UniProtKB - Q90ZH8 (SX18A_XENLA)
Protein
Transcription factor Sox-18A
Gene
sox18-a
Organism
Xenopus laevis (African clawed frog)
Status
Functioni
Probable transcription factor. Binds to the consensus DNA sequence 5'-AACAAT-3'. Also binds 5'-CACAAT-3' and 5'-AATAAT-3' with similar affinity.Sequence analysis1 Publication
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 68 – 136 | HMG boxPROSITE-ProRule annotationAdd BLAST | 69 |
GO - Molecular functioni
- sequence-specific DNA binding Source: UniProtKB
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Transcription factor Sox-18AShort name: xSox18alpha1 Publication Alternative name(s): SRY (sex determining region Y)-box 18A |
Gene namesi | Name:sox18-a Synonyms:sox18 |
Organismi | Xenopus laevis (African clawed frog) |
Taxonomic identifieri | 8355 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Amphibia › Batrachia › Anura › Pipoidea › Pipidae › Xenopodinae › Xenopus › Xenopus |
Organism-specific databases
Xenbasei | XB-GENE-864957, sox18.L |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000375978 | 1 – 363 | Transcription factor Sox-18AAdd BLAST | 363 |
Expressioni
Tissue specificityi
Expressed in the adult spleen, lung, heart and kidney, and at a lower level in the adult testis, liver and brain.1 Publication
Developmental stagei
Expressed in adults but not in embryos.1 Publication
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 236 – 362 | Sox C-terminalPROSITE-ProRule annotationAdd BLAST | 127 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 70 – 83 | Interaction with DNABy similarityAdd BLAST | 14 | |
Regioni | 94 – 106 | Interaction with DNABy similarityAdd BLAST | 13 | |
Regioni | 149 – 210 | Important for transcriptional activationBy similarityAdd BLAST | 62 |
Domaini
Binds target DNA via the HMG box domain.By similarity
Phylogenomic databases
OMAi | DRHEFDQ |
OrthoDBi | 1042753at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
i Sequence
Sequence statusi: Complete.
Q90ZH8-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHRSESSYCR EETTLCQGVN STWVPPADTV PEVSLIPSSP PAPDSPAPSP
60 70 80 90 100
KPGYGFSTCE EKHGDPRIRR PMNAFMVWAK DERKRLAQQN PDLHNAVLSK
110 120 130 140 150
MLGQSWKNLT SVEKRPFVEE AERLRVQHLQ DHPNYKYRPR RKKQAKKLKR
160 170 180 190 200
MDPSPLLRNE GFTRGQPMVN LSHFRNLHPL GGSGELESYG LPTPEMSPLD
210 220 230 240 250
VLEPSEPAFF PPHMREDTDP VPFRTYQHGM DFSQEKTMRE ISLPYSSSPS
260 270 280 290 300
HMGSFLRTPT PSAFYYKAHG GSPVCTPLGQ LSPPPEAPAL DAMDHLNQAE
310 320 330 340 350
LWGDFDRNEF DQYLNMSRTQ RPGYSFPMSK LGAPRTIPCE ENSLISALSD
360
ASTAMYYTPC ITG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052692 mRNA Translation: BAB60829.1 BC169575 mRNA Translation: AAI69575.1 |
RefSeqi | NP_001082102.1, NM_001088633.1 |
Genome annotation databases
GeneIDi | 398226 |
KEGGi | xla:398226 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB052692 mRNA Translation: BAB60829.1 BC169575 mRNA Translation: AAI69575.1 |
RefSeqi | NP_001082102.1, NM_001088633.1 |
3D structure databases
SMRi | Q90ZH8 |
ModBasei | Search... |
Genome annotation databases
GeneIDi | 398226 |
KEGGi | xla:398226 |
Organism-specific databases
CTDi | 398226 |
Xenbasei | XB-GENE-864957, sox18.L |
Phylogenomic databases
OMAi | DRHEFDQ |
OrthoDBi | 1042753at2759 |
Family and domain databases
Gene3Di | 1.10.30.10, 1 hit |
InterProi | View protein in InterPro IPR009071, HMG_box_dom IPR036910, HMG_box_dom_sf IPR033392, Sox7/17/18_central IPR021934, Sox_C |
Pfami | View protein in Pfam PF00505, HMG_box, 1 hit PF12067, Sox17_18_mid, 1 hit |
SMARTi | View protein in SMART SM00398, HMG, 1 hit |
SUPFAMi | SSF47095, SSF47095, 1 hit |
PROSITEi | View protein in PROSITE PS50118, HMG_BOX_2, 1 hit PS51516, SOX_C, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | SX18A_XENLA | |
Accessioni | Q90ZH8Primary (citable) accession number: Q90ZH8 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 26, 2009 |
Last sequence update: | December 1, 2001 | |
Last modified: | December 2, 2020 | |
This is version 81 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |