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Entry version 124 (29 Sep 2021)
Sequence version 1 (01 Nov 1996)
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Protein

C4a anaphylatoxin

Gene

c4a.L

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.951

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
C4a anaphylatoxinARBA annotation
Alternative name(s):
Complement C4 gamma chainARBA annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:c4a.LImported
Synonyms:c4aImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-478885, c4a.L

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell junction, Cell projectionARBA annotation, SecretedARBA annotation, SynapseARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 21Sequence analysisAdd BLAST21
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500431886622 – 1683C4a anaphylatoxinSequence analysisAdd BLAST1662

Keywords - PTMi

Disulfide bondARBA annotation, SulfationARBA annotation, Thioester bondARBA annotation

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini683 – 719Anaphylatoxin-likeInterPro annotationAdd BLAST37
Domaini1538 – 1681NTRInterPro annotationAdd BLAST144

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1275 – 1295Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, SignalSequence analysis

Phylogenomic databases

Identification of Orthologs from Complete Genome Data

More...
OMAi
TWEIHAV

Database of Orthologous Groups

More...
OrthoDBi
28894at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017, ANATO, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR041425, C3/4/5_MG1
IPR037569, Complement_C4A
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold

The PANTHER Classification System

More...
PANTHERi
PTHR11412:SF86, PTHR11412:SF86, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q91741-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGPPPLLYAL VWAAVCMVAK AQQPNFLVVA PRILHVGVKE VIGIQFEWPQ
60 70 80 90 100
GSLPPAGDIK VELSLRNQLS MIGCSGEEKL FLNKRNDYTI LTNLMLTSQR
110 120 130 140 150
LITCKLNERR SGRYVQLVVK SDVLGKQPKV VSIPVAYQRG YLFIQTDKSI
160 170 180 190 200
YTPKETVHIR SFTLDHVLRP TEEQVTLSVF NAQGFQVRKV EKISKDSVVA
210 220 230 240 250
DNLQIPDIST PGVWRISVHY TDAPETNFTA EFEVKPYVLP NFEVKIIPEV
260 270 280 290 300
PYFLMTKDSF TFRVEARYVY GEHVAGVGYM RVGITAQNGK RYMLRGLEKQ
310 320 330 340 350
TTLIDGDTTV TIRMADIKEK IQQDMGNLLG TSLYFAASVV EKASGVLEEK
360 370 380 390 400
EFTSVKFVSS PYKLDLSKTK RYFIPGTPAQ IVVEVSHIDG SPAAGVSVSL
410 420 430 440 450
SKSNAQLFEY KTDNNGVVAF HVNTASDEKK CDIRVKANFD SGSETESITL
460 470 480 490 500
LPYTSKASSY LFLNVPNQVL DPGSSFKVTL KAIISNKQNV EKIYYMVLNK
510 520 530 540 550
GQLLSLDSIR RTEVNEMLIT VKPSMIPSFR VIAYYYLGSE IISNSVWVDV
560 570 580 590 600
ADVCEGKLEL HASKKILAPG EALKLDVRTE GTATVSLSAV DTAVYILNSK
610 620 630 640 650
NKLTPQKMFK AMNAYDLGCS PGGGKDFINV FTDAGLAFVS SAGYTQINEL
660 670 680 690 700
GCRVHQRKKR AIDFQALTQQ KAYSYTTTEL QRCCQHGMML PPGKMSRVCT
710 720 730 740 750
KRAARVPDPT CRKAFLDCCE YAENLRKQLT LEKRKTQGFG RTQNVDGSDE
760 770 780 790 800
DFADESDIQI RSFFPETWLW RTVKVYNGLF SEAVYMPDSI TTWEIQAIGM
810 820 830 840 850
SREKGFCIAE PLKVKVFKDF HIYLRVPYSV KRFEQMELRP ILYNYNNKDL
860 870 880 890 900
EVKVYMEQAE DICSPGSGDS KPLIKEVTVG ANSALPVPFV VVPIGKSNPV
910 920 930 940 950
VSVVALGRSF VSDGVKKAMK IVKEGASVFE EKSYIIDPAD ITRRSIDFDE
960 970 980 990 1000
EFPSNMIPDG DFRSSIKVTM DSSMNTINNS LGADGISKLI RVPYGCAEQT
1010 1020 1030 1040 1050
MISTSPGVYA LRYLDHTEKW NLLSPDRKDE GLENMRQGYL RILQFKKADG
1060 1070 1080 1090 1100
SYGAWLHRTS STWLTAFVVK VLSLCRNYID VNVEDIRLSA QYLATMQKDT
1110 1120 1130 1140 1150
GAFQEKVSVI HQDMLGGSTT IDAEVSITAY VTVSLYHSLD SLSEDNVAVK
1160 1170 1180 1190 1200
SKISKAVDYL RGKLDTIKHP YSLALTTYAL TLTSKDSVLK DKAYNKLMSH
1210 1220 1230 1240 1250
AQGDPNKKEL YFGPKGTALA VETTSYVLLI TLLRGNIKDA EKMYTWLSEQ
1260 1270 1280 1290 1300
QNYGGGFKST QDTVMALEAL SEYWIRTFKQ DDNTLEIEVN SLEKQHSQKF
1310 1320 1330 1340 1350
KLRKEDNLQE ELRSMGTKFN IKVSGKGKGI LTVIKMYNIL QMQNTSCTEL
1360 1370 1380 1390 1400
GLDVTVSDAC EEAGMNEDDD YDYDEEMADE PREPIVWHDL RRRSRREATF
1410 1420 1430 1440 1450
TKEKEVKLLY EVCLWKKSSN VRLSGMAIVD ITLLSGIEPV IDDLKKLAES
1460 1470 1480 1490 1500
SERYISHYEY QPGRLLLYFD KVPDTWDCVA FEAVQTVKVS LLQPASAVIY
1510 1520 1530 1540 1550
DFYEPNIKCT VFYGAPSKPN FVSTLCSGDV CQCAEGLCPK KISSFKSTET
1560 1570 1580 1590 1600
ERQTFACYSP RVVFGYRVMV ENIAEQDAFI VYTARILEVL QRNSDEDIKP
1610 1620 1630 1640 1650
EDTRLFYQPM SCKMRLAKET EYLIMGQDGV TKNEHGHIRY ILEKNFWVEE
1660 1670 1680
LPGEQKCAAT RYRNFCTDAR NFMDKYKENG CMV
Length:1,683
Mass (Da):189,707
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i0F055063F4A58D96
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
D78003 mRNA Translation: BAA11188.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T30885

