UniProtKB - Q91119 (GLHA_MORSA)
Protein
Glycoprotein hormones alpha chain
Gene
cga
Organism
Morone saxatilis (Striped bass) (Perca saxatilis)
Status
Functioni
Shared alpha chain of heterodimeric glycoprotein hormones. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. Involved in gametogenesis and steroidogenesis.By similarity
GO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
GO - Biological processi
- G protein-coupled receptor signaling pathway Source: UniProtKB
- positive regulation of steroid biosynthetic process Source: UniProtKB
- regulation of signaling receptor activity Source: UniProtKB
Keywordsi
Molecular function | Hormone |
Names & Taxonomyi
Protein namesi | Recommended name: Glycoprotein hormones alpha chainAlternative name(s): GTH-alpha Gonadotropin alpha chain |
Gene namesi | Name:cga |
Organismi | Morone saxatilis (Striped bass) (Perca saxatilis) |
Taxonomic identifieri | 34816 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Neoteleostei › Acanthomorphata › Eupercaria › Moronidae › Morone |
Subcellular locationi
Extracellular region or secreted
- Secreted By similarity
Extracellular region or secreted
- extracellular space Source: UniProtKB
- follicle-stimulating hormone complex Source: UniProtKB
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 23 | By similarityAdd BLAST | 23 | |
ChainiPRO_0000011668 | 24 – 117 | Glycoprotein hormones alpha chainAdd BLAST | 94 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 34 ↔ 57 | By similarity | ||
Disulfide bondi | 37 ↔ 86 | By similarity | ||
Disulfide bondi | 54 ↔ 107 | By similarity | ||
Disulfide bondi | 58 ↔ 109 | By similarity | ||
Glycosylationi | 78 | N-linked (GlcNAc...) asparagineBy similarity | 1 | |
Disulfide bondi | 85 ↔ 112 | By similarity | ||
Glycosylationi | 103 | N-linked (GlcNAc...) asparagineBy similarity | 1 |
Keywords - PTMi
Disulfide bond, GlycoproteinInteractioni
Subunit structurei
Heterodimer. Glycoprotein hormones are heterodimers composed of a common alpha chain described here and a unique beta chain which confers their biological specificity to the different hormones.
By similarityGO - Molecular functioni
- follicle-stimulating hormone activity Source: UniProtKB
Family & Domainsi
Sequence similaritiesi
Belongs to the glycoprotein hormones subunit alpha family.Curated
Keywords - Domaini
SignalFamily and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q91119-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MGSVKSAGLS LLLLSFILYV VDSYPSMDLS NMGCEECTLR KNSVFSRDRP
60 70 80 90 100
VYQCMGCCFS RAYPTPLKAM KTMTIPKNIT SEATCCVAKH SYETEVAGIK
110
VRNHTDCHCS TCYFHKI
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35071 mRNA Translation: AAB66489.1 |
PIRi | I50992 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | L35071 mRNA Translation: AAB66489.1 |
PIRi | I50992 |
3D structure databases
SMRi | Q91119 |
ModBasei | Search... |
Family and domain databases
Gene3Di | 2.10.90.10, 1 hit |
InterProi | View protein in InterPro IPR029034, Cystine-knot_cytokine IPR000476, Glyco_hormone |
PANTHERi | PTHR11509, PTHR11509, 1 hit |
Pfami | View protein in Pfam PF00236, Hormone_6, 1 hit |
PRINTSi | PR00274, GLYCOHORMONE |
SMARTi | View protein in SMART SM00067, GHA, 1 hit |
SUPFAMi | SSF57501, SSF57501, 1 hit |
PROSITEi | View protein in PROSITE PS00779, GLYCO_HORMONE_ALPHA_1, 1 hit PS00780, GLYCO_HORMONE_ALPHA_2, 1 hit PS50277, GLYCO_HORMONE_ALPHA_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | GLHA_MORSA | |
Accessioni | Q91119Primary (citable) accession number: Q91119 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 15, 1998 |
Last sequence update: | January 1, 1998 | |
Last modified: | December 11, 2019 | |
This is version 67 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |