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Entry version 130 (02 Jun 2021)
Sequence version 1 (01 Dec 2001)
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Protein

Protein jagged-1a

Gene

jag1a

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Ligand for multiple Notch receptors and involved in the mediation of Notch signaling (By similarity).

Seems to be involved in cell-fate decisions.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental protein
Biological processNotch signaling pathway
LigandCalcium

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein jagged-1a
Short name:
Jagged1
Short name:
Jagged1a
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:jag1a
Synonyms:jag1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesDanionidaeDanioninaeDanio
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000437 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unplaced

Organism-specific databases

Zebrafish Information Network genome database

More...
ZFINi
ZDB-GENE-011128-2, jag1a

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini29 – 1070ExtracellularSequence analysisAdd BLAST1042
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1071 – 1095HelicalSequence analysisAdd BLAST25
Topological domaini1096 – 1242CytoplasmicSequence analysisAdd BLAST147

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 28Sequence analysisAdd BLAST28
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000000762829 – 1242Protein jagged-1aAdd BLAST1214

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi141N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi188 ↔ 197By similarity
Disulfide bondi201 ↔ 213By similarity
Glycosylationi218N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi221 ↔ 230By similarity
Disulfide bondi235 ↔ 246By similarity
Disulfide bondi239 ↔ 252By similarity
Disulfide bondi254 ↔ 263By similarity
Disulfide bondi266 ↔ 277By similarity
Disulfide bondi272 ↔ 283By similarity
Disulfide bondi285 ↔ 294By similarity
Disulfide bondi301 ↔ 313By similarity
Disulfide bondi307 ↔ 323By similarity
Disulfide bondi325 ↔ 334By similarity
Disulfide bondi341 ↔ 352By similarity
Disulfide bondi346 ↔ 361By similarity
Disulfide bondi363 ↔ 372By similarity
Disulfide bondi379 ↔ 390By similarity
Disulfide bondi384 ↔ 399By similarity
Glycosylationi385N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi401 ↔ 410By similarity
Disulfide bondi417 ↔ 428By similarity
Disulfide bondi422 ↔ 437By similarity
Disulfide bondi439 ↔ 448By similarity
Disulfide bondi455 ↔ 465By similarity
Disulfide bondi459 ↔ 474By similarity
Disulfide bondi476 ↔ 485By similarity
Disulfide bondi492 ↔ 503By similarity
Disulfide bondi497 ↔ 512By similarity
Disulfide bondi514 ↔ 523By similarity
Disulfide bondi530 ↔ 541By similarity
Disulfide bondi535 ↔ 550By similarity
Disulfide bondi552 ↔ 561By similarity
Glycosylationi560N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi600 ↔ 618By similarity
Disulfide bondi620 ↔ 629By similarity
Disulfide bondi636 ↔ 647By similarity
Disulfide bondi641 ↔ 656By similarity
Disulfide bondi658 ↔ 667By similarity
Disulfide bondi674 ↔ 685By similarity
Disulfide bondi679 ↔ 694By similarity
Disulfide bondi696 ↔ 705By similarity
Disulfide bondi712 ↔ 723By similarity
Disulfide bondi717 ↔ 732By similarity
Disulfide bondi734 ↔ 743By similarity
Glycosylationi748N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi751 ↔ 762By similarity
Disulfide bondi756 ↔ 771By similarity
Disulfide bondi773 ↔ 782By similarity
Disulfide bondi789 ↔ 800By similarity
Disulfide bondi794 ↔ 809By similarity
Disulfide bondi811 ↔ 820By similarity
Disulfide bondi827 ↔ 838By similarity
Disulfide bondi832 ↔ 847By similarity
Disulfide bondi849 ↔ 858By similarity
Glycosylationi960N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi991N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi1046N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q90Y57

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
7955.ENSDARP00000121170

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q90Y57

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini186 – 230DSLPROSITE-ProRule annotationAdd BLAST45
Domaini231 – 264EGF-like 1PROSITE-ProRule annotationAdd BLAST34
Domaini265 – 295EGF-like 2; atypicalPROSITE-ProRule annotationAdd BLAST31
Domaini297 – 335EGF-like 3PROSITE-ProRule annotationAdd BLAST39
Domaini337 – 373EGF-like 4PROSITE-ProRule annotationAdd BLAST37
Domaini375 – 411EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini413 – 449EGF-like 6; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini451 – 486EGF-like 7; calcium-bindingPROSITE-ProRule annotationAdd BLAST36
Domaini488 – 524EGF-like 8; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini526 – 562EGF-like 9PROSITE-ProRule annotationAdd BLAST37
Domaini575 – 630EGF-like 10PROSITE-ProRule annotationAdd BLAST56
Domaini632 – 668EGF-like 11; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini670 – 706EGF-like 12; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini708 – 744EGF-like 13PROSITE-ProRule annotationAdd BLAST37
Domaini747 – 783EGF-like 14PROSITE-ProRule annotationAdd BLAST37
Domaini785 – 821EGF-like 15; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini823 – 859EGF-like 16; calcium-bindingPROSITE-ProRule annotationAdd BLAST37
Domaini917 – 959EGF-like 17PROSITE-ProRule annotationAdd BLAST43

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1191 – 1242DisorderedSequence analysisAdd BLAST52

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1191 – 1235Basic and acidic residuesSequence analysisAdd BLAST45

Keywords - Domaini

EGF-like domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1217, Eukaryota

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q90Y57

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR033108, Jag1
IPR026219, Jagged/Serrate
IPR011651, Notch_ligand_N
IPR001007, VWF_dom

The PANTHER Classification System

More...
PANTHERi
PTHR24049:SF18, PTHR24049:SF18, 2 hits

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 11 hits
PF12661, hEGF, 2 hits
PF07657, MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR02059, JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 16 hits
SM00179, EGF_CA, 14 hits
SM00214, VWC, 1 hit
SM00215, VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF57184, SSF57184, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00010, ASX_HYDROXYL, 9 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 16 hits
PS01186, EGF_2, 12 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q90Y57-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MILRPSATFA ALSAHVLLRC LWMRVCEASG HFEMQVLSMQ NVNGELQSGA
60 70 80 90 100
CCDGARDPAE RSCAADQCDT FFRVCLKEYQ SRVSSGGPCS YGSGSTPVIG
110 120 130 140 150
GNTFSVKPLD QTNDKTRIVL PFSFAWPRSY TLIVEALDFN NDSSTGSING
160 170 180 190 200
QVIEKAVQSG MINPNRQWQV LKHNGPVAQF QYQIRVTCDE HYFGFGCNKF
210 220 230 240 250
CRPRDDFFGH YTCDHNGNKT CLEGWAGPEC NTAICKQGCS IEHGSCKVPG
260 270 280 290 300
NCRCLYGWQG EYCDQCIPHP GCVHGTCIEP WQCLCDTNWG GQLCDKDLNT
310 320 330 340 350
CGTLQPCLNG GTCSNTGPDK YHCACPDGYS GQNCERADNA CLSEPCLNGG
360 370 380 390 400
LCVESSLGFE CQCAAGWTGP SCNINEDDCS PNPCNHSGVC VDLVDGFKCI
410 420 430 440 450
CPVQWTGKTC LIDANECEES PCVNAHSCRN LIGGYFCECL PGWTGQNCDI
460 470 480 490 500
NVNDCHGQCL NGGLCKDLVN GYRCVCAAGF AGDRCERDVD ECASRPCLNG
510 520 530 540 550
GRCQDTLNGF QCLCPPGFSG ATCQLDLDYC ESGPCQNGAQ CFSLASDYYC
560 570 580 590 600
KCPEDYEGKN CSQLKDHCLI TPCQVIDSCT VAVVSNSTPG GLRLISSSVC
610 620 630 640 650
GPHGRCRSHS HAGGHFSCDC QDGFTGTYCH ENINDCESSP CLSGGTCIDK
660 670 680 690 700
INAYQCICAD GWEGPNCETN IDDCRTNPCR DRGVCRDLVN DFYCECENGW
710 720 730 740 750
KGKTCHSRES QCDEDTCNNG GTCSDEGDSF KCLCSPGWEG ATCNIAKNSS
760 770 780 790 800
CLPNPCENGA TCVVTGDGFT CVCKEGWEGP TCSQNSNDCN PQPCYNSGTC
810 820 830 840 850
VDGDNWYRCE CASGFAGPDC RININECQSS PCAFGSTCVD EINGYRCLCP
860 870 880 890 900
PGRTGPRCQE VTGRPCVIGG RIAVDGAKWA EDCNTCYCHK GIVTCTKLFC
910 920 930 940 950
GPKACRMLGS GRGDCPTGQL CVPVRDEQCF VKPCSSQGEC WSAHRPAVRT
960 970 980 990 1000
HCQPDSHCAN VTFTFNKDTM PQGVTVEQVC RELRHLYVTK NVTSEFSISV
1010 1020 1030 1040 1050
SCELSSAASN EIHVAIHVTE NGIHGRVPVK EITDNIIDLV SKHSANSSVI
1060 1070 1080 1090 1100
GSIAEVRVQR KQPQNPNVDY MVPLLVSVVT AIWVLALASV FLWCIRHHRK
1110 1120 1130 1140 1150
QSSSATAINP TSPFSTPEEN TANNAREHLN QIKNHIEKNA SNGSLPGKEL
1160 1170 1180 1190 1200
HCDDKNTVNA KIRTQFPESD ASRRLQKTRF PHQPAYMLVD RDDRLSSNGT
1210 1220 1230 1240
DIKKHPQWTN KRDNRDLESQ HRVPDSQHRD SQHSLQKMEY IV
Length:1,242
Mass (Da):135,343
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i59557A4B7F052860
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B8JKQ5B8JKQ5_DANRE
Delta-like protein
jag1a
1,253Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F1QP77F1QP77_DANRE
Delta-like protein
jag1a
1,242Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF229448 mRNA Translation: AAL08213.1

NCBI Reference Sequences

More...
RefSeqi
NP_571936.1, NM_131861.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
140421

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
dre:140421

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229448 mRNA Translation: AAL08213.1
RefSeqiNP_571936.1, NM_131861.1

3D structure databases

SMRiQ90Y57
ModBaseiSearch...

Protein-protein interaction databases

STRINGi7955.ENSDARP00000121170

Proteomic databases

PaxDbiQ90Y57

Genome annotation databases

GeneIDi140421
KEGGidre:140421

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
140421
ZFINiZDB-GENE-011128-2, jag1a

Phylogenomic databases

eggNOGiKOG1217, Eukaryota
InParanoidiQ90Y57

Miscellaneous databases

Protein Ontology

More...
PROi
PR:Q90Y57

Family and domain databases

InterProiView protein in InterPro
IPR001774, DSL
IPR001881, EGF-like_Ca-bd_dom
IPR013032, EGF-like_CS
IPR000742, EGF-like_dom
IPR000152, EGF-type_Asp/Asn_hydroxyl_site
IPR018097, EGF_Ca-bd_CS
IPR009030, Growth_fac_rcpt_cys_sf
IPR033108, Jag1
IPR026219, Jagged/Serrate
IPR011651, Notch_ligand_N
IPR001007, VWF_dom
PANTHERiPTHR24049:SF18, PTHR24049:SF18, 2 hits
PfamiView protein in Pfam
PF01414, DSL, 1 hit
PF00008, EGF, 11 hits
PF12661, hEGF, 2 hits
PF07657, MNNL, 1 hit
PRINTSiPR02059, JAGGEDFAMILY
SMARTiView protein in SMART
SM00051, DSL, 1 hit
SM00181, EGF, 16 hits
SM00179, EGF_CA, 14 hits
SM00214, VWC, 1 hit
SM00215, VWC_out, 1 hit
SUPFAMiSSF57184, SSF57184, 3 hits
PROSITEiView protein in PROSITE
PS00010, ASX_HYDROXYL, 9 hits
PS51051, DSL, 1 hit
PS00022, EGF_1, 16 hits
PS01186, EGF_2, 12 hits
PS50026, EGF_3, 15 hits
PS01187, EGF_CA, 8 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiJAG1A_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90Y57
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 2, 2002
Last sequence update: December 1, 2001
Last modified: June 2, 2021
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome
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