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Protein

Suppressor of hairless protein homolog

Gene

rbpj

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Transcriptional regulator that plays a central role in Notch signaling, a signaling pathway involved in cell-cell communication that regulates a broad spectrum of cell-fate determinations. Acts as a transcriptional repressor when it is not associated with Notch proteins. When associated with some NICD product of Notch proteins (Notch intracellular domain), it acts as a transcriptional activator that activates transcription of Notch target genes (By similarity). Required for the transcriptional activation of ESR1, suggesting that it is required during primary neurogenesis in embryos. Binds to the oxygen responsive element of COX4I2 and activates its transcription under hypoxia conditions (4% oxygen) (By similarity).By similarity1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi59 – 66By similarity8
DNA bindingi193 – 202By similarity10
DNA bindingi266 – 298By similarityAdd BLAST33

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, Developmental protein, DNA-binding, Repressor
Biological processNotch signaling pathway, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of hairless protein homolog
Alternative name(s):
X-Su(H)
Gene namesi
Name:rbpj
Synonyms:rbpsuh, suh
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865998 rbpj

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002085691 – 501Suppressor of hairless protein homologAdd BLAST501

Proteomic databases

PRIDEiQ91880

Interactioni

Subunit structurei

Interacts with activated Notch proteins (By similarity). Forms a ternary complex with nrarp and the intracellular domain (NICD) of notch1. Interacts with rita1, leading to nuclear export, prevent the interaction between rbpj and NICD product and subsequent down-regulation of the Notch signaling pathway.By similarity2 Publications

Protein-protein interaction databases

ELMiQ91880
IntActiQ91880, 2 interactors
MINTiQ91880

Structurei

3D structure databases

ProteinModelPortaliQ91880
SMRiQ91880
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini356 – 446IPT/TIGAdd BLAST91

Sequence similaritiesi

Belongs to the Su(H) family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG006618
KOiK06053

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q91880-1) [UniParc]FASTAAdd to basket
Also known as: X-Su(H)1

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MQPGIPKYTP SAIQLAPVVT GKFGERPQPK RLTREAMRNY LKERGDQTVL
60 70 80 90 100
ILHAKVAQKS YGNEKRFFCP PPCVYLMGSG WKKKKEQMER DGCSEQESQP
110 120 130 140 150
CAFIGIGNSE QEMQQLNLEG KNYCTAKTLY ISDSDKRKHF MLSVKMFYGN
160 170 180 190 200
SDDIGVFLSK RIKVISKPSK KKQSLKNADL CIASGTKVAL FNRLRSQTVS
210 220 230 240 250
TRYLHVEGGN FHASSQQWGA FYIHLLDDEE SEGEEFTVRD GYIHYGQTVK
260 270 280 290 300
LVCSVTGMAL PRLIIRKVDK QTALLDADDP VSQLHKCAFY LKDTERMYLC
310 320 330 340 350
LSQERIIQFQ ATPCPKEPNK EMINDGASWT IISTDKAEYT FYEGMGPINA
360 370 380 390 400
PVTPVPVVES LQLNGGGDVA MLELTGQNFT PNLRVWFGDV EAETMYRCAE
410 420 430 440 450
SMLCVVPDIS AFREGWRWVR QPVQVPVTLV RNDGVIYSTS LTFTYTPEPG
460 470 480 490 500
PRPHCSAAGA ILRANSSLLA SNEPNTNSEG SYTNISTNSA NVTSSTAAVV

S
Length:501
Mass (Da):55,864
Last modified:November 1, 1996 - v1
Checksum:i2B2A271F38E843C2
GO
Isoform 2 (identifier: Q91880-2) [UniParc]FASTAAdd to basket
Also known as: X-Su(H)2

The sequence of this isoform differs from the canonical sequence as follows:
     1-20: Missing.
     21-21: G → M

Show »
Length:481
Mass (Da):53,844
Checksum:i461AA3FF0C6F5BAF
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0083941 – 20Missing in isoform 2. 1 PublicationAdd BLAST20
Alternative sequenceiVSP_00839521G → M in isoform 2. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60093 mRNA Translation: AAB05478.1
U60094 Genomic DNA Translation: AAB05479.1
RefSeqiNP_001084347.1, NM_001090878.1 [Q91880-1]
UniGeneiXl.12006

Genome annotation databases

GeneIDi399453
KEGGixla:399453

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60093 mRNA Translation: AAB05478.1
U60094 Genomic DNA Translation: AAB05479.1
RefSeqiNP_001084347.1, NM_001090878.1 [Q91880-1]
UniGeneiXl.12006

3D structure databases

ProteinModelPortaliQ91880
SMRiQ91880
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ91880
IntActiQ91880, 2 interactors
MINTiQ91880

Proteomic databases

PRIDEiQ91880

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi399453
KEGGixla:399453

Organism-specific databases

CTDi399453
XenbaseiXB-GENE-865998 rbpj

Phylogenomic databases

HOVERGENiHBG006618
KOiK06053

Family and domain databases

CDDicd01176 IPT_RBP-Jkappa, 1 hit
Gene3Di2.60.40.10, 1 hit
2.60.40.1450, 1 hit
InterProiView protein in InterPro
IPR015350 Beta-trefoil_DNA-bd_dom
IPR036358 BTD_sf
IPR013783 Ig-like_fold
IPR014756 Ig_E-set
IPR002909 IPT_dom
IPR008967 p53-like_TF_DNA-bd
IPR015351 RBP-J/Cbf11/Cbf12_DNA-bd
IPR037095 RBP-J/Cbf11/Cbf12_DNA-bd_sf
IPR038007 RBP-Jkappa_IPT
PfamiView protein in Pfam
PF09270 BTD, 1 hit
PF09271 LAG1-DNAbind, 1 hit
PF01833 TIG, 1 hit
SMARTiView protein in SMART
SM01268 BTD, 1 hit
SM01267 LAG1_DNAbind, 1 hit
SUPFAMiSSF110217 SSF110217, 1 hit
SSF49417 SSF49417, 1 hit
SSF81296 SSF81296, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiSUH_XENLA
AccessioniPrimary (citable) accession number: Q91880
Secondary accession number(s): Q91881
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 26, 2003
Last sequence update: November 1, 1996
Last modified: November 7, 2018
This is version 102 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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