UniProtKB - Q90980 (CNG3_CHICK)
Protein
Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Functioni
Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Binding sitei | 498 | cAMPSequence analysis | 1 | |
Binding sitei | 513 | cAMPSequence analysis | 1 |
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Nucleotide bindingi | 439 – 561 | cAMPBy similarityAdd BLAST | 123 |
GO - Molecular functioni
- cAMP binding Source: UniProtKB-KW
- cGMP binding Source: GO_Central
- intracellular cAMP-activated cation channel activity Source: GO_Central
- intracellular cGMP-activated cation channel activity Source: GO_Central
GO - Biological processi
- response to stimulus Source: UniProtKB-KW
- visual perception Source: UniProtKB-KW
Keywordsi
Molecular function | Ion channel, Ligand-gated ion channel |
Biological process | Ion transport, Sensory transduction, Transport, Vision |
Ligand | cAMP, cAMP-binding, Nucleotide-binding |
Enzyme and pathway databases
Reactomei | R-GGA-2485179, Activation of the phototransduction cascade R-GGA-2514859, Inactivation, recovery and regulation of the phototransduction cascade |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclic nucleotide-gated channel rod photoreceptor subunit alphaAlternative name(s): CNG channel 3 Short name: CNG-3 Short name: CNG3 |
Organismi | Gallus gallus (Chicken) |
Taxonomic identifieri | 9031 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus |
Proteomesi |
|
Subcellular locationi
Other locations
Plasma Membrane
- photoreceptor outer segment membrane Source: Ensembl
Other locations
- integral component of membrane Source: UniProtKB-KW
Topology
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Topological domaini | 1 – 117 | CytoplasmicSequence analysisAdd BLAST | 117 | |
Transmembranei | 118 – 137 | Helical; Name=H1Sequence analysisAdd BLAST | 20 | |
Topological domaini | 138 – 150 | ExtracellularSequence analysisAdd BLAST | 13 | |
Transmembranei | 151 – 169 | Helical; Name=H2Sequence analysisAdd BLAST | 19 | |
Topological domaini | 170 – 193 | CytoplasmicSequence analysisAdd BLAST | 24 | |
Transmembranei | 194 – 213 | Helical; Name=H3Sequence analysisAdd BLAST | 20 | |
Topological domaini | 214 – 251 | ExtracellularSequence analysisAdd BLAST | 38 | |
Transmembranei | 252 – 274 | Helical; Name=H4Sequence analysisAdd BLAST | 23 | |
Topological domaini | 275 – 326 | CytoplasmicSequence analysisAdd BLAST | 52 | |
Transmembranei | 327 – 346 | Helical; Name=H5Sequence analysisAdd BLAST | 20 | |
Topological domaini | 347 – 430 | ExtracellularSequence analysisAdd BLAST | 84 | |
Transmembranei | 431 – 451 | Helical; Name=H6Sequence analysisAdd BLAST | 21 | |
Topological domaini | 452 – 645 | CytoplasmicSequence analysisAdd BLAST | 194 |
Keywords - Cellular componenti
MembranePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000219325 | 1 – 645 | Cyclic nucleotide-gated channel rod photoreceptor subunit alphaAdd BLAST | 645 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Glycosylationi | 377 | N-linked (GlcNAc...) asparagineSequence analysis | 1 |
Keywords - PTMi
GlycoproteinProteomic databases
PaxDbi | Q90980 |
Family & Domainsi
Sequence similaritiesi
Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Curated
Keywords - Domaini
Transmembrane, Transmembrane helixPhylogenomic databases
eggNOGi | KOG0500, Eukaryota |
GeneTreei | ENSGT00940000156074 |
HOGENOMi | CLU_005746_12_0_1 |
InParanoidi | Q90980 |
OMAi | YWLIFDY |
OrthoDBi | 1073751at2759 |
PhylomeDBi | Q90980 |
TreeFami | TF319048 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 1.20.120.350, 1 hit 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032406, CLZ_dom IPR032945, CNGA1 IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR014710, RmlC-like_jellyroll IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45638:SF9, PTHR45638:SF9, 1 hit |
Pfami | View protein in Pfam PF16526, CLZ, 1 hit PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q90980-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKVGVIETHH SHPIIPSVVV QDTSEDPGLI EKGENRFARQ WYLPGAFAQY
60 70 80 90 100
NINNNSNKDE EKKKKKEKKS KSENKKDGER QKNKEKKEKH KNKDKKKGKE
110 120 130 140 150
EEKKKDIFII DPAGNMYYNW LFCITMPVMY NWTMIIARAC FDELQNDYLA
160 170 180 190 200
VWFIVDYVSD VIYIADMFVR TRTGYLEQGL LVKEEQKLKE KYKSSLQFKL
210 220 230 240 250
DFLSIIPTDL LYFKLGLNYP ELRINRLLRV ARMFEFFQRT ETRTNYPNIF
260 270 280 290 300
RISNLVMYIV IIIHWNACVY YSISKAIGFG ADTWVYPNTS HPEFARLTRK
310 320 330 340 350
YVYSLYWSTL TLTTIGETPP PVRDSEYFFV VVDFLVGVLI FATIVGNVGS
360 370 380 390 400
MISNMNAARA EFQAKIDAIK QYMHFRNVSK DMEKRVIKWF DYLWTNKKAV
410 420 430 440 450
DEREVLKYLP DKLRAEIAIN VHLETLKKVR IFADCEAGLL VELVLKLQPQ
460 470 480 490 500
VYSPGDYICR KGDIGREMYI IKEGKLAVVA DDGVTQFVVL SDGSYFGEIS
510 520 530 540 550
ILNIKGSKAG NRRTANIRSI GYSDLFCLSK DDLMEALTEY PDAKAMLEEK
560 570 580 590 600
GKQILMKDGL LDIEVANLGS DPKDLEEKVA YMEGSMDRLQ TKFARLLAEY
610 620 630 640
DAAQQKLKKR LTQIEKILKP VMEQEFLDFE EADPPTDKPG VTKTE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89599 mRNA Translation: CAA61758.1 |
PIRi | I50680 |
RefSeqi | NP_990551.1, NM_205220.2 |
Genome annotation databases
Ensembli | ENSGALT00000022870; ENSGALP00000022830; ENSGALG00000014136 |
GeneIDi | 396143 |
KEGGi | gga:396143 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | X89599 mRNA Translation: CAA61758.1 |
PIRi | I50680 |
RefSeqi | NP_990551.1, NM_205220.2 |
3D structure databases
SMRi | Q90980 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 9031.ENSGALP00000022830 |
Proteomic databases
PaxDbi | Q90980 |
Genome annotation databases
Ensembli | ENSGALT00000022870; ENSGALP00000022830; ENSGALG00000014136 |
GeneIDi | 396143 |
KEGGi | gga:396143 |
Organism-specific databases
CTDi | 1259 |
Phylogenomic databases
eggNOGi | KOG0500, Eukaryota |
GeneTreei | ENSGT00940000156074 |
HOGENOMi | CLU_005746_12_0_1 |
InParanoidi | Q90980 |
OMAi | YWLIFDY |
OrthoDBi | 1073751at2759 |
PhylomeDBi | Q90980 |
TreeFami | TF319048 |
Enzyme and pathway databases
Reactomei | R-GGA-2485179, Activation of the phototransduction cascade R-GGA-2514859, Inactivation, recovery and regulation of the phototransduction cascade |
Miscellaneous databases
PROi | PR:Q90980 |
Family and domain databases
CDDi | cd00038, CAP_ED, 1 hit |
Gene3Di | 1.20.120.350, 1 hit 2.60.120.10, 1 hit |
InterProi | View protein in InterPro IPR032406, CLZ_dom IPR032945, CNGA1 IPR018490, cNMP-bd-like IPR018488, cNMP-bd_CS IPR000595, cNMP-bd_dom IPR005821, Ion_trans_dom IPR014710, RmlC-like_jellyroll IPR027359, Volt_channel_dom_sf |
PANTHERi | PTHR45638:SF9, PTHR45638:SF9, 1 hit |
Pfami | View protein in Pfam PF16526, CLZ, 1 hit PF00027, cNMP_binding, 1 hit PF00520, Ion_trans, 1 hit |
SMARTi | View protein in SMART SM00100, cNMP, 1 hit |
SUPFAMi | SSF51206, SSF51206, 1 hit |
PROSITEi | View protein in PROSITE PS00888, CNMP_BINDING_1, 1 hit PS00889, CNMP_BINDING_2, 1 hit PS50042, CNMP_BINDING_3, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CNG3_CHICK | |
Accessioni | Q90980Primary (citable) accession number: Q90980 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 1, 1997 |
Last sequence update: | November 1, 1997 | |
Last modified: | December 2, 2020 | |
This is version 130 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families