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Protein

Iroquois-class homeodomain protein irx-5

Gene

irx5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Acts partially redundantly with other irx members in neural patterning. Required for formation of the posterior forebrain, midbrain, hindbrain, and to a lesser extent, spinal cord. Patterns the neuroectoderm in both the anterior/posterior and dorsal/ventral axes. Does not appear to play a role in pronephros kidney development. Involved in craniofacial and gonadal development. Modulates the migration of progenitor cell populations in branchial arches and gonads by repressing CXCL12.2 Publications

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi109 – 171Homeobox; TALE-typePROSITE-ProRule annotationAdd BLAST63

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDevelopmental protein, DNA-binding
Biological processDifferentiation, Neurogenesis, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Iroquois-class homeodomain protein irx-51 Publication
Alternative name(s):
Iroquois homeobox protein 5By similarity
Gene namesi
Name:irx5
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-865076 irx5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003887211 – 474Iroquois-class homeodomain protein irx-5Add BLAST474

Expressioni

Tissue specificityi

Early in gastrulation, expressed in cells beneath the blastopore lip. Subsequently expressed in the neural plate in overlapping patterns with other irx members, which all share an anterior border of expression. At the time of neural tube closure (stage 19) in regions of the midbrain, hindbrain, neural tube and optic vesicle, where expression continues during tailbud stages. In stage 34, expressed throughout the eye retina. Does not appear to be expressed in the developing heart or pronephros.5 Publications

Inductioni

By hoxb4 and hoxb5. Down-regulated by hoxb9.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90XW5
SMRiQ90XW5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the TALE/IRO homeobox family.Sequence analysis

Keywords - Domaini

Homeobox

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q90XW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSYPQGYLYQ PSASLALYSC PAYSTTVISG PRTDELGRSP SGSAFSPYAG
60 70 80 90 100
STAFTASSAG FSSPLQYSGD PAAAFTSYVG SPYDHSAGMA GSLEYHPYAA
110 120 130 140 150
PLGIYAYGDP AYRKNASRDA TATLKAWLNE HRKNPYPTKG EKIMLAIITK
160 170 180 190 200
MTLTQVSTWF ANARRRLKKE NKMTWTPRNR SEDEDDDENI DLEKNEEDDP
210 220 230 240 250
SKLEENGNQD GDAGDQKRSP DGVDFVRLEG EVHLGKELDQ TRNNSELNEL
260 270 280 290 300
DERNGHLSNS SSPPTPPLCP PDQSPQAQED QNLHGHTHQS IQQLLHHSNQ
310 320 330 340 350
PHPLDLVNRN TSVQHGPVTN NATSVIHSPP ASTSKPKLWS LAEIATSSDK
360 370 380 390 400
VKERSNAAEV AGTTAAKSMV VSASSPSRSP SAQCHFPNNT VLSRPLYYSI
410 420 430 440 450
PFYPGYTNYG TFSHLHSHHG PSSSVNSTYH FNGINQPVLN KAEGLAKECK
460 470
HISQSQDDLN KGTPYEMKKG MSSI
Length:474
Mass (Da):51,757
Last modified:December 1, 2001 - v1
Checksum:i094450C6A0D02730
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338158 mRNA Translation: AAK96066.1
RefSeqiNP_001079223.1, NM_001085754.1
UniGeneiXl.12085

Genome annotation databases

GeneIDi373841
KEGGixla:373841

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF338158 mRNA Translation: AAK96066.1
RefSeqiNP_001079223.1, NM_001085754.1
UniGeneiXl.12085

3D structure databases

ProteinModelPortaliQ90XW5
SMRiQ90XW5
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi373841
KEGGixla:373841

Organism-specific databases

CTDi373841
XenbaseiXB-GENE-865076 irx5

Family and domain databases

CDDicd00086 homeodomain, 1 hit
InterProiView protein in InterPro
IPR009057 Homeobox-like_sf
IPR017970 Homeobox_CS
IPR001356 Homeobox_dom
IPR008422 Homeobox_KN_domain
IPR003893 Iroquois_homeo
PfamiView protein in Pfam
PF05920 Homeobox_KN, 1 hit
SMARTiView protein in SMART
SM00389 HOX, 1 hit
SM00548 IRO, 1 hit
SUPFAMiSSF46689 SSF46689, 1 hit
PROSITEiView protein in PROSITE
PS00027 HOMEOBOX_1, 1 hit
PS50071 HOMEOBOX_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiIRX5_XENLA
AccessioniPrimary (citable) accession number: Q90XW5
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 3, 2009
Last sequence update: December 1, 2001
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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