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Protein

Cobra venom factor

Gene
N/A
Organism
Naja kaouthia (Monocled cobra) (Naja siamensis)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Complement-activating protein in cobra venom. It is a structural and functional analog of complement component C3b, the activated form of C3. It binds factor B (CFB), which is subsequently cleaved by factor D (CFD) to form the bimolecular complex CVF/Bb. CVF/Bb is a C3/C5 convertase that cleaves both complement components C3 and C5. Structurally, it resembles the C3b degradation product C3c, which is not able to form a C3/C5 convertase. Unlike C3b/Bb, CVF/Bb is a stable complex and completely resistant to the actions of complement regulatory factors H (CFH) and I (CFI). Therefore, CVF continuously activates complement resulting in the depletion of complement activity.

Miscellaneous

CVF has been used to study the complement pathways and to investigate the role of complement in disease pathophysiology. It has also been used to consume complement to prevent the hyperactive rejection of organs in xenotransplantation and for targeted complement-mediated cell killing. CVF can be safely administered to laboratory animals for temporary depletion of complement activity. Interestingly, it is able to deplete complement in serum from all vertebrates tested, except cobras. The only side effect from massive activation of complement in vivo by CVF has been an acute and fleeting inflammatory injury of the lungs (PubMed:20417224).1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the ‘Description’ field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi516Magnesium; via carbonyl oxygen1
Metal bindingi539Magnesium1
Metal bindingi540Magnesium; via carbonyl oxygen1
Metal bindingi542Magnesium1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionComplement system impairing toxin, Toxin
Biological processInflammatory response
LigandMetal-binding

Protein family/group databases

MEROPS protease database

More...
MEROPSi
I39.950

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cobra venom factor
Short name:
CVF
Short name:
CVFk
Alternative name(s):
Complement C3 homolog
Cleaved into the following 3 chains:
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNaja kaouthia (Monocled cobra) (Naja siamensis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri8649 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeElapinaeNaja

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22By similarityAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000592823 – 1642Cobra venom factorAdd BLAST1620
ChainiPRO_000000592923 – 649Cobra venom factor alpha chainAdd BLAST627
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes a propeptide, which is a part of a protein that is cleaved during maturation or activation. Once cleaved, a propeptide generally has no independent biological function.<p><a href='/help/propep' target='_top'>More...</a></p>PropeptideiPRO_0000423372650 – 732Add BLAST83
ChainiPRO_0000005930733 – 984Cobra venom factor gamma chainAdd BLAST252
PropeptideiPRO_0000423373985 – 1263Add BLAST279
ChainiPRO_00000059311264 – 1642Cobra venom factor beta chainAdd BLAST379

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi153N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi158N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi209N-linked (GlcNAc...) asparagine2 Publications1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi544 ↔ 801Interchain (between alpha and gamma chains)
Disulfide bondi609 ↔ 644
Disulfide bondi677 ↔ 704By similarity
Disulfide bondi678 ↔ 711By similarity
Disulfide bondi691 ↔ 712By similarity
Disulfide bondi857 ↔ 1492Interchain (between gamma and beta chains)
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section describes <strong>covalent linkages</strong> of various types formed <strong>between two proteins (interchain cross-links)</strong> or <strong>between two parts of the same protein (intrachain cross-links)</strong>, except the disulfide bonds that are annotated in the <a href="http://www.uniprot.org/manual/disulfid">'Disulfide bond'</a> subsection.<p><a href='/help/crosslnk' target='_top'>More...</a></p>Cross-linki993 ↔ 996Isoglutamyl cysteine thioester (Cys-Gln)By similarity
Disulfide bondi1340 ↔ 1468
Glycosylationi1346N-linked (GlcNAc...) asparagine2 Publications1
Disulfide bondi1368 ↔ 1437
Disulfide bondi1485 ↔ 1490
Disulfide bondi1497 ↔ 1569
Disulfide bondi1516 ↔ 1640
Disulfide bondi1616 ↔ 1625

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationi

First processed by the removal of 4 Arg residues by furin-type protease, forming two chains, alpha and gamma/beta precursor, linked by a disulfide bond. Probably, the cobrin cleaves the C3a-like domain and then the C3d-like domain, generating the mature cobra venom factor (CVF). This mature CVF is composed of three chains: alpha, gamma and beta.
Contains 3 N-linked oligosaccharide chains, two in the alpha-chain and one in the beta-chain. Glycosylation is not required for the biological activity. However, it contributes to the immunogenicity of CVF. The carbohydrate content is 7.4. The major oligosaccharide is a symmetric fucosylated biantennary complex-type chain with an unusual alpha-galactosylated Le(x) structure at its non-reducing end.3 Publications

Keywords - PTMi

Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Thioester bond

Proteomic databases

PRoteomics IDEntifications database

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PRIDEi
Q91132

Consortium for Top Down Proteomics

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TopDownProteomicsi
Q91132

PTM databases

GlyConnect protein glycosylation platform

More...
GlyConnecti
105

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q91132

UniCarbKB; an annotated and curated database of glycan structures

More...
UniCarbKBi
Q91132

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed by the venom gland.

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Heterotrimer of alpha, beta and gamma chains; disulfide-linked. Is active with factor B in the presence of factor D.3 Publications

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction_section%27">Interaction</a> section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

WithEntry#Exp.IntActNotes
C5P010312EBI-7081824,EBI-8558308From Homo sapiens.

Protein-protein interaction databases

Protein interaction database and analysis system

More...
IntActi
Q91132, 3 interactors

Molecular INTeraction database

More...
MINTi
Q91132

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

11642
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q91132

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q91132

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q91132

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini677 – 712Anaphylatoxin-likePROSITE-ProRule annotationAdd BLAST36
Domaini1497 – 1640NTRPROSITE-ProRule annotationAdd BLAST144

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni654 – 732C3a-like domainBy similarityAdd BLAST79
Regioni736 – 747Factor B binding siteBy similarityAdd BLAST12
Regioni985 – 1263C3d-like domainBy similarityAdd BLAST279
Regioni1190 – 1253Factor H binding siteBy similarityAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi650 – 653Poly-Arg4

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the venom complement C3 homolog family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

The HOVERGEN Database of Homologous Vertebrate Genes

More...
HOVERGENi
HBG005110

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00017 ANATO, 1 hit
cd03583 NTR_complement_C3, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 2 hits
2.60.40.690, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR035711 Complement_C3-like
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035815 NTR_complement_C3
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold

The PANTHER Classification System

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PANTHERi
PTHR11412:SF81 PTHR11412:SF81, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00004 ANAPHYLATOXN

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

Q91132-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERMALYLVA ALLIGFPGSS HGALYTLITP AVLRTDTEEQ ILVEAHGDST
60 70 80 90 100
PKQLDIFVHD FPRKQKTLFQ TRVDMNPAGG MLVTPTIEIP AKEVSTDSRQ
110 120 130 140 150
NQYVVVQVTG PQVRLEKVVL LSYQSSFLFI QTDKGIYTPG SPVLYRVFSM
160 170 180 190 200
DHNTSKMNKT VIVEFQTPEG ILVSSNSVDL NFFWPYNLPD LVSLGTWRIV
210 220 230 240 250
AKYEHSPENY TAYFDVRKYV LPSFEVRLQP SEKFFYIDGN ENFHVSITAR
260 270 280 290 300
YLYGEEVEGV AFVLFGVKID DAKKSIPDSL TRIPIIDGDG KATLKRDTFR
310 320 330 340 350
SRFPNLNELV GHTLYASVTV MTESGSDMVV TEQSGIHIVA SPYQIHFTKT
360 370 380 390 400
PKYFKPGMPY ELTVYVTNPD GSPAAHVPVV SEAFHSMGTT LSDGTAKLIL
410 420 430 440 450
NIPLNAQSLP ITVRTNHGDL PRERQATKSM TAIAYQTQGG SGNYLHVAIT
460 470 480 490 500
STEIKPGDNL PVNFNVKGNA NSLKQIKYFT YLILNKGKIF KVGRQPRRDG
510 520 530 540 550
QNLVTMNLHI TPDLIPSFRF VAYYQVGNNE IVADSVWVDV KDTCMGTLVV
560 570 580 590 600
KGDNLIQMPG AAMKIKLEGD PGARVGLVAV DKAVYVLNDK YKISQAKIWD
610 620 630 640 650
TIEKSDFGCT AGSGQNNLGV FEDAGLALTT STNLNTKQRS AAKCPQPANR
660 670 680 690 700
RRRSSVLLLD SNASKAAEFQ DQDLRKCCED VMHENPMGYT CEKRAKYIQE
710 720 730 740 750
GDACKAAFLE CCRYIKGVRD ENQRESELFL ARDDNEDGFI ADSDIISRSD
760 770 780 790 800
FPKSWLWLTK DLTEEPNSQG ISSKTMSFYL RDSITTWVVL AVSFTPTKGI
810 820 830 840 850
CVAEPYEIRV MKVFFIDLQM PYSVVKNEQV EIRAILHNYV NEDIYVRVEL
860 870 880 890 900
LYNPAFCSAS TKGQRYRQQF PIKALSSRAV PFVIVPLEQG LHDVEIKASV
910 920 930 940 950
QEALWSDGVR KKLKVVPEGV QKSIVTIVKL DPRAKGVGGT QLEVIKARKL
960 970 980 990 1000
DDRVPDTEIE TKIIIQGDPV AQIIENSIDG SKLNHLIITP SGCGEQNMIR
1010 1020 1030 1040 1050
MAAPVIATYY LDTTEQWETL GINRRTEAVN QIVTGYAQQM VYKKADHSYA
1060 1070 1080 1090 1100
AFTNRASSSW LTAYVVKVFA MAAKMVAGIS HEIICGGVRW LILNRQQPDG
1110 1120 1130 1140 1150
AFKENAPVLS GTMQGGIQGA EEEVYLTAFI LVALLESKTI CNDYVNSLDS
1160 1170 1180 1190 1200
SIKKATNYLL KKYEKLQRPY TTALTAYALA AADQLNDDRV LMAASTGRDH
1210 1220 1230 1240 1250
WEEYNAHTHN IEGTSYALLA LLKMKKFDQT GPIVRWLTDQ NFYGETYGQT
1260 1270 1280 1290 1300
QATVMAFQAL AEYEIQMPTH KDLNLDITIE LPDREVPIRY RINYENALLA
1310 1320 1330 1340 1350
RTVETKLNQD ITVTASGDGK ATMTILTFYN AQLQEKANVC NKFHLNVSVE
1360 1370 1380 1390 1400
NIHLNAMGAK GALMLKICTR YLGEVDSTMT IIDISMLTGF LPDAEDLTRL
1410 1420 1430 1440 1450
SKGVDRYISR YEVDNNMAQK VAVIIYLNKV SHSEDECLHF KILKHFEVGF
1460 1470 1480 1490 1500
IQPGSVKVYS YYNLDEKCTK FYHPDKGTGL LNKICIGNVC RCAGETCSSL
1510 1520 1530 1540 1550
NHQERIDVPL QIEKACETNV DYVYKTKLLR IEEQDGNDIY VMDVLEVIKQ
1560 1570 1580 1590 1600
GTDENPRAKT HQYISQRKCQ EALNLKVNDD YLIWGSRSDL LPTKDKISYI
1610 1620 1630 1640
ITKNTWIERW PHEDECQEEE FQKLCDDFAQ FSYTLTEFGC PT
Length:1,642
Mass (Da):184,518
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2A71B2BD61D612A3
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U09969 mRNA Translation: AAA68989.1
AY497579 Genomic DNA Translation: AAR89520.1
AY586272 Genomic DNA Translation: AAS97956.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U09969 mRNA Translation: AAA68989.1
AY497579 Genomic DNA Translation: AAR89520.1
AY586272 Genomic DNA Translation: AAS97956.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

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RCSB PDBi

Protein Data Bank Japan

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PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3FRPX-ray2.61A23-649[»]
B1264-1642[»]
G733-984[»]
3HRZX-ray2.20A23-649[»]
B733-984[»]
C1264-1642[»]
3HS0X-ray3.00A/F23-649[»]
B/G733-984[»]
C/H1264-1642[»]
3PRXX-ray4.30B/D1-1642[»]
3PVMX-ray4.30B/D1-1642[»]
ProteinModelPortaliQ91132
SMRiQ91132
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ91132, 3 interactors
MINTiQ91132

Protein family/group databases

MEROPSiI39.950

PTM databases

GlyConnecti105
iPTMnetiQ91132
UniCarbKBiQ91132

Proteomic databases

PRIDEiQ91132
TopDownProteomicsiQ91132

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG005110

Miscellaneous databases

EvolutionaryTraceiQ91132

Family and domain databases

CDDicd00017 ANATO, 1 hit
cd03583 NTR_complement_C3, 1 hit
Gene3Di2.60.40.10, 2 hits
2.60.40.690, 1 hit
InterProiView protein in InterPro
IPR009048 A-macroglobulin_rcpt-bd
IPR036595 A-macroglobulin_rcpt-bd_sf
IPR011625 A2M_N_BRD
IPR011626 Alpha-macroglobulin_TED
IPR000020 Anaphylatoxin/fibulin
IPR018081 Anaphylatoxin_comp_syst
IPR001840 Anaphylatoxn_comp_syst_dom
IPR035711 Complement_C3-like
IPR013783 Ig-like_fold
IPR001599 Macroglobln_a2
IPR019742 MacrogloblnA2_CS
IPR002890 MG2
IPR001134 Netrin_domain
IPR018933 Netrin_module_non-TIMP
IPR035815 NTR_complement_C3
IPR008930 Terpenoid_cyclase/PrenylTrfase
IPR008993 TIMP-like_OB-fold
PANTHERiPTHR11412:SF81 PTHR11412:SF81, 1 hit
PfamiView protein in Pfam
PF00207 A2M, 1 hit
PF07703 A2M_BRD, 1 hit
PF07677 A2M_recep, 1 hit
PF01821 ANATO, 1 hit
PF01835 MG2, 1 hit
PF01759 NTR, 1 hit
PF07678 TED_complement, 1 hit
PRINTSiPR00004 ANAPHYLATOXN
SMARTiView protein in SMART
SM01360 A2M, 1 hit
SM01359 A2M_N_2, 1 hit
SM01361 A2M_recep, 1 hit
SM00104 ANATO, 1 hit
SM00643 C345C, 1 hit
SUPFAMiSSF47686 SSF47686, 1 hit
SSF48239 SSF48239, 1 hit
SSF49410 SSF49410, 1 hit
SSF50242 SSF50242, 1 hit
PROSITEiView protein in PROSITE
PS00477 ALPHA_2_MACROGLOBULIN, 1 hit
PS01178 ANAPHYLATOXIN_2, 1 hit
PS50189 NTR, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiVCO3_NAJKA
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q91132
Secondary accession number(s): Q6PQH3, Q6RHR7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 11, 2004
Last sequence update: November 1, 1996
Last modified: December 5, 2018
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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