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UniProtKB - Q91QZ3 (RDRP_CLBVS)
Protein
RNA replication polyprotein
Gene
ORF1
Organism
Citrus leaf blotch virus (isolate Nagami kumquat/France/SRA-153/1984) (CLBV)
Status
Functioni
RNA replication polyprotein: RNA-directed RNA polymerase involved in viral RNA replication.
By similarityProtease: Thiol protease that cleaves the polyprotein.
By similarityCatalytic activityi
Cofactori
Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Metal bindingi | 892 | IronPROSITE-ProRule annotation | 1 | |
Metal bindingi | 894 | IronPROSITE-ProRule annotation | 1 | |
Metal bindingi | 946 | IronPROSITE-ProRule annotation | 1 | |
Binding sitei | 954 | 2-oxoglutaratePROSITE-ProRule annotation | 1 | |
Active sitei | 982 | By similarity | 1 | |
Active sitei | 1062 | By similarity | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 1164 – 1171 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP hydrolysis activity Source: RHEA
- cysteine-type peptidase activity Source: UniProtKB-KW
- dioxygenase activity Source: UniProtKB-KW
- metal ion binding Source: UniProtKB-KW
- mRNA methyltransferase activity Source: InterPro
- RNA binding Source: InterPro
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
- RNA helicase activity Source: UniProtKB-EC
GO - Biological processi
- RNA processing Source: InterPro
- transcription, DNA-templated Source: InterPro
- viral RNA genome replication Source: InterPro
Keywordsi
Molecular function | Dioxygenase, Helicase, Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Oxidoreductase, Protease, RNA-directed RNA polymerase, Thiol protease, Transferase |
Biological process | Viral RNA replication |
Ligand | ATP-binding, Iron, Metal-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: RNA replication polyproteinBy similarityAlternative name(s): ORF1 proteinBy similarity Including the following 5 domains: Putative Fe(2+) 2-oxoglutarate dioxygenaseSequence analysis (EC:1.14.11.-PROSITE-ProRule annotation) |
Gene namesi | ORF Names:ORF1By similarity |
Organismi | Citrus leaf blotch virus (isolate Nagami kumquat/France/SRA-153/1984) (CLBV) |
Taxonomic identifieri | 686981 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Kitrinoviricota › Alsuviricetes › Tymovirales › Betaflexiviridae › Trivirinae › Citrivirus › |
Virus hosti | Citrus [TaxID: 2706] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000401088 | 1 – 1962 | RNA replication polyproteinAdd BLAST | 1962 |
Post-translational modificationi
Specific enzymatic cleavages by the viral protease yield mature proteins.By similarity
Proteomic databases
PRIDEi | Q91QZ3 |
Structurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 64 – 261 | Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST | 198 | |
Domaini | 683 – 794 | OTUPROSITE-ProRule annotationAdd BLAST | 112 | |
