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UniProtKB - Q90980 (CNG3_CHICK)

Entry version 130 (02 Dec 2020)
Sequence version 1 (01 Nov 1997)
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Protein

Cyclic nucleotide-gated channel rod photoreceptor subunit alpha

Gene
N/A
Organism
Gallus gallus (Chicken)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Visual signal transduction is mediated by a G-protein coupled cascade using cGMP as second messenger. This protein can be activated by cGMP which leads to an opening of the cation channel and thereby causing a depolarization of rod photoreceptors.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the interaction between a single amino acid and another chemical entity. Priority is given to the annotation of physiological ligands.<p><a href='/help/binding' target='_top'>More...</a></p>Binding sitei498cAMPSequence analysis1
Binding sitei513cAMPSequence analysis1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi439 – 561cAMPBy similarityAdd BLAST123

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionIon channel, Ligand-gated ion channel
Biological processIon transport, Sensory transduction, Transport, Vision
LigandcAMP, cAMP-binding, Nucleotide-binding

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...Reactomei		R-GGA-2485179, Activation of the phototransduction cascade
R-GGA-2514859, Inactivation, recovery and regulation of the phototransduction cascade

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Cyclic nucleotide-gated channel rod photoreceptor subunit alpha
Alternative name(s):
CNG channel 3
Short name:
CNG-3
Short name:
CNG3
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiGallus gallus (Chicken)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9031 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Archelosauria › Archosauria › Dinosauria › Saurischia › Theropoda › Coelurosauria › Aves › Neognathae › Galloanserae › Galliformes › Phasianidae › Phasianinae › Gallus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000539 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 117CytoplasmicSequence analysisAdd BLAST117
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei118 – 137Helical; Name=H1Sequence analysisAdd BLAST20
Topological domaini138 – 150ExtracellularSequence analysisAdd BLAST13
Transmembranei151 – 169Helical; Name=H2Sequence analysisAdd BLAST19
Topological domaini170 – 193CytoplasmicSequence analysisAdd BLAST24
Transmembranei194 – 213Helical; Name=H3Sequence analysisAdd BLAST20
Topological domaini214 – 251ExtracellularSequence analysisAdd BLAST38
Transmembranei252 – 274Helical; Name=H4Sequence analysisAdd BLAST23
Topological domaini275 – 326CytoplasmicSequence analysisAdd BLAST52
Transmembranei327 – 346Helical; Name=H5Sequence analysisAdd BLAST20
Topological domaini347 – 430ExtracellularSequence analysisAdd BLAST84
Transmembranei431 – 451Helical; Name=H6Sequence analysisAdd BLAST21
Topological domaini452 – 645CytoplasmicSequence analysisAdd BLAST194

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002193251 – 645Cyclic nucleotide-gated channel rod photoreceptor subunit alphaAdd BLAST645

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi377N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q90980

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		9031.ENSGALP00000022830

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q90980

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the cyclic nucleotide-gated cation channel (TC 1.A.1.5) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG0500, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00940000156074

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_005746_12_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q90980

Identification of Orthologs from Complete Genome Data

More...OMAi		YWLIFDY

Database of Orthologous Groups

More...OrthoDBi		1073751at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q90980

TreeFam database of animal gene trees

More...TreeFami		TF319048

Family and domain databases

Conserved Domains Database

More...CDDi		cd00038, CAP_ED, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.20.120.350, 1 hit
2.60.120.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR032406, CLZ_dom
IPR032945, CNGA1
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR014710, RmlC-like_jellyroll
IPR027359, Volt_channel_dom_sf

The PANTHER Classification System

More...PANTHERi		PTHR45638:SF9, PTHR45638:SF9, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF16526, CLZ, 1 hit
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00100, cNMP, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF51206, SSF51206, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00888, CNMP_BINDING_1, 1 hit
PS00889, CNMP_BINDING_2, 1 hit
PS50042, CNMP_BINDING_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q90980-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKVGVIETHH SHPIIPSVVV QDTSEDPGLI EKGENRFARQ WYLPGAFAQY 
        60         70         80         90        100
NINNNSNKDE EKKKKKEKKS KSENKKDGER QKNKEKKEKH KNKDKKKGKE 
       110        120        130        140        150
EEKKKDIFII DPAGNMYYNW LFCITMPVMY NWTMIIARAC FDELQNDYLA 
       160        170        180        190        200
VWFIVDYVSD VIYIADMFVR TRTGYLEQGL LVKEEQKLKE KYKSSLQFKL 
       210        220        230        240        250
DFLSIIPTDL LYFKLGLNYP ELRINRLLRV ARMFEFFQRT ETRTNYPNIF 
       260        270        280        290        300
RISNLVMYIV IIIHWNACVY YSISKAIGFG ADTWVYPNTS HPEFARLTRK 
       310        320        330        340        350
YVYSLYWSTL TLTTIGETPP PVRDSEYFFV VVDFLVGVLI FATIVGNVGS 
       360        370        380        390        400
MISNMNAARA EFQAKIDAIK QYMHFRNVSK DMEKRVIKWF DYLWTNKKAV 
       410        420        430        440        450
DEREVLKYLP DKLRAEIAIN VHLETLKKVR IFADCEAGLL VELVLKLQPQ 
       460        470        480        490        500
VYSPGDYICR KGDIGREMYI IKEGKLAVVA DDGVTQFVVL SDGSYFGEIS 
       510        520        530        540        550
ILNIKGSKAG NRRTANIRSI GYSDLFCLSK DDLMEALTEY PDAKAMLEEK 
       560        570        580        590        600
GKQILMKDGL LDIEVANLGS DPKDLEEKVA YMEGSMDRLQ TKFARLLAEY 
       610        620        630        640 
DAAQQKLKKR LTQIEKILKP VMEQEFLDFE EADPPTDKPG VTKTE
Length:645
Mass (Da):74,779
Last modified:November 1, 1997 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i989D515F61AC7D31
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
X89599 mRNA Translation: CAA61758.1

Protein sequence database of the Protein Information Resource

More...PIRi		I50680

NCBI Reference Sequences

More...RefSeqi		NP_990551.1, NM_205220.2

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENSGALT00000022870; ENSGALP00000022830; ENSGALG00000014136

Database of genes from NCBI RefSeq genomes

More...GeneIDi		396143

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		gga:396143

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X89599 mRNA Translation: CAA61758.1
PIRiI50680
RefSeqiNP_990551.1, NM_205220.2

3D structure databases

SMRiQ90980
ModBaseiSearch...

Protein-protein interaction databases

STRINGi9031.ENSGALP00000022830

Proteomic databases

PaxDbiQ90980

Genome annotation databases

EnsembliENSGALT00000022870; ENSGALP00000022830; ENSGALG00000014136
GeneIDi396143
KEGGigga:396143

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		1259

Phylogenomic databases

eggNOGiKOG0500, Eukaryota
GeneTreeiENSGT00940000156074
HOGENOMiCLU_005746_12_0_1
InParanoidiQ90980
OMAiYWLIFDY
OrthoDBi1073751at2759
PhylomeDBiQ90980
TreeFamiTF319048

Enzyme and pathway databases

ReactomeiR-GGA-2485179, Activation of the phototransduction cascade
R-GGA-2514859, Inactivation, recovery and regulation of the phototransduction cascade

Miscellaneous databases

Protein Ontology

More...PROi		PR:Q90980

Family and domain databases

CDDicd00038, CAP_ED, 1 hit
Gene3Di1.20.120.350, 1 hit
2.60.120.10, 1 hit
InterProiView protein in InterPro
IPR032406, CLZ_dom
IPR032945, CNGA1
IPR018490, cNMP-bd-like
IPR018488, cNMP-bd_CS
IPR000595, cNMP-bd_dom
IPR005821, Ion_trans_dom
IPR014710, RmlC-like_jellyroll
IPR027359, Volt_channel_dom_sf
PANTHERiPTHR45638:SF9, PTHR45638:SF9, 1 hit
PfamiView protein in Pfam
PF16526, CLZ, 1 hit
PF00027, cNMP_binding, 1 hit
PF00520, Ion_trans, 1 hit
SMARTiView protein in SMART
SM00100, cNMP, 1 hit
SUPFAMiSSF51206, SSF51206, 1 hit
PROSITEiView protein in PROSITE
PS00888, CNMP_BINDING_1, 1 hit
PS00889, CNMP_BINDING_2, 1 hit
PS50042, CNMP_BINDING_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCNG3_CHICK
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q90980
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: December 2, 2020
This is version 130 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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