI
  • neuron maturation Source: MGI
  • regulation of transcription, DNA-templated Source: GO_Central
  • response to stimulus Source: UniProtKB-KW
  • retinal bipolar neuron differentiation Source: MGI
  • visual perception Source: MGI

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processSensory transduction, Transcription, Transcription regulation, Vision

Names & Taxonomyi

Protein namesi
Recommended name:
Visual system homeobox 1
Alternative name(s):
Homeodomain protein RINX
Retinal inner nuclear layer homeobox protein
Transcription factor VSX1
Gene namesi
Name:Vsx1
Synonyms:Rinx
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:1890816 Vsx1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000493561 – 363Visual system homeobox 1Add BLAST363

Proteomic databases

PaxDbiQ91V10
PRIDEiQ91V10

PTM databases

PhosphoSitePlusiQ91V10

Expressioni

Tissue specificityi

In the adult, expressed exclusively in the cells of the neural retina with expression restricted to postnatal cone bipolar interneurons.

Developmental stagei

Expressed at P5, solely within the inner nuclear layer (INL) of the central neuroretina. By days P6 and P7, expression expands peripherally during neurogenesis. By P12, expression is restricted to the outer margin of the INL and reaches the outer periphery of the neuroretina.

Gene expression databases

BgeeiENSMUSG00000033080 Expressed in 29 organ(s), highest expression level in camera-type eye
CleanExiMM_VSX1
ExpressionAtlasiQ91V10 baseline and differential
GenevisibleiQ91V10 MM

Interactioni

Protein-protein interaction databases

BioGridi227900, 1 interactor
STRINGi10090.ENSMUSP00000039088

Structurei

3D structure databases

ProteinModelPortaliQ91V10
SMRiQ91V10
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini231 – 283CVCPROSITE-ProRule annotationAdd BLAST53

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi31 – 38Octapeptide motif8
Motifi168 – 173Nuclear localization signalSequence analysis6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi44 – 127Pro-richAdd BLAST84
Compositional biasi80 – 93Gly/Leu-richAdd BLAST14
Compositional biasi142 – 152Asp/Glu-rich (acidic)Add BLAST11

Sequence similaritiesi

Belongs to the paired homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0494 Eukaryota
ENOG410ZN24 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000115909
HOVERGENiHBG036251
InParanoidiQ91V10
KOiK09335
OMAiWGSDHLK
OrthoDBiEOG091G14DA
PhylomeDBiQ91V10
TreeFamiTF350743

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR023339 CVC
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51496 CVC, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q91V10-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTGRDGLSDA RSRSRALAPG CPPTGSRLRS FAINDLLGLE ADLPTPAEPG
60 70 80 90 100
LRSNSGDPAE AIGSGPGPGP GLCGSCPARG ALPLGLGLLC GFGAQPPSAA
110 120 130 140 150
AAARARCLLL ADLRLLPSAG PEPAVAQGPV HPPPALGSQQ RSESVSTSDG
160 170 180 190 200
DSPSEEKNDP KMSLILGKRK KRRHRTVFTA HQLEELEKAF GEAHYPDVYA
210 220 230 240 250
REMLAAKTEL PEDRIQVWFQ NRRAKWRKRE KRWGGSSVMA EYGLYGAMVR
260 270 280 290 300
HCIPLPDSVL NSADSLQGSC APWLLGMHKK STGMRKPESE DKLAGLWEFD
310 320 330 340 350
HLKKGANKDE DGPERGPDET TQNPENSLED VAIDLSSSSR QETKKMPPGS
360
STQLPQPPQV GAS
Length:363
Mass (Da):38,755
Last modified:December 1, 2001 - v1
Checksum:iE250D452C77228C2
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY056825 mRNA Translation: AAL11431.1
AF395732 mRNA Translation: AAL08947.1
AF391757 Genomic DNA Translation: AAL09584.1
AF391758 mRNA Translation: AAL09585.1
BC057647 mRNA Translation: AAH57647.1
CCDSiCCDS16860.1
PIRiJC7750
RefSeqiNP_473409.1, NM_054068.2
UniGeneiMm.207061

Genome annotation databases

EnsembliENSMUST00000046095; ENSMUSP00000039088; ENSMUSG00000033080
GeneIDi114889
KEGGimmu:114889
UCSCiuc008muh.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY056825 mRNA Translation: AAL11431.1
AF395732 mRNA Translation: AAL08947.1
AF391757 Genomic DNA Translation: AAL09584.1
AF391758 mRNA Translation: AAL09585.1
BC057647 mRNA Translation: AAH57647.1
CCDSiCCDS16860.1
PIRiJC7750
RefSeqiNP_473409.1, NM_054068.2
UniGeneiMm.207061

3D structure databases

ProteinModelPortaliQ91V10
SMRiQ91V10
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi227900, 1 interactor
STRINGi10090.ENSMUSP00000039088

PTM databases

PhosphoSitePlusiQ91V10

Proteomic databases

PaxDbiQ91V10
PRIDEiQ91V10

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000046095; ENSMUSP00000039088; ENSMUSG00000033080
GeneIDi114889
KEGGimmu:114889
UCSCiuc008muh.2 mouse

Organism-specific databases

CTDi30813
MGIiMGI:1890816 Vsx1

Phylogenomic databases

eggNOGiKOG0494 Eukaryota
ENOG410ZN24 LUCA
GeneTreeiENSGT00900000140809
HOGENOMiHOG000115909
HOVERGENiHBG036251
InParanoidiQ91V10
KOiK09335
OMAiWGSDHLK
OrthoDBiEOG091G14DA
PhylomeDBiQ91V10
TreeFamiTF350743

Miscellaneous databases

PROiPR:Q91V10
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000033080 Expressed in 29 organ(s), highest expression level in camera-type eye
CleanExiMM_VSX1
ExpressionAtlasiQ91V10 baseline and differential
GenevisibleiQ91V10 MM

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR023339 CVC
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
PfamiView protein in Pfam
PF00046 Homeobox, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51496 CVC, 1 hit
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiVSX1_MOUSE
AccessioniPrimary (citable) accession number: Q91V10
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 8, 2002
Last sequence update: December 1, 2001
Last modified: November 7, 2018
This is version 135 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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