Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Erabutoxin b

Gene
N/A
Organism
Laticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Binds with high affinity to muscular nicotinic acetylcholine receptors (nAChRs), and with low affinity to neuronal alpha-7 nAChRs and inhibit acetylcholine from binding to the receptor, thereby impairing neuromuscular transmission. Binds to T.marmorata nAChR (Kd=0.07 nM) (PubMed:7721859).Produces peripheral paralysis by blocking neuromuscular transmission at the postsynaptic site.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei27Moderately important residue for binding to acetylcholine receptorBy similarity1
Sitei28Very important residue for binding to acetylcholine receptorBy similarity1
Sitei29Key residue for binding to acetylcholine receptorBy similarity1
Sitei30Moderately important residue for binding to acetylcholine receptorBy similarity1
Sitei31Key residue for binding to acetylcholine receptorBy similarity1
Sitei46Moderately important residue for binding to acetylcholine receptorBy similarity1
Sitei48Key residue for binding to acetylcholine receptorBy similarity1
Sitei50Very important residue for binding to acetylcholine receptorBy similarity1
Sitei52Very important residue for binding to acetylcholine receptorBy similarity1
Sitei53Moderately important residue for binding to acetylcholine receptorBy similarity1
Sitei54Key residue for binding to acetylcholine receptorBy similarity1
Sitei55Moderately important residue for binding to acetylcholine receptorBy similarity1
Sitei57Very important residue for binding to acetylcholine receptorBy similarity1
Sitei59Very important residue for binding to acetylcholine receptorBy similarity1
Sitei68Very important residue for binding to acetylcholine receptorBy similarity1

GO - Molecular functioni

Keywordsi

Molecular functionAcetylcholine receptor inhibiting toxin, Ion channel impairing toxin, Neurotoxin, Postsynaptic neurotoxin, Toxin

Names & Taxonomyi

Protein namesi
Recommended name:
Erabutoxin b1 Publication
Short name:
ETXB
Short name:
Eb1 Publication
Alternative name(s):
Short neurotoxin 1b
OrganismiLaticauda semifasciata (Black-banded sea krait) (Pseudolaticauda semifasciata)
Taxonomic identifieri8631 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiLepidosauriaSquamataBifurcataUnidentataEpisquamataToxicoferaSerpentesColubroideaElapidaeLaticaudinaeLaticauda

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 211 PublicationAdd BLAST21
ChainiPRO_000003544722 – 83Erabutoxin b1 PublicationAdd BLAST62

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi24 ↔ 455 PublicationsImported
Disulfide bondi38 ↔ 625 PublicationsImported
Disulfide bondi64 ↔ 755 PublicationsImported
Disulfide bondi76 ↔ 815 PublicationsImported

Keywords - PTMi

Disulfide bond

Expressioni

Tissue specificityi

Expressed by the venom gland.1 Publication

Structurei

Secondary structure

183
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ90VW1
SMRiQ90VW1
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ90VW1

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni24 – 38Loop IBy similarityAdd BLAST15
Regioni39 – 44Stretch between loop I and loop IIBy similarity6
Regioni45 – 62Loop IIBy similarityAdd BLAST18
Regioni64 – 75Loop IIIBy similarityAdd BLAST12

Sequence similaritiesi

Keywords - Domaini

Signal

Phylogenomic databases

HOVERGENiHBG006553

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q90VW1-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTLLLTLVV VTIVCLDLGY TRICFNHQSS QPQTTKTCSP GESSCYHKQW
60 70 80
SDFRGTIIER GCGCPTVKPG IKLSCCESEV CNN
Length:83
Mass (Da):9,160
Last modified:December 1, 2001 - v1
Checksum:iBBB499DA36BE50E4
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural varianti80V → R May be a real difference between the Philippine and Japanese populations. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16950 mRNA Translation: CAA34824.1
AB017929 mRNA Translation: BAA75749.1
AB017930 mRNA Translation: BAA75750.1
AB017931 mRNA Translation: BAA75751.1
AB098528 Genomic DNA Translation: BAC78201.1
AB098529 Genomic DNA Translation: BAC78202.1
PIRiS06931

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X16950 mRNA Translation: CAA34824.1
AB017929 mRNA Translation: BAA75749.1
AB017930 mRNA Translation: BAA75750.1
AB017931 mRNA Translation: BAA75751.1
AB098528 Genomic DNA Translation: BAC78201.1
AB098529 Genomic DNA Translation: BAC78202.1
PIRiS06931

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1ERANMR-A22-83[»]
1FRANMR-A22-83[»]
1NXBX-ray1.38A22-83[»]
3EBXX-ray1.40A22-83[»]
6EBXX-ray1.70A/B22-83[»]
ProteinModelPortaliQ90VW1
SMRiQ90VW1
ModBaseiSearch...
MobiDBiSearch...

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Phylogenomic databases

HOVERGENiHBG006553

Miscellaneous databases

EvolutionaryTraceiQ90VW1

Family and domain databases

CDDicd00206 snake_toxin, 1 hit
InterProiView protein in InterPro
IPR003571 Snake_3FTx
IPR018354 Snake_toxin_con_site
IPR035076 Toxin/TOLIP
PfamiView protein in Pfam
PF00087 Toxin_TOLIP, 1 hit
PROSITEiView protein in PROSITE
PS00272 SNAKE_TOXIN, 1 hit
ProtoNetiSearch...

Entry informationi

Entry namei3S1EB_LATSE
AccessioniPrimary (citable) accession number: Q90VW1
Secondary accession number(s): P01435
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 21, 1986
Last sequence update: December 1, 2001
Last modified: October 10, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
Annotation programAnimal Toxin Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again