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Protein

Hemagglutinin-neuraminidase

Gene

HN

Organism
Newcastle disease virus (strain Chicken/United States/B1/48) (NDV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Attaches the virus to sialic acid-containing cell receptors and thereby initiating infection. Binding of HN protein to the receptor induces a conformational change that allows the F protein to trigger virion/cell membranes fusion (By similarity).By similarity
Neuraminidase activity ensures the efficient spread of the virus by dissociating the mature virions from the neuraminic acid containing glycoproteins.By similarity

Catalytic activityi

Hydrolysis of alpha-(2->3)-, alpha-(2->6)-, alpha-(2->8)- glycosidic linkages of terminal sialic acid residues in oligosaccharides, glycoproteins, glycolipids, colominic acid and synthetic substrates.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHemagglutinin, Hydrolase
Biological processHost-virus interaction, Viral attachment to host cell, Virus entry into host cell

Protein family/group databases

CAZyiGH83 Glycoside Hydrolase Family 83

Names & Taxonomyi

Protein namesi
Recommended name:
Hemagglutinin-neuraminidase (EC:3.2.1.18)
Gene namesi
Name:HN
OrganismiNewcastle disease virus (strain Chicken/United States/B1/48) (NDV)
Taxonomic identifieri652953 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA negative-strand virusesMononegaviralesParamyxoviridaeAvulavirus
Virus hostiGallus gallus (Chicken) [TaxID: 9031]
Proteomesi
  • UP000002328 Componenti: Genome

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 26IntravirionSequence analysisAdd BLAST26
Transmembranei27 – 47HelicalSequence analysisAdd BLAST21
Topological domaini48 – 577Virion surfaceSequence analysisAdd BLAST530

GO - Cellular componenti

Keywords - Cellular componenti

Host cell membrane, Host membrane, Membrane, Viral envelope protein, Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003906221 – 577Hemagglutinin-neuraminidaseAdd BLAST577

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi341N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi433N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi481N-linked (GlcNAc...) asparagine; by hostSequence analysis1
Glycosylationi538N-linked (GlcNAc...) asparagine; by hostSequence analysis1

Keywords - PTMi

Glycoprotein

Structurei

3D structure databases

ProteinModelPortaliQ91UL0
SMRiQ91UL0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi518 – 521Poly-Ser4

Sequence similaritiesi

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

KOiK19247
OrthoDBiVOG090000BM

Family and domain databases

InterProiView protein in InterPro
IPR016285 Hemagglutn-neuramid
IPR000665 Hemagglutn/HN
IPR036278 Sialidase_sf
PfamiView protein in Pfam
PF00423 HN, 1 hit
PIRSFiPIRSF001072 Hemagglut-neuramid_paramyxoV, 1 hit
SUPFAMiSSF50939 SSF50939, 1 hit

Sequencei

Sequence statusi: Complete.

Q91UL0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDRAVSQVAL ENDEREAKNT WRLIFRIAIL FLTVVTLAIS VASLLYSMGA
60 70 80 90 100
STPSDLVGIP TRISRAEEKI TSTLGSNQDV VDRIYKQVAL ESPLALLNTE
110 120 130 140 150
TTIMNAITSL SYQINGAANN SGWGAPIHDP DYIGGIGKEL IVDDASDVTS
160 170 180 190 200
FYPSAFQEHL NFIPAPTTGS GCTRIPSFDM SATHYCYTHN VILSGCRDHS
210 220 230 240 250
HSYQYLALGV LRTSATGRVF FSTLRSINLD DTQNRKSCSV SATPLGCDML
260 270 280 290 300
CSKATETEEE DYNSAVPTRM VHGRLGFDGQ YHEKDLDVTT LFGDWVANYP
310 320 330 340 350
GVGGGSFIDS RVWFSVYGGL KPNSPSDTVQ EGKYVIYKRY NDTCPDEQDY
360 370 380 390 400
QIRMAKSSYK PGRFGGKRIQ QAILSIKVST SLGEDPVLTV PPNTVTLMGA
410 420 430 440 450
EGRILTVGTS HFLYQRGSSY FSPALLYPMT VSNKTATLHS PYTFNAFTRP
460 470 480 490 500
GSIPCQASAR CPNSCVTGVY TDPYPLIFYR NHTLRGVFGT MLDGEQARLN
510 520 530 540 550
PASAVFDSTS RSRITRVSSS SIKAAYTTST CFKVVKTNKT YCLSIAEISN
560 570
TLFGEFRIVP LLVEILKDDG VREARSG
Length:577
Mass (Da):63,227
Last modified:December 1, 2001 - v1
Checksum:i23DD6748352C8C17
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF309418 Genomic RNA Translation: AAG36979.1
RefSeqiNP_071470.1, NC_002617.1

Genome annotation databases

GeneIDi912270
KEGGivg:912270

Similar proteinsi

Entry informationi

Entry nameiHN_NDVB1
AccessioniPrimary (citable) accession number: Q91UL0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 19, 2010
Last sequence update: December 1, 2001
Last modified: October 25, 2017
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Glycosyl hydrolases
    Classification of glycosyl hydrolase families and list of entries
  2. SIMILARITY comments
    Index of protein domains and families

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