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UniProtKB - Q91UL0 (HN_NDVB1)
Protein
Hemagglutinin-neuraminidase
Gene
HN
Organism
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV)
Status
Functioni
Mediates the viral entry into the host cell together with fusion/F protein. Attaches the virus to sialic acid-containing cell receptors and thereby initiates infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion.
6 PublicationsNeuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.
1 PublicationCatalytic activityi
- Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates. EC:3.2.1.18
GO - Molecular functioni
- exo-alpha-(2->3)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->6)-sialidase activity Source: UniProtKB-EC
- exo-alpha-(2->8)-sialidase activity Source: UniProtKB-EC
- host cell surface receptor binding Source: InterPro
GO - Biological processi
- viral entry into host cell Source: UniProtKB-KW
- virion attachment to host cell Source: UniProtKB-KW
Keywordsi
Molecular function | Hemagglutinin, Hydrolase |
Biological process | Host-virus interaction, Viral attachment to host cell, Virus entry into host cell |
Protein family/group databases
CAZyi | GH83, Glycoside Hydrolase Family 83 |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:HN |
Organismi | Newcastle disease virus (strain Chicken/United States/B1/48) (NDV) |
Taxonomic identifieri | 652953 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Negarnaviricota › Haploviricotina › Monjiviricetes › Mononegavirales › Paramyxoviridae › Avulavirinae › Orthoavulavirus › Avian orthoavulavirus 1 |
Virus hosti | Gallus gallus (Chicken) [TaxID: 9031] |
Proteomesi |
|
Subcellular locationi
- Virion membrane 1 Publication; Single-pass type II membrane protein Curated
- Host cell membrane 1 Publication; Single-pass type II membrane protein Curated
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 26 | IntravirionSequence analysisAdd BLAST | 26 | |
Transmembranei | 27 – 47 | HelicalSequence analysisAdd BLAST | 21 | |
Topological domaini | 48 – 577 | Virion surfaceSequence analysisAdd BLAST | 530 |
Keywords - Cellular componenti
Host cell membrane, Host membrane, Membrane, Viral envelope protein, VirionPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 83 | R → T: About 95% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 97 | L → T: About 95% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 133 | I → A: About 80% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 140 | L → A: About 80% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 158 | E → A: About 98% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 160 | L → A: About 97% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 220 | F → A: About 97% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 224 | L → A: About 97% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 526 | Y → Q: About 30% to 50% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 536 | K → A: About 96% loss of the fusion promotion activities. 1 Publication | 1 | |
Mutagenesisi | 557 | R → A: About 99% loss of the fusion promotion activities. 1 Publication | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000390622 | 1 – 577 | Hemagglutinin-neuraminidaseAdd BLAST | 577 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 341 | N-linked (GlcNAc...) asparagine; by host1 Publication | 1 | |
Glycosylationi | 433 | N-linked (GlcNAc...) asparagine; by host1 Publication | 1 | |
Glycosylationi | 481 | N-linked (GlcNAc...) asparagine; by host1 Publication | 1 | |
Glycosylationi | 538 | N-linked (GlcNAc...) asparagine; by hostSequence analysis | 1 |
Keywords - PTMi
GlycoproteinPTM databases
iPTMneti | Q91UL0 |
Interactioni
Subunit structurei
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 124 – 152 | Important for interaction with fusion/F protein1 PublicationAdd BLAST | 29 |
Sequence similaritiesi
Belongs to the paramyxoviruses hemagglutinin-neuraminidase family.Curated
Keywords - Domaini
Signal-anchor, Transmembrane, Transmembrane helixFamily and domain databases
CDDi | cd15469, HN, 1 hit |
InterProi | View protein in InterPro IPR016285, Hemagglutn-neuramid IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
PIRSFi | PIRSF001072, Hemagglut-neuramid_paramyxoV, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91UL0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MDRAVSQVAL ENDEREAKNT WRLIFRIAIL FLTVVTLAIS VASLLYSMGA
60 70 80 90 100
STPSDLVGIP TRISRAEEKI TSTLGSNQDV VDRIYKQVAL ESPLALLNTE
110 120 130 140 150
TTIMNAITSL SYQINGAANN SGWGAPIHDP DYIGGIGKEL IVDDASDVTS
160 170 180 190 200
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS
210 220 230 240 250
HSYQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKATETEEE DYNSAVPTRM VHGRLGFDGQ YHEKDLDVTT LFGDWVANYP
310 320 330 340 350
GVGGGSFIDS RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA
410 420 430 440 450
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDGEQARLN
510 520 530 540 550
PASAVFDSTS RSRITRVSSS SIKAAYTTST CFKVVKTNKT YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKDDG VREARSG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF309418 Genomic RNA Translation: AAG36979.1 |
RefSeqi | NP_071470.1, NC_002617.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF309418 Genomic RNA Translation: AAG36979.1 |
RefSeqi | NP_071470.1, NC_002617.1 |
3D structure databases
SMRi | Q91UL0 |
ModBasei | Search... |
Protein family/group databases
CAZyi | GH83, Glycoside Hydrolase Family 83 |
PTM databases
iPTMneti | Q91UL0 |
Family and domain databases
CDDi | cd15469, HN, 1 hit |
InterProi | View protein in InterPro IPR016285, Hemagglutn-neuramid IPR000665, Hemagglutn/HN IPR036278, Sialidase_sf |
Pfami | View protein in Pfam PF00423, HN, 1 hit |
PIRSFi | PIRSF001072, Hemagglut-neuramid_paramyxoV, 1 hit |
SUPFAMi | SSF50939, SSF50939, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | HN_NDVB1 | |
Accessioni | Q91UL0Primary (citable) accession number: Q91UL0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | January 19, 2010 |
Last sequence update: | December 1, 2001 | |
Last modified: | June 2, 2021 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- Glycosyl hydrolases
Classification of glycosyl hydrolase families and list of entries - SIMILARITY comments
Index of protein domains and families