UniProtKB - Q91637 (KIF2A_XENLA)
Protein
Kinesin-like protein KIF2A
Gene
kif2a
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Plus end-directed microtubule-dependent motor. May regulate microtubule dynamics during axonal growth (By similarity). Required for normal progression through mitosis. Required for normal congress of chromosomes at the metaphase plate. Required for normal spindle dynamics during mitosis. Promotes spindle turnover. Implicated in formation of bipolar mitotic spindles Has microtubule depolymerization activity.By similarity1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 288 – 295 | ATPPROSITE-ProRule annotation | 8 |
GO - Molecular functioni
- ATP binding Source: UniProtKB-KW
- ATP-dependent microtubule motor activity Source: InterPro
- microtubule binding Source: InterPro
GO - Biological processi
- cell division Source: UniProtKB-KW
- microtubule-based movement Source: InterPro
- mitotic spindle organization Source: UniProtKB
Keywordsi
Molecular function | Motor protein |
Biological process | Cell cycle, Cell division, Mitosis |
Ligand | ATP-binding, Nucleotide-binding |
Names & Taxonomyi
Protein namesi | Recommended name: Kinesin-like protein KIF2AAlternative name(s): Kinesin-related protein xKIF2 |
Gene namesi | Name:kif2a Synonyms:kif2 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-951759, kif2a.L |
Subcellular locationi
Cytoplasm and Cytosol
- Cytoplasm By similarity
Cytoskeleton
- centrosome 1 Publication
- spindle pole 1 Publication
- spindle 1 Publication
Note: Localized to the spindle microtubules and spindle poles from prophase to metaphase. Efficient targeting to spindle microtubules and spindle poles requires the kinase activity of plk1.
Cytoskeleton
- microtubule Source: UniProtKB-KW
- microtubule organizing center Source: UniProtKB-SubCell
- spindle pole Source: UniProtKB-SubCell
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, Cytoskeleton, MicrotubulePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000125416 | 1 – 682 | Kinesin-like protein KIF2AAdd BLAST | 682 |
Post-translational modificationi
Phosphorylation by plk1 promotes location at spindle microtubules and spindle poles, and enhances its microtubule depolymerization activity.1 Publication
Phosphorylation by AURKA interferes with location at spindle microtubules and spindle poles, and inhibits its microtubule depolymerization activity.1 Publication
Proteomic databases
PRIDEi | Q91637 |
Interactioni
Subunit structurei
Interacts with aurka and plk1.
1 PublicationGO - Molecular functioni
- microtubule binding Source: InterPro
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 198 – 528 | Kinesin motorPROSITE-ProRule annotationAdd BLAST | 331 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 192 | GlobularSequence analysisAdd BLAST | 192 |
Coiled coil
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Coiled coili | 638 – 673 | Sequence analysisAdd BLAST | 36 |
Sequence similaritiesi
Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. MCAK/KIF2 subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Coiled coilPhylogenomic databases
OrthoDBi | 418348at2759 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q91637-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MVTSLNEDSE SITVEWIENG DTKGKEIDLE SIFSLNHDLA PDEEIDPGPE
60 70 80 90 100
MPPPPAPTTK VNKIVKNRRT VAPVKNETPA KDNRVAAVGS ARARPIQPIE
110 120 130 140 150
QSASRQQNGS VSDISPDQPG KKDFGLASRR KSNCVKEVEK LQEKRERRRL
160 170 180 190 200
QQQELREKKA QDFDATNPNY EIMCMIKDFR GSLDYRPLTT SDPIDEHRIC
210 220 230 240 250
VCVRKRPLNK KETTIKDLDV ITIPIKDVVM VHEPKQKVDL TRFLENQTFR
260 270 280 290 300
FDYAFDETAP NETVYRFTAR PLVETIFERG MATCFAYGQT GSGKTHTMGG
310 320 330 340 350
DFSGKNQDCS KGIYALAARD VFQMLKKPNY KKLELQVYAT FFEIYSGKVF
360 370 380 390 400
DLLNRKTKLR VLEDGKQQVQ VVGLQEREVK CVEDVLKLIE IGNSCRTSGQ
410 420 430 440 450
TSANAHSSRS HAVFQIILRK KGKMHGKFSL IDLAGNERGA DTSSADRQTR
460 470 480 490 500
LEGAEINKSL LALKECIRAL GRNKPHTPFR ASKLTQVLRD SFIGENSRTC
510 520 530 540 550
MIATISPGMA SCENTLNTLR YANRVKELDP SRCRRPPPHD TSCPQTSWMT
560 570 580 590 600
WKQCGEWGVA PQRDDLKLLC EQNEEEVSPQ LFTFHEAVSQ MVEMEEQVVE
610 620 630 640 650
DHRAVFPGTS IRWLEGLKKC LLEMTEEVDY DADSYATQLE AILEKKIDIL
660 670 680
TELRDKVKSF RAALQEEEHA SKQINPKRPR AL
Sequence cautioni
The sequence AAC59744 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36486 mRNA Translation: AAC59744.2 Different initiation. |
RefSeqi | NP_001079931.1, NM_001086462.1 |
Genome annotation databases
GeneIDi | 379622 |
KEGGi | xla:379622 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U36486 mRNA Translation: AAC59744.2 Different initiation. |
RefSeqi | NP_001079931.1, NM_001086462.1 |
3D structure databases
SMRi | Q91637 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q91637 |
Genome annotation databases
GeneIDi | 379622 |
KEGGi | xla:379622 |
Organism-specific databases
CTDi | 379622 |
Xenbasei | XB-GENE-951759, kif2a.L |
Phylogenomic databases
OrthoDBi | 418348at2759 |
Family and domain databases
Gene3Di | 3.40.850.10, 1 hit |
InterProi | View protein in InterPro IPR027640, Kinesin-like_fam IPR019821, Kinesin_motor_CS IPR001752, Kinesin_motor_dom IPR036961, Kinesin_motor_dom_sf IPR027417, P-loop_NTPase |
PANTHERi | PTHR24115, PTHR24115, 1 hit |
Pfami | View protein in Pfam PF00225, Kinesin, 1 hit |
PRINTSi | PR00380, KINESINHEAVY |
SMARTi | View protein in SMART SM00129, KISc, 1 hit |
SUPFAMi | SSF52540, SSF52540, 1 hit |
PROSITEi | View protein in PROSITE PS00411, KINESIN_MOTOR_1, 1 hit PS50067, KINESIN_MOTOR_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KIF2A_XENLA | |
Accessioni | Q91637Primary (citable) accession number: Q91637 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | May 4, 2001 | |
Last modified: | April 7, 2021 | |
This is version 99 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |