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Entry version 108 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

Fibronectin

Gene

fn1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity).

Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).

By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi907 – 1172By similarityAdd BLAST266

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processAcute phase, Cell adhesion, Cell shape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
FibronectinBy similarity
Short name:
FN
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fn1By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 31Sequence analysisAdd BLAST31
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001923832 – 2481FibronectinAdd BLAST2450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi55 ↔ 81By similarity
Disulfide bondi79 ↔ 90By similarity
Disulfide bondi100 ↔ 128By similarity
Disulfide bondi126 ↔ 138By similarity
Disulfide bondi144 ↔ 172By similarity
Disulfide bondi170 ↔ 182By similarity
Disulfide bondi189 ↔ 218By similarity
Disulfide bondi216 ↔ 228By similarity
Disulfide bondi234 ↔ 263By similarity
Disulfide bondi261 ↔ 273By similarity
Disulfide bondi309 ↔ 336By similarity
Disulfide bondi334 ↔ 343By similarity
Disulfide bondi361 ↔ 387By similarity
Disulfide bondi375 ↔ 402By similarity
Disulfide bondi421 ↔ 447By similarity
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi431N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi471 ↔ 499By similarity
Disulfide bondi497 ↔ 509By similarity
Disulfide bondi519 ↔ 546By similarity
Glycosylationi529N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi543N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi544 ↔ 556By similarity
Disulfide bondi562 ↔ 590By similarity
Disulfide bondi588 ↔ 600By similarity
Glycosylationi877N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1244N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1291N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi2202N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi2301 ↔ 2330By similarity
Disulfide bondi2328 ↔ 2340By similarity
Disulfide bondi2346 ↔ 2373By similarity
Disulfide bondi2371 ↔ 2383By similarity
Disulfide bondi2390 ↔ 2416By similarity
Disulfide bondi2414 ↔ 2425By similarity
Disulfide bondi2459Interchain (with C-2463)PROSITE-ProRule annotation
Disulfide bondi2463Interchain (with C-2459)PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q91740

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

In early Xenopus embryo, cellular forms of fibronectin predominate which include both extra domains. In fibronectin of embryonic and adult liver the connecting strand 3 can be either completely excluded or included.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91740

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini53 – 93Fibronectin type-I 1PROSITE-ProRule annotationAdd BLAST41
Domaini98 – 141Fibronectin type-I 2PROSITE-ProRule annotationAdd BLAST44
Domaini142 – 185Fibronectin type-I 3PROSITE-ProRule annotationAdd BLAST44
Domaini187 – 231Fibronectin type-I 4PROSITE-ProRule annotationAdd BLAST45
Domaini232 – 276Fibronectin type-I 5PROSITE-ProRule annotationAdd BLAST45
Domaini307 – 346Fibronectin type-I 6PROSITE-ProRule annotationAdd BLAST40
Domaini356 – 404Fibronectin type-II 1PROSITE-ProRule annotationAdd BLAST49
Domaini416 – 464Fibronectin type-II 2PROSITE-ProRule annotationAdd BLAST49
Domaini469 – 512Fibronectin type-I 7PROSITE-ProRule annotationAdd BLAST44
Domaini517 – 559Fibronectin type-I 8PROSITE-ProRule annotationAdd BLAST43
Domaini560 – 603Fibronectin type-I 9PROSITE-ProRule annotationAdd BLAST44
Domaini611 – 703Fibronectin type-III 1Add BLAST93
Domaini720 – 808Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST89
Domaini811 – 904Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST94
Domaini909 – 998Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST90
Domaini999 – 1088Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini1089 – 1175Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST87
Domaini1176 – 1270Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST95
Domaini1271 – 1359Fibronectin type-III 8; extra domain BPROSITE-ProRule annotationAdd BLAST89
Domaini1360 – 1452Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST93
Domaini1453 – 1540Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST88
Domaini1541 – 1634Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST94
Domaini1635 – 1726Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST92
Domaini1727 – 1814Fibronectin type-III 13; extra domain APROSITE-ProRule annotationAdd BLAST88
Domaini1815 – 1908Fibronectin type-III 14PROSITE-ProRule annotationAdd BLAST94
Domaini1909 – 1995Fibronectin type-III 15PROSITE-ProRule annotationAdd BLAST87
Domaini1996 – 2086Fibronectin type-III 16PROSITE-ProRule annotationAdd BLAST91
Domaini2195 – 2299Fibronectin type-III 17PROSITE-ProRule annotationAdd BLAST105
Domaini2299 – 2343Fibronectin type-I 10PROSITE-ProRule annotationAdd BLAST45
Domaini2344 – 2386Fibronectin type-I 11PROSITE-ProRule annotationAdd BLAST43
Domaini2388 – 2431Fibronectin type-I 12PROSITE-ProRule annotationAdd BLAST44

