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Entry version 93 (07 Oct 2020)
Sequence version 1 (01 Dec 2001)
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Protein

RNA-directed RNA polymerase L

Gene

L

Organism
Spring viremia of carp virus (Rhabdovirus carpia)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA-directed RNA polymerase that catalyzes the transcription of viral mRNAs, their capping and polyadenylation. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The viral polymerase binds to the genomic RNA at the 3' leader promoter, and transcribes subsequently all viral mRNAs with a decreasing efficiency. The first gene is the most transcribed, and the last the least transcribed. The viral phosphoprotein acts as a processivity factor. Capping is concommitant with initiation of mRNA transcription. Indeed, a GDP polyribonucleotidyl transferase (PRNTase) adds the cap structure when the nascent RNA chain length has reached few nucleotides. Ribose 2'-O methylation of viral mRNA cap precedes and facilitates subsequent guanine-N-7 methylation, both acticities being carried by the viral polymerase. Polyadenylation of mRNAs occur by a stuttering mechanism at a slipery stop site present at the end viral genes. After finishing transcription of a mRNA, the polymerase can resume transcription of the downstream gene.By similarity
RNA-directed RNA polymerase that catalyzes the replication of viral genomic RNA. The template is composed of the viral RNA tightly encapsidated by the nucleoprotein (N). The replicase mode is dependent on intracellular N protein concentration. In this mode, the polymerase replicates the whole viral genome without recognizing transcriptional signals, and the replicated genome is not caped or polyadenylated.By similarity

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi1652 – 1661ATPSequence analysis10

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferase, Multifunctional enzyme, Nucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processmRNA capping, mRNA processing, Viral RNA replication, Viral transcription
LigandATP-binding, Nucleotide-binding, S-adenosyl-L-methionine

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA-directed RNA polymerase L
Short name:
Protein L
Alternative name(s):
Large structural protein
Replicase
Transcriptase
Including the following 4 domains:
RNA-directed RNA polymerase (EC:2.7.7.48By similarity)
mRNA (guanine-N(7)-)-methyltransferase (EC:2.1.1.56By similarity)
GDP polyribonucleotidyltransferase (EC:2.7.7.88By similarity)
Cap-specific mRNA (nucleoside-2'-O-)-methyltransferase 2 (EC:2.1.1.296By similarity)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:L
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiSpring viremia of carp virus (Rhabdovirus carpia)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri696863 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaOrthornaviraeNegarnaviricotaHaploviricotinaMonjiviricetesMononegaviralesRhabdoviridaeSprivivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCyprinus carpio (Common carp) [TaxID: 7962]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000007541 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm, Virion

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002872611 – 2095RNA-directed RNA polymerase LAdd BLAST2095

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q91DR9

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

May form homodimer.

Interacts with the P protein.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91DR9

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini587 – 773RdRp catalyticPROSITE-ProRule annotationAdd BLAST187
Domaini1625 – 1822Mononegavirus-type SAM-dependent 2'-O-MTasePROSITE-ProRule annotationAdd BLAST198

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the rhabdoviridae protein L family.Curated

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR039530, L_methyltransferase_rhabdo
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR017234, RNA-dir_pol_rhabdovirus

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14314, Methyltrans_Mon, 1 hit
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF037546, RNA_pol_RhabdoV_sub, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR04198, paramyx_RNAcap, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q91DR9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MFEWESQDTP SGLPDEESYF PTSKLSVEER MHYLNNVDYN LNSPLISDDI
60 70 80 90 100
EYLTLKHFGR AIPSLWKVKN WEIPLEMLKG VGIIKTWDQI HPWMGKWFDS
110 120 130 140 150
EHNCPQGESF LRTVQAESEL TSEIPVTFIK GWIGKEIKFP VKRGHHAVHL
160 170 180 190 200
LMQKVLDLHK LTLLINSVDS GETEKLCESF GLNSKQSKFE TYSLGTVRYC
210 220 230 240 250
PGWIFIDKAE ILLDRNFLLM MKDTLIGRLQ TLLSMLGNCE MEVEQIYTHT
260 270 280 290 300
ETMLSLYSYG DQIIEKAGNN GYSKIKLLEP ICNLRLSELA HKYRPLVPDF
310 320 330 340 350
PHFQEHVETS VREEDTTDGL LSAILSLVNN TEDIQLILTI YGSFRHWGHP
360 370 380 390 400
FISYFEGLQK LHDQVTLPKQ IDKEYAAALA SDLAYTVLQR KFSEEKKWYV
410 420 430 440 450
DSIALSSKHP LKEHVDNGTW PTAAQIQDFG DRWHLLPLTK CFEVPDLLDP
460 470 480 490 500
SVIYSDKSHS MNRKEVIDHV ISTPNKPIPS KKVLETMINN PATDWPTFLK
510 520 530 540 550
AVDEEGLPRD NLIIGLKGKE RELKIAGRFF SLMSWQLREY FVITEYLIKT
560 570 580 590 600
HYVPLFKGLT MADDLTSVVK KMLDNTNGQG LDDYSSICIA NHIDYEKWNN
610 620 630 640 650
HQRKESNGPV FRVMGQFLGY PRLFERTHEF FESSLIYYNG RPDLMDVRGD
660 670 680 690 700
SLVNTTDKMV CWEGQAGGLE GLRQKGWSVL NLLVINRESS IRNTVVKVLA
710 720 730 740 750
QGDNQVICTQ YKTKNYKNED ELKMLLTAMV ENNQTIMNGI ITGTGKLGLI
760 770 780 790 800
INNDETMQSA DYLNYGKVPV FRGILRGLET KRWSRVTCIT NDQIPTLAGV
810 820 830 840 850
MSSVSTNALT VAHFAASPIN AILQYHYFAN FCLMMIAMHN PAIRSSMYTK
860 870 880 890 900
MFRKCHIMSK EFKAATLYLD PSLGGVCGIS LARFLIRSFP DPVTEGLAFW
910 920 930 940 950
KMIHHNCQSD WLKALSKRCG NPKLARFRPE HIPKIIEDPA ALNISMGMSA
960 970 980 990 1000
SNLLKTEVKG HLIRTADTIQ NQIIREAAEY LGQEEASLNE FLWDIEPFFP
1010 1020 1030 1040 1050
RFLSEFRSST FVGVTDSLIG LFQNSKTIRG LFKSYYKREL DRLVVKSELS
1060 1070 1080 1090 1100
SLEHLGSYRK ETPDSIWECS STQADLLREK SWGRSVIGMT VPHPLEMFGK
1110 1120 1130 1140 1150
GHQKELECIP CQTSGLTYIS SYCPRGINNW YSTVGSLAAY LGSKTSETTS
1160 1170 1180 1190 1200
ILQPWEKDSK IPIIKRATKL RDSISWFVPP DSKLAKSIQQ NLKALTGEDW
1210 1220 1230 1240 1250
EEDIQGFKRT GSALHRFTTS RVSNGGFSAQ SPAKLTRIMT TTDTMRDLGD
1260 1270 1280 1290 1300
QNYDFMFQAG ILYSQMTTGE LRENSTNSTA THYHITCKSC LREIQEPMLE
1310 1320 1330 1340 1350
SRIVYNPPSS SRVIKSWIPN ATEIMEESKP IKLREVDWDP LTRYEKSYHI
1360 1370 1380 1390 1400
GRCQGFLYGD LTYQKTGRSE ESSIFPLSIQ YKVEGSGFMR GFCDGIIRAS
1410 1420 1430 1440 1450
AVQALHRRVS SIVSTADVIY GGALYLTNQV GDSPPFQNLC RSGPLREELE
1460 1470 1480 1490 1500
RIPHKMTSSY PTSNSDMGYL IRNYLKRSLK QLSRGRYETK EGPIWVFSDV
1510 1520 1530 1540 1550
RTKKFLGPFS LSTDALNCLY KNKLSKRDKN AVRNLSQLSS RMRSGDLSDE
1560 1570 1580 1590 1600
EIGKVEARFS FTPAEMRHAC KFTIGKTQVP IVMSEWGQEA YGNITMYPVF
1610 1620 1630 1640 1650
YSTTKTEKPD WTFSRLQNPT ISGLRISQQA TGAHYKLRSL LKGMKIHYQD
1660 1670 1680 1690 1700
AIGCGDGSGG LSSCLLRENK HCRVIFNSLL ELTGNTLRGS TPDPPSAING
1710 1720 1730 1740 1750
IPQIRDRCVN LNNVWEHPSD LSHPDTWKYF GELKAQFNMD VDLIVMDMEV
1760 1770 1780 1790 1800
QDIDISRRIE QNLRDHVHSL LSRHGTVIYK TYMTIMSENE KSVLDIVGVL
1810 1820 1830 1840 1850
FEDVQLCQTQ YSSSQTSEVY CVMRRLRQKV DSQHVDWQSL VRQGINSKVY
1860 1870 1880 1890 1900
CNLPLDKEFE RALNLYQIDT LVGVPRGLIP NLAVELETLL EIGGLSGGIL
1910 1920 1930 1940 1950
GKLVLNIEEG KLGFTMALIV SCILISESAI CTTRLSNKRE VPSSGACQRM
1960 1970 1980 1990 2000
AVCLIGAAIL LSVHHRSIEN HKGAIRMLRH SVPIRISSKL RKDGKLQSRW
2010 2020 2030 2040 2050
SSISREGLAK DVRLNSNMAG VGAWIRVWSR MKDRERRWEA READSWLKTH
2060 2070 2080 2090
NKGLSMEHVR RHTGVLDILH GTGDRLDRSV PTVSSAPRES GTWVE
Length:2,095
Mass (Da):238,192
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB43D47D061379AC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AJ318079 Genomic RNA Translation: CAC51337.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ318079 Genomic RNA Translation: CAC51337.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5H5ZX-ray1.74C828-836[»]
5Y91X-ray1.90C828-836[»]
SMRiQ91DR9
ModBaseiSearch...
PDBe-KBiSearch...

Proteomic databases

PRIDEiQ91DR9

Family and domain databases

InterProiView protein in InterPro
IPR039530, L_methyltransferase_rhabdo
IPR039736, L_poly_C
IPR026890, Mononeg_mRNAcap
IPR014023, Mononeg_RNA_pol_cat
IPR025786, Mononega_L_MeTrfase
IPR017234, RNA-dir_pol_rhabdovirus
PfamiView protein in Pfam
PF14314, Methyltrans_Mon, 1 hit
PF14318, Mononeg_mRNAcap, 1 hit
PF00946, Mononeg_RNA_pol, 1 hit
PIRSFiPIRSF037546, RNA_pol_RhabdoV_sub, 1 hit
TIGRFAMsiTIGR04198, paramyx_RNAcap, 1 hit
PROSITEiView protein in PROSITE
PS50526, RDRP_SSRNA_NEG_NONSEG, 1 hit
PS51590, SAM_MT_MNV_L, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiL_SVCV
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91DR9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: December 1, 2001
Last modified: October 7, 2020
This is version 93 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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