Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

NS3 protease

Gene
N/A
Organism
Hepacivirus C
Status
Unreviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi97ZincCombined sources1
Metal bindingi99ZincCombined sources1
Metal bindingi145ZincCombined sources1

GO - Molecular functioni

  • metal ion binding Source: UniProtKB-KW
  • serine-type peptidase activity Source: CACAO

GO - Biological processi

  • self proteolysis Source: CACAO
  • transformation of host cell by virus Source: InterPro

Keywordsi

Molecular functionHydrolase, ProteaseImported
LigandMetal-bindingCombined sources, ZincCombined sources

Names & Taxonomyi

Protein namesi
Submitted name:
NS3 proteaseImported
OrganismiHepacivirus CImported
Taxonomic identifieri11103 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageFlaviviridaeHepacivirus

Pathology & Biotechi

Chemistry databases

ChEMBLiCHEMBL3988605
DrugBankiDB13879 Glecaprevir
DB07582 N-[(2R,3S)-1-((2S)-2-{[(CYCLOPENTYLAMINO)CARBONYL]AMINO}-3-METHYLBUTANOYL)-2-(1-FORMYL-1-CYCLOBUTYL)PYRROLIDINYL]CYCLOPROPANECARBOXAMIDE
DB06290 Simeprevir

PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi97 ↔ 145Combined sources
Disulfide bondi97 ↔ 99Combined sources
Disulfide bondi99 ↔ 145Combined sources

Interactioni

Chemistry databases

BindingDBiQ91RS4

Structurei

3D structure databases

ProteinModelPortaliQ91RS4
SMRiQ91RS4
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ91RS4

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 181Peptidase S29InterPro annotationAdd BLAST181

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
PfamiView protein in Pfam
PF02907 Peptidase_S29, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS51822 HV_PV_NS3_PRO, 1 hit

Sequencei

Sequence statusi: Fragment.

Q91RS4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
APITAYAQQT RGLLGCIITS LTGRDKNQVE GEVQIVSTAA QTFLATCING
60 70 80 90 100
VCWTVYHGAG TRTIASPKGP VIQMYTNVDQ DLVGWPAPQG ARSLTPCTCG
110 120 130 140 150
SSDLYLVTRH ADVIPVRRRG DSRGSLLSPR PISYLKGSSG GPLLCPAGHA
160 170 180
VGLFRAAVCT RGVAKAVDFI PVENLETTMR S
Length:181
Mass (Da):19,114
Last modified:December 1, 2001 - v1
Checksum:i574AC47AEDFEB0D2
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Non-terminal residuei1Imported1
Non-terminal residuei181Imported1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369229 Genomic RNA Translation: AAK54554.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF369229 Genomic RNA Translation: AAK54554.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2A4QX-ray2.45A/C1-181[»]
2F9UX-ray2.60A/C1-181[»]
2OBOX-ray2.60A/C1-181[»]
2P59X-ray2.90A/B1-181[»]
2XCNX-ray3.02A/B1-180[»]
ProteinModelPortaliQ91RS4
SMRiQ91RS4
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

BindingDBiQ91RS4
ChEMBLiCHEMBL3988605
DrugBankiDB13879 Glecaprevir
DB07582 N-[(2R,3S)-1-((2S)-2-{[(CYCLOPENTYLAMINO)CARBONYL]AMINO}-3-METHYLBUTANOYL)-2-(1-FORMYL-1-CYCLOBUTYL)PYRROLIDINYL]CYCLOPROPANECARBOXAMIDE
DB06290 Simeprevir

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

euHCVdbiAF369229

Miscellaneous databases

EvolutionaryTraceiQ91RS4

Family and domain databases

InterProiView protein in InterPro
IPR009003 Peptidase_S1_PA
IPR004109 Peptidase_S29_NS3
PfamiView protein in Pfam
PF02907 Peptidase_S29, 1 hit
SUPFAMiSSF50494 SSF50494, 1 hit
PROSITEiView protein in PROSITE
PS51822 HV_PV_NS3_PRO, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ91RS4_9HEPC
AccessioniPrimary (citable) accession number: Q91RS4
Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 89 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again