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni28 – 51DisorderedSequence analysisAdd BLAST24
Regioni55 – 275Fibrin- and heparin-binding 1Add BLAST221
Regioni309 – 609Collagen-bindingAdd BLAST301
Regioni1358 – 1631Cell-attachmentAdd BLAST274
Regioni1812 – 2082Heparin-binding 2Add BLAST271
Regioni2083 – 2205V region (type III connecting segment, IIICS)Add BLAST123
Regioni2111 – 2138DisorderedSequence analysisAdd BLAST28
Regioni2301 – 2432Fibrin-binding 2Add BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi1615 – 1617Cell attachment site3

Keywords - Domaini

Repeat, Signal

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 16 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.10.10.10, 2 hits
2.60.40.10, 17 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039, fn1, 11 hits
PF00040, fn2, 2 hits
PF00041, fn3, 17 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 17 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265, SSF49265, 10 hits
SSF57440, SSF57440, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022, EGF_1, 2 hits
PS01253, FN1_1, 11 hits
PS51091, FN1_2, 12 hits
PS51092, FN2_2, 2 hits
PS50853, FN3, 17 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 1 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoform i produced by alternative splicing. AlignAdd to basket
Note: A number of isoforms are produced. The diversity of isoforms depends on the V region and either of the two extra domain which can be either included or excluded (partially or completely for the V region).Curated
Isoform 1 (identifier: Q91740-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MRRGALTGLL LVLCLSVVLR AAPSATSKKR RQAQQQQQQQ VVQPQGTQDN
60 70 80 90 100
HQKGCYDNGK YYQINQQWER TYLGNTLVCT CYGGGRGFNC ESKPESEETC
110 120 130 140 150
FDKYTGVSYR VGETYERPKD NMIWDCTCIG AGRGRISCTI ANRCHEGGQS
160 170 180 190 200
YKIGDTWRRP HETGGYMLEC VCLGNGKGEW TCKPVAERCY DNTAGTSYVV
210 220 230 240 250
GQTWEKPYQG WMMVDCTCLG EGNGRITCSS KNRCNDQDTK TSYRIGDTWS
260 270 280 290 300
KTDTRGNLLQ CICTGNGRGE WKCERHSSAQ ATGTGSNPIT NIQTALYQPD
310 320 330 340 350
SQLEPYGHCV TDNGVLYSLG MRWLRTQGSK QMLCTCLGNG VSCEETVATI
360 370 380 390 400
TFGGNANGEP CAIPFTHDGK TYYSCTSEGR QDGKLWCATT SNYDSDKKYS
410 420 430 440 450
FCTEQLALVQ TRGGNSNGAL CNFPFLYNNL NYTDSTSEGR QDSMKWCGTT
460 470 480 490 500
ANYDADQKFG FCPMAAHEEI CTTNEGVMYR VGDQWDKQHD QGHMMRCTCV
510 520 530 540 550
GNGRGEWSCV AYSQLKDQCI VDGLTYNVNS SFTKLHEEGH MMNCTCFGQG
560 570 580 590 600
RGRWKCDAID QCQDTETRQF YQIGDSWEKH LQGVQYQCYC YGKGIGEWHC
610 620 630 640 650
QPLSTSQAGT GPVQVIITES ANFPTSHPIQ WNAPQASHIK NYILRWKPKL
660 670 680 690 700
KAGPWKQATI PGHLNSYTIS GLKPGILYEG QLISILQYGN REVTTFDFTT
710 720 730 740 750
TTTIHRHSQT ESGETTPLPP LVSISESVTE ITASSFLVSW VSASDTVSGF
760 770 780 790 800
RVEYELSEDG DEKRYLELPN TATSVNIPDL LPGRRYNVNV YQITEEGEKS
810 820 830 840 850
LILSTTQTTA PDAPPEHNVE NVDDTSIMIK WNKPQAPITG YRVVYSPSVE
860 870 880 890 900
GSSTELNLPS TANSVTLTEL LPGIEYNITI YAVEDSLESV PVFIQQGTTG
910 920 930 940 950
TPQTVIVPSP TDLQLVEVTD VKIIIMWTSP QSEVSGYRVV VKPVSPAGRD
960 970 980 990 1000
VQNLPVNRNT FAEVVNLQPG RTYSFEVYAV NRGQESEPLV GEFATKLDAP
1010 1020 1030 1040 1050
TDLQFTDVTE STVVIIWIPP QAKIGRYLLS VGQTRGGQPS QFPINPSVTN
1060 1070 1080 1090 1100
HKLDNLLPGT EYTVSLVALK GNQQSASASG VFSTLEPVGS IPHYNTEVTE
1110 1120 1130 1140 1150
TTIVVTWTPV PRIGFKLDVR PSQGGEAPRE VISESGSIVI SGLTPGVEYT
1160 1170 1180 1190 1200
YSISVLTDGV EKDIPITKTV VTPLSPPTNL RLQPSRDSAT LTVYWDRSIS
1210 1220 1230 1240 1250
PGITGYRIST TPTPMQVGNS LEEEVGPSQT YCVFENLSPG VEYNVSVYAV
1260 1270 1280 1290 1300
KEEEESAPLS QMFLQEIPQL TDIKYDDVTD TSIDLRWTPL NSSNIIGYRI
1310 1320 1330 1340 1350
TVVAAGESVP IYEEFVGPTD GYYKVSGLEP GIDYEISLIT LINGGESAPT
1360 1370 1380 1390 1400
TIIQHTAVPP PTNLRFTNIG PDNIRVTWSP PTSIELSSYL VRYSPVKKPD
1410 1420 1430 1440 1450
DVTELSLSPS TNMVVLSNLL PFTEYLVSVH SVYEERESSS LNGVAKTHLD
1460 1470 1480 1490 1500
SPTGIAFSEI TPNSFTVHWI APRGPITGYR IRYQLESGAG RPKEERVPPS
1510 1520 1530 1540 1550
RNSITLTHLI PGSEYLVSII AINGQQESLP LAGQQATVSD VPTDLEVTSS
1560 1570 1580 1590 1600
SPNTLTISWE APAVSVRYYR ITYSQTGGHG PEKEFTVPGT SNTATIRGLN
1610 1620 1630 1640 1650
PGVSYTITVY AVTGRGDSPA SSKPLTIIHK TDVDQPIDMA VTDIQDHSIH
1660 1670 1680 1690 1700
VKWSPPPGPV TGYRVTSVPK SGQGETFSQV ISPDQTEVTI VGLQPAVEYV
1710 1720 1730 1740 1750
VSIYSQGENG ESEPLVETAV TNIDNPKGLT FTDVGVDSIR LAWEVPDGQV
1760 1770 1780 1790 1800
TRYRVTYSSP EDGVKELFPA PEGDDDTAEL HGLRPGTEYT VSIVALHDDM
1810 1820 1830 1840 1850
ESKPLIGIQS TAIPAPTNLQ FSQVTPSGFS LSWHAPTVHL TGYLVRVNPK
1860 1870 1880 1890 1900
EKTGPTKEVR LSPGVAATTV TGLMVATKYE VNVYALKDSL TSQPLQGLIS
1910 1920 1930 1940 1950
TLDNVSPPRR PRIQDVTETT VTLSWRTKTE TITGFQIDAI PADGQNPIRR
1960 1970 1980 1990 2000
TVDADLRTFT ITGLQPGTDY KIYLYTLNDN ARSSPVTVDV TTAVDSPSNL
2010 2020 2030 2040 2050
RFLTTTSNSL LFTWQPPRAR ITGYIIRYEK AGGLIKEHLP RLPAGTTEST
2060 2070 2080 2090 2100
LTNLEPGTEY IIYIIAVRNN MKSEPLVGRK RTDELPRLVT LPHPGQGPEI
2110 2120 2130 2140 2150
LDVPTDEENT PHITQTKLDN GNGIQLPGSN GQQPSSDHEG QLIEEHGFRS
2160 2170 2180 2190 2200
PLAPTTAVPV RPGKFAPGRY PQERVDIELD TFPVQHGDFD GPYPHGLGPQ
2210 2220 2230 2240 2250
LNDSGVQEVA SHTTISWRPE LETTEYIISC HPIDHEEAPL QFRVPGTSSS
2260 2270 2280 2290 2300
ATLNGLTRGA TYNIVVEAQK GTDKHKVLEK RVTVGSPGSP EGVLQPVEDT
2310 2320 2330 2340 2350
CYDTFSGAHY SVGQEWERMS ESGFRLWCKC LGYGSGHFRC DSSKWCHDNG
2360 2370 2380 2390 2400
VNHRIGEKWD RRGENGQMMS CTCLGNGKGE FKCEPPEATC YDEGKMYNVG
2410 2420 2430 2440 2450
EQWQKEYLGA ICSCTCYGGQ QGWRCDNCRR PGAVSPDGTA GQTVSQFTQR
2460 2470 2480
YQQNYNLNCP IECYLPLGLQ ADTQHSQQTQ K
Length:2,481
Mass (Da):272,680
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7E47DF4F6CE72C93
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
M77820 mRNA Translation: AAA49707.1

Protein sequence database of the Protein Information Resource

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PIRi
A43908

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M77820 mRNA Translation: AAA49707.1
PIRiA43908

3D structure databases

SMRiQ91740
ModBaseiSearch...

Proteomic databases

PRIDEiQ91740

Family and domain databases

CDDicd00061, FN1, 12 hits
cd00062, FN2, 2 hits
cd00063, FN3, 16 hits
Gene3Di2.10.10.10, 2 hits
2.60.40.10, 17 hits
InterProiView protein in InterPro
IPR000083, Fibronectin_type1
IPR003961, FN3_dom
IPR036116, FN3_sf
IPR000562, FN_type2_dom
IPR036943, FN_type2_sf
IPR013783, Ig-like_fold
IPR013806, Kringle-like
PfamiView protein in Pfam
PF00039, fn1, 11 hits
PF00040, fn2, 2 hits
PF00041, fn3, 17 hits
SMARTiView protein in SMART
SM00058, FN1, 12 hits
SM00059, FN2, 2 hits
SM00060, FN3, 17 hits
SUPFAMiSSF49265, SSF49265, 10 hits
SSF57440, SSF57440, 2 hits
PROSITEiView protein in PROSITE
PS00022, EGF_1, 2 hits
PS01253, FN1_1, 11 hits
PS51091, FN1_2, 12 hits
PS51092, FN2_2, 2 hits
PS50853, FN3, 17 hits

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFINC_XENLA
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91740
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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