RNA replication polyprotein

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactorⁱ

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• ATP binding Source: UniProtKB-KW
• cysteine-type peptidase activity Source: UniProtKB-KW
• dioxygenase activity Source: UniProtKB-KW
• helicase activity Source: UniProtKB-KW
• metal ion binding Source: UniProtKB-KW
• mRNA methyltransferase activity Source: InterPro
• RNA binding Source: InterPro
• RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• RNA processing Source: InterPro
• transcription, DNA-templated Source: InterPro
• viral RNA genome replication Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

Proteomic databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Compositional bias

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MALMSNKTAI ESILGNFEKK HVDAIYNAAA QTILSHSEFR NKHFAYSLNS 
        60         70         80         90        100
YQKKIASKVG IELYPNGYLP HSHPLSKIFE NHLLFDVLPG VVNTSRLVMC 
       110        120        130        140        150
SIKESKVLVF KGIRDKSRRQ VSDLNALNSL NNSHTSFINR LVASKDVSRY 
       160        170        180        190        200
TEEADAFFQS KKGSPELFSR NFIKSLENKE AVFFHDEVHH WTKAQMFSFL 
       210        220        230        240        250
KSTKVKRFIF TVVYPPEILK KFANSQNPKV YDFKVDKGRL FFFPDGVKTE 
       260        270        280        290        300
AYEQKLNMEW LFSASHLRSG DCVWTVTRHK SIYAHHLFEI SIGELVTDSK 
       310        320        330        340        350
LFFSDYNSID MSKIFLDRFR SYEVFPISIE HLYKVYSYLL CLKKPDLESG 
       360        370        380        390        400
LAKLRQIIGD DVEIKEFLFF EQFCKRLIER QTSWGLFGHS FFEKLTDMAL 
       410        420        430        440        450
SSLPNSIARI FPQWKKKNTF EFLFSLGTLV VDVERKVCFE HVLEEWGFEV 
       460        470        480        490        500
VITDENAYLD PLSIFAINEN FNEDRVDDGY LERIRLPFWN LNDYDLKRKR 
       510        520        530        540        550
VNAYNILSYR FEEERKIESA QKGPNKMLQI EWYGIKEFKV DPFISNSITE 
       560        570        580        590        600
FTLLEALLGK RIDPKKYSYS KQACTLSNYL TFLCAEGLDG FNLEEHLERR 
       610        620        630        640        650
LKAAGHDVSD DEEEELTSAE QAGPIKILAD PLGFMKECLE EIPIETEPSL 
       660        670        680        690        700
EERGQFSTDY HSEKFEINYN DIFNPHNCMN THGDEIPTPS DGNCFFSAFT 
       710        720        730        740        750
ETFEVERPDT LRSDFSDWLM EFNGGSYASL AEMIRPNGVF MEAELIYLFC 
       760        770        780        790        800
VFRGVTLIIH DRTHEKENVY AVHRGFEEGH MVHRGNHFVG IETYNISTLT 
       810        820        830        840        850
SDPLLGDIPC GFSEEITKFH FRPDHFNCAQ FRGRKAAFIT KVDADYGHNG 
       860        870        880        890        900
MVYPHNSWVP SLEEIIQICG QGDDFNCALI NFYEANSSLG FHRDNERVYN 
       910        920        930        940        950
DDPILTVCTF GEGRFTIEFK DQVTSFLMTA GSFFLMPKGF QKKARHSVSN 
       960        970        980        990       1000
EMSRVSITFR KHVRRLNGSP IAIREENYKN TCLINAFSKA MKRSKQAIIA 
      1010       1020       1030       1040       1050
KLKTVNSPFW SRYLSEGNGG SIEDCQSACE ALDVTVDLNV NGKCVVLGKG 
      1060       1070       1080       1090       1100
ALRISMALRN NHFSVINAAQ LMERTFVSHL LEKGNVNVLE GFDAMLSGDV 
      1110       1120       1130       1140       1150
GAAGVNKIQF AANFEFARIL ANSFLNMTTG ICLGKALDNG EKYFLHILKD 
      1160       1170       1180       1190       1200
RVKQIGIDVT MVCGFAGSGK SRKLQSWLHS RKKGNFCVVS PRTNLAADWA 
      1210       1220       1230       1240       1250
FKLELEPNEQ RKVSTFEKFI KTDKSKLDLI VIDELTLFPN GYLDLLVYEL 
      1260       1270       1280       1290       1300
ADVNRHCQII LLFDPLQARY HNKMDESILT FEHDVDRLIG GQNIEYIYST 
      1310       1320       1330       1340       1350
HRMSRYFNRF FDVPCFNQAD RTEEQRLWIF DDVYSIPSIC SDRQEPCDVL 
      1360       1370       1380       1390       1400
LVESDLEKKA FSPIINVMTF GESQGLTFNH VCILLSESSA ASNEFRWMVA 
      1410       1420       1430       1440       1450
LTRARTRFSL CSTFLGGIEE FKVKRKESLI TSILQGEKIT FNRLNLMLKC 
      1460       1470       1480       1490       1500
NLIRREKENG CRDEVDREER LEGDPFLKPF IFLGQRVEKD EDEVEEVKIR 
      1510       1520       1530       1540       1550
EPTCQTHLYI TEPNFGLCYN FDFIREKEQR EYREDMLVTN QFCDSYDKVH 
      1560       1570       1580       1590       1600
INGKRETPGP LRFKAIYPKH SADDDMTFWM AVRKRLVFRE EEENYQRLSR 
      1610       1620       1630       1640       1650
AHLVGGLLYT NFKKKMGLEF TFDQGLLEES INAFEKKKLE KSCGTIKSHS 
      1660       1670       1680       1690       1700
IRSDIDWALN DVFLFMKSQL CTKYEKQFVD AKAGQTLACF QHLILVQFAP 
      1710       1720       1730       1740       1750
WCRYLETQIR NQLPEEIYIH SNKNFDDLNA WVKKFFQRDI CVESDYEAFD 
      1760       1770       1780       1790       1800
ASQDEYILSF EIHLMKDAHF PQKIIDAYID LKCKLGCKLG HFSIMRFTGE 
      1810       1820       1830       1840       1850
FCTFLFNTLA NMAFTMCRYE WRRGQPIAFA GDDMCALNNL AVCHDFDDLF 
      1860       1870       1880       1890       1900
ELISLKAKVE RTETPMFCGW RLTPYGIVKE PELVYNRFQV AIEEGKVLEC 
      1910       1920       1930       1940       1950
LENYAIEVSY AYSLSERLYE VLKSERQVQY HQAVVRFIVT HIDKLKTKVR 
      1960 
DLFLEQSSDE DI                                          

Sequence databases

Genome annotation databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 100% Identity
• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