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UniProtKB - Q91757 (GSK3B_XENLA)
Protein
Glycogen synthase kinase-3 beta
Gene
gsk3b
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Plays a role in the organization of the formation of the main body axis of developing embryo. Acts as an inhibitor of differentiation of primary neurons. Inhibits the ability of ectopically expressed NEUROD1 and other bHLH factors to promote early retinal cell differentiation. May participate in the Wnt signaling pathway. May regulate the circadian clock via phosphorylation of the major clock components.
4 PublicationsCatalytic activityi
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 85 | ATPPROSITE-ProRule annotation | 1 | |
Active sitei | 181 | Proton acceptorPROSITE-ProRule annotation | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 62 – 70 | ATPPROSITE-ProRule annotation | 9 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- protein serine/threonine kinase activity Source: UniProtKB
- tau-protein kinase activity Source: UniProtKB-EC
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- negative regulation of canonical Wnt signaling pathway Source: BHF-UCL
- negative regulation of transcription, DNA-templated Source: BHF-UCL
- nervous system development Source: UniProtKB-KW
- rhythmic process Source: UniProtKB-KW
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Kinase, Serine/threonine-protein kinase, Transferase |
Biological process | Biological rhythms, Differentiation, Neurogenesis, Wnt signaling pathway |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Glycogen synthase kinase-3 beta (EC:2.7.11.26)Short name: GSK-3 beta Alternative name(s): Xgsk-3 protein |
Gene namesi | Name:gsk3b Synonyms:Xgsk-3 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-865674, gsk3b.L |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Nucleus
- Nucleus By similarity
Plasma membrane
- Cell membrane By similarity
Nucleus
- nucleus Source: UniProtKB-SubCell
Plasma Membrane
- plasma membrane Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cell membrane, Cytoplasm, Membrane, NucleusPathology & Biotechi
Mutagenesis
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Mutagenesisi | 85 | K → R: Inhibits enzymatic activity. Induces duplication of the anterior dorsal axis. 2 Publications | 1 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000412070 | 1 – 420 | Glycogen synthase kinase-3 betaAdd BLAST | 420 |
Post-translational modificationi
Phosphorylated. Activated by phosphorylation at Tyr-216.
Keywords - PTMi
PhosphoproteinExpressioni
Developmental stagei
Expressed in the unfertilized egg and throughout the early embryonic stages. Expressed in the neural plate at stage 13. Expressed throughout the eye primordia and cranial ganglia at stage 25. Highly expressed in the differentiated retinal ganglion cell layer at stage 40.3 Publications
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 340 | Protein kinasePROSITE-ProRule annotationAdd BLAST | 285 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 50 | DisorderedSequence analysisAdd BLAST | 50 | |
Regioni | 384 – 420 | DisorderedSequence analysisAdd BLAST | 37 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 28 | Polar residuesSequence analysisAdd BLAST | 28 |
Sequence similaritiesi
Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.Curated
Phylogenomic databases
OrthoDBi | 990896at2759 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91757-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSGRPRTTSF AESCKPVQQP SSFGSMKVSR DKDGSKVTTV VATPGQGPDR
60 70 80 90 100
QQEVTYTDTK VIGNGSFGVV YQAKLCDTGE LVAIKKVLQD KRFKNRELQI
110 120 130 140 150
MRKLDHCNIV RLRYFFYSSG EKKDEVYLNL VLDYVPETVY RVARHYSRAK
160 170 180 190 200
QALPIIYVKL YMYQLFRSLA YIHSFGICHR DIKPQNLLLD PETAVLKLCD
210 220 230 240 250
FGSAKQLVRG EPNVSYICSR YYRAPELIFG ATDYTSSIDV WSAGCVLAEL
260 270 280 290 300
LLGQPIFPGD SGVDQLVEII KVLGTPTREQ IREMNPNYTE FKFPQIKAHP
310 320 330 340 350
WTKVFRARTP PEAIALCSRL LEYTPTSRLT PLDACAHSFF DELRDPNLKL
360 370 380 390 400
PNGREFPALF NFTTQELSSN PSLSSILIPA HARNQAAVST TSNTTSTSDS
410 420
NTGERGSTNN AASASASNSS
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 55 | T → S in AAA84444 (PubMed:7667318).Curated | 1 | |
Sequence conflicti | 88 | L → P in AAA84444 (PubMed:7667318).Curated | 1 | |
Sequence conflicti | 336 | A → V in AAA84444 (PubMed:7667318).Curated | 1 | |
Sequence conflicti | 399 | D → N in AAA84444 (PubMed:7667318).Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38492 mRNA Translation: AAC42224.1 U31862 mRNA Translation: AAA84444.1 BC108581 mRNA Translation: AAI08582.1 |
PIRi | I51425 I51692 |
RefSeqi | NP_001083752.1, NM_001090283.1 XP_018100414.1, XM_018244925.1 |
Genome annotation databases
GeneIDi | 399097 |
KEGGi | xla:399097 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L38492 mRNA Translation: AAC42224.1 U31862 mRNA Translation: AAA84444.1 BC108581 mRNA Translation: AAI08582.1 |
PIRi | I51425 I51692 |
RefSeqi | NP_001083752.1, NM_001090283.1 XP_018100414.1, XM_018244925.1 |
3D structure databases
SMRi | Q91757 |
ModBasei | Search... |
Protein-protein interaction databases
ELMi | Q91757 |
Protocols and materials databases
DNASUi | 399097 |
Genome annotation databases
GeneIDi | 399097 |
KEGGi | xla:399097 |
Organism-specific databases
CTDi | 399097 |
Xenbasei | XB-GENE-865674, gsk3b.L |
Phylogenomic databases
OrthoDBi | 990896at2759 |
Family and domain databases
CDDi | cd14137, STKc_GSK3, 1 hit |
InterProi | View protein in InterPro IPR033573, GSK3B IPR011009, Kinase-like_dom_sf IPR000719, Prot_kinase_dom IPR017441, Protein_kinase_ATP_BS IPR008271, Ser/Thr_kinase_AS IPR039192, STKc_GSK3 |
PANTHERi | PTHR24057:SF8, PTHR24057:SF8, 1 hit |
Pfami | View protein in Pfam PF00069, Pkinase, 1 hit |
SMARTi | View protein in SMART SM00220, S_TKc, 1 hit |
SUPFAMi | SSF56112, SSF56112, 1 hit |
PROSITEi | View protein in PROSITE PS00107, PROTEIN_KINASE_ATP, 1 hit PS50011, PROTEIN_KINASE_DOM, 1 hit PS00108, PROTEIN_KINASE_ST, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | GSK3B_XENLA | |
Accessioni | Q91757Primary (citable) accession number: Q91757 Secondary accession number(s): Q91627 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 27, 2011 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 124 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |