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Entry version 121 (03 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Alternatively spliced tenascin 190, 200 and 230 kd variants

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Caution

Lacks conserved residue(s) required for the propagation of feature annotation.PROSITE-ProRule annotation

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Alternatively spliced tenascin 190, 200 and 230 kd variantsImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiArchelosauriaArchosauriaDinosauriaSaurischiaTheropodaCoelurosauriaAvesNeognathaeGalloanseraeGalliformesPhasianidaePhasianinaeGallus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 22Sequence analysisAdd BLAST22
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500432069323 – 1532Sequence analysisAdd BLAST1510

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi192 ↔ 202PROSITE-ProRule annotation
Disulfide bondi209 ↔ 218PROSITE-ProRule annotation
Disulfide bondi285 ↔ 295PROSITE-ProRule annotation
Disulfide bondi302 ↔ 311PROSITE-ProRule annotation
Disulfide bondi378 ↔ 388PROSITE-ProRule annotation
Disulfide bondi395 ↔ 404PROSITE-ProRule annotation
Disulfide bondi440 ↔ 450PROSITE-ProRule annotation
Disulfide bondi457 ↔ 466PROSITE-ProRule annotation
Disulfide bondi533 ↔ 543PROSITE-ProRule annotation
Disulfide bondi550 ↔ 559PROSITE-ProRule annotation

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Disulfide bondPROSITE-ProRule annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini188 – 219EGF-likeInterPro annotationAdd BLAST32
Domaini281 – 312EGF-likeInterPro annotationAdd BLAST32
Domaini374 – 405EGF-likeInterPro annotationAdd BLAST32
Domaini436 – 467EGF-likeInterPro annotationAdd BLAST32
Domaini529 – 560EGF-likeInterPro annotationAdd BLAST32
Domaini595 – 685Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini686 – 775Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini776 – 866Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini867 – 957Fibronectin type-IIIInterPro annotationAdd BLAST91
Domaini958 – 1041Fibronectin type-IIIInterPro annotationAdd BLAST84
Domaini1043 – 1132Fibronectin type-IIIInterPro annotationAdd BLAST90
Domaini1133 – 1219Fibronectin type-IIIInterPro annotationAdd BLAST87
Domaini1220 – 1308Fibronectin type-IIIInterPro annotationAdd BLAST89
Domaini1306 – 1521Fibrinogen C-terminalInterPro annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and domains’ section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili119 – 139Sequence analysisAdd BLAST21

Keywords - Domaini

Coiled coilSequence analysis, EGF-like domainPROSITE-ProRule annotation, SignalSequence analysis

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234355

Family and domain databases

Conserved Domains Database

More...
CDDi
cd00063 FN3, 8 hits
cd00087 FReD, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 8 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07974 EGF_2, 3 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 8 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00181 EGF, 13 hits
SM00186 FBG, 1 hit
SM00060 FN3, 8 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 8 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90994-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGLPSQVLAC AILGLLYQHA SGGLIKRIIR QKRETGLNVT LPEDNQPVVF
60 70 80 90 100
NHVYNIKLPV GSLCSVDLDT ASGDADLKAE IEPVKNYEEH TVNEGNQIVF
110 120 130 140 150
THRINIPRRA CGCAAAPDIK DLLSRLEELE GLVSSLREQC ASGAGCCPNS
160 170 180 190 200
QTAEGRLDTA PYCSGHGNYS TEICGCVCEP GWKGPNCSEP ACPRNCLNRG
210 220 230 240 250
LCVRGKCICE EGFTGEDCSQ AACPSDCNDQ GKCVDGVCVC FEGYTGPDCG
260 270 280 290 300
EELCPHGCGI HGRCVGGRCV CHEGFTGEDC NEPLCPNNCH NRGRCVDNEC
310 320 330 340 350
VCDEGYTGED CGELICPNDC FDRGRCINGT CFCEEGYTGE DCGELTCPNN
360 370 380 390 400
CNGNGRCENG LCVCHEGFVG DDCSQKRCPK DCNNRGHCVD GRCVCHEGYL
410 420 430 440 450
GEDCGELRCP NDCHNRGRCI NGQCVCDEGF IGEDCGELRC PNDCHNRGRC
460 470 480 490 500
VNGQCECHEG FIGEDCGELR CPNDCNSHGR CVNGQCVCDE GYTGEDCGEL
510 520 530 540 550
RCPNDCHNRG RCVEGRCVCD NGFMGEDCGE LSCPNDCHQH GRCVDGRCVC
560 570 580 590 600
HEGFTGEDCR ERSCPNDCNN VGRCVEGRCV CEEGYMGIDC SDVSPPTELT
610 620 630 640 650
VTNVTDKTVN LEWKHENLVN EYLVTYVPTS SGGLDLQFTV PGNQTSATIH
660 670 680 690 700
ELEPGVEYFI RVFAILKNKK SIPVSARVAT YLPAPEGLKF KSVRETSVQV
710 720 730 740 750
EWDPLSISFD GWELVFRNMQ KKDDNGDITS SLKRPETSYM QPGLAPGQQY
760 770 780 790 800
NVSLHIVKNN TRGPGLSRVI TTKLDAPSQI EAKDVTDTTA LITWSKPLAE
810 820 830 840 850
IEGIELTYGP KDVPGDRTTI DLSEDENQYS IGNLRPHTEY EVTLISRRGD
860 870 880 890 900
MESDPAKEVF VTDLDAPRNL KRVSQTDNSI TLEWKNSHAN IDNYRIKFAP
910 920 930 940 950
ISGGDHTELT VPKGNQATTR ATLTGLRPGT EYGIGVTAVR QDRESAPATI
960 970 980 990 1000
NAGTDLDNPK DLEVSDPTET TLSLRWRRPV AKFDRYRLTY VSPSGKKNEM
1010 1020 1030 1040 1050
EIPVDSTSFI LRGLDAGTEY TISLVAEKGR HKSKPTTIKG STAPKGISFS
1060 1070 1080 1090 1100
DITENSATVS WTPPRSRVDS YRVSYVPITG GTPNVVTVDG SKTRTKLVKL
1110 1120 1130 1140 1150
VPGVDYNVNI ISVKGFEESE PISGILKTAL DSPSGLVVMN ITDSEALATW
1160 1170 1180 1190 1200
QPAIAAVDNY IVSYSSEDEP EVTQMVSGNT VEYDLNGLRP ATEYTLRVHA
1210 1220 1230 1240 1250
VKDAQKSETL STQFTTGLDA PKDLSATEVQ SETAVITWRP PRAPVTDYLL
1260 1270 1280 1290 1300
TYESIDGRVK EVILDPETTS YTLTELSPST QYTVKLQALS RSMRSKMIQT
1310 1320 1330 1340 1350
VFTTTGLLYP YPKDCSQALL NGEVTSGLYT IYLNGDRTQP LQVFCDMAED
1360 1370 1380 1390 1400
GGGWIVFLRR QNGKEDFYRN WKNYVAGFGD PKDEFWIGLE NLHKISSQGQ
1410 1420 1430 1440 1450
YELRVDLRDR GETAYAVYDK FSVGDAKTRY RLRVDGYSGT AGDSMTYHNG
1460 1470 1480 1490 1500
RSFSTFDKDN DSAITNCALS YKGAFWYKNC HRVNLMGRYG DNNHSQGVNW
1510 1520 1530
FHWKGHEYSI QFAEMKLRPS SFRNLEGRRK RA
Length:1,532
Mass (Da):168,633
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1E62E9ED8AFC3ACB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
M23121 mRNA Translation: AAA49085.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
M23121 mRNA Translation: AAA49085.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Phylogenomic databases

HOGENOMiHOG000234355

Family and domain databases

CDDicd00063 FN3, 8 hits
cd00087 FReD, 1 hit
Gene3Di2.60.40.10, 8 hits
InterProiView protein in InterPro
IPR013032 EGF-like_CS
IPR000742 EGF-like_dom
IPR013111 EGF_extracell
IPR041161 EGF_Tenascin
IPR036056 Fibrinogen-like_C
IPR002181 Fibrinogen_a/b/g_C_dom
IPR003961 FN3_dom
IPR036116 FN3_sf
IPR013783 Ig-like_fold
PfamiView protein in Pfam
PF07974 EGF_2, 3 hits
PF18720 EGF_Tenascin, 9 hits
PF00147 Fibrinogen_C, 1 hit
PF00041 fn3, 8 hits
SMARTiView protein in SMART
SM00181 EGF, 13 hits
SM00186 FBG, 1 hit
SM00060 FN3, 8 hits
SUPFAMiSSF49265 SSF49265, 5 hits
SSF56496 SSF56496, 1 hit
PROSITEiView protein in PROSITE
PS00022 EGF_1, 4 hits
PS01186 EGF_2, 4 hits
PS50026 EGF_3, 5 hits
PS51406 FIBRINOGEN_C_2, 1 hit
PS50853 FN3, 8 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ90994_CHICK
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90994
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 3, 2019
This is version 121 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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