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UniProtKB - Q91452 (Q91452_ONCMY)

Entry version 85 (25 May 2022)
Sequence version 1 (01 Nov 1996)
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Protein

Anion exchange protein

Gene
N/A
Organism
Oncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Functions both as a transporter that mediates electroneutral anion exchange across the cell membrane and as a structural protein. Major integral membrane glycoprotein of the erythrocyte membrane; required for normal flexibility and stability of the erythrocyte membrane and for normal erythrocyte shape via the interactions of its cytoplasmic domain with cytoskeletal proteins, glycolytic enzymes, and hemoglobin. Functions as a transporter that mediates the 1:1 exchange of inorganic anions across the erythrocyte membrane. Mediates chloride-bicarbonate exchange in the kidney, and is required for normal acidification of the urine.

ARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processAnion exchangeARBA annotation, Ion transport, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Anion exchange proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiOncorhynchus mykiss (Rainbow trout) (Salmo gairdneri)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8022 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Protacanthopterygii › Salmoniformes › Salmonidae › Salmoninae › Oncorhynchus

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei388 – 411HelicalUniRule annotationAdd BLAST24
Transmembranei423 – 449HelicalUniRule annotationAdd BLAST27
Transmembranei469 – 490HelicalUniRule annotationAdd BLAST22
Transmembranei502 – 520HelicalUniRule annotationAdd BLAST19
Transmembranei578 – 595HelicalUniRule annotationAdd BLAST18
Transmembranei615 – 631HelicalUniRule annotationAdd BLAST17
Transmembranei666 – 687HelicalUniRule annotationAdd BLAST22
Transmembranei708 – 731HelicalUniRule annotationAdd BLAST24
Transmembranei764 – 783HelicalUniRule annotationAdd BLAST20
Transmembranei790 – 809HelicalUniRule annotationAdd BLAST20
Transmembranei836 – 853HelicalUniRule annotationAdd BLAST18
Transmembranei860 – 881HelicalUniRule annotationAdd BLAST22

Keywords - Cellular componenti

Cell membraneARBA annotation, Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini101 – 176Band_3_cytoInterPro annotationAdd BLAST76
Domaini201 – 308Band_3_cytoInterPro annotationAdd BLAST108
Domaini361 – 842HCO3_cotranspInterPro annotationAdd BLAST482

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 42DisorderedSequence analysisAdd BLAST42

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1 – 16Acidic residuesSequence analysisAdd BLAST16
Compositional biasi17 – 31Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the anion exchanger (TC 2.A.31) family. [View classification]UniRule annotationARBA annotation

Keywords - Domaini

Transmembrane, Transmembrane helixUniRule annotationARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...OrthoDBi		265068at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.930.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001717, Anion_exchange
IPR002977, Anion_exchange_1
IPR018241, Anion_exchange_CS
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr

The PANTHER Classification System

More...PANTHERi		PTHR11453, PTHR11453, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF07565, Band_3_cyto, 2 hits
PF00955, HCO3_cotransp, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR00165, ANIONEXCHNGR
PR01187, ANIONEXHNGR1
PR01231, HCO3TRNSPORT

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF55804, SSF55804, 1 hit

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR00834, ae, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00219, ANION_EXCHANGER_1, 1 hit
PS00220, ANION_EXCHANGER_2, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q91452-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MENDLSFGED VMSSEEESDS AFPSPTRPGN YDLEQSRHEE DSNQAIQSIV 
        60         70         80         90        100
IHTDPEAYLN LNTNANTRGD AQAYVELNEL IGSSWQETGR WVGYEENLNP 
       110        120        130        140        150
ATGKWGPSHV SYLTFKSLIQ LRKIMSTGAI ILDLQASSLS AVAEKVVDEL 
       160        170        180        190        200
RTKGEIRATD RDGLLRALLQ RRSQSEGAVA QPLGGDIEMQ TFSVTKQRDT 
       210        220        230        240        250
TDSVEASIVL SGVMDSLEKP AVAFVRLGDS VVIEGALEAP VPVRFVFVLV 
       260        270        280        290        300
GPSQGGVDYH ESGRAMAALM ADWVFSLEAY LAQTNKELTN AIADFMDCSI 
       310        320        330        340        350
VIPPTEIQDK GMLQPIIDFQ KKMLKDRLRP SDTRIIFGGG AKADEADEEP 
       360        370        380        390        400
REDPLARTGI PFGGMIKDMK RRYRHYISDF TDALDPQVLA AVIFIYFAAL 
       410        420        430        440        450
SPAITFGGLL ADKTEHMMGV SELMISTCVQ GIIFAFIAAQ PTLVIGFSGP 
       460        470        480        490        500
LLVFEEAFFA FCKSQEIEYI VGRIWVGLWL VIIVVVIVAV EGSFLVKFIS 
       510        520        530        540        550
RFTQEIFSIL ISLIFIYETF SKLGKIFKAH PLILNYEHLN DSLDNPFHPV 
       560        570        580        590        600
VKERIEYQDD GNKTVHEVIH ERAYPNTALL SMCLMFGCFF IAYFLRQFKN 
       610        620        630        640        650
GHFLPGPIRR MIGDFGVPIA IFFMIAVDIT IEDAYTQKLV VPKGLMVSNP 
       660        670        680        690        700
NARGWFINPL GEKKPFPAWM MGACCVPALL VFILIFLESQ ITTLIVSKPE 
       710        720        730        740        750
RKMVKGSGFH LDLLILVTMG GIASLFGVPW LSAATVRSVT HANALTVMSK 
       760        770        780        790        800
GPKPEIEKVL EQRISGMLVA AMVGVSILLE PILKMIPMTA LFGIFLYMGI 
       810        820        830        840        850
TSLSGIQMWD RMLLLIVPRK YYPRDAYAQR VTTMKMHLFT LIQMVCLGAL 
       860        870        880        890        900
WMVKMSAFSL ALPFVLILTI PLRMAITGTL FTDKEMKCLD ASDGKVKFEE 
       910 
EPGEDMYESP LP
Length:912
Mass (Da):101,372
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAAECD81EAF5CD695
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
Z50848 mRNA Translation: CAA90701.1

Protein sequence database of the Protein Information Resource

More...PIRi		S59861

NCBI Reference Sequences

More...RefSeqi		NP_001118213.1, NM_001124741.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		100136955

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		omy:100136955

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z50848 mRNA Translation: CAA90701.1
PIRiS59861
RefSeqiNP_001118213.1, NM_001124741.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi100136955
KEGGiomy:100136955

Phylogenomic databases

OrthoDBi265068at2759

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR001717, Anion_exchange
IPR002977, Anion_exchange_1
IPR018241, Anion_exchange_CS
IPR013769, Band3_cytoplasmic_dom
IPR011531, HCO3_transpt-like_TM_dom
IPR003020, HCO3_transpt_euk
IPR016152, PTrfase/Anion_transptr
PANTHERiPTHR11453, PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565, Band_3_cyto, 2 hits
PF00955, HCO3_cotransp, 1 hit
PRINTSiPR00165, ANIONEXCHNGR
PR01187, ANIONEXHNGR1
PR01231, HCO3TRNSPORT
SUPFAMiSSF55804, SSF55804, 1 hit
TIGRFAMsiTIGR00834, ae, 1 hit
PROSITEiView protein in PROSITE
PS00219, ANION_EXCHANGER_1, 1 hit
PS00220, ANION_EXCHANGER_2, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ91452_ONCMY
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91452
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: May 25, 2022
This is version 85 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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