Domaini | 874 – 963 | Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 978 – 1067 | Peptidase C23PROSITE-ProRule annotationAdd BLAST | 90 | |
Domaini | 1122 – 1297 | (+)RNA virus helicase ATP-bindingAdd BLAST | 176 | |
Domaini | 1298 – 1445 | (+)RNA virus helicase C-terminalAdd BLAST | 148 | |
Domaini | 1739 – 1846 | RdRp catalyticPROSITE-ProRule annotationAdd BLAST | 108 |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR037151, AlkB-like_sf IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR044861, IPNS-like_FE2OG_OXY IPR003323, OTU_dom IPR005123, Oxoglu/Fe-dep_dioxygenase IPR027417, P-loop_NTPase IPR008041, Peptidase_C23 IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit PF05379, Peptidase_C23, 1 hit PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51471, FE2OG_OXY, 1 hit PS50802, OTU, 1 hit PS51492, PEPTIDASE_C23, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91QZ3-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MALMSNKTAI ESILGNFEKK HVDAIYNAAA QTILSHSEFR NKHFAYSLNS
60 70 80 90 100
YQKKIASKVG IELYPNGYLP HSHPLSKIFE NHLLFDVLPG VVNTSRLVMC
110 120 130 140 150
SIKESKVLVF KGIRDKSRRQ VSDLNALNSL NNSHTSFINR LVASKDVSRY
160 170 180 190 200
TEEADAFFQS KKGSPELFSR NFIKSLENKE AVFFHDEVHH WTKAQMFSFL
210 220 230 240 250
KSTKVKRFIF TVVYPPEILK KFANSQNPKV YDFKVDKGRL FFFPDGVKTE
260 270 280 290 300
AYEQKLNMEW LFSASHLRSG DCVWTVTRHK SIYAHHLFEI SIGELVTDSK
310 320 330 340 350
LFFSDYNSID MSKIFLDRFR SYEVFPISIE HLYKVYSYLL CLKKPDLESG
360 370 380 390 400
LAKLRQIIGD DVEIKEFLFF EQFCKRLIER QTSWGLFGHS FFEKLTDMAL
410 420 430 440 450
SSLPNSIARI FPQWKKKNTF EFLFSLGTLV VDVERKVCFE HVLEEWGFEV
460 470 480 490 500
VITDENAYLD PLSIFAINEN FNEDRVDDGY LERIRLPFWN LNDYDLKRKR
510 520 530 540 550
VNAYNILSYR FEEERKIESA QKGPNKMLQI EWYGIKEFKV DPFISNSITE
560 570 580 590 600
FTLLEALLGK RIDPKKYSYS KQACTLSNYL TFLCAEGLDG FNLEEHLERR
610 620 630 640 650
LKAAGHDVSD DEEEELTSAE QAGPIKILAD PLGFMKECLE EIPIETEPSL
660 670 680 690 700
EERGQFSTDY HSEKFEINYN DIFNPHNCMN THGDEIPTPS DGNCFFSAFT
710 720 730 740 750
ETFEVERPDT LRSDFSDWLM EFNGGSYASL AEMIRPNGVF MEAELIYLFC
760 770 780 790 800
VFRGVTLIIH DRTHEKENVY AVHRGFEEGH MVHRGNHFVG IETYNISTLT
810 820 830 840 850
SDPLLGDIPC GFSEEITKFH FRPDHFNCAQ FRGRKAAFIT KVDADYGHNG
860 870 880 890 900
MVYPHNSWVP SLEEIIQICG QGDDFNCALI NFYEANSSLG FHRDNERVYN
910 920 930 940 950
DDPILTVCTF GEGRFTIEFK DQVTSFLMTA GSFFLMPKGF QKKARHSVSN
960 970 980 990 1000
EMSRVSITFR KHVRRLNGSP IAIREENYKN TCLINAFSKA MKRSKQAIIA
1010 1020 1030 1040 1050
KLKTVNSPFW SRYLSEGNGG SIEDCQSACE ALDVTVDLNV NGKCVVLGKG
1060 1070 1080 1090 1100
ALRISMALRN NHFSVINAAQ LMERTFVSHL LEKGNVNVLE GFDAMLSGDV
1110 1120 1130 1140 1150
GAAGVNKIQF AANFEFARIL ANSFLNMTTG ICLGKALDNG EKYFLHILKD
1160 1170 1180 1190 1200
RVKQIGIDVT MVCGFAGSGK SRKLQSWLHS RKKGNFCVVS PRTNLAADWA
1210 1220 1230 1240 1250
FKLELEPNEQ RKVSTFEKFI KTDKSKLDLI VIDELTLFPN GYLDLLVYEL
1260 1270 1280 1290 1300
ADVNRHCQII LLFDPLQARY HNKMDESILT FEHDVDRLIG GQNIEYIYST
1310 1320 1330 1340 1350
HRMSRYFNRF FDVPCFNQAD RTEEQRLWIF DDVYSIPSIC SDRQEPCDVL
1360 1370 1380 1390 1400
LVESDLEKKA FSPIINVMTF GESQGLTFNH VCILLSESSA ASNEFRWMVA
1410 1420 1430 1440 1450
LTRARTRFSL CSTFLGGIEE FKVKRKESLI TSILQGEKIT FNRLNLMLKC
1460 1470 1480 1490 1500
NLIRREKENG CRDEVDREER LEGDPFLKPF IFLGQRVEKD EDEVEEVKIR
1510 1520 1530 1540 1550
EPTCQTHLYI TEPNFGLCYN FDFIREKEQR EYREDMLVTN QFCDSYDKVH
1560 1570 1580 1590 1600
INGKRETPGP LRFKAIYPKH SADDDMTFWM AVRKRLVFRE EEENYQRLSR
1610 1620 1630 1640 1650
AHLVGGLLYT NFKKKMGLEF TFDQGLLEES INAFEKKKLE KSCGTIKSHS
1660 1670 1680 1690 1700
IRSDIDWALN DVFLFMKSQL CTKYEKQFVD AKAGQTLACF QHLILVQFAP
1710 1720 1730 1740 1750
WCRYLETQIR NQLPEEIYIH SNKNFDDLNA WVKKFFQRDI CVESDYEAFD
1760 1770 1780 1790 1800
ASQDEYILSF EIHLMKDAHF PQKIIDAYID LKCKLGCKLG HFSIMRFTGE
1810 1820 1830 1840 1850
FCTFLFNTLA NMAFTMCRYE WRRGQPIAFA GDDMCALNNL AVCHDFDDLF
1860 1870 1880 1890 1900
ELISLKAKVE RTETPMFCGW RLTPYGIVKE PELVYNRFQV AIEEGKVLEC
1910 1920 1930 1940 1950
LENYAIEVSY AYSLSERLYE VLKSERQVQY HQAVVRFIVT HIDKLKTKVR
1960
DLFLEQSSDE DI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ318061 Genomic RNA Translation: CAC39422.1 |
RefSeqi | NP_624333.1, NC_003877.1 |
Genome annotation databases
GeneIDi | 944478 |
KEGGi | vg:944478 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AJ318061 Genomic RNA Translation: CAC39422.1 |
RefSeqi | NP_624333.1, NC_003877.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Proteomic databases
PRIDEi | Q91QZ3 |
Genome annotation databases
GeneIDi | 944478 |
KEGGi | vg:944478 |
Family and domain databases
Gene3Di | 2.60.120.590, 1 hit 3.40.50.300, 1 hit |
InterProi | View protein in InterPro IPR027351, (+)RNA_virus_helicase_core_dom IPR037151, AlkB-like_sf IPR002588, Alphavirus-like_MT_dom IPR043502, DNA/RNA_pol_sf IPR044861, IPNS-like_FE2OG_OXY IPR003323, OTU_dom IPR005123, Oxoglu/Fe-dep_dioxygenase IPR027417, P-loop_NTPase IPR008041, Peptidase_C23 IPR007094, RNA-dir_pol_PSvirus IPR001788, Tymovirus_RNA-dep_RNA_pol |
Pfami | View protein in Pfam PF03171, 2OG-FeII_Oxy, 1 hit PF05379, Peptidase_C23, 1 hit PF00978, RdRP_2, 1 hit PF01443, Viral_helicase1, 1 hit PF01660, Vmethyltransf, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit SSF56672, SSF56672, 1 hit |
PROSITEi | View protein in PROSITE PS51743, ALPHAVIRUS_MT, 1 hit PS51471, FE2OG_OXY, 1 hit PS50802, OTU, 1 hit PS51492, PEPTIDASE_C23, 1 hit PS51657, PSRV_HELICASE, 1 hit PS50507, RDRP_SSRNA_POS, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_CLBVS | |
Accessioni | Q91QZ3Primary (citable) accession number: Q91QZ3 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 2, 2010 |
Last sequence update: | December 1, 2001 | |
Last modified: | February 23, 2022 | |
This is version 94 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |