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Protein

PAX-interacting protein 1

Gene

paxip1

Organism
Xenopus laevis (African clawed frog)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in DNA damage response. Promotes ubiquitination of PCNA following UV irradiation and may regulate recruitment of polymerase eta and rad51 to chromatin after DNA damage. May function as transcriptional cofactor in TGF beta signaling. Accentuates smad2-dependent transcription.2 Publications

GO - Biological processi

Keywordsi

Biological processDNA damage, DNA repair, Transcription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
PAX-interacting protein 1
Alternative name(s):
PAX transactivation activation domain-interacting protein
SMAD wing for transcriptional activation
Short name:
Protein Swift
Gene namesi
Name:paxip1
ORF Names:K14
OrganismiXenopus laevis (African clawed frog)
Taxonomic identifieri8355 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiAmphibiaBatrachiaAnuraPipoideaPipidaeXenopodinaeXenopusXenopus

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002962651 – 1256PAX-interacting protein 1Add BLAST1256

Proteomic databases

PRIDEiQ90WJ3

Expressioni

Developmental stagei

Maternally expressed, expression declines during gastrulation and continues at a lower level until late stages. Ubiquitously expressed at gastrula stage. Later in development, becomes enriched in the head and brain.1 Publication

Interactioni

Subunit structurei

Interacts with smad2 via its last three BRCT domain-containing regions in an activin signal-dependent manner.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ90WJ3
SMRiQ90WJ3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini8 – 93BRCT 1PROSITE-ProRule annotationAdd BLAST86
Domaini94 – 183BRCT 2PROSITE-ProRule annotationAdd BLAST90
Domaini794 – 883BRCT 3PROSITE-ProRule annotationAdd BLAST90
Domaini890 – 978BRCT 4PROSITE-ProRule annotationAdd BLAST89
Domaini1053 – 1134BRCT 5PROSITE-ProRule annotationAdd BLAST82
Domaini1155 – 1196BRCT 6PROSITE-ProRule annotationAdd BLAST42

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi857 – 874Nuclear localization signalSequence analysisAdd BLAST18

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi189 – 205Glu-richAdd BLAST17
Compositional biasi340 – 779Gln-richAdd BLAST440

Keywords - Domaini

Repeat

Phylogenomic databases

HOVERGENiHBG061191

Family and domain databases

CDDicd00027 BRCT, 5 hits
Gene3Di3.40.50.10190, 6 hits
InterProiView protein in InterPro
IPR001357 BRCT_dom
IPR036420 BRCT_dom_sf
PfamiView protein in Pfam
PF00533 BRCT, 1 hit
PF12738 PTCB-BRCT, 2 hits
PF16770 RTT107_BRCT_5, 1 hit
SMARTiView protein in SMART
SM00292 BRCT, 6 hits
SUPFAMiSSF52113 SSF52113, 5 hits
PROSITEiView protein in PROSITE
PS50172 BRCT, 4 hits

Sequencei

Sequence statusi: Complete.

Q90WJ3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAEDEVKVPE DMFKDVKFYP VGDLDPKVVQ MLKAGKAKEV SYNALATHII
60 70 80 90 100
AEDGDNPEVG EAREVFDLPV VKPSWVILSV RCGVRLPENG FSPESGQIFF
110 120 130 140 150
GVTACLSQVS PDDRNSLWAL TTFYGGDCQL SLNKKCTHLI VPEPKGNKYE
160 170 180 190 200
YAFQRGSIKI VTPDWVLDSV SEKTKKDEAL YHPRLIVYEE EEEEEEEEAE
210 220 230 240 250
NEEQESQNGS DEDKYSSKSS PVTSRDGSPV HNRESSPKRS SSDKIKSELM
260 270 280 290 300
FDDSSDSSPE KQERNLNWTP AEVPQMSTAK RQLHQGAPGS ERPDMMAFRS
310 320 330 340 350
PAVRTLRNIT NSADVQQVNR PSNVAHILQT LSASTKSLEQ RVNHPQQGHP
360 370 380 390 400
NAVLFGQVKP LTSEAQHLIQ QSHQPHHQQQ QQQQNHPIVQ LQPQQLLQLQ
410 420 430 440 450
QQQQQITQQV FPQHQFPQVN QQHPFTQLQF PQQQLHPQQQ LHRPQQQTIQ
460 470 480 490 500
HFQQQHALQQ QLHQLQQQHL QPKPQTLQQN MQQQNLQQPN LQQILQHQQT
510 520 530 540 550
IQQTPSQQQA LQPAIQQQQM LQPNIQQQQT LQSNLQQQTL QPIIQQQQGL
560 570 580 590 600
QQQNLQQSLQ QIQQQMQHLT PQQKQQIQQQ QQQMLQKQQL QSQSLQQQQM
610 620 630 640 650
QTHVLQQQQI QTQALQQQQQ IQNQALQQPQ QNQVQTHALQ QHRLQSQTLQ
660 670 680 690 700
QQHHVQGQTV QQQTHQLQTQ TLQQQHQIQT LQIPHQIPAP NQQHQIPPQM
710 720 730 740 750
LQQQTLQLQQ QMQPQIQQPQ MQSGVQQQSS LQPQQMQQHK HNLQQVQHQL
760 770 780 790 800
QQLQQQRMQQ RQMALPQQIA NQQPPQPHQL HGHDPSVEIP EDFFLLGCVF
810 820 830 840 850
AIADYPEQMP DKQLLATWKR IIQTHGGTVD AALSSRCTHL LCESQVSSMY
860 870 880 890 900
AQALKERKRC ITAHWLNAVL KKKKMVPPYR ALHFPVAFPP GGKPCSQHII
910 920 930 940 950
SVTGFVDSDR DDLKLMGYLA GAKYTGYLCR SNTVLICKEP SGLKYEKAKE
960 970 980 990 1000
WRIPCVNALW LCDILLGNLE ALRQIQHSRY TVFNLQDPLA PSPHLVTDDL
1010 1020 1030 1040 1050
LDAWRMPLKV SSEVLMSIRM PLKPKQNEPA VQPKRPRIED IPPPTKKLSP
1060 1070 1080 1090 1100
DQTPHVIFTG FDPLQVQQYI KKLYILGGEV ADTAQKCTHL VANKVTRTVK
1110 1120 1130 1140 1150
FLTAISVAKH IVTPEWLDES FKSQKFAEEQ NYILRDAEAE VLFCFSLEES
1160 1170 1180 1190 1200
LKKAHVNPLF KGKYFYITPG ICPSLSTMKA IVECAGGKIL TKQPSFRKIM
1210 1220 1230 1240 1250
EHKQNKRLAE IILISCENDL HLCREYFAGS VDVHNAEFVL TGVLTQALDY

ESYKFT
Length:1,256
Mass (Da):144,187
Last modified:December 1, 2001 - v1
Checksum:iE7795B12C1A42DE1
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF172855 mRNA Translation: AAK55123.1
UniGeneiXl.11950

Similar proteinsi

Entry informationi

Entry nameiPAXI1_XENLA
AccessioniPrimary (citable) accession number: Q90WJ3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 24, 2007
Last sequence update: December 1, 2001
Last modified: May 23, 2018
This is version 56 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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