UniProtKB - Q90998 (Q90998_CHICK)
Protein
Submitted name:
Transforming growth factor-beta type III receptor
Gene
TGFBR3
Organism
Gallus gallus (Chicken)
Status
Functioni
GO - Molecular functioni
- activin binding Source: AgBase
- coreceptor activity Source: Ensembl
- fibroblast growth factor binding Source: AgBase
- glycosaminoglycan binding Source: BHF-UCL
- heparin binding Source: AgBase
- SMAD binding Source: Ensembl
- transforming growth factor beta-activated receptor activity Source: GO_Central
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor activity, type III Source: BHF-UCL
- transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: GO_Central
GO - Biological processi
- angiogenesis Source: GO_Central
- animal organ regeneration Source: AgBase
- BMP signaling pathway Source: Ensembl
- cardiac epithelial to mesenchymal transition Source: BHF-UCL
- cell growth Source: AgBase
- cell migration Source: BHF-UCL
- embryonic digestive tract development Source: AgBase
- embryonic organ development Source: AgBase
- endothelial cell activation Source: AgBase
- epithelial to mesenchymal transition Source: BHF-UCL
- eye development Source: AgBase
- heart development Source: AgBase
- heart morphogenesis Source: BHF-UCL
- immune response Source: Ensembl
- intracellular signal transduction Source: Ensembl
- kidney development Source: AgBase
- liver development Source: AgBase
- lung development Source: AgBase
- mesenchymal cell differentiation Source: AgBase
- negative regulation of cell adhesion Source: AgBase
- negative regulation of cell-cell adhesion Source: AgBase
- negative regulation of cellular component movement Source: Ensembl
- negative regulation of transforming growth factor beta receptor signaling pathway Source: AgBase
- nervous system development Source: AgBase
- pathway-restricted SMAD protein phosphorylation Source: Ensembl
- positive regulation of cell migration Source: AgBase
- positive regulation of gene expression Source: AgBase
- positive regulation of transforming growth factor beta receptor signaling pathway Source: AgBase
- protein-containing complex assembly Source: AgBase
- regulation of protein binding Source: AgBase
- regulation of transforming growth factor beta receptor signaling pathway Source: GO_Central
- response to follicle-stimulating hormone Source: Ensembl
- response to hypoxia Source: AgBase
- response to luteinizing hormone Source: Ensembl
- response to prostaglandin E Source: Ensembl
- transforming growth factor beta receptor complex assembly Source: AgBase
- transforming growth factor beta receptor signaling pathway Source: GO_Central
- vasculogenesis Source: GO_Central
Keywordsi
Molecular function | ReceptorImported |
Names & Taxonomyi
Protein namesi | Submitted name: Transforming growth factor-beta type III receptorImported |
Gene namesi | Name:TGFBR3Imported |
Organismi | Gallus gallus (Chicken)Imported |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Extracellular region or secreted
- extracellular matrix Source: AgBase
- extracellular space Source: AgBase
Plasma Membrane
- external side of plasma membrane Source: Ensembl
- inhibin-betaglycan-ActRII complex Source: Ensembl
- integral component of plasma membrane Source: BHF-UCL
Other locations
- cell surface Source: GO_Central
- cytoplasm Source: AgBase
- integral component of membrane Source: AgBase
- membrane Source: AgBase
- receptor complex Source: AgBase
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Transmembranei | 775 – 799 | HelicalSequence analysisAdd BLAST | 25 |
Keywords - Cellular componenti
Membrane, SecretedARBA annotationPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Signal peptidei | 1 – 20 | Sequence analysisAdd BLAST | 20 | |
ChainiPRO_5014312419 | 21 – 841 | Sequence analysisAdd BLAST | 821 |
Expressioni
Gene expression databases
Bgeei | ENSGALG00000006038, Expressed in spleen and 13 other tissues |
Interactioni
Binary interactionsi
Q90998
With | #Exp. | IntAct |
---|---|---|
TGFB1 [P01137] from Homo sapiens. | 2 | EBI-6620843,EBI-779636 |
GO - Molecular functioni
- fibroblast growth factor binding Source: AgBase
- SMAD binding Source: Ensembl
- transforming growth factor beta binding Source: BHF-UCL
