UniProtKB - Q91289 (FINC_PLEWA)
Protein
Fibronectin
Gene
N/A
Organism
Pleurodeles waltl (Iberian ribbed newt)
Status
Functioni
Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).By similarity
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | ‹1 – 13 | By similarityAdd BLAST | ›13 |
GO - Molecular functioni
- heparin binding Source: UniProtKB-KW
GO - Biological processi
- acute-phase response Source: UniProtKB-KW
- cell adhesion Source: UniProtKB-KW
- regulation of cell shape Source: UniProtKB-KW
Keywordsi
Molecular function | Heparin-binding |
Biological process | Acute phase, Cell adhesion, Cell shape |
Names & Taxonomyi
Protein namesi | Recommended name: FibronectinShort name: FN |
Organismi | Pleurodeles waltl (Iberian ribbed newt) |
Taxonomic identifieri | 8319 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Caudata › Salamandroidea › Salamandridae › Pleurodelinae › Pleurodeles |
Subcellular locationi
Extracellular region or secreted
- extracellular region Source: InterPro
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000158533 | ‹1 – 1328 | FibronectinAdd BLAST | ›1328 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 89 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 1157 ↔ 1186 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1184 ↔ 1196 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1202 ↔ 1229 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1227 ↔ 1240 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1247 ↔ 1272 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1270 ↔ 1281 | PROSITE-ProRule annotation | ||
Disulfide bondi | 1320 | Interchain (with C-1324)PROSITE-ProRule annotation | ||
Disulfide bondi | 1324 | Interchain (with C-1320)PROSITE-ProRule annotation |
Post-translational modificationi
Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PRIDEi | Q91289 |
Interactioni
Subunit structurei
Dimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends.
By similarityFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | ‹1 – 14 | Fibronectin type-III 1Add BLAST | ›14 | |
Domaini | 17 – 112 | Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST | 96 | |
Domaini | 114 – 202 | Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST | 89 | |
Domaini | 205 – 295 | Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 296 – 386 | Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST | 91 | |
Domaini | 387 – 480 | Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 481 – 572 | Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 573 – 660 | Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST | 88 | |
Domaini | 661 – 754 | Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST | 94 | |
Domaini | 755 – 841 | Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST | 87 | |
Domaini | 842 – 933 | Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 1054 – 1145 | Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST | 92 | |
Domaini | 1155 – 1199 | Fibronectin type-I 1PROSITE-ProRule annotationAdd BLAST | 45 | |
Domaini | 1200 – 1243 | Fibronectin type-I 2PROSITE-ProRule annotationAdd BLAST | 44 | |
Domaini | 1245 – 1287 | Fibronectin type-I 3PROSITE-ProRule annotationAdd BLAST | 43 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 203 – 477 | Cell-attachmentAdd BLAST | 275 | |
Regioni | 658 – 929 | Heparin-binding 2By similarityAdd BLAST | 272 | |
Regioni | 930 – 1064 | Connecting strand 3 (CS-3) (V region)Add BLAST | 135 | |
Regioni | 1157 – 1288 | Fibrin-binding 2By similarityAdd BLAST | 132 |
Motif
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Motifi | 461 – 463 | Cell attachment site | 3 |
Keywords - Domaini
RepeatFamily and domain databases
CDDi | cd00061 FN1, 3 hits cd00063 FN3, 11 hits |
Gene3Di | 2.60.40.10, 11 hits |
InterProi | View protein in InterPro IPR000083 Fibronectin_type1 IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold |
Pfami | View protein in Pfam PF00039 fn1, 3 hits PF00041 fn3, 11 hits |
SMARTi | View protein in SMART SM00058 FN1, 3 hits SM00060 FN3, 11 hits |
SUPFAMi | SSF49265 SSF49265, 7 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 1 hit PS01253 FN1_1, 1 hit PS51091 FN1_2, 3 hits PS50853 FN3, 11 hits |
i Sequence
Sequence statusi: Fragment.
