Insulin-like growth factor-binding protein 3

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

Caution

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• fibronectin binding Source: GO_Central <p>Inferred from Biological aspect of Ancestor</p> <p>A type of phylogenetic evidence whereby an aspect of a descendent is inferred through the characterization of an aspect of a ancestral gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iba">GO evidence code guide</a></p> Inferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: ZFIN <p>Inferred from Direct Assay</p> <p>Used to indicate a direct assay for the function, process or component indicated by the GO term.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#ida">GO evidence code guide</a></p> Inferred from direct assayⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor II binding Source: ZFINInferred from direct assayⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]

GO - Biological processⁱ

• inner ear morphogenesis Source: ZFIN <p>Inferred from Mutant Phenotype</p> <p>Describes annotations that are concluded from looking at variations or changes in a gene product such as mutations or abnormal levels and includes techniques such as knockouts, overexpression, anti-sense experiments and use of specific protein inhibitors.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#imp">GO evidence code guide</a></p> Inferred from mutant phenotypeⁱ
  • "Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation."
    Li Y., Xiang J., Duan C.
    J Biol Chem 280:3613-3620(2005) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor receptor signaling pathway Source: ZFIN <p>Inferred from Expression Pattern</p> <p>Covers cases where the annotation is inferred from the timing or location of expression of a gene.</p> <p>More information in the <a href="http://geneontology.org/page/guide%2Dgo%2Devidence%2Dcodes#iep">GO evidence code guide</a></p> Inferred from expression patternⁱ
  • "Molecular cloning and tissue-specific, developmental-stage-specific, and hormonal regulation of IGFBP3 gene in zebrafish."
    Chen J.Y., Chen J.C., Huang W.T., Liu C.W., Hui C.F., Chen T.T., Wu J.L.
    Mar Biotechnol (NY) 6:1-7(2004) [PubMed] [Europe PMC] [Abstract]
• negative regulation of BMP signaling pathway Source: ZFINInferred from direct assayⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]
• otic vesicle formation Source: ZFINInferred from mutant phenotypeⁱ
  • "Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation."
    Li Y., Xiang J., Duan C.
    J Biol Chem 280:3613-3620(2005) [PubMed] [Europe PMC] [Abstract]
• pharyngeal system development Source: ZFINInferred from mutant phenotypeⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]
• regulation of insulin-like growth factor receptor signaling pathway Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• skeletal system development Source: ZFINInferred from mutant phenotypeⁱ
  • "Insulin-like growth factor-binding protein-3 plays an important role in regulating pharyngeal skeleton and inner ear formation and differentiation."
    Li Y., Xiang J., Duan C.
    J Biol Chem 280:3613-3620(2005) [PubMed] [Europe PMC] [Abstract]

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Protein family/group databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

Keywords - Cellular componentⁱ

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Keywords - PTMⁱ

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

GO - Molecular functionⁱ

• fibronectin binding Source: GO_CentralInferred from biological aspect of ancestorⁱ
  • "Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium."
    Gaudet P., Livstone M.S., Lewis S.E., Thomas P.D.
    Brief Bioinform 12:449-462(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor I binding Source: ZFINInferred from direct assayⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]
• insulin-like growth factor II binding Source: ZFINInferred from direct assayⁱ
  • "IGF binding protein 3 exerts its ligand-independent action by antagonizing BMP in zebrafish embryos."
    Zhong Y., Lu L., Zhou J., Li Y., Liu Y., Clemmons D.R., Duan C.
    J Cell Sci 124:1925-1935(2011) [PubMed] [Europe PMC] [Abstract]

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Compositional bias

Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequenceⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

        10         20         30         40         50
MTGLCALCLT ALLAAFARLA ESVSPVVRCE PCDDGAMVLC KPLPWDCDEP 
        60         70         80         90        100
VKEPGCGCCL TCPLTEGQAC GVYTGRCGTG LSCQHRPGES KPLQALLEGR 
       110        120        130        140        150
GVCAKAPDKK QSGSPSHGHD NPETEGKEQN GTRTAGTGEA ETVHHTTDIS 
       160        170        180        190        200
RDVQGGSRTP SEPSDPMMHS NKLEMIQKEQ VKKSQVHKVV PFSGWIVQDI 
       210        220        230        240        250
HNFSLESKRE NEYGPCRREM ESVMKQLKFT NVLNPRRFRI PNCDQKGFYK 
       260        270        280        290 
KKQCSPSKGR KRGHCWCVDK YGQPLPGYDG KEKVHCYNME TK         

Sequence databases

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

• 90% Identity
• 50% Identity

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein family/group databases

Organism-specific databases

Phylogenomic databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