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Entry version 84 (08 May 2019)
Sequence version 1 (01 Nov 1996)
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Protein

Fibronectin

Gene
N/A
Organism
Pleurodeles waltl (Iberian ribbed newt)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. May be involved in osteoblast compaction (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position and type of each DNA-binding domain present within the protein.<p><a href='/help/dna_bind' target='_top'>More...</a></p>DNA bindingi‹1 – 13By similarityAdd BLAST›13

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHeparin-binding
Biological processAcute phase, Cell adhesion, Cell shape

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Fibronectin
Short name:
FN
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPleurodeles waltl (Iberian ribbed newt)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8319 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaCaudataSalamandroideaSalamandridaePleurodelinaePleurodeles

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_0000158533‹1 – 1328FibronectinAdd BLAST›1328

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi89N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi1157 ↔ 1186PROSITE-ProRule annotation
Disulfide bondi1184 ↔ 1196PROSITE-ProRule annotation
Disulfide bondi1202 ↔ 1229PROSITE-ProRule annotation
Disulfide bondi1227 ↔ 1240PROSITE-ProRule annotation
Disulfide bondi1247 ↔ 1272PROSITE-ProRule annotation
Disulfide bondi1270 ↔ 1281PROSITE-ProRule annotation
Disulfide bondi1320Interchain (with C-1324)PROSITE-ProRule annotation
Disulfide bondi1324Interchain (with C-1320)PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

Forms covalent cross-links mediated by a transglutaminase, such as F13A or TGM2, between a glutamine and the epsilon-amino group of a lysine residue, forming homopolymers and heteropolymers (e.g. fibrinogen-fibronectin, collagen-fibronectin heteropolymers).

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q91289

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Dimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends.

By similarity

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q91289

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini‹1 – 14Fibronectin type-III 1Add BLAST›14
Domaini17 – 112Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST96
Domaini114 – 202Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST89
Domaini205 – 295Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST91
Domaini296 – 386Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST91
Domaini387 – 480Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST94
Domaini481 – 572Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST92
Domaini573 – 660Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST88
Domaini661 – 754Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST94
Domaini755 – 841Fibronectin type-III 10PROSITE-ProRule annotationAdd BLAST87
Domaini842 – 933Fibronectin type-III 11PROSITE-ProRule annotationAdd BLAST92
Domaini1054 – 1145Fibronectin type-III 12PROSITE-ProRule annotationAdd BLAST92
Domaini1155 – 1199Fibronectin type-I 1PROSITE-ProRule annotationAdd BLAST45
Domaini1200 – 1243Fibronectin type-I 2PROSITE-ProRule annotationAdd BLAST44
Domaini1245 – 1287Fibronectin type-I 3PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni203 – 477Cell-attachmentAdd BLAST275
Regioni658 – 929Heparin-binding 2By similarityAdd BLAST272
Regioni930 – 1064Connecting strand 3 (CS-3) (V region)Add BLAST135
Regioni1157 – 1288Fibrin-binding 2By similarityAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi461 – 463Cell attachment site3

Keywords - Domaini

Repeat

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00061 FN1, 3 hits
cd00063 FN3, 11 hits

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 11 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00039 fn1, 3 hits
PF00041 fn3, 11 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00058 FN1, 3 hits
SM00060 FN3, 11 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 7 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 1 hit
PS01253 FN1_1, 1 hit
PS51091 FN1_2, 3 hits
PS50853 FN3, 11 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Fragment.

