UniProtKB - Q91055 (CRVP_HELHO)
Protein
Cysteine-rich venom protein helothermine
Gene
N/A
Organism
Heloderma horridum horridum (Mexican beaded lizard)
Status
Functioni
Alters a variety of ion channel activities, including voltage-gated potassium channels (Kv) (PubMed:8071987), voltage-gated calcium channels (L-, N-, and P-type) (Cav) (PubMed:8817251) and ryanodine receptors (RyR) (PubMed:7647234). Is toxic to mice (causes lethargy, partial paralysis of rear limbs and lowering of body temperature).3 Publications
Miscellaneous
IC50=0.52 µM on IA-type current, and 0.86 µM on delayed rectifier current.1 Publication
GO - Molecular functioni
- toxin activity Source: UniProtKB-KW
Keywordsi
Protein family/group databases
TCDBi | 8.B.9.1.3, the triflin toxin (triflin or crisp) family |
Names & Taxonomyi
Protein namesi | Recommended name: Cysteine-rich venom protein helothermineShort name: CRVP HLTx |
Organismi | Heloderma horridum horridum (Mexican beaded lizard) |
Taxonomic identifieri | 8552 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Lepidosauria › Squamata › Bifurcata › Unidentata › Episquamata › Toxicofera › Anguimorpha › Neoanguimorpha › Helodermatidae › Heloderma › |
Subcellular locationi
Extracellular region or secreted
Extracellular region or secreted
- extracellular region Source: UniProtKB-SubCell
Keywords - Cellular componenti
SecretedPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 19 | 1 PublicationAdd BLAST | 19 | |
ChainiPRO_0000006272 | 20 – 242 | Cysteine-rich venom protein helothermineAdd BLAST | 223 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 77 ↔ 155 | PROSITE-ProRule annotation | ||
Disulfide bondi | 94 ↔ 170 | PROSITE-ProRule annotation | ||
Disulfide bondi | 150 ↔ 167 | PROSITE-ProRule annotation | ||
Disulfide bondi | 189 ↔ 196 | PROSITE-ProRule annotation | ||
Disulfide bondi | 192 ↔ 201 | PROSITE-ProRule annotation | ||
Disulfide bondi | 205 ↔ 237 | PROSITE-ProRule annotation | ||
Disulfide bondi | 214 ↔ 231 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 235 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondExpressioni
Tissue specificityi
Expressed by the venom gland.
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 41 – 169 | SCPAdd BLAST | 129 | |
Domaini | 205 – 237 | ShKTPROSITE-ProRule annotationAdd BLAST | 33 |
Sequence similaritiesi
Belongs to the CRISP family.Curated
Keywords - Domaini
SignalFamily and domain databases
CDDi | cd05383, CAP_CRISP, 1 hit |
Gene3Di | 1.10.10.740, 1 hit 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244, Allrgn_V5/Tpx1_CS IPR014044, CAP_domain IPR035940, CAP_sf IPR042076, Crisp-like_dom IPR001283, CRISP-related IPR013871, Cysteine_rich_secretory IPR034117, SCP_CRISP IPR003582, ShKT_dom |
PANTHERi | PTHR10334, PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188, CAP, 1 hit PF08562, Crisp, 1 hit |
PRINTSi | PR00837, V5TPXLIKE |
SMARTi | View protein in SMART SM00198, SCP, 1 hit |
SUPFAMi | SSF55797, SSF55797, 1 hit |
PROSITEi | View protein in PROSITE PS01009, CRISP_1, 1 hit PS51670, SHKT, 1 hit |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q91055-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MILLSLYLCL AAMLHQSEGE ASPKLPGLMT SNPDQQTEIT DKHNNLRRIV
60 70 80 90 100
EPTASNMLKM TWSNKIAQNA QRSANQCTLE HTSKEERTID GVECGENLFF
110 120 130 140 150
SSAPYTWSYA IQNWFDERKY FRFNYGPTAQ NVMIGHYTQV VWYRSYELGC
160 170 180 190 200
AIAYCPDQPT YKYYQVCQYC PGGNIRSRKY TPYSIGPPCG DCPDACDNGL
210 220 230 240
CTNPCKQNDV YNNCPDLKKQ VGCGHPIMKD CMATCKCLTE IK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13619 mRNA Translation: AAC59730.1 |
PIRi | A34859 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U13619 mRNA Translation: AAC59730.1 |
PIRi | A34859 |
3D structure databases
SMRi | Q91055 |
ModBasei | Search... |
Protein family/group databases
TCDBi | 8.B.9.1.3, the triflin toxin (triflin or crisp) family |
Family and domain databases
CDDi | cd05383, CAP_CRISP, 1 hit |
Gene3Di | 1.10.10.740, 1 hit 3.40.33.10, 1 hit |
InterProi | View protein in InterPro IPR018244, Allrgn_V5/Tpx1_CS IPR014044, CAP_domain IPR035940, CAP_sf IPR042076, Crisp-like_dom IPR001283, CRISP-related IPR013871, Cysteine_rich_secretory IPR034117, SCP_CRISP IPR003582, ShKT_dom |
PANTHERi | PTHR10334, PTHR10334, 1 hit |
Pfami | View protein in Pfam PF00188, CAP, 1 hit PF08562, Crisp, 1 hit |
PRINTSi | PR00837, V5TPXLIKE |
SMARTi | View protein in SMART SM00198, SCP, 1 hit |
SUPFAMi | SSF55797, SSF55797, 1 hit |
PROSITEi | View protein in PROSITE PS01009, CRISP_1, 1 hit PS51670, SHKT, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CRVP_HELHO | |
Accessioni | Q91055Primary (citable) accession number: Q91055 Secondary accession number(s): P46693 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 26, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Animal Toxin Annotation Program | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Direct protein sequencingDocuments
- SIMILARITY comments
Index of protein domains and families