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UniProtKB - Q90Y56 (Q90Y56_DANRE)
Protein
Delta-like protein
Gene
jag2b
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Putative Notch ligand involved in the mediation of Notch signaling.
UniRule annotationCaution
Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation
GO - Molecular functioni
- calcium ion binding Source: InterPro
- Notch binding Source: InterPro
GO - Biological processi
- establishment or maintenance of epithelial cell apical/basal polarity Source: GO_Central
- exocrine pancreas development Source: ZFIN
- heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules Source: GO_Central
- intrahepatic bile duct development Source: ZFIN
- liver development Source: ZFIN
- Notch signaling pathway Source: InterPro
- pancreas development Source: ZFIN
- pronephros development Source: ZFIN
- spinal cord motor neuron differentiation Source: ZFIN
- ventral spinal cord interneuron differentiation Source: ZFIN
Keywordsi
Molecular function | Developmental proteinUniRule annotationARBA annotation |
Names & Taxonomyi
Protein namesi | Recommended name: Delta-like proteinUniRule annotation |
Gene namesi | |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio)Imported |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Organism-specific databases
ZFINi | ZDB-GENE-011128-3, jag2b |
Subcellular locationi
Other locations
- Membrane UniRule annotationARBA annotation; Single-pass type I membrane protein UniRule annotationARBA annotation
Plasma Membrane
- plasma membrane Source: GO_Central
Other locations
- integral component of membrane Source: ZFIN
- protein-containing complex Source: GO_Central
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 1084 – 1108 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 26 | Sequence analysisAdd BLAST | 26 | |
ChainiPRO_5004318571 | 27 – 1254 | Delta-like proteinSequence analysisAdd BLAST | 1228 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Disulfide bondi | 190 ↔ 199 | PROSITE-ProRule annotation | ||
Disulfide bondi | 203 ↔ 215 | PROSITE-ProRule annotation | ||
Disulfide bondi | 223 ↔ 232 | PROSITE-ProRule annotation | ||
Disulfide bondi | 327 ↔ 336 | PROSITE-ProRule annotation | ||
Disulfide bondi | 365 ↔ 374 | PROSITE-ProRule annotation | ||
Disulfide bondi | 403 ↔ 412 | PROSITE-ProRule annotation | ||
Disulfide bondi | 441 ↔ 450 | PROSITE-ProRule annotation | ||
Disulfide bondi | 457 ↔ 467 | PROSITE-ProRule annotation | ||
Disulfide bondi | 479 ↔ 488 | PROSITE-ProRule annotation | ||
Disulfide bondi | 517 ↔ 526 | PROSITE-ProRule annotation | ||
Disulfide bondi | 559 ↔ 568 | PROSITE-ProRule annotation | ||
Disulfide bondi | 625 ↔ 634 | PROSITE-ProRule annotation | ||
Disulfide bondi | 663 ↔ 672 | PROSITE-ProRule annotation | ||
Disulfide bondi | 701 ↔ 710 | PROSITE-ProRule annotation | ||
Disulfide bondi | 739 ↔ 748 | PROSITE-ProRule annotation | ||
Disulfide bondi | 778 ↔ 787 | PROSITE-ProRule annotation | ||
Disulfide bondi | 816 ↔ 825 | PROSITE-ProRule annotation | ||
Disulfide bondi | 854 ↔ 863 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bondPROSITE-ProRule annotationARBA annotationStructurei
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 188 – 232 | DSLInterPro annotationAdd BLAST | 45 | |
Domaini | 299 – 337 | EGF-likeInterPro annotationAdd BLAST | 39 | |
Domaini | 339 – 375 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 377 – 413 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 415 – 451 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 453 – 489 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 491 – 527 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 533 – 569 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 596 – 635 | EGF-likeInterPro annotationAdd BLAST | 40 | |
Domaini | 637 – 673 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 675 – 711 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 713 – 749 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 752 – 788 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 790 – 826 | EGF-likeInterPro annotationAdd BLAST | 37 | |
Domaini | 828 – 864 | EGF-likeInterPro annotationAdd BLAST | 37 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1135 – 1170 | DisorderedSequence analysisAdd BLAST | 36 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1137 – 1154 | Basic and acidic residuesSequence analysisAdd BLAST | 18 |
Keywords - Domaini
EGF-like domainPROSITE-ProRule annotationARBA annotation, RepeatUniRule annotationARBA annotation, SignalUniRule annotation, Transmembrane, Transmembrane helixUniRule annotationPhylogenomic databases
OrthoDBi | 72177at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR033108, Jag1 IPR026219, Jagged/Serrate IPR011651, Notch_ligand_N IPR001007, VWF_dom |
PANTHERi | PTHR24049:SF18, PTHR24049:SF18, 1 hit |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 12 hits PF07645, EGF_CA, 1 hit PF07657, MNNL, 1 hit |
PRINTSi | PR02059, JAGGEDFAMILY |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 16 hits SM00179, EGF_CA, 14 hits SM00215, VWC_out, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 7 hits PS51051, DSL, 1 hit PS00022, EGF_1, 15 hits PS01186, EGF_2, 10 hits PS50026, EGF_3, 14 hits PS01187, EGF_CA, 3 hits |
i Sequence
Sequence statusi: Complete.