NCBI Reference Sequences

More...
RefSeqi
NP_001080934.1, NM_001087465.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
394275

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:394275

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D78003 mRNA Translation: BAA11188.1
PIRiT30885
RefSeqiNP_001080934.1, NM_001087465.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

MEROPSiI39.951

Genome annotation databases

GeneIDi394275
KEGGixla:394275

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
394275
XenbaseiXB-GENE-478885, c4a.L

Phylogenomic databases

OMAiTWEIHAV
OrthoDBi28894at2759

Family and domain databases

CDDicd00017, ANATO, 1 hit
Gene3Di2.40.50.120, 1 hit
2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048, A-macroglobulin_rcpt-bd
IPR036595, A-macroglobulin_rcpt-bd_sf
IPR011625, A2M_N_BRD
IPR011626, Alpha-macroglobulin_TED
IPR000020, Anaphylatoxin/fibulin
IPR018081, Anaphylatoxin_comp_syst
IPR041425, C3/4/5_MG1
IPR037569, Complement_C4A
IPR013783, Ig-like_fold
IPR001599, Macroglobln_a2
IPR019742, MacrogloblnA2_CS
IPR002890, MG2
IPR041555, MG3
IPR040839, MG4
IPR001134, Netrin_domain
IPR018933, Netrin_module_non-TIMP
IPR008930, Terpenoid_cyclase/PrenylTrfase
IPR008993, TIMP-like_OB-fold
PANTHERiPTHR11412:SF86, PTHR11412:SF86, 1 hit
PfamiView protein in Pfam
PF00207, A2M, 1 hit
PF07703, A2M_BRD, 1 hit
PF07677, A2M_recep, 1 hit
PF01821, ANATO, 1 hit
PF17790, MG1, 1 hit
PF01835, MG2, 1 hit
PF17791, MG3, 1 hit
PF17789, MG4, 1 hit
PF01759, NTR, 1 hit
PF07678, TED_complement, 1 hit
SMARTiView protein in SMART
SM01360, A2M, 1 hit
SM01359, A2M_N_2, 1 hit
SM01361, A2M_recep, 1 hit
SM00104, ANATO, 1 hit
SM00643, C345C, 1 hit
SUPFAMiSSF47686, SSF47686, 1 hit
SSF48239, SSF48239, 1 hit
SSF49410, SSF49410, 1 hit
SSF50242, SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477, ALPHA_2_MACROGLOBULIN, 1 hit
PS01178, ANAPHYLATOXIN_2, 1 hit
PS50189, NTR, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ91741_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91741
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: September 29, 2021
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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