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Protein

Movement and silencing protein TGBp1

Gene

ORF2

Organism
Indian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Transports viral genome to neighboring plant cells directly through plasmosdesmata, without any budding. The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier. Increases plasmodesma size exclusion limit. Acts as a suppressor of RNA-mediated gene silencing, also known as post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (By similarity).By similarity

Miscellaneous

TGBp1, TGBp2 and TGBp3 seem to act together for cell-to-cell propagation. TGBp1 is the main movement protein that physically cross the plasmodesma with the viral genome. TGBp2 and TGBp3 would facilitate TGBp1 function.

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionRNA-binding, Suppressor of RNA silencing, Viral movement protein
Biological processHost-virus interaction, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Movement and silencing protein TGBp1
Alternative name(s):
25 kDa protein
Silencing suppressor P25
Triple gene block 1 protein
Short name:
TGBp1
Gene namesi
ORF Names:ORF2
OrganismiIndian citrus ringspot virus (isolate Kinnow mandarin/India/K1/1996) (ICRSV)
Taxonomic identifieri651357 [NCBI]
Taxonomic lineageiVirusesssRNA virusesssRNA positive-strand viruses, no DNA stageTymoviralesAlphaflexiviridaeMandarivirus
Virus hostiCitrus [TaxID: 2706]
Proteomesi
  • UP000000394 Componenti: Genome

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Host cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004010791 – 225Movement and silencing protein TGBp1Add BLAST225

Interactioni

Subunit structurei

Homodimer and homooligomer. Interacts with capsid protein. Interacts with host AGO1; this interaction targets the host protein for degradation, thereby suppressing the antiviral RNA silencing (By similarity).By similarity

Structurei

3D structure databases

SMRiQ918W2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 110(+)RNA virus helicase ATP-bindingAdd BLAST110
Domaini111 – 225(+)RNA virus helicase C-terminalAdd BLAST115

Sequence similaritiesi

Belongs to the Tymovirales TGBp1 protein family.Curated

Phylogenomic databases

OrthoDBiVOG090000NV

Family and domain databases

InterProiView protein in InterPro
IPR027351 (+)RNA_virus_helicase_core_dom
PfamiView protein in Pfam
PF01443 Viral_helicase1, 1 hit
PROSITEiView protein in PROSITE
PS51657 PSRV_HELICASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q918W2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDFAELLESK AFTRTRLPLS KPIVVHAVAG AGKTSLLENY ARINPAARIY
60 70 80 90 100
TPIAQQSNSL LLSPFTQSLE QADIVDEYPL STLHPGVEYV LADPIQYLGS
110 120 130 140 150
KDLLKPHYIC PTTHRFGHST AEFLTSLGIE TYAHKPDRLT IANIFKTEPH
160 170 180 190 200
GQVIACDLDT QQLAARHSLD YLRPCQSIGK TFKDTTILIS HELNRDTLTK
210 220
EIYIALTRHT NSVTILTPDA PSTSS
Length:225
Mass (Da):24,954
Last modified:December 1, 2001 - v1
Checksum:iEFBB309C3032DCA7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF406744 Genomic RNA Translation: AAK97523.1
RefSeqiNP_203554.1, NC_003093.1

Genome annotation databases

GeneIDi922108
KEGGivg:922108

Similar proteinsi

Entry informationi

Entry nameiTGB1_ICRSV
AccessioniPrimary (citable) accession number: Q918W2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 2, 2010
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 51 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programViral Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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