Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 84 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
Previous versions | rss
Add a publicationFeedback
Protein

Transporter

Gene

slc6a3

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processSymportUniRule annotationARBA annotation, Transport

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
TransporterUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:slc6a3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-010316-1, slc6a3

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei85 – 103HelicalSequence analysisAdd BLAST19
Transmembranei115 – 136HelicalSequence analysisAdd BLAST22
Transmembranei157 – 184HelicalSequence analysisAdd BLAST28
Transmembranei247 – 264HelicalSequence analysisAdd BLAST18
Transmembranei276 – 300HelicalSequence analysisAdd BLAST25
Transmembranei320 – 341HelicalSequence analysisAdd BLAST22
Transmembranei361 – 380HelicalSequence analysisAdd BLAST20
Transmembranei400 – 427HelicalSequence analysisAdd BLAST28
Transmembranei456 – 481HelicalSequence analysisAdd BLAST26
Transmembranei487 – 510HelicalSequence analysisAdd BLAST24
Transmembranei531 – 552HelicalSequence analysisAdd BLAST22
Transmembranei564 – 586HelicalSequence analysisAdd BLAST23

Keywords - Cellular componenti

Membrane

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90ZV1

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 32DisorderedSequence analysisAdd BLAST32
Regioni51 – 76DisorderedSequence analysisAdd BLAST26

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi15 – 30Polar residuesSequence analysisAdd BLAST16

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. [View classification]UniRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helixSequence analysisARBA annotation

Phylogenomic databases

Database of Orthologous Groups

More...
OrthoDBi
250396at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q90ZV1

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000175, Na/ntran_symport
IPR037272, SNS_sf

The PANTHER Classification System

More...
PANTHERi
PTHR11616, PTHR11616, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00209, SNF, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00176, NANEUSMPORT

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF161070, SSF161070, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90ZV1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPMLRGRPAV THTRTRTHTH MSSVSGSSSA AGPREVELVL VKEQNGVQFT
60 70 80 90 100
SSSLRNPGAH SHTHTHTHTH PSGQQRETWG KKIDFLLSVI GFAVDLANVW
110 120 130 140 150
RFPYLCYKNG GGAFLVPYLL FMVIAGMPLF YMELALGQYN REGAAGVWKI
160 170 180 190 200
CPIFKGVGFT VILISLYVGS YYNVIIAWAL FYLFSSFSGE LPWIHCNNTW
210 220 230 240 250
NSPNCSDPNA TLLNDTYKTT PALEYFERGV LHVHESSGID DLGAPRWQLT
260 270 280 290 300
ACLAVVIVVL YFSLWKGVKT SGKVVWITAT MPYVVLTVLL LRGVTLPGAI
310 320 330 340 350
DGIKAYLSVD FLRLYDAQVW IEAATQICFS LGVGFGVLIA FSSYNKFSNN
360 370 380 390 400
CYRDAIITSS INSLTSFFSG FVIFSFLGYM SQKHNVALDK VATDGPGLVF
410 420 430 440 450
IIYPEAIATL PGSSVWAVIF FIMLLTLGID SAMGGMESVI TGLIDEFKFL
460 470 480 490 500
HKHRELFTLF IVVSTFLISL ICVTNGGIYV FTLLDHFAAG TSILFGVLIE
510 520 530 540 550
AIGIAWFYGV DRFSDDIEEM IGQRPGLYWR LCWKFVSPCF LLFMVVVSFA
560 570 580 590 600
TFNPPKYGSY YFPTWATMVG WCLSISSMIM VPLYAFYKFC SLPGSFCDKL
610 620
AYAITPETDH HLVERGEVRQ FTLHHWLVV
Length:629
Mass (Da):70,162
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEF7CD46C30F8C8CB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF318177 mRNA Translation: AAK52449.1

NCBI Reference Sequences

More...
RefSeqi
NP_571830.1, NM_131755.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
80787

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:80787

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF318177 mRNA Translation: AAK52449.1
RefSeqiNP_571830.1, NM_131755.1

3D structure databases

SMRiQ90ZV1
ModBaseiSearch...

Genome annotation databases

GeneIDi80787
KEGGidre:80787

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
6531
ZFINiZDB-GENE-010316-1, slc6a3

Phylogenomic databases

OrthoDBi250396at2759
PhylomeDBiQ90ZV1

Family and domain databases

InterProiView protein in InterPro
IPR000175, Na/ntran_symport
IPR037272, SNS_sf
PANTHERiPTHR11616, PTHR11616, 1 hit
PfamiView protein in Pfam
PF00209, SNF, 1 hit
PRINTSiPR00176, NANEUSMPORT
SUPFAMiSSF161070, SSF161070, 1 hit
PROSITEiView protein in PROSITE
PS00610, NA_NEUROTRAN_SYMP_1, 1 hit
PS00754, NA_NEUROTRAN_SYMP_2, 1 hit
PS50267, NA_NEUROTRAN_SYMP_3, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90ZV1_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90ZV1
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 84 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again