ephb1-a

Functionⁱ

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. May play a role in axon guidance during nervous system development. May also play an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. More generally, may play a role in targeted cell migration and adhesion. Upon activation by ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively.1 Publication

Catalytic activityⁱ

ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.PROSITE-ProRule annotation

Sites

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Binding siteⁱ	652	ATPPROSITE-ProRule annotation		1
Active siteⁱ	745	Proton acceptorPROSITE-ProRule annotation		1

Regions

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Nucleotide bindingⁱ	626 – 634	ATPPROSITE-ProRule annotation		9

GO - Molecular functionⁱ

ATP binding Source: UniProtKB-KW
transmembrane-ephrin receptor activity Source: UniProtKB

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

axon guidance Source: UniProtKB
cell chemotaxis Source: UniProtKB
cell-substrate adhesion Source: UniProtKB
dendritic spine development Source: UniProtKB
dendritic spine morphogenesis Source: UniProtKB
ephrin receptor signaling pathway Source: UniProtKB
establishment of cell polarity Source: UniProtKB
positive regulation of synapse assembly Source: UniProtKB
protein autophosphorylation Source: UniProtKB
regulation of ERK1 and ERK2 cascade Source: UniProtKB
regulation of JNK cascade Source: UniProtKB

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Kinase, Receptor, Transferase, Tyrosine-protein kinase
Biological process	Cell adhesion, Neurogenesis
Ligand	ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 6725

BRENDAⁱ

2.7.10.1 6725

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Ephrin type-B receptor 1-A (EC:2.7.10.1) Alternative name(s): Tyrosine-protein kinase receptor XEK
Gene namesⁱ	Name:ephb1-a Synonyms:xek
Organismⁱ	Xenopus laevis (African clawed frog)
Taxonomic identifierⁱ	8355 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus

Organism-specific databases

Xenbaseⁱ	XB-GENE-865799 ephb1

Xenbaseⁱ

XB-GENE-865799 ephb1

Topology

Feature key	Position(s)	DescriptionActions	Length
Topological domainⁱ	20 – 542	ExtracellularSequence analysisAdd BLAST	523
Transmembraneⁱ	543 – 563	HelicalSequence analysisAdd BLAST	21
Topological domainⁱ	564 – 985	CytoplasmicSequence analysisAdd BLAST	422

Keywords - Cellular componentⁱ

Cell membrane, Cell projection, Endosome, Membrane

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Signal peptideⁱ	1 – 19	Sequence analysisAdd BLAST		19
ChainⁱPRO_0000016826	20 – 985	Ephrin type-B receptor 1-AAdd BLAST		966

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Glycosylationⁱ	336	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	428	N-linked (GlcNAc...) asparagineSequence analysis	1
Glycosylationⁱ	482	N-linked (GlcNAc...) asparagineSequence analysis	1

Post-translational modificationⁱ

Phosphorylated. Autophosphorylation is stimulated by ligands (By similarity).By similarity

Keywords - PTMⁱ

Glycoprotein, Phosphoprotein

Proteomic databases

PRIDEⁱ	Q91571

PRIDEⁱ

Q91571

Expressionⁱ

Developmental stageⁱ

Maternally expressed, it decreases at mid blastula transition and reappears at late neurulation. Expressed at higher levels in the anterior and dorsal regions of embryonic stages 16, 24 and 37. In adult it appears to be ubiquitously expressed with higher expression in brain and ovary. Expression in the brain, brachial arches, trigeminal facial ganglion, and the retina of swimming tadpole stage of development.

Interactionⁱ

Subunit structureⁱ

Heterotetramer upon binding of the ligand. The heterotetramer is composed of an ephrin dimer and a receptor dimer. Oligomerization is probably required to induce biological responses (By similarity).By similarity

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q91571
SMRⁱ	Q91571
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Length
Domainⁱ	21 – 203	Eph LBDPROSITE-ProRule annotationAdd BLAST	183
Domainⁱ	324 – 434	Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST	111
Domainⁱ	435 – 532	Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST	98
Domainⁱ	620 – 883	Protein kinasePROSITE-ProRule annotationAdd BLAST	264
Domainⁱ	912 – 976	SAMPROSITE-ProRule annotationAdd BLAST	65

Motif

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Motifⁱ	983 – 985	PDZ-bindingSequence analysis		3

Compositional bias

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Compositional biasⁱ	185 – 321	Cys-richAdd BLAST		137

Sequence similaritiesⁱ

Belongs to the protein kinase superfamily. Tyr protein kinase family. Ephrin receptor subfamily.PROSITE-ProRule annotation

Keywords - Domainⁱ

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

HOVERGENⁱ	HBG062180
KEGG Orthology (KO) More...KOⁱ	K05110

Family and domain databases

Conserved Domains Database More...CDDⁱ	cd10476 EphR_LBD_B1, 1 hit cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.120.260, 1 hit 2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR027936 Eph_TM IPR034231 EphB1_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR009030 Growth_fac_rcpt_cys_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF00041 fn3, 1 hit PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit
PIRSFⁱ	PIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00454 SAM, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS01186 EGF_2, 1 hit PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit

Sequenceⁱ

Sequence statusⁱ: Complete.

Sequence processingⁱ: The displayed sequence is further processed into a mature form.

Q91571-1 [UniParc]FASTA Add to basket

« Hide

        10         20         30         40         50
MELNVLLLLL CLSGGQVGAV EETLMDTRTA TAELGWTANP SSGWEEVSGY 
        60         70         80         90        100
DENLNTIRTY QVCNVFGPKQ NNWLLTTFIP RRGAHRVYVE MRFTVRDCSS 
       110        120        130        140        150
LPNVPGSCKE TFNLYYYETD SNIENKISTF WNESPYLKVD TIAADESFSQ 
       160        170        180        190        200
VDFGGRLMKV NTEVRSFGPL TRSGFYLAFQ DYGACMSLLS VRVFFKEMPS 
       210        220        230        240        250
VVQNLLVFPE TMTGAESTSL VIARGTCIPN AEEVDVPIKL YCNGDGEWMV 
       260        270        280        290        300
PIGKCTCKAG YEPENHVVCK ACPAAMFKAN QGMGICAQCP ANSRSTSEAS 
       310        320        330        340        350
PICICRNGYY RADFDTPEAP CTSVPSGPRN VISIVNETAI TLEWHPPRET 
       360        370        380        390        400
GGRDDVDYNI VCKKCRADRR ACSRCDDNVD FVPRQLGLTD TRVFISNLWA 
       410        420        430        440        450
HTPYTFETQA VNGVTNKSPF PPQHVSVNIT TNQAAPSSVP IMHQVKATMK 
       460        470        480        490        500
SITLSWPQQE QPNGIILDYE IRYYEKDHHE FNSSLARSQT NTARRTGGRV 
       510        520        530        540        550
WMFMSVQVRA RTVAGYGKFS SKCGFQTLTA EDYKSELREQ LPLTGSAAAG 
       560        570        580        590        600
VVFIVSLVAI SIVCSRKRTY SKEAVYSDKL QHYSTGRGSP GMKIYIDPFT 
       610        620        630        640        650
YEDPNEAVRE FAKEIDVSFV KIEEVIGAGE FGEVYKGRLK LPSKREISVA 
       660        670        680        690        700
IKTLKAGYSE KQRRDFLSEA SIMGQFDHPN IIRLEGVVTK SRPVMIITEF 
       710        720        730        740        750
MENGALDSFL RQNDGQFTVI QLVGMLRGIA AGMKYLSEMN YVHRDLAARN 
       760        770        780        790        800
ILVNSNLVCK VSDFGLSRYL QDDTSDPTYT SSLGGKIPVR WTAQEAIAYR 
       810        820        830        840        850
KFTSASDVWS YGIVMWEVMS YGERPYWTMS NQDVINAIEQ DYRLPPPMDC 
       860        870        880        890        900
PAALHQLMLD CWQKDRNSRP RLAEIVNTLR PMIRNPASLK TVATIPAVPS 
       910        920        930        940        950
QPLLDRSIPD ISAFTSVDDW LSAIKMGQYR DNFLSSGFTS LQLVAQMTSE 
       960        970        980 
DLLRIGITLA GHQKKILNSI QSMRVQITQS PTSIA

Length:985

Mass (Da):110,104

Last modified:November 1, 1996 - v1

Checksum:ⁱBE72CD1BFF51E623

GO

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14164 mRNA Translation: AAA74888.1
PIRⁱ	I51672
NCBI Reference Sequences More...RefSeqⁱ	NP_001084070.1, NM_001090601.1
UniGeneⁱ	Xl.1028

Genome annotation databases

GeneIDⁱ	399288
KEGGⁱ	xla:399288

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q91571	Uncharacterized protein		XENLA		1003	UniRef90_Q91571
UPI00084706C0		XENTR		988

