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Protein
Submitted name:

Prospero-related homeodomain protein 1

Gene

prox1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Prospero-related homeodomain protein 1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:prox1aImported
Synonyms:prox1Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-980526-397 prox1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Eukaryotic Linear Motif resource for Functional Sites in Proteins

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ELMi
Q90ZL7

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

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ProteinModelPortali
Q90ZL7

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q90ZL7

Database of comparative protein structure models

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ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini579 – 737ProsperoInterPro annotationAdd BLAST159

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili229 – 256Sequence analysisAdd BLAST28

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coilSequence analysis, HomeoboxImported

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG3779 Eukaryota
ENOG410ZE21 LUCA

The HOVERGEN Database of Homologous Vertebrate Genes

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HOVERGENi
HBG053693

KEGG Orthology (KO)

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KOi
K20211

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

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Gene3Di
1.10.10.500, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain
IPR007738 Prox1

The PANTHER Classification System

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PANTHERi
PTHR12198 PTHR12198, 1 hit
PTHR12198:SF6 PTHR12198:SF6, 1 hit

Pfam protein domain database

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Pfami
View protein in Pfam
PF05044 HPD, 1 hit

Superfamily database of structural and functional annotation

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SUPFAMi
SSF46689 SSF46689, 1 hit

PROSITE; a protein domain and family database

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PROSITEi
View protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90ZL7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPDHDSTSLL SRQTKRRRVD IGVKRTVGQA SVVFTRAKAT FLSAMNPHGS
60 70 80 90 100
EQDVECSVVQ HADGEKSNVL RKLLKRANSY EDAVMPFPGA TIISQLLKNN
110 120 130 140 150
LTKNGGSEPN FQGSGLSSTG SEMQQEDACS NSSRGSPQEC LSPFSRPSMT
160 170 180 190 200
QFEMERLTDE HLRAKRARVE NIIRGMSHSP SVTLRAGDND REGAAQPPSP
210 220 230 240 250
RENYRENKRK QKLPQQQQQS FQQLVSARKE QKHEERRQLK LQLEDMQKQL
260 270 280 290 300
RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SDGMDNRAHD SVPDRSDNEM
310 320 330 340 350
SDLDPGHFLD RARALIREQS MMEGDKPKRD GSRGKSQGPT SMHAEGKQLA
360 370 380 390 400
ETLKQELNTA MSQVVDTVVK VFAKPPRPVP QVFPPLHMES PDRFAVNGEN
410 420 430 440 450
PNFHTANQRL QCFGDVIIPN PLDTFGSMQV PNSNDQTEAL PLVVRKNSSD
460 470 480 490 500
QTGSLSTPGG HHHHPSLHPP PLSSTMGFSP PSFRHPFPLP LMGYPFQSPL
510 520 530 540 550
GAPTGPYPGK DRSSPESLDL SRETTSLRTK MSSNHLSHHR SISPTHPGNE
560 570 580 590 600
GLSLSLIKSE CGDLQDMSDI SPYSGSTIQE GLSPNHLKKA KLMFFYTRYP
610 620 630 640 650
SSNMLKMFFS DVKFNRCITS QLIKWFSNFR EFYYIQMEKF ARQAINDGVT
660 670 680 690 700
GSEELSVSRD CELFRALNMH YNKANDFEVP ERFLEVAQIT LREFFNAIVA
710 720 730
GKDVDPSWKK AIYKVICKLD SEVPEIFKSP NCLQELLHE
Length:739
Mass (Da):83,214
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iB01AC5910ADB6CA6
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY032595 mRNA Translation: AAK40357.1

NCBI Reference Sequences

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RefSeqi
NP_571480.2, NM_131405.2

UniGene gene-oriented nucleotide sequence clusters

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UniGenei
Dr.81273

Genome annotation databases

Database of genes from NCBI RefSeq genomes

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GeneIDi
30679

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
dre:30679

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY032595 mRNA Translation: AAK40357.1
RefSeqiNP_571480.2, NM_131405.2
UniGeneiDr.81273

3D structure databases

ProteinModelPortaliQ90ZL7
SMRiQ90ZL7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ELMiQ90ZL7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi30679
KEGGidre:30679

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
30679
ZFINiZDB-GENE-980526-397 prox1a

Phylogenomic databases

eggNOGiKOG3779 Eukaryota
ENOG410ZE21 LUCA
HOVERGENiHBG053693
KOiK20211

Family and domain databases

Gene3Di1.10.10.500, 1 hit
InterProiView protein in InterPro
IPR023082 Homeo_prospero_dom
IPR037131 Homeo_prospero_dom_sf
IPR009057 Homeobox-like_sf
IPR039350 Prospero_homeodomain
IPR007738 Prox1
PANTHERiPTHR12198 PTHR12198, 1 hit
PTHR12198:SF6 PTHR12198:SF6, 1 hit
PfamiView protein in Pfam
PF05044 HPD, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS51818 HOMEO_PROSPERO, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90ZL7_DANRE
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90ZL7
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: December 5, 2018
This is version 113 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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