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Protein

RNA-directed RNA polymerase

Gene

VP1

Organism
Drosophila x virus (isolate Chung/1996) (DXV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

RNA-dependent RNA polymerase which is found both free and covalently attached to the genomic RNA. May also contain guanylyl and methyl transferase activities (By similarity).By similarity

Catalytic activityi

Nucleoside triphosphate + RNA(n) = diphosphate + RNA(n+1).PROSITE-ProRule annotation

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi256 – 263GTPSequence analysis8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionNucleotidyltransferase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandGTP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
RNA-directed RNA polymerase (EC:2.7.7.48)
Short name:
RDRP
Alternative name(s):
Protein VP1
Gene namesi
Name:VP1
OrganismiDrosophila x virus (isolate Chung/1996) (DXV)
Taxonomic identifieri654931 [NCBI]
Taxonomic lineageiVirusesdsRNA virusesBirnaviridaeEntomobirnavirus
Virus hostiDrosophila melanogaster (Fruit fly) [TaxID: 7227]
Proteomesi
  • UP000000515 Componenti: Genome

Subcellular locationi

  • Virion By similarity
  • Note: Minor amounts are incorporated in the virion.By similarity

GO - Cellular componenti

  • virion Source: UniProtKB-SubCell

Keywords - Cellular componenti

Virion

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003784121 – 997RNA-directed RNA polymeraseAdd BLAST997

Post-translational modificationi

May exist in multiple phosphorylated forms.

Keywords - PTMi

Covalent protein-RNA linkage, Phosphoprotein

Proteomic databases

PRIDEiQ91CD5

Interactioni

Subunit structurei

Interacts with VP3 in the cytoplasm.By similarity

Structurei

3D structure databases

SMRiQ91CD5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini420 – 616RdRp catalyticPROSITE-ProRule annotationAdd BLAST197

Phylogenomic databases

OrthoDBiVOG0900001R

Family and domain databases

InterProiView protein in InterPro
IPR007100 RNA-dir_pol_birnavirus
IPR007098 RNA-dir_pol_mononegavirus
PfamiView protein in Pfam
PF04197 Birna_RdRp, 1 hit
PROSITEiView protein in PROSITE
PS50524 RDRP_DSRNA_BIR, 1 hit

Sequencei

Sequence statusi: Complete.

Q91CD5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSDIFNQQGL KSKFSNIVKN EGQGDSDIRE VFNELARPQA EVGRDIEYSE
60 70 80 90 100
LSQALNDNSV KVFRPQPYDE LVNIPFIEAA SPRMMALYGE LLDSKDVSLP
110 120 130 140 150
VGSGLHIPTY KPGHEVTPPL LTLPNSLSYE YMHYIANSAN DTWDKQIYET
160 170 180 190 200
LKELLVAQAT NRFSTGSLLG QVKRVAAGQD VAYGRKGHHK NKSFKEMGIT
210 220 230 240 250
PYRVMEWLDE YMPISDDEPE ITLSNTLDWL VYTPEEAELM GVPDSLPDIT
260 270 280 290 300
QSSAAGLPWL GKKKGEVAVS ALITANMLIK DVSQLLKENL FTGSNNPLDP
310 320 330 340 350
KKEGVAEVTT KNPRRAADQF SRQVLDRIIK EYSYTMMGLL FPKGERYAIA
360 370 380 390 400
DHLTKTRNIW SASYVTHLIG STISDQPAKR MLNVLTSTSR TPSLAKFSPT
410 420 430 440 450
QGGMEALINI ILNATDIVEL VYADNAYIYY PNEDIWYSID LTKGEANCTR
460 470 480 490 500
DVAMTTAMYL LTRGWTSKQG TPIYNYTWAY LALYGIPYMT VDSISVLKNF
510 520 530 540 550
QIKNPGQGSG NPWTFLNNHV LTTILMNKWS EIGKPQPSPD VIEKLASMTG
560 570 580 590 600
IDFKVELVVT NFREKLIAAS RHSIPTSNRV EPRTIVEMDM LGWDVTHTEF
610 620 630 640 650
GFTPVLSKER LFKSIACPQP PSSTFQTSVA KQVHKYIQNV ALLYVGAWAY
660 670 680 690 700
PCIAQTIEGY ALNHWNTINI MIRNKEYDLD KAIGKAVEAS PFSEVISLLS
710 720 730 740 750
LDRPMHEQNY AQVLYQQKTI EKKEAKPKVS NPLYKRDKET YHEYTTRMAR
760 770 780 790 800
MRINDDMVGP QWEPIINLVT KLYPREATGE NQKSRESMTR VKIRGLLENM
810 820 830 840 850
ERQLESNGRS MDVWYNAYLT GKKPSGVDKK LATLLVLLAP KRTKKLPSGV
860 870 880 890 900
YQKLLGYPPI DKSPVPSLTS DEAYLYDTNS LEYNRIAYVS KLNEDDITVY
910 920 930 940 950
ANKYMVYSST LLSNLLPDKV DWPELRSMNV EGASDPYQVK GYKKKELKPR
960 970 980 990
FGEEILDDEP TGKKSSSEKR RLQRKGQKAK LQRQAATGTT FVRKPLN
Length:997
Mass (Da):112,779
Last modified:March 1, 2002 - v2
Checksum:i2CE74CA091D9AC29
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF196645 Genomic RNA Translation: AAL13168.2
RefSeqiNP_690806.1, NC_004169.1

Genome annotation databases

GeneIDi993339
KEGGivg:993339

Similar proteinsi

Entry informationi

Entry nameiRDRP_DXV96
AccessioniPrimary (citable) accession number: Q91CD5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 7, 2009
Last sequence update: March 1, 2002
Last modified: May 23, 2018
This is version 46 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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