UniProtKB - Q90WY6 (ADA2C_DANRE)
Protein
Alpha-2C adrenergic receptor
Gene
adra2c
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins. The order of potency for this receptor is dexmedetomidine > norepinephrine > epinephrine.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 115 | Implicated in ligand bindingBy similarity | 1 | |
Sitei | 198 | Implicated in catechol agonist binding and receptor activationBy similarity | 1 | |
Sitei | 202 | Implicated in catechol agonist binding and receptor activationBy similarity | 1 |
GO - Molecular functioni
- adrenergic receptor activity Source: GO_Central
- alpha2-adrenergic receptor activity Source: UniProtKB
GO - Biological processi
- adenylate cyclase-activating adrenergic receptor signaling pathway Source: GO_Central
- adenylate cyclase-inhibiting adrenergic receptor signaling pathway Source: UniProtKB
- adenylate cyclase-modulating G protein-coupled receptor signaling pathway Source: GO_Central
- G protein-coupled receptor signaling pathway Source: ZFIN
- platelet activation Source: InterPro
- regulation of smooth muscle contraction Source: InterPro
- regulation of vasoconstriction Source: InterPro
Keywordsi
Molecular function | G-protein coupled receptor, Receptor, Transducer |
Enzyme and pathway databases
Reactomei | R-DRE-390696 Adrenoceptors R-DRE-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-DRE-400042 Adrenaline,noradrenaline inhibits insulin secretion R-DRE-418594 G alpha (i) signalling events R-DRE-418597 G alpha (z) signalling events |
Names & Taxonomyi
Protein namesi | Recommended name: Alpha-2C adrenergic receptorAlternative name(s): Alpha-2C adrenoreceptor Short name: Alpha-2C adrenoceptor Short name: Alpha-2CAR |
Gene namesi | Name:adra2c |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Cyprinidae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-021010-3 adra2c |
Subcellular locationi
Plasma membrane
Plasma Membrane
- integral component of plasma membrane Source: GO_Central
- plasma membrane Source: ZFIN
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 35 | ExtracellularBy similarityAdd BLAST | 35 | |
Transmembranei | 36 – 60 | Helical; Name=1By similarityAdd BLAST | 25 | |
Topological domaini | 61 – 72 | CytoplasmicBy similarityAdd BLAST | 12 | |
Transmembranei | 73 – 98 | Helical; Name=2By similarityAdd BLAST | 26 | |
Topological domaini | 99 – 108 | ExtracellularBy similarity | 10 | |
Transmembranei | 109 – 131 | Helical; Name=3By similarityAdd BLAST | 23 | |
Topological domaini | 132 – 152 | CytoplasmicBy similarityAdd BLAST | 21 | |
Transmembranei | 153 – 175 | Helical; Name=4By similarityAdd BLAST | 23 | |
Topological domaini | 176 – 191 | ExtracellularBy similarityAdd BLAST | 16 | |
Transmembranei | 192 – 215 | Helical; Name=5By similarityAdd BLAST | 24 | |
Topological domaini | 216 – 351 | CytoplasmicBy similarityAdd BLAST | 136 | |
Transmembranei | 352 – 379 | Helical; Name=6By similarityAdd BLAST | 28 | |
Topological domaini | 380 – 392 | ExtracellularBy similarityAdd BLAST | 13 | |
Transmembranei | 393 – 413 | Helical; Name=7By similarityAdd BLAST | 21 | |
Topological domaini | 414 – 432 | CytoplasmicBy similarityAdd BLAST | 19 |
Keywords - Cellular componenti
Cell membrane, MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000069108 | 1 – 432 | Alpha-2C adrenergic receptorAdd BLAST | 432 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 3 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 23 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Glycosylationi | 26 | N-linked (GlcNAc...) asparagineSequence analysis | 1 | |
Disulfide bondi | 108 ↔ 186 | PROSITE-ProRule annotation |
Keywords - PTMi
Disulfide bond, GlycoproteinProteomic databases
PaxDbi | Q90WY6 |
Expressioni
Gene expression databases
Bgeei | ENSDARG00000069669 Expressed in 7 organ(s), highest expression level in spleen |
ExpressionAtlasi | Q90WY6 baseline |
Family & Domainsi
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 281 – 331 | Ser-richAdd BLAST | 51 |
Sequence similaritiesi
Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2C sub-subfamily.PROSITE-ProRule annotation
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161707 |
HOGENOMi | HOG000239242 |
InParanoidi | Q90WY6 |
KOi | K04140 |
OMAi | ELMNYWY |
OrthoDBi | 737211at2759 |
PhylomeDBi | Q90WY6 |
TreeFami | TF316350 |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF25 PTHR24248:SF25, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q90WY6-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MHNLSYASEE DTYTDTDFTP SGNSTNSTSY SPATIIGLAG LVSFLILFTI
60 70 80 90 100
VGNVLVVIAV LTSRALKPPQ NLFLVSLASA DILVATLIIP FSLANELMGY
110 120 130 140 150
WFFGEVWCNI YLALDVLFCT SSIVHLCAIS LDRYWSVTQA VEYNLKRTPR
160 170 180 190 200
RVKGMIVVVW LISAVISFPP LISMDRNTVD ERRPMCQLND HTWYILYSSI
210 220 230 240 250
GSFFAPCVIM ILVYIRIYQV AKTRTRNMSE KRRDPDGGSG TPRLENGLSR
260 270 280 290 300
EDSRRENGHC SSSPGERKPA EDNPDADLED SSSSDEKAKR SQNETAPSKK
310 320 330 340 350
DRRSSRKNSS SSKHSSRKSR ASSKSLDLFS SRRKRRNTIS RKKISQAREK
360 370 380 390 400
RFTFVLAVVM GVFVVCWFPF FFSYSLYGIC REPCAIPDPL FKFFFWIGYC
410 420 430
NSSLNPVIYT IFNQDFRRAF QKILCKSWKR SF
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8QN31 | A0A2R8QN31_DANRE | Alpha-2C adrenergic receptor | adra2c | 432 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048969 Genomic DNA Translation: AAL07508.1 |
RefSeqi | NP_997522.1, NM_207639.1 |
Genome annotation databases
Ensembli | ENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669 ENSDART00000188270; ENSDARP00000152698; ENSDARG00000109788 |
GeneIDi | 266752 |
KEGGi | dre:266752 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY048969 Genomic DNA Translation: AAL07508.1 |
RefSeqi | NP_997522.1, NM_207639.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000101388 |
Protein family/group databases
GPCRDBi | Search... |
Proteomic databases
PaxDbi | Q90WY6 |
Genome annotation databases
Ensembli | ENSDART00000101562; ENSDARP00000101388; ENSDARG00000069669 ENSDART00000188270; ENSDARP00000152698; ENSDARG00000109788 |
GeneIDi | 266752 |
KEGGi | dre:266752 |
Organism-specific databases
CTDi | 152 |
ZFINi | ZDB-GENE-021010-3 adra2c |
Phylogenomic databases
eggNOGi | KOG3656 Eukaryota ENOG410XRW9 LUCA |
GeneTreei | ENSGT00940000161707 |
HOGENOMi | HOG000239242 |
InParanoidi | Q90WY6 |
KOi | K04140 |
OMAi | ELMNYWY |
OrthoDBi | 737211at2759 |
PhylomeDBi | Q90WY6 |
TreeFami | TF316350 |
Enzyme and pathway databases
Reactomei | R-DRE-390696 Adrenoceptors R-DRE-392023 Adrenaline signalling through Alpha-2 adrenergic receptor R-DRE-400042 Adrenaline,noradrenaline inhibits insulin secretion R-DRE-418594 G alpha (i) signalling events R-DRE-418597 G alpha (z) signalling events |
Miscellaneous databases
PROi | PR:Q90WY6 |
Gene expression databases
Bgeei | ENSDARG00000069669 Expressed in 7 organ(s), highest expression level in spleen |
ExpressionAtlasi | Q90WY6 baseline |
Family and domain databases
InterProi | View protein in InterPro IPR002233 ADR_fam IPR000735 ADRA2C_rcpt IPR000276 GPCR_Rhodpsn IPR017452 GPCR_Rhodpsn_7TM |
PANTHERi | PTHR24248:SF25 PTHR24248:SF25, 1 hit |
Pfami | View protein in Pfam PF00001 7tm_1, 1 hit |
PRINTSi | PR01103 ADRENERGICR PR00560 ADRENRGCA2CR PR00237 GPCRRHODOPSN |
SMARTi | View protein in SMART SM01381 7TM_GPCR_Srsx, 1 hit |
PROSITEi | View protein in PROSITE PS00237 G_PROTEIN_RECEP_F1_1, 1 hit PS50262 G_PROTEIN_RECEP_F1_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | ADA2C_DANRE | |
Accessioni | Q90WY6Primary (citable) accession number: Q90WY6 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | June 21, 2005 |
Last sequence update: | December 1, 2001 | |
Last modified: | November 13, 2019 | |
This is version 122 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Complete proteome, Reference proteomeDocuments
- 7-transmembrane G-linked receptors
List of 7-transmembrane G-linked receptor entries - SIMILARITY comments
Index of protein domains and families