Q90Y56-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MWNCIRIRNW LPIACLLLTM WTKVSQSSGY FELQLIAVEN VNGELWDGEC
60 70 80 90 100
CDSTRNSQDQ RCVRDECDTY FKVCLKEYQS EVTTTGQCTF GSGSTDVLGG
110 120 130 140 150
NIFSFKTAKN SPSKTSDVGK IIIPFHFAWP RSYTLILEAW DWDNSTQNNG
160 170 180 190 200
EENLIERHIH ASMVNPGDHW QSIRHPGITA HIEYRIRVRC DENYYGSKCN
210 220 230 240 250
KQCRPRDDYF GHYRCDPSGN IVCLDGWMGE DCRTAICKQG CNLIHGGCAV
260 270 280 290 300
PGECKCNYGW QGQFCDECLP YPGCLHGTCV MPWQCTCEKN WGGLLCDKDL
310 320 330 340 350
NYCGTHHPCV NGGTCMNSEP DEYNCACPEG YSGKNCEIAE HACVSNPCAN
360 370 380 390 400
GGTCHEVPTG FECHCPPGWE GPTCAKDMDE CASSPCAQGG TCIDLENGFE
410 420 430 440 450
CVCPPQWVGK TCQIDANECM GKPCVNAHSC KNMIGGYHCD CFQGWAGQNC
460 470 480 490 500
DINLNGCHGQ CQNGATCKEL VHGGYHCQCP AGFVGLHCEV SRNKCASGPC
510 520 530 540 550
QNGGRCHVIL DSFVCECPSN YAGMLCEVES LSHPNPCEPN PCQNTALCYS
560 570 580 590 600
LPGDFYCACP EDYEGKTCEN RKDHCKMTPC QVIDSCTIAV ASNSSDGGVR
610 620 630 640 650
HINSNVCGPH GRCISQPGGN FTCTCELGFT GTYCHENVND CVSNPCRNGG
660 670 680 690 700
TCIDGISSFQ CFCPDGWEGD LCSINVNECS RSPCKNGGHC VDLVNDFYCE
710 720 730 740 750
CANGWKGKTC HSRESQCDSS TCSNGGTCYD HGDAFRCACP PGWEGSTCNT
760 770 780 790 800
AKNSTCASGP CLNGGTCVGG GDTFTCICKD GWEGATCAQN TNDCNPHPCY
810 820 830 840 850
NGGICVDGVN WFRCECAPGF AGPDCRINID ECQSSPCAYG ATCVDEINGF
860 870 880 890 900
RCVCPLGRTG PQCQEFIGIG KTCHYAGLQF PHGSRWEEEC NTCQCVNGKV
910 920 930 940 950
ECTKVVCGRK PCLLPGTPGR ELHYCPGGRE CLEHNFLTCL SPPCHQWGFC
960 970 980 990 1000
SSPETPPTLQ TKCEPNSVYL DKSCARITLI FNRDKLPTGT TVENVCSELR
1010 1020 1030 1040 1050
YMPATRSLAK DHKLLVLCDL SYKNQDAVEV AISFQHDEQP SHSQIQEAAS
1060 1070 1080 1090 1100
TIVSTLSKRH NSTVMLAVIE VKVEMPVTSQ PVDYLVPVLC VVLCVLWVFC
1110 1120 1130 1140 1150
VIVCVWWTRK RRKERERRER VPVEESVNNQ WEPLRPVTRP QHKDNRDAQF
1160 1170 1180 1190 1200
ERTKLMGSPD RTCNSGDDEE DMEEDELELV EEWCGTEGGK HPVQKYSKSA
1210 1220 1230 1240 1250
ARTKNGLICT TRSTSGSSSP SLKAAYWTGF SPKDNNCKNV NNATAGQEHK
EHCV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF229449 mRNA Translation: AAL08214.1 |
RefSeqi | NP_571937.1, NM_131862.1 |
Genome annotation databases
GeneIDi | 140422 |
KEGGi | dre:140422 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF229449 mRNA Translation: AAL08214.1 |
RefSeqi | NP_571937.1, NM_131862.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Genome annotation databases
GeneIDi | 140422 |
KEGGi | dre:140422 |
Organism-specific databases
CTDi | 140422 |
ZFINi | ZDB-GENE-011128-3, jag2b |
Phylogenomic databases
OrthoDBi | 72177at2759 |
Family and domain databases
InterProi | View protein in InterPro IPR001774, DSL IPR001881, EGF-like_Ca-bd_dom IPR000742, EGF-like_dom IPR000152, EGF-type_Asp/Asn_hydroxyl_site IPR018097, EGF_Ca-bd_CS IPR009030, Growth_fac_rcpt_cys_sf IPR033108, Jag1 IPR026219, Jagged/Serrate IPR011651, Notch_ligand_N IPR001007, VWF_dom |
PANTHERi | PTHR24049:SF18, PTHR24049:SF18, 1 hit |
Pfami | View protein in Pfam PF01414, DSL, 1 hit PF00008, EGF, 12 hits PF07645, EGF_CA, 1 hit PF07657, MNNL, 1 hit |
PRINTSi | PR02059, JAGGEDFAMILY |
SMARTi | View protein in SMART SM00051, DSL, 1 hit SM00181, EGF, 16 hits SM00179, EGF_CA, 14 hits SM00215, VWC_out, 1 hit |
SUPFAMi | SSF57184, SSF57184, 1 hit |
PROSITEi | View protein in PROSITE PS00010, ASX_HYDROXYL, 7 hits PS51051, DSL, 1 hit PS00022, EGF_1, 15 hits PS01186, EGF_2, 10 hits PS50026, EGF_3, 14 hits PS01187, EGF_CA, 3 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | Q90Y56_DANRE | |
Accessioni | Q90Y56Primary (citable) accession number: Q90Y56 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | December 1, 2001 |
Last sequence update: | December 1, 2001 | |
Last modified: | January 19, 2022 | |
This is version 132 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |