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Protein

Insulin-like growth factor-binding protein 5

Gene

igfbp5

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes anterior neural development by stimulating insulin growth factor (IGF) signaling via IGF receptors.Curated1 Publication

GO - Molecular functioni

GO - Biological processi

  • anterior/posterior pattern specification Source: UniProtKB
  • insulin-like growth factor receptor signaling pathway Source: UniProtKB
  • nervous system development Source: UniProtKB
  • regulation of cell growth Source: InterPro

Keywordsi

Molecular functionDevelopmental protein, Growth factor binding

Protein family/group databases

MEROPSiI31.952

Names & Taxonomyi

Protein namesi
Recommended name:
Insulin-like growth factor-binding protein 5
Short name:
IBP-5
Short name:
IGF-binding protein 5
Short name:
IGFBP-5
Short name:
xIGFBP-5
Gene namesi
Name:igfbp5Imported
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Organism-specific databases

XenbaseiXB-GENE-485077 igfbp5

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000022389422 – 265Insulin-like growth factor-binding protein 5Add BLAST244

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi46 ↔ 60PROSITE-ProRule annotation
Disulfide bondi68 ↔ 81PROSITE-ProRule annotation
Disulfide bondi185 ↔ 212PROSITE-ProRule annotationBy similarity
Disulfide bondi223 ↔ 234PROSITE-ProRule annotationBy similarity
Disulfide bondi236 ↔ 256PROSITE-ProRule annotationBy similarity

Keywords - PTMi

Disulfide bond

Expressioni

Developmental stagei

Expressed both maternally and zygotically. Expressed on the dorsal side during gastrulation. Becomes confined to the floor plate, notochord and dorsal endoderm during neurulation. Expressed in additional domains at the tailbud stage in cranial nerves, ear vesicle, dorsal fin and somites. Dorsal midline expression becomes restricted to the floor plate and hypochord.1 Publication

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ90WV8
SMRiQ90WV8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini24 – 104IGFBP N-terminalPROSITE-ProRule annotationAdd BLAST81
Domaini182 – 256Thyroglobulin type-1PROSITE-ProRule annotationAdd BLAST75

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG002631

Family and domain databases

CDDicd00191 TY, 1 hit
Gene3Di4.10.800.10, 1 hit
InterProiView protein in InterPro
IPR009030 Growth_fac_rcpt_cys_sf
IPR012213 IGFBP-5
IPR000867 IGFBP-like
IPR009168 IGFBP1-6
IPR022321 IGFBP_1-6_chordata
IPR017891 Insulin_GF-bd_Cys-rich_CS
IPR000716 Thyroglobulin_1
IPR036857 Thyroglobulin_1_sf
PANTHERiPTHR11551 PTHR11551, 1 hit
PTHR11551:SF4 PTHR11551:SF4, 1 hit
PfamiView protein in Pfam
PF00219 IGFBP, 1 hit
PF00086 Thyroglobulin_1, 1 hit
PRINTSiPR01976 IGFBPFAMILY
PR01981 IGFBPFAMILY5
SMARTiView protein in SMART
SM00121 IB, 1 hit
SM00211 TY, 1 hit
SUPFAMiSSF57184 SSF57184, 1 hit
SSF57610 SSF57610, 1 hit
PROSITEiView protein in PROSITE
PS00222 IGFBP_N_1, 1 hit
PS51323 IGFBP_N_2, 1 hit
PS00484 THYROGLOBULIN_1_1, 1 hit
PS51162 THYROGLOBULIN_1_2, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90WV8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEMLLPMCLL LVSLCLGQCQ ALGSFVHCEP CDDKAMSMCP PTPVGCELVK
60 70 80 90 100
EPGCGCCMTC ALAEGHRCGV YTEHCAKGLR CLPEQGEEKP LHALLHGRGV
110 120 130 140 150
CLNLKNHRDQ SKIDRESREE DPTTSETEDI YQSKHRGKMR LSDQKAIALN
160 170 180 190 200
TFRQKKHSQS RIVSVEKVQS PSTPEHSIEI DMGPCRRQVE TLMQEMKLSH
210 220 230 240 250
RVYPRAFYLP NCDRKGFYKR KQCKPSRGRK RGLCWCVDKY GLKLPGIDYV
260
NGDLQCHSFD SSNTE
Length:265
Mass (Da):29,995
Last modified:December 1, 2001 - v1
Checksum:iE0B943382778A8DA
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY052629 mRNA Translation: AAL12250.1
RefSeqiNP_001083938.1, NM_001090469.1
XP_018089692.1, XM_018234203.1
UniGeneiXl.5266

Genome annotation databases

GeneIDi399201
KEGGixla:399201

Similar proteinsi

Entry informationi

Entry nameiIBP5_XENLA
AccessioniPrimary (citable) accession number: Q90WV8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: December 1, 2001
Last modified: February 28, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

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