Q91289-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
HESEAPITRT VVTPISPPTD LHLEPSPDFA TLTVSWSRSP SPGITGYRIN
60 70 80 90 100
TALLLGIRLH SGYTLEEEVT ESQSRVCIFD NLSPGVEYNV SVVSVKDDQE
110 120 130 140 150
SEPIWKTITQ EVPSLTDLNF VDVTDTSIDL RWTPLKGPTI IGYRVTVVAA
160 170 180 190 200
GESVPIYEDK VGPTQGYYKV SGLEPGIDYD ISVITLVTDG ESAPTTLTTA
210 220 230 240 250
DCCPTATDLR FTNVGPDSML VTWSAPPSMV LSSFLVRYVP SKNEEDAAEL
260 270 280 290 300
TISPSDNMVV LTNLLPGTEY IVSVFAVYEE RESTPLTGVQ RTGLDSPTGL
310 320 330 340 350
DFSDTTSSSF TVYWMAPRAT VTGYKIQYHP ETGGAGQKEE RCVPPSRNSL
360 370 380 390 400
TLTNLTPGTE YVVSIFAVNG RQESVPLVGQ QATVSDTPTN LEVTSSTPTS
410 420 430 440 450
MSISWDAPPV GVRYYRITYT ETGGETPVQE FTVPGDRSDA PIRGLKPGAE
460 470 480 490 500
YIITVYAVTG RGDSPASSKP VTVTHKTVVD KPTQLQVTDV QDHSIQVRWM
510 520 530 540 550
PSSTPVTGYR VTSVPKSGVG PTVSHVVPPD QTEMTIEGLE PTVEYVVSVY
560 570 580 590 600
AQGKNGETEP LVETAVTNID RPKGLAFTEV DVDSLKLVWE SPKGQVTTYK
610 620 630 640 650
VTYSNPEDGI HELVPAPNGD EDTAQLHGLR PGAEYTVSVV ALHDDMESQP
660 670 680 690 700
LIGTQVTAIP PPTNLLFSQI TPTSVTVSWR PPNVQLTGYR VRVHPKEKAG
710 720 730 740 750
PMKEINLSPD STSAVVTGLM VATKYEVSVY ALKDSLTSRP AQGIVTTQEN
760 770 780 790 800
VSPPRRRRIT DVTETTVTIT WRTKTETITG FHIDAIPAGG QNPIQRTISP
810 820 830 840 850
DLRTYVITGL QPGTDYKIHI YTLNDNARSS PVTIDATTAV DSPSNLRFLT
860 870 880 890 900
TTSNSLLFSW QPPRSKLTGY IIKYEKPGGP VREVVPRPHP GATESQQSQN
910 920 930 940 950
LEPGTEYTIY IIAVRSNYKS GPLVGKKRTD ELPRLVTLAQ PGQQGRILDV
960 970 980 990 1000
PSLVENTPFI SQTSFDNGNG IQLPGTSGQQ NIGHQGQQVF LEEHGFRSPV
1010 1020 1030 1040 1050
LPTTATPVKP GYQAPEQHTL DKYTPGQHVP TIREDIELAR FPPRQIDMDR
1060 1070 1080 1090 1100
PTSHDSGPQQ VDRTGQEAQT TISWRPLLET TEYIITCHPV GNEETPQQFT
1110 1120 1130 1140 1150
VPGTSSSATL NGLTRGATYN IIVEALKGKN KHKSRELVTV TSAAHGSGVL
1160 1170 1180 1190 1200
HGLEDTCYDI TTGSSYSIGQ EWERMSESGF KLWCRCLGLG SGHFKCDSSK
1210 1220 1230 1240 1250
WCHDSGLNYR VGEKWDRSGE NGQMMSCTCL GMEWKGEFKC EPHEATCYDD
1260 1270 1280 1290 1300
GKMYVGEQWQ KEYLGAICSC TCYGGQQGWR CDNCRRPGAG VTPSADGVVG
1310 1320
QTLSHFSQRY QQNANFNLKC PIECYLPL
Length:1,328
Mass (Da):145,037
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iE31BF7968A1D1E74
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section is used for sequence fragments to indicate that the residue at the extremity of the sequence is not the actual terminal residue in the complete protein sequence.<p><a href='/help/non_ter' target='_top'>More...</a></p>Non-terminal residuei11

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X66813 mRNA Translation: CAA47292.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X66813 mRNA Translation: CAA47292.1

3D structure databases

SMRiQ91289
ModBaseiSearch...

Proteomic databases

PRIDEiQ91289

Family and domain databases

CDDicd00061 FN1, 3 hits
cd00063 FN3, 11 hits
Gene3Di2.60.40.10, 11 hits
InterProiView protein in InterPro
IPR000083 Fibronectin_type1
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF00039 fn1, 3 hits
PF00041 fn3, 11 hits
SMARTiView protein in SMART
SM00058 FN1, 3 hits
SM00060 FN3, 11 hits
SUPFAMiSSF49265 SSF49265, 7 hits
PROSITEiView protein in PROSITE
PS00022 EGF_1, 1 hit
PS01253 FN1_1, 1 hit
PS51091 FN1_2, 3 hits
PS50853 FN3, 11 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFINC_PLEWA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91289
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1996
Last modified: May 8, 2019
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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