Q91289-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
HESEAPITRT VVTPISPPTD LHLEPSPDFA TLTVSWSRSP SPGITGYRIN
60 70 80 90 100
TALLLGIRLH SGYTLEEEVT ESQSRVCIFD NLSPGVEYNV SVVSVKDDQE
110 120 130 140 150
SEPIWKTITQ EVPSLTDLNF VDVTDTSIDL RWTPLKGPTI IGYRVTVVAA
160 170 180 190 200
GESVPIYEDK VGPTQGYYKV SGLEPGIDYD ISVITLVTDG ESAPTTLTTA
210 220 230 240 250
DCCPTATDLR FTNVGPDSML VTWSAPPSMV LSSFLVRYVP SKNEEDAAEL
260 270 280 290 300
TISPSDNMVV LTNLLPGTEY IVSVFAVYEE RESTPLTGVQ RTGLDSPTGL
310 320 330 340 350
DFSDTTSSSF TVYWMAPRAT VTGYKIQYHP ETGGAGQKEE RCVPPSRNSL
360 370 380 390 400
TLTNLTPGTE YVVSIFAVNG RQESVPLVGQ QATVSDTPTN LEVTSSTPTS
410 420 430 440 450
MSISWDAPPV GVRYYRITYT ETGGETPVQE FTVPGDRSDA PIRGLKPGAE
460 470 480 490 500
YIITVYAVTG RGDSPASSKP VTVTHKTVVD KPTQLQVTDV QDHSIQVRWM
510 520 530 540 550
PSSTPVTGYR VTSVPKSGVG PTVSHVVPPD QTEMTIEGLE PTVEYVVSVY
560 570 580 590 600
AQGKNGETEP LVETAVTNID RPKGLAFTEV DVDSLKLVWE SPKGQVTTYK
610 620 630 640 650
VTYSNPEDGI HELVPAPNGD EDTAQLHGLR PGAEYTVSVV ALHDDMESQP
660 670 680 690 700
LIGTQVTAIP PPTNLLFSQI TPTSVTVSWR PPNVQLTGYR VRVHPKEKAG
710 720 730 740 750
PMKEINLSPD STSAVVTGLM VATKYEVSVY ALKDSLTSRP AQGIVTTQEN
760 770 780 790 800
VSPPRRRRIT DVTETTVTIT WRTKTETITG FHIDAIPAGG QNPIQRTISP
810 820 830 840 850
DLRTYVITGL QPGTDYKIHI YTLNDNARSS PVTIDATTAV DSPSNLRFLT
860 870 880 890 900
TTSNSLLFSW QPPRSKLTGY IIKYEKPGGP VREVVPRPHP GATESQQSQN
910 920 930 940 950
LEPGTEYTIY IIAVRSNYKS GPLVGKKRTD ELPRLVTLAQ PGQQGRILDV
960 970 980 990 1000
PSLVENTPFI SQTSFDNGNG IQLPGTSGQQ NIGHQGQQVF LEEHGFRSPV
1010 1020 1030 1040 1050
LPTTATPVKP GYQAPEQHTL DKYTPGQHVP TIREDIELAR FPPRQIDMDR
1060 1070 1080 1090 1100
PTSHDSGPQQ VDRTGQEAQT TISWRPLLET TEYIITCHPV GNEETPQQFT
1110 1120 1130 1140 1150
VPGTSSSATL NGLTRGATYN IIVEALKGKN KHKSRELVTV TSAAHGSGVL
1160 1170 1180 1190 1200
HGLEDTCYDI TTGSSYSIGQ EWERMSESGF KLWCRCLGLG SGHFKCDSSK
1210 1220 1230 1240 1250
WCHDSGLNYR VGEKWDRSGE NGQMMSCTCL GMEWKGEFKC EPHEATCYDD
1260 1270 1280 1290 1300
GKMYVGEQWQ KEYLGAICSC TCYGGQQGWR CDNCRRPGAG VTPSADGVVG
1310 1320
QTLSHFSQRY QQNANFNLKC PIECYLPL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Non-terminal residuei | 1 | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66813 mRNA Translation: CAA47292.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X66813 mRNA Translation: CAA47292.1 |
3D structure databases
SMRi | Q91289 |
ModBasei | Search... |
Proteomic databases
PRIDEi | Q91289 |
Family and domain databases
CDDi | cd00061 FN1, 3 hits cd00063 FN3, 11 hits |
Gene3Di | 2.60.40.10, 11 hits |
InterProi | View protein in InterPro IPR000083 Fibronectin_type1 IPR003961 FN3_dom IPR036116 FN3_sf IPR013783 Ig-like_fold |
Pfami | View protein in Pfam PF00039 fn1, 3 hits PF00041 fn3, 11 hits |
SMARTi | View protein in SMART SM00058 FN1, 3 hits SM00060 FN3, 11 hits |
SUPFAMi | SSF49265 SSF49265, 7 hits |
PROSITEi | View protein in PROSITE PS00022 EGF_1, 1 hit PS01253 FN1_1, 1 hit PS51091 FN1_2, 3 hits PS50853 FN3, 11 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FINC_PLEWA | |
Accessioni | Q91289Primary (citable) accession number: Q91289 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | May 8, 2019 | |
This is version 84 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |