UniProtKB - Q90ZH9 (S17AB_XENLA)
Protein
Transcription factor Sox-17-alpha-B
Gene
sox17a-b
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Transcription activator. Binds to the DNA sequence 5'-AACAAT-3'. All of the sox17 proteins are required for embryonic endoderm development and gastrulation movements, and show some redundancy in function. In addition, the sox17 proteins have distinct but overlapping roles in later gut development. Acts downstream of vegt-signaling in endoderm differentiation to induce a range of endodermal genes both directly (including endodermin and dhh/chh) and indirectly. Also represses wnt-responsive genes to inhibit wnt/beta-catenin signaling.By similarity5 Publications
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 58 – 126 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- beta-catenin binding Source: UniProtKB
- sequence-specific DNA binding Source: UniProtKB
GO - Biological processi
- cell migration involved in gastrulation Source: UniProtKB
- endoderm development Source: UniProtKB
- hindgut morphogenesis Source: UniProtKB
- midgut development Source: UniProtKB
- positive regulation of transcription, DNA-templated Source: UniProtKB
- positive regulation of transcription by RNA polymerase II Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Activator, Developmental protein, DNA-binding |
Biological process | Gastrulation, Transcription, Transcription regulation, Wnt signaling pathway |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sox-17-alpha-BShort name: xSox17alpha2Imported |
Gene namesi | Name:sox17a-b Synonyms:sox17a21 Publication |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-6255435, sox17a.S |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotationBy similarity
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000376051 | 1 – 377 | Transcription factor Sox-17-alpha-BAdd BLAST | 377 |
Expressioni
Tissue specificityi
Enriched in the embryonic endoderm. Expressed in the embryonic gut, with strong expression in the posterior gut during tailbud stages. Expressed at a low level in the adult kidney and spleen.3 Publications
Inductioni
Involved in multiple regulatory feedback loops with other endodermal factors, including the nodal-related factors/Xnrs. Autoinduces.1 Publication
Interactioni
Subunit structurei
Interacts (via C-terminus) with ctnnb1/beta-catenin (via Armadillo repeats); this interaction is required for inhibition of wnt-signaling.
By similarityGO - Molecular functioni
- beta-catenin binding Source: UniProtKB
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 262 – 376 | Sox C-terminalPROSITE-ProRule annotationAdd BLAST | 115 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 326 – 331 | Required for transcriptional activity and interaction with ctnnb1By similarity | 6 |
Phylogenomic databases
OMAi | REPQAMA |
OrthoDBi | 1042753at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q90ZH9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSPDGGYGS DDQNQGKCSV PIMMSGLGQC QWSEPMTSLG EGKLKSDANS
60 70 80 90 100
RSKAEGRIRR PMNAFMVWAK DERKRLAQQN PDLHNAELSK MLGKSWKALS
110 120 130 140 150
LAEKRPFVEE AERLRVQHMQ DHPNYKYRPR RRKQVKRMKR AENGFMHMTE
160 170 180 190 200
AQESAVMGTD GRMCLENFNL GFHEQTYPQL PQASHYREPQ AMAPHYDGYS
210 220 230 240 250
LPTPESSPLD LAEADPVFFT SPAQDECQMM PYSYNSSYTH QHNSGASMLV
260 270 280 290 300
RQMPQTEQIG EGSPVEGMMA CQSSPHMYYG QMYLPGSTRH HQHPQAGQPS
310 320 330 340 350
PPPEAQQLGR ADQTQQADMM AEDRTEFEQY LSYVSKSDLG MNYHGQESVG
360 370
PTADNGPISS VLSDATTAVY YCNYPSA
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 33 | S → A in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 50 | S → Y in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 56 | G → T in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 159 | T → A in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 261 | E → Q in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 342 | N → H in AAH60350 (Ref. 2) Curated | 1 | |
Sequence conflicti | 350 | G → V in AAH60350 (Ref. 2) Curated | 1 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052691 mRNA Translation: BAB60828.1 BC060350 mRNA Translation: AAH60350.1 |
RefSeqi | NP_001083136.1, NM_001089667.1 |
Genome annotation databases
GeneIDi | 398765 |
KEGGi | xla:398765 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052691 mRNA Translation: BAB60828.1 BC060350 mRNA Translation: AAH60350.1 |
RefSeqi | NP_001083136.1, NM_001089667.1 |
3D structure databases
SMRi | Q90ZH9 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 398765 |
KEGGi | xla:398765 |
Organism-specific databases
CTDi | 398765 |
Xenbasei | XB-GENE-6255435, sox17a.S |
Phylogenomic databases
OMAi | REPQAMA |
OrthoDBi | 1042753at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | S17AB_XENLA | |
Accessioni | Q90ZH9Primary (citable) accession number: Q90ZH9 Secondary accession number(s): Q6PAE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 87 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |