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Entry version 113 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Tumor suppressor

Gene

dcc

Organism
Xenopus laevis (African clawed frog)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Tumor suppressorImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dccImported
Synonyms:XDCCaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiXenopus laevis (African clawed frog)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8355 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

Xenopus laevis and tropicalis biology and genomics resource

More...
Xenbasei
XB-GENE-5872596 dcc

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1080 – 1104HelicalSequence analysisAdd BLAST25

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
MAZP562702EBI-1809954,EBI-1809742From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q91562, 1 interactor

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini11 – 133Ig-likeInterPro annotationAdd BLAST123
Domaini139 – 229Ig-likeInterPro annotationAdd BLAST91
Domaini239 – 326Ig-likeInterPro annotationAdd BLAST88
Domaini331 – 416Ig-likeInterPro annotationAdd BLAST86
Domaini431 – 524Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini530 – 620Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini625 – 718Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini728 – 821Fibronectin type-IIIInterPro annotationAdd BLAST94
Domaini828 – 924Fibronectin type-IIIInterPro annotationAdd BLAST97
Domaini929 – 1026Fibronectin type-IIIInterPro annotationAdd BLAST98

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni707 – 731DisorderedSequence analysisAdd BLAST25
Regioni1108 – 1200DisorderedSequence analysisAdd BLAST93
Regioni1281 – 1311DisorderedSequence analysisAdd BLAST31
Regioni1374 – 1401DisorderedSequence analysisAdd BLAST28

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili1402 – 1422Sequence analysisAdd BLAST21

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1122 – 1148PolyampholyteSequence analysisAdd BLAST27
Compositional biasi1149 – 1200PolarSequence analysisAdd BLAST52
Compositional biasi1281 – 1309PolarSequence analysisAdd BLAST29
Compositional biasi1385 – 1399PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

Coiled coilSequence analysis, RepeatSAAS annotation, Transmembrane, Transmembrane helixSequence analysis

Phylogenomic databases

KEGG Orthology (KO)

More...
KOi
K06765

Database of Orthologous Groups

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OrthoDBi
217780at2759

Family and domain databases

Conserved Domains Database

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CDDi
cd00063 FN3, 6 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 10 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C

The PANTHER Classification System

More...
PANTHERi
PTHR44170:SF8 PTHR44170:SF8, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q91562-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENCLGFYSL PKLVFLLYGF TLLNLNLTVS GSQVKSFTSL WFLSEPSDAV
60 70 80 90 100
TMRGGNVVLN CSAQSDRGAP IIKWKKDGVY LNLVIDERRQ QLPSGSFLIQ
110 120 130 140 150
NVVHSRHHRP DEGVYQCEAS LDSVGTIVSR TAKVLVAGPL RILSQTESVT
160 170 180 190 200
AFVGDTALLR CEITGEPMPT ISWQKNEEDL KVTPGDPRLL VLPSGTLQIS
210 220 230 240 250
RLQTADGGVY RCLAKNPGSA RVGNEAELRI LSESGLHRQQ VFLQRPSNVV
260 270 280 290 300
AIEGQDAVLE CAVSGYPTPT IVWMQGDEPV PIRTRKYSVL GGSNLLISNV
310 320 330 340 350
TDDDAGAYTC VATYKNENTS FSADLTVMVP PQFLNHPANL YAYESMDIEF
360 370 380 390 400
ECAVSGKPSP TVKWTKNGEV VIPSDYFQIV DGSNLRILGL VKSDEGYYQC
410 420 430 440 450
IAENEAGNIQ TYAQLIIPDP AVPSSSILPS APRDVVPVLV SSRFVRLSWR
460 470 480 490 500
PPVESKGNIQ TYTVYFSKQG VQRERAVNTS QPISLQITVG NLTPEETYNF
510 520 530 540 550
RVVAYNEWGP GESSQEVKVV TQPELQVPGP VENLQVVSTA PTSVLISWDP
560 570 580 590 600
PAYANGPVQG YRLFCAETFS GREQNIEVDG IVYRLEGLRK FTEYSIRVLA
610 620 630 640 650
YNRYGPGVSS EEHTVVTLSD VPSAMPQNVS LEVANSRSIK VSWLPPPPGT
660 670 680 690 700
QNGFITGYKI RHRKTTRRGE LETLEPNNLW YLFTGLEKGS QYSFQVAAMT
710 720 730 740 750
VNGTGPSSDW YTAETPENDL DESQVPDQPS SLHVRPLTTS IIMSWTPPLN
760 770 780 790 800
PNIVVRGYII GYGVGSPYAE TVRVDSKQRY YSIENLEPSS HYVISLKAFN
810 820 830 840 850
NAGEGVPLYE SATTRSQTVP DMSTPMLPPV GVQAVALTHD AVRVSWADNS
860 870 880 890 900
VLKNQKTTEV RFYTIRWRTS YSASSKYKSA DTTSLSHTVT GLKPNTMYEF
910 920 930 940 950
SVMVTKGRRS STWSMTAHAT TYETAPTSAP KDLTVITRER KPRAVIVSWQ
960 970 980 990 1000
PPIEANGKII DFILFYTLDK NLQLDDWIMV TITGDRLTHE ILDLNLDTAY
1010 1020 1030 1040 1050
YFRIQARNAK GLGPLSEPIT FRTPKVEHPD KMANDQGRHG DGGYWSVDTN
1060 1070 1080 1090 1100
LIDRSSLNEP PIGQMHPPHG SVTPQKNSNL LVIIVVTVGA ITILVVVIVA
1110 1120 1130 1140 1150
VICTRRSSAQ QRKKRATHSA GKRKGSQKDL RPPDLWIHHE EMEMKNIEKP
1160 1170 1180 1190 1200
SGSDTQGRDS PRQSCQDITP VSHSQSESQL GSKSTSHSGP DADEVGSNIS
1210 1220 1230 1240 1250
TLERTLAARR ATRAKLMIPM DSQPSSNPPV VSAIPVPTLE SAQYPGILPS
1260 1270 1280 1290 1300
PTCGYPHPQF TLRPVPFPTL TVDRGFGTSR VTEVPASQQS SVLSHPQPEH
1310 1320 1330 1340 1350
STSEDAPSRT IPTACVRPTH PLRSFANPLL PPPMTAMEPK VPYTTLLSQT
1360 1370 1380 1390 1400
GSGLSKAQVK TASLGLAGKA RSPLLPVSVP TAPEVSEESH KHTDDPSSVY
1410 1420
EQDDLSEQMA SLEGLMKQLN AITGSAF
Length:1,427
Mass (Da):156,534
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i61FEA12C8A674972
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U10986 mRNA Translation: AAA70168.1

Protein sequence database of the Protein Information Resource

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PIRi
I51669

NCBI Reference Sequences

More...
RefSeqi
NP_001079254.1, NM_001085785.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
378529

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
xla:378529

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10986 mRNA Translation: AAA70168.1
PIRiI51669
RefSeqiNP_001079254.1, NM_001085785.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

IntActiQ91562, 1 interactor

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi378529
KEGGixla:378529

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
378529
XenbaseiXB-GENE-5872596 dcc

Phylogenomic databases

KOiK06765
OrthoDBi217780at2759

Family and domain databases

CDDicd00063 FN3, 6 hits
Gene3Di2.60.40.10, 10 hits
InterProiView protein in InterPro
IPR033012 DCC
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR010560 Neogenin_C
PANTHERiPTHR44170:SF8 PTHR44170:SF8, 1 hit
PfamiView protein in Pfam
PF00041 fn3, 6 hits
PF07679 I-set, 3 hits
PF13895 Ig_2, 1 hit
PF06583 Neogenin_C, 1 hit
SMARTiView protein in SMART
SM00060 FN3, 6 hits
SM00409 IG, 5 hits
SM00408 IGc2, 4 hits
SUPFAMiSSF48726 SSF48726, 4 hits
SSF49265 SSF49265, 4 hits
PROSITEiView protein in PROSITE
PS50853 FN3, 6 hits
PS50835 IG_LIKE, 4 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ91562_XENLA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91562
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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