- transforming growth factor beta receptor binding Source: AgBase
- type II transforming growth factor beta receptor binding Source: GO_Central
Protein-protein interaction databases
IntActi | Q90998, 1 interactor |
STRINGi | 9031.ENSGALP00000032713 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 446 – 723 | ZPInterPro annotationAdd BLAST | 278 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 521 – 543 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 807 – 841 | DisorderedSequence analysisAdd BLAST | 35 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 525 – 539 | AcidicSequence analysisAdd BLAST | 15 | |
Compositional biasi | 813 – 841 | PolarSequence analysisAdd BLAST | 29 |
Keywords - Domaini
SignalSequence analysis, Transmembrane, Transmembrane helixSequence analysisPhylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
GeneTreei | ENSGT00530000063861 |
HOGENOMi | CLU_018613_0_0_1 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
TreeFami | TF337375 |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All
Q90998-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSSCVTPVF ALMILCFADA GPVPRSECVL SPVNSSHPVH ALLESFTVLS
60 70 80 90 100
GCASRGTTGL PQEVHVLNLR NPDEGLDHHE REVTLHLTPI SSVHIHQKPL
110 120 130 140 150
VFLLNSPLPL VWKLKTERLA PGIRRVFFVS SGSIVWFEKG NFSLSAETEE
160 170 180 190 200
KNFPERNEHL LQWAQKEYGA VTSFTELKIS RNIYIKVGED QVFPPTCNIE
210 220 230 240 250
KNFLSLNYLA GYLQPKRAEG CLMSNLVQER EVHIIELITP NSNPYSAFQV
260 270 280 290 300
DIIVDIKPSQ PGAKLERNVV LILKCKKSVN WVIKSHDVQG KLEVITSNSI
310 320 330 340 350
GFGKETERSM TMSKSVIPDI PSSHESLIKW AYEHKYSPVT SYTKAPVANR
360 370 380 390 400
FHLQLEHTEE MNDEEDHSLP PELTELLHGA KNPALSDGLT FPFHINRGGH
410 420 430 440 450
ETGGEGIFPS RDSVDTLINH DFEHSLSKHK EPEEVQGSAD VALSIKCDDK
460 470 480 490 500
VMTVAVEKDS LQASGYTRTE LSLLDHSCKA RMNGTHFILE SLPNKCGTRT
510 520 530 540 550
SYILDKIVYF NSIVIQLSSP AEGSSFDDDD MESGDNGFPG DADEGDVTFS
560 570 580 590 600
NWPEIAFNCT LHQPEKDFFN PAMFWPPEPH ITNVTFNMEL YKTDLFLAPS
610 620 630 640 650
QGLFSVAENG PIYVEVSVTK ADISLGFAIQ TCFVSPFSNP DRMSDYTIIE
660 670 680 690 700
NICPKDESVK FYSTEKLNFP IAHAQKDKKR FSFVFKPIFN ISLLFLHCEL
710 720 730 740 750
TLCTNIDKDT QRLPKCVPPD EACTSLNVDM ILAMMHNKKT FTKPLVITHE
760 770 780 790 800
GKPEDSSLPK SNVRQPSVFY GLDTLTVVGI AFAAFVIGAL LTGALWFIYS
810 820 830 840
HTGEAAGRRQ VPTSPPASEN SSAAHSIGST QSTPCSSSSA T
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketA0A1D5NU81 | A0A1D5NU81_CHICK | ZP domain-containing protein | TGFBR3 | 820 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000647 Genomic DNA No translation available. L01121 mRNA Translation: AAA49090.1 |
PIRi | I50428 |
RefSeqi | NP_989670.1, NM_204339.1 |
Genome annotation databases
Ensembli | ENSGALT00000033354; ENSGALP00000032713; ENSGALG00000006038 |
GeneIDi | 374251 |
KEGGi | gga:374251 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AADN05000647 Genomic DNA No translation available. L01121 mRNA Translation: AAA49090.1 |
PIRi | I50428 |
RefSeqi | NP_989670.1, NM_204339.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
IntActi | Q90998, 1 interactor |
STRINGi | 9031.ENSGALP00000032713 |
Genome annotation databases
Ensembli | ENSGALT00000033354; ENSGALP00000032713; ENSGALG00000006038 |
GeneIDi | 374251 |
KEGGi | gga:374251 |
Organism-specific databases
CTDi | 7049 |
Phylogenomic databases
eggNOGi | ENOG502QWNZ, Eukaryota |
GeneTreei | ENSGT00530000063861 |
HOGENOMi | CLU_018613_0_0_1 |
OMAi | FRSPCEL |
OrthoDBi | 1263397at2759 |
TreeFami | TF337375 |
Gene expression databases
Bgeei | ENSGALG00000006038, Expressed in spleen and 13 other tissues |
Family and domain databases
InterProi | View protein in InterPro IPR001507, ZP_dom IPR017977, ZP_dom_CS |
Pfami | View protein in Pfam PF00100, Zona_pellucida, 1 hit |
PRINTSi | PR00023, ZPELLUCIDA |
SMARTi | View protein in SMART SM00241, ZP, 1 hit |
PROSITEi | View protein in PROSITE PS00682, ZP_1, 1 hit PS51034, ZP_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q90998_CHICK | |
Accessioni | Q90998Primary (citable) accession number: Q90998 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | November 1, 1996 |
Last sequence update: | November 1, 1996 | |
Last modified: | December 2, 2020 | |
This is version 139 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |