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Protein

Ribonuclease H1

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.UniRule annotation

Catalytic activityi

Endonucleolytic cleavage to 5'-phosphomonoester.UniRule annotation

Cofactori

Mg2+UniRule annotation

GO - Molecular functioni

Keywordsi

Molecular functionEndonucleaseUniRule annotation, Hydrolase, Nuclease
LigandMagnesiumUniRule annotation, Metal-bindingUniRule annotation

Names & Taxonomyi

Protein namesi
Recommended name:
Ribonuclease H1UniRule annotation (EC:3.1.26.4UniRule annotation)
Short name:
RNase H1UniRule annotation
OrganismiGallus gallus (Chicken)Imported
Taxonomic identifieri9031 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 20Sequence analysisAdd BLAST20
ChainiPRO_500431868821 – 293Ribonuclease H1Sequence analysisAdd BLAST273

Structurei

3D structure databases

ProteinModelPortaliQ91953
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini143 – 289RNase HInterPro annotationAdd BLAST147

Sequence similaritiesi

Belongs to the RNase H family.UniRule annotation

Keywords - Domaini

SignalSequence analysis

Phylogenomic databases

eggNOGiKOG3752 Eukaryota
COG0328 LUCA
HOGENOMiHOG000040465
HOVERGENiHBG002135
KOiK03469
PhylomeDBiQ91953

Family and domain databases

Gene3Di3.30.420.10, 1 hit
3.40.970.10, 1 hit
InterProiView protein in InterPro
IPR009027 Ribosomal_L9/RNase_H1_N
IPR017067 RNase_H1_euk
IPR011320 RNase_H1_N
IPR037056 RNase_H1_N_sf
IPR012337 RNaseH-like_sf
IPR002156 RNaseH_domain
IPR036397 RNaseH_sf
PfamiView protein in Pfam
PF01693 Cauli_VI, 1 hit
PF00075 RNase_H, 1 hit
PIRSFiPIRSF036852 Ribonuclease_H1_euk, 1 hit
SUPFAMiSSF53098 SSF53098, 1 hit
SSF55658 SSF55658, 1 hit
PROSITEiView protein in PROSITE
PS50879 RNASE_H, 1 hit

Sequencei

Sequence statusi: Complete.

Q91953-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRWLVALLS HSCFVSKGGG MFYAVRKGRQ TGVYRTWAEC QQQVNRFPSA
60 70 80 90 100
SFKKFATEKE AWAFVGAGPP DGQQSAPAET HGASAVAQEN ASHREEPETD
110 120 130 140 150
VLCCNACKRP YEQSTNEEHT VRRAKHDEEQ STPVVSEAKF SYMGEFAVVY
160 170 180 190 200
TDGCCSGNGR NRARAGIGVY WGPGHPLNIS ERLPGRQTNQ RAEIHAACKA
210 220 230 240 250
IEQAKSQNIK KLIIYTDSKF TINGITSWVE NWKTNGWRTS SGGSVINKED
260 270 280 290
FQKLDSLSKG IEIQWMHIPG HAGFQGNEEA DRLAREGASK QKL
Length:293
Mass (Da):32,499
Last modified:November 1, 1996 - v1
Checksum:i2B86AD6DC722682B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D26340 mRNA Translation: BAA05382.1
RefSeqiNP_990329.1, NM_204998.1
UniGeneiGga.500

Genome annotation databases

GeneIDi395848
KEGGigga:395848

Similar proteinsi

Entry informationi

Entry nameiQ91953_CHICK
AccessioniPrimary (citable) accession number: Q91953
Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: February 28, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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