Protein	Similar proteins		Species	Score	Length	Source
Q91571	Isoform 2 of Ephrin type-A receptor 4		HUMAN		935	UniRef50_P54764-2
Ephrin type-A receptor 3		DANRE		981
Ephrin type-A receptor 4		FUKDA		1073
EPH receptor A4 (Fragment)		MUSPF		74
EPH receptor A4		FICAL		957
+615

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U14164 mRNA Translation: AAA74888.1
PIRⁱ	I51672
RefSeqⁱ	NP_001084070.1, NM_001090601.1
UniGeneⁱ	Xl.1028

3D structure databases

ProteinModelPortalⁱ	Q91571
SMRⁱ	Q91571
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Proteomic databases

PRIDEⁱ	Q91571

PRIDEⁱ

Q91571

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	399288
KEGGⁱ	xla:399288

Organism-specific databases

CTDⁱ	399288
Xenbaseⁱ	XB-GENE-865799 ephb1

Phylogenomic databases

HOVERGENⁱ	HBG062180
KOⁱ	K05110

Enzyme and pathway databases

BRENDAⁱ	2.7.10.1 6725

BRENDAⁱ

2.7.10.1 6725

Family and domain databases

CDDⁱ	cd10476 EphR_LBD_B1, 1 hit cd00063 FN3, 2 hits
Gene3Dⁱ	2.60.120.260, 1 hit 2.60.40.10, 2 hits
InterProⁱ	View protein in InterPro IPR027936 Eph_TM IPR034231 EphB1_rcpt_lig-bd IPR001090 Ephrin_rcpt_lig-bd_dom IPR003961 FN3_dom IPR036116 FN3_sf IPR008979 Galactose-bd-like_sf IPR009030 Growth_fac_rcpt_cys_sf IPR013783 Ig-like_fold IPR011009 Kinase-like_dom_sf IPR000719 Prot_kinase_dom IPR017441 Protein_kinase_ATP_BS IPR001660 SAM IPR013761 SAM/pointed_sf IPR001245 Ser-Thr/Tyr_kinase_cat_dom IPR011641 Tyr-kin_ephrin_A/B_rcpt-like IPR008266 Tyr_kinase_AS IPR020635 Tyr_kinase_cat_dom IPR016257 Tyr_kinase_ephrin_rcpt IPR001426 Tyr_kinase_rcpt_V_CS
Pfamⁱ	View protein in Pfam PF14575 EphA2_TM, 1 hit PF01404 Ephrin_lbd, 1 hit PF00041 fn3, 1 hit PF07714 Pkinase_Tyr, 1 hit PF00536 SAM_1, 1 hit
PIRSFⁱ	PIRSF000666 TyrPK_ephrin_receptor, 1 hit
PRINTSⁱ	PR00109 TYRKINASE
SMARTⁱ	View protein in SMART SM00615 EPH_lbd, 1 hit SM01411 Ephrin_rec_like, 1 hit SM00060 FN3, 2 hits SM00454 SAM, 1 hit SM00219 TyrKc, 1 hit
SUPFAMⁱ	SSF47769 SSF47769, 1 hit SSF49265 SSF49265, 1 hit SSF49785 SSF49785, 1 hit SSF56112 SSF56112, 1 hit SSF57184 SSF57184, 2 hits
PROSITEⁱ	View protein in PROSITE PS01186 EGF_2, 1 hit PS51550 EPH_LBD, 1 hit PS50853 FN3, 2 hits PS00107 PROTEIN_KINASE_ATP, 1 hit PS50011 PROTEIN_KINASE_DOM, 1 hit PS00109 PROTEIN_KINASE_TYR, 1 hit PS00791 RECEPTOR_TYR_KIN_V_2, 1 hit PS50105 SAM_DOMAIN, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	EPB1A_XENLA
Accessionⁱ	Q91571Primary (citable) accession number: Q91571
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	November 1, 1996
	Last modified:	May 23, 2018
	This is version 138 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

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UniProtKB - Q91571 (EPB1A_XENLA)

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Ephrin type-B receptor 1-A

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Sites

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Endosome

Other locations

Endosome

Plasma Membrane

Other locations

Topology

Keywords - Cellular componenti

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Sequence databases

Genome annotation databases

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Sequence databases

3D structure databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Cross-referencesⁱ

Entry informationⁱ