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Entry version 83 (31 Jul 2019)
Sequence version 1 (01 Dec 2001)
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Protein

RNA replication protein

Gene

ORF1

Organism
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

RNA replication. The central part of this protein possibly functions as an ATP-binding helicase (Probable).Curated

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Fe2+PROSITE-ProRule annotationNote: Binds 1 Fe2+ ion per subunit.PROSITE-ProRule annotation

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi592IronPROSITE-ProRule annotation1
Metal bindingi594IronPROSITE-ProRule annotation1
Metal bindingi647IronPROSITE-ProRule annotation1
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei6562-oxoglutaratePROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Helicase, Hydrolase, Multifunctional enzyme, Nucleotidyltransferase, Oxidoreductase, RNA-directed RNA polymerase, Transferase
Biological processViral RNA replication
LigandATP-binding, Iron, Metal-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
RNA replication protein
Including the following 2 domains:
RNA-directed RNA polymerase (EC:2.7.7.48)
Helicase (EC:3.6.4.13)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:ORF1
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiIndian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri651357 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiVirusesRiboviriaTymoviralesAlphaflexiviridaeMandarivirus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section only exists in viral entries and indicates the host(s) either as a specific organism or taxonomic group of organisms that are susceptible to be infected by a virus.<p><a href='/help/virus_host' target='_top'>More...</a></p>Virus hostiCitrus [TaxID: 2706]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000394 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Genome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004010781 – 1658RNA replication proteinAdd BLAST1658

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q918W3

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q918W3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini59 – 224Alphavirus-like MTPROSITE-ProRule annotationAdd BLAST166
Domaini574 – 665Fe2OG dioxygenasePROSITE-ProRule annotationAdd BLAST92
Domaini910 – 1065(+)RNA virus helicase ATP-bindingAdd BLAST156
Domaini1066 – 1199(+)RNA virus helicase C-terminalAdd BLAST134
Domaini1437 – 1544RdRp catalyticPROSITE-ProRule annotationAdd BLAST108

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi755 – 758Poly-Thr4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.590, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR027450 AlkB-like
IPR037151 AlkB-like_sf
IPR002588 Alphavirus-like_MT_dom
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR027417 P-loop_NTPase
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13532 2OG-FeII_Oxy_2, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51471 FE2OG_OXY, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q918W3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MATIRGAIDR ITDTTVRTTL QEEACRQIRT ELKNVEHVNR YAIPPDAADA
60 70 80 90 100
LEHLGIGTNP FSVKLHTHGA CKAIENQLLY VVGTLLPKER VTMLFLKKAK
110 120 130 140 150
LNFMKRCPKF QDIFLNQHIE PRDVSRYCDF NVQSTSTSIP THTAYISDTL
160 170 180 190 200
HFMDRKDLVR LFINSPNLDT LYATIVLPVE AAYRQPSRYP DLYQINYDFD
210 220 230 240 250
GFQYIPGGHG GGAYHHEFSH LEWLDVGHIH WRGPDNKDIQ LTITAQMIES
260 270 280 290 300
LGANHLFCFR RGNLRTPRVR TFGRDTQVLL PKIFRPVDKN FNRAIPLTLA
310 320 330 340 350
NKMLLYAKSI NTVTFRDVVA KTRQLMKDKE LETYTGADLL HMANYFFVVG
360 370 380 390 400
ALSGVNSYDQ MLGLSAWEAC TMALKNTVTN LWERITGKRE FGKLLEALEW
410 420 430 440 450
ETLTYSRQVT QKYVGGTPAR LPLPDITDQE EIFAQQEALD ALTSGATKIT
460 470 480 490 500
THHLMSAAAR RSTEGPTMPT PAAQVPPTQN PKHTIDEVAS RALVTKLQKN
510 520 530 540 550
KRVYIQDDGP EYIMGHMAEV PAWYLEQDET TTRLRNRCAW FFGPPTHRYG
560 570 580 590 600
HNDIEYHTTE YYPWVERIGN IFGKFNTCLA QTHDQGARIG YHADDEDCYD
610 620 630 640 650
KDVTVATVNL TGNATFSLKT ATGTRTWKLK PGDFIVLKPG AQGCTKHAIS
660 670 680 690 700
DCTTNRTSLT FRWQARPCPS QLRRVVNLGN VNNPKRKSKA QQWTPKTSNS
710 720 730 740 750
DSPRLTQTPN SPTPKDVPVV SPKLADATAP TIRAVPENGA HTNMACVELT
760 770 780 790 800
DLPETTTTHR PGKEPINDLT DSEPETESEQ TENLVLNRFI QDLPTTSTHA
810 820 830 840 850
WASETDSICS FQAEALGPSS VEALPWHEHL ELINSLGFTG LERQYGPDNN
860 870 880 890 900
LIWPITHYRT LPKSRTIEAP TDLVELLDTI DRHPTDVPYS KTRASAFGSD
910 920 930 940 950
VKNLRIGALV KNQDKQWRAS LALLCEENEH VLPTTVIHGA GGSGKSHLLQ
960 970 980 990 1000
QWVSSTERGN VVVILPTIEL LRDWLNKCPT TPKDSFKTFE KALVQNSAPV
1010 1020 1030 1040 1050
VIMDDYSKLP PGYIEAYVAL KGQCKLLVLT GDPRQSHYHE ENPEALISTL
1060 1070 1080 1090 1100
DPATDYFSKY CTYNINATHR NATTFANALG VYSERKLPVS VTCSSYQKSG
1110 1120 1130 1140 1150
WPTLVPSILK KTALNDMGQR SLTYAGCQGL TTPKVQIVLD NATPLCSEQV
1160 1170 1180 1190 1200
MYTALSRAVD QIHFFNTGPN HSDYWEKMNA TPFLKTFIDH TREENLKEHQ
1210 1220 1230 1240 1250
PAEPTVREHT PATHFPPANE ALALEPWVEP LTDKHSRELH HKALGHSNCV
1260 1270 1280 1290 1300
QTDNPVVQLF PHQQAKDETL FWKTIDARIK ITTPEENVRN FNMASDIGDI
1310 1320 1330 1340 1350
LFLNYKEAMC LPADPIPFQQ SLWDSCQAEV QQTYLSKPLA ALANAAQRQD
1360 1370 1380 1390 1400
PDFDSNKIQL FLKSQWVKKV EKLGCLKIKP GQTIASFMQQ TVMLYGTMAR
1410 1420 1430 1440 1450
YMRRIRISLC PSHIMINCET NPTQISSWVR ENWDFSGQSH ENDFEAFDQS
1460 1470 1480 1490 1500
QDANMLQFEL IKAKFHSIPE EIIAGYKHLK CHAHIFLGTI AIMRLSGEGP
1510 1520 1530 1540 1550
TFDANTECSI AYNHTRYFVP KGCAQLYAGD DSACAAPLSE KPSFQHISPE
1560 1570 1580 1590 1600
LSLKSKAKIR SQTKGDYATF CGWLITPKGF IKNPTQLYAS WLLAKHNKDL
1610 1620 1630 1640 1650
QDVARNYALD LRIAYQLKDE LYELLSPEEL DHHQLLVREM VKHKMGHLLN

LPEGFKQT
Length:1,658
Mass (Da):187,256
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i801A6ED698812DD7
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF406744 Genomic RNA Translation: AAK97522.1

NCBI Reference Sequences

More...
RefSeqi
NP_203553.1, NC_003093.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
922105

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
vg:922105

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406744 Genomic RNA Translation: AAK97522.1
RefSeqiNP_203553.1, NC_003093.1

3D structure databases

SMRiQ918W3
ModBaseiSearch...

Proteomic databases

PRIDEiQ918W3

Genome annotation databases

GeneIDi922105
KEGGivg:922105

Family and domain databases

Gene3Di2.60.120.590, 1 hit
InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
IPR027450 AlkB-like
IPR037151 AlkB-like_sf
IPR002588 Alphavirus-like_MT_dom
IPR005123 Oxoglu/Fe-dep_dioxygenase
IPR027417 P-loop_NTPase
IPR007094 RNA-dir_pol_PSvirus
IPR001788 Tymovirus_RNA-dep_RNA_pol
PfamiView protein in Pfam
PF13532 2OG-FeII_Oxy_2, 1 hit
PF00978 RdRP_2, 1 hit
PF01443 Viral_helicase1, 1 hit
PF01660 Vmethyltransf, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS51743 ALPHAVIRUS_MT, 1 hit
PS51471 FE2OG_OXY, 1 hit
PS51657 PSRV_HELICASE, 1 hit
PS50507 RDRP_SSRNA_POS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiRDRP_ICRSV
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q918W3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 1, 2001
Last modified: July 31, 2019
This is version 83 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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