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Protein

Alpha-synuclein

Gene

SNCA

Organism
Serinus canaria (Island canary) (Fringilla canaria)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of dopamine release and transport.
May be involved in neuronal plasticity.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi2CopperBy similarity1
Metal bindingi50CopperBy similarity1

GO - Molecular functioni

GO - Biological processi

Keywordsi

LigandCopper, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Alpha-synuclein
Alternative name(s):
Synelfin
Gene namesi
Name:SNCA
OrganismiSerinus canaria (Island canary) (Fringilla canaria)
Taxonomic identifieri9135 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaePasseriformesPasseroideaFringillidaeCarduelinaeSerinus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cytoplasm, Membrane, Nucleus, Secreted, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001840331 – 143Alpha-synucleinAdd BLAST143

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei1N-acetylmethionineBy similarity1

Post-translational modificationi

Acetylation at Met-1 seems to be important for proper folding and native oligomeric structure.By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PRIDEiQ91448

Expressioni

Tissue specificityi

Brain.

Structurei

3D structure databases

ProteinModelPortaliQ91448
SMRiQ91448
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati20 – 301Add BLAST11
Repeati31 – 412Add BLAST11
Repeati42 – 563; approximateAdd BLAST15
Repeati57 – 674Add BLAST11

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni20 – 674 X 11 AA tandem repeats of [EGS]-K-T-K-[EQ]-[GQ]-V-X(4)Add BLAST48

Sequence similaritiesi

Belongs to the synuclein family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG000481
OrthoDBiEOG091G11PA

Family and domain databases

InterProiView protein in InterPro
IPR001058 Synuclein
IPR002460 Synuclein_alpha
PANTHERiPTHR13820 PTHR13820, 1 hit
PTHR13820:SF5 PTHR13820:SF5, 1 hit
PfamiView protein in Pfam
PF01387 Synuclein, 1 hit
PRINTSiPR01212 ASYNUCLEIN
PR01211 SYNUCLEIN

Sequencei

Sequence statusi: Complete.

Q91448-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MDVFMKGLSK AKEGVVAAAE KTKQGVAEAA GKTKEGVLYV GSRTKEGVVH
60 70 80 90 100
GVTTVAEKTK EQVSNVGGAV VTGVTAVAQK TVEGAGNIAA ATGLVKKDQL
110 120 130 140
AKQNEEGFLQ EGMVNNTGAA VDPDNEAYEM PPEEEYQDYE PEA
Length:143
Mass (Da):14,874
Last modified:November 1, 1996 - v1
Checksum:i9C3AB9C9902C54A7
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L33860 mRNA Translation: AAA93538.1
RefSeqiNP_001289028.1, NM_001302099.1

Genome annotation databases

GeneIDi103826045

Similar proteinsi

Entry informationi

Entry nameiSYUA_SERCA
AccessioniPrimary (citable) accession number: Q91448
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 23, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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