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UniProtKB - Q90Y56 (Q90Y56_DANRE)

Entry version 124 (11 Dec 2019)
Sequence version 1 (01 Dec 2001)
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Protein

Delta-like protein

Gene

jag2b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Unreviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Putative Notch ligand involved in the mediation of Notch signaling.UniRule annotation

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDevelopmental proteinUniRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Delta-like proteinUniRule annotation
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:jag2bImported
Synonyms:jag2Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri7955 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio

Organism-specific databases

Zebrafish Information Network genome database

More...ZFINi		ZDB-GENE-011128-3 jag2b

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1084 – 1108HelicalSequence analysisAdd BLAST25

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 26Sequence analysisAdd BLAST26
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500431857127 – 1254Delta-like proteinSequence analysisAdd BLAST1228

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi190 ↔ 199PROSITE-ProRule annotation
Disulfide bondi203 ↔ 215PROSITE-ProRule annotation
Disulfide bondi223 ↔ 232PROSITE-ProRule annotation
Disulfide bondi287 ↔ 296PROSITE-ProRule annotation
Disulfide bondi327 ↔ 336PROSITE-ProRule annotation
Disulfide bondi365 ↔ 374PROSITE-ProRule annotation
Disulfide bondi403 ↔ 412PROSITE-ProRule annotation
Disulfide bondi441 ↔ 450PROSITE-ProRule annotation
Disulfide bondi457 ↔ 467PROSITE-ProRule annotation
Disulfide bondi479 ↔ 488PROSITE-ProRule annotation
Disulfide bondi517 ↔ 526PROSITE-ProRule annotation
Disulfide bondi559 ↔ 568PROSITE-ProRule annotation
Disulfide bondi625 ↔ 634PROSITE-ProRule annotation
Disulfide bondi663 ↔ 672PROSITE-ProRule annotation
Disulfide bondi701 ↔ 710PROSITE-ProRule annotation
Disulfide bondi739 ↔ 748PROSITE-ProRule annotation
Disulfide bondi778 ↔ 787PROSITE-ProRule annotation
Disulfide bondi816 ↔ 825PROSITE-ProRule annotation
Disulfide bondi854 ↔ 863PROSITE-ProRule annotation

Keywords - PTMi

Disulfide bondPROSITE-ProRule annotationSAAS annotation

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Complete GO annotation on QuickGO ...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 232DSLInterPro annotationAdd BLAST45
Domaini266 – 297EGF-likeInterPro annotationAdd BLAST32
Domaini299 – 337EGF-likeInterPro annotationAdd BLAST39
Domaini339 – 375EGF-likeInterPro annotationAdd BLAST37
Domaini377 – 413EGF-likeInterPro annotationAdd BLAST37
Domaini415 – 451EGF-likeInterPro annotationAdd BLAST37
Domaini453 – 489EGF-likeInterPro annotationAdd BLAST37
Domaini491 – 527EGF-likeInterPro annotationAdd BLAST37
Domaini533 – 569EGF-likeInterPro annotationAdd BLAST37
Domaini596 – 635EGF-likeInterPro annotationAdd BLAST40
Domaini637 – 673EGF-likeInterPro annotationAdd BLAST37
Domaini675 – 711EGF-likeInterPro annotationAdd BLAST37
Domaini713 – 749EGF-likeInterPro annotationAdd BLAST37
Domaini752 – 788EGF-likeInterPro annotationAdd BLAST37
Domaini790 – 826EGF-likeInterPro annotationAdd BLAST37
Domaini828 – 864EGF-likeInterPro annotationAdd BLAST37

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1135 – 1170DisorderedSequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1137 – 1154PolyampholyteSequence analysisAdd BLAST18

Keywords - Domaini

EGF-like domainPROSITE-ProRule annotationSAAS annotation, RepeatUniRule annotationSAAS annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotation

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1217 Eukaryota
ENOG410XP6K LUCA

KEGG Orthology (KO)

More...KOi		K21635

Database of Orthologous Groups

More...OrthoDBi		72177at2759

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom

The PANTHER Classification System

More...PANTHERi		PTHR24049:SF18 PTHR24049:SF18, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 12 hits
PF07645 EGF_CA, 1 hit
PF07657 MNNL, 1 hit

Protein Motif fingerprint database; a protein domain database

More...PRINTSi		PR02059 JAGGEDFAMILY

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00215 VWC_out, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF57184 SSF57184, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00010 ASX_HYDROXYL, 7 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 10 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90Y56-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MWNCIRIRNW LPIACLLLTM WTKVSQSSGY FELQLIAVEN VNGELWDGEC 
        60         70         80         90        100
CDSTRNSQDQ RCVRDECDTY FKVCLKEYQS EVTTTGQCTF GSGSTDVLGG 
       110        120        130        140        150
NIFSFKTAKN SPSKTSDVGK IIIPFHFAWP RSYTLILEAW DWDNSTQNNG 
       160        170        180        190        200
EENLIERHIH ASMVNPGDHW QSIRHPGITA HIEYRIRVRC DENYYGSKCN 
       210        220        230        240        250
KQCRPRDDYF GHYRCDPSGN IVCLDGWMGE DCRTAICKQG CNLIHGGCAV 
       260        270        280        290        300
PGECKCNYGW QGQFCDECLP YPGCLHGTCV MPWQCTCEKN WGGLLCDKDL 
       310        320        330        340        350
NYCGTHHPCV NGGTCMNSEP DEYNCACPEG YSGKNCEIAE HACVSNPCAN 
       360        370        380        390        400
GGTCHEVPTG FECHCPPGWE GPTCAKDMDE CASSPCAQGG TCIDLENGFE 
       410        420        430        440        450
CVCPPQWVGK TCQIDANECM GKPCVNAHSC KNMIGGYHCD CFQGWAGQNC 
       460        470        480        490        500
DINLNGCHGQ CQNGATCKEL VHGGYHCQCP AGFVGLHCEV SRNKCASGPC 
       510        520        530        540        550
QNGGRCHVIL DSFVCECPSN YAGMLCEVES LSHPNPCEPN PCQNTALCYS 
       560        570        580        590        600
LPGDFYCACP EDYEGKTCEN RKDHCKMTPC QVIDSCTIAV ASNSSDGGVR 
       610        620        630        640        650
HINSNVCGPH GRCISQPGGN FTCTCELGFT GTYCHENVND CVSNPCRNGG 
       660        670        680        690        700
TCIDGISSFQ CFCPDGWEGD LCSINVNECS RSPCKNGGHC VDLVNDFYCE 
       710        720        730        740        750
CANGWKGKTC HSRESQCDSS TCSNGGTCYD HGDAFRCACP PGWEGSTCNT 
       760        770        780        790        800
AKNSTCASGP CLNGGTCVGG GDTFTCICKD GWEGATCAQN TNDCNPHPCY 
       810        820        830        840        850
NGGICVDGVN WFRCECAPGF AGPDCRINID ECQSSPCAYG ATCVDEINGF 
       860        870        880        890        900
RCVCPLGRTG PQCQEFIGIG KTCHYAGLQF PHGSRWEEEC NTCQCVNGKV 
       910        920        930        940        950
ECTKVVCGRK PCLLPGTPGR ELHYCPGGRE CLEHNFLTCL SPPCHQWGFC 
       960        970        980        990       1000
SSPETPPTLQ TKCEPNSVYL DKSCARITLI FNRDKLPTGT TVENVCSELR 
      1010       1020       1030       1040       1050
YMPATRSLAK DHKLLVLCDL SYKNQDAVEV AISFQHDEQP SHSQIQEAAS 
      1060       1070       1080       1090       1100
TIVSTLSKRH NSTVMLAVIE VKVEMPVTSQ PVDYLVPVLC VVLCVLWVFC 
      1110       1120       1130       1140       1150
VIVCVWWTRK RRKERERRER VPVEESVNNQ WEPLRPVTRP QHKDNRDAQF 
      1160       1170       1180       1190       1200
ERTKLMGSPD RTCNSGDDEE DMEEDELELV EEWCGTEGGK HPVQKYSKSA 
      1210       1220       1230       1240       1250
ARTKNGLICT TRSTSGSSSP SLKAAYWTGF SPKDNNCKNV NNATAGQEHK 

EHCV
Length:1,254
Mass (Da):137,720
Last modified:December 1, 2001 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iAFF70717DF190FEB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AF229449 mRNA Translation: AAL08214.1

NCBI Reference Sequences

More...RefSeqi		NP_571937.1, NM_131862.1

Genome annotation databases

Database of genes from NCBI RefSeq genomes

More...GeneIDi		140422

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		dre:140422

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF229449 mRNA Translation: AAL08214.1
RefSeqiNP_571937.1, NM_131862.1

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Genome annotation databases

GeneIDi140422
KEGGidre:140422

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		140422
ZFINiZDB-GENE-011128-3 jag2b

Phylogenomic databases

eggNOGiKOG1217 Eukaryota
ENOG410XP6K LUCA
KOiK21635
OrthoDBi72177at2759

Family and domain databases

InterProiView protein in InterPro
IPR001774 DSL
IPR001881 EGF-like_Ca-bd_dom
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR000152 EGF-type_Asp/Asn_hydroxyl_site
IPR018097 EGF_Ca-bd_CS
IPR009030 Growth_fac_rcpt_cys_sf
IPR033108 Jag2
IPR026219 Jagged/Serrate
IPR011651 Notch_ligand_N
IPR001007 VWF_dom
PANTHERiPTHR24049:SF18 PTHR24049:SF18, 1 hit
PfamiView protein in Pfam
PF01414 DSL, 1 hit
PF00008 EGF, 12 hits
PF07645 EGF_CA, 1 hit
PF07657 MNNL, 1 hit
PRINTSiPR02059 JAGGEDFAMILY
SMARTiView protein in SMART
SM00051 DSL, 1 hit
SM00181 EGF, 16 hits
SM00179 EGF_CA, 14 hits
SM00215 VWC_out, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
PROSITEiView protein in PROSITE
PS00010 ASX_HYDROXYL, 7 hits
PS51051 DSL, 1 hit
PS00022 EGF_1, 15 hits
PS01186 EGF_2, 10 hits
PS50026 EGF_3, 15 hits
PS01187 EGF_CA, 3 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90Y56_DANRE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90Y56
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: December 11, 2019
This is version 124 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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