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Protein

Cardiotoxin 7''

Gene
N/A
Organism
Naja atra (Chinese cobra)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Has low cytotoxic activity.By similarity

Miscellaneous

Is classified as a P-type cytotoxin, since a proline residue stands at position 52 (Pro-31 in standard classification).By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionToxin
Biological processCytolysis, Hemolysis

Names & Taxonomyi

Protein namesi
Recommended name:
Cardiotoxin 7''Imported
Alternative name(s):
Cardiotoxin 7'Imported
Cardiotoxin VIIImported
OrganismiNaja atra (Chinese cobra)
Taxonomic identifieri8656 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Secreted, Target cell membrane, Target membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21By similarityAdd BLAST21
ChainiPRO_000003538422 – 83Cardiotoxin 7''Add BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 43By similarity
Disulfide bondi36 ↔ 61By similarity
Disulfide bondi65 ↔ 76By similarity
Disulfide bondi77 ↔ 82By similarity

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.Curated

Structurei

3D structure databases

ProteinModelPortaliQ91996
SMRiQ91996
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003572 Cytotoxin_Cobra
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PRINTSiPR00282 CYTOTOXIN
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q91996-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTLVV VTIVCLDLGY TLKCHNTQLP FIYKTCPEGK NLCFKATLKK
60 70 80
FPLKFPVKRG CADNCPKNSA LLKYVCCSTD KCN
Length:83
Mass (Da):9,305
Last modified:November 1, 1996 - v1
Checksum:i34D396A5C4C851DD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58517 mRNA Translation: AAB03219.1
U42584 mRNA Translation: AAB01540.1
U58491 mRNA Translation: AAB18387.1
U77488 mRNA Translation: AAB36928.1
PIRiS70374

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U58517 mRNA Translation: AAB03219.1
U42584 mRNA Translation: AAB01540.1
U58491 mRNA Translation: AAB18387.1
U77488 mRNA Translation: AAB36928.1
PIRiS70374

3D structure databases

ProteinModelPortaliQ91996
SMRiQ91996
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003572 Cytotoxin_Cobra
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PRINTSiPR00282 CYTOTOXIN
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3SOFP_NAJAT
AccessioniPrimary (citable) accession number: Q91996
Secondary accession number(s): O13172, O13229
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 80 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programAnimal Toxin Annotation Program
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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Main funding by: National Institutes